Search clinical trials for: Single arm

Total 18964 results

BioMarin Pharmaceutical

Completed

Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients at a Dose of 4E13 vg/kg (GENEr8-2)

Hemophilia A

United States
UroGen Pharma Ltd.

Active, not recruiting

A Phase 3 Single-Arm Study of UGN-102 for Treatment of Low Grade Intermediate Risk Non-Muscle-Invasive Bladder Cancer (ENVISION)

Bladder Cancer | Urothelial Carcinoma Bladder | Urothelial Carcinoma

United States, Spain, Lithuania, Georgia, Bulgaria, Estonia, Latvia, Poland, Serbia, Austria
The Second Affiliated Hospital of Fujian Medical...

Active, not recruiting

Efficacy and Safety of SOX Regimen Combined With Camrelizumab as Neoadjuvant Treatment in Locally Advanced Gastric Cancer: a Phase II, Single-arm Study

Digestive System Diseases | Neoplasms | Neoplasms by Site | Stomach Neoplasms | Digestive System Neoplasms | Stomach Diseases

China
Sichuan Cancer Hospital and Research Institute

Active, not recruiting

PD-1 Inhibitors Plus Chemoradiotherapy for Metastatic Nasopharyngeal Carcinoma: an Open-label Single-arm, Phase II Trial

Nasopharyngeal Carcinoma | Chemoradiotherapy | PD-1 Inhibitors

China
University of Florida
Live Like Bella Pediatric Cancer Research

Completed

Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

Common Variable Immunodeficiency | Severe Combined Immunodeficiency | Sickle Cell Disease | Hurler Syndrome | Chronic Granulomatous Disease | Thalassemia | Wiskott-Aldrich Syndrome | Adrenoleukodystrophy | X-linked Lymphoproliferative Disease | Diamond Blackfan Anemia | Bone Marrow Failure Syndrome | Hemophagocytic... and other conditions

United States
Swiss Group for Clinical Cancer Research

Active, not recruiting

Thoracic Radiotherapy Plus Maintenance Durvalumab After First Line Carboplatin and Etoposide Plus Durvalumab in Extensive-stage Disease Small Cell Lung Cancer (ED-SCLC).

Small Cell Lung Cancer | Lung Cancer

Switzerland
Milton S. Hershey Medical Center

Completed

Single-center, Double-arm, Prospective Clinical Trial to Compare Visual Performance of Non-diffractive Extended Vision and Neutral Aspheric Monofocal Intraocular Lenses

Cataract | Presbyopia

United States
AstraZeneca
Parexel

Completed

A Study of Adavosertib as Treatment for Uterine Serous Carcinoma (ADAGIO)

Uterine Serous Carcinoma

United States, Italy, Spain, France, Canada
Dartmouth-Hitchcock Medical Center
National Cancer Institute (NCI)

Completed

A Single Arm Pilot Study to Refine a Novel Approach to Exercise Promotion Based on Affect-regulation

Breast Cancer

United States
M.D. Anderson Cancer Center

Terminated

Single-arm Study With Bimiralisib in Patients With HNSCC Harboring NOTCH1 Loss of Function Mutations (HNSCC)

HNSCC

United States
Fujian Cancer Hospital

Enrolling by invitation

An Exploratory Single-arm Study: PD-1 With Recombinant Human Adenovirus Type 5 Injection for Malignant Melanomas

Malignant Melanomas

China
QED Therapeutics, Inc.
Helsinn Healthcare SA

Terminated

A Phase II, Single Arm Study of BGJ398 in Patients With Advanced Cholangiocarcinoma

FGFR2 Gene Mutation | Advanced Cholangiocarcinoma

United States, Belgium, Germany, Italy, Korea, Republic of, Russian Federation, Singapore, Spain, Taiwan, Thailand, United Kingdom
Celgene

Completed

Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (OPTIMISMM)

Multiple Myeloma

United States, Spain, United Kingdom, Italy, Israel, Portugal, Germany, Turkey, Greece, Ireland, Austria, Norway, Netherlands, Denmark, Poland, France, Russian Federation, Canada, Finland, Japan, Puerto Rico, Sweden
Cutera Inc.

Completed

A Single-Center 2-Arm Study for Lentigines on the Hands

Lentigines

United States
University of Botswana

Completed

'Extended Balloon Catheter' Labour Induction; a Single Arm Pilot Trial'

Labor, Induced

Botswana
University of Florida

Terminated

Monitoring Postoperative Pain and Recovery Following Orthopedic Surgery

Pain, Postoperative

United States
University of Rochester

Completed

Time-restricted Eating in Cancer Survivorship: A Single-arm Feasibility Pilot Study

Cancer Survivorship

United States
Fundación EPIC

Active, not recruiting

A Prospective Study, Single-arm, Multicentre, Observational to Evaluate Safety and Effectiveness of Stent Ultimaster Tansei Coronary Stent in Complex Coronary Lesions. (TANSEI)

Coronary Artery Disease | Ischemic Heart Disease

Spain
Imperial College Healthcare NHS Trust
Imperial College London; University of Oxford; Oxford University Hospitals NHS...

Withdrawn

SABRE: A Single-arm Prospective Study Measuring Safety and Tolerability of SARS-CoV-2 Neutralising Antibodies in High-risk Populations (SABRE)

Lymphoma | Leukemia | Immune Thrombocytopenia | SARS-CoV2 Infection | SARS-CoV-2 Acute Respiratory Disease | Myeloma | Thrombotic Thrombocytopenic Purpura (TTP)

United Kingdom
Farapulse, Inc.

Completed

A Single Arm Pilot Study of Pulsed Field Ablation in the Treatment of Paroxysmal Atrial Fibrillation (FARA-Free)

Paroxysmal Atrial Fibrillation

Croatia
Hennepin Healthcare Research Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National... and other collaborators

Completed

Diabetes Homeless Medication Support Single Arm Treatment Development Trial (D-Homes)

Type 2 Diabetes | Homeless Persons

United States
Technical University of Munich
Novartis

Completed

Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum

Pyoderma Gangrenosum

Germany
Region Östergötland
Linkoeping University; Örebro University, Sweden

Active, not recruiting

Evaluation of Interventions for Safe Patient Handling and Movement in the Healthcare Sector

Occupational Health

Sweden
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Bayer; United States Department of Defense; Canadian...

Terminated

Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

Node Positive HER2 Negative Breast Cancer

United States, Canada, Puerto Rico, Guam
RedHill Biopharma Limited

Completed

A Study of ABC294640 (Yeliva ®) Alone and in Combination With Hydroxychloroquine Sulfate in Treatment of Patients With Advanced Cholangiocarcinoma

Cholangiocarcinoma | Cholangiocarcinoma Non-resectable | Cholangiocarcinoma, Perihilar | Cholangiocarcinoma, Extrahepatic | Cholangiocarcinoma, Intrahepatic

United States
Rennes University Hospital

Completed

Trial Involving Subjects Over 70 Years of Age With Non Small-cell Lung Cancer of Stage IV and Comparing a "Classical" Strategy of Treatment Allocation, With an"Optimized" Strategy Allocating the Same Treatments (ESOGIA)

Non Small-cell Lung Cancer

France
Nektar Therapeutics
Bristol-Myers Squibb

Completed

A Single-Arm Study of Bempegaldesleukin (NKTR-214) Plus Nivolumab in Cisplatin Ineligible Patients Who Have Locally Advanced or Metastatic Urothelial Cancer (PIVOT-10)

Neoplasm Metastasis | Urinary Bladder Neoplasm

United States, Spain, United Kingdom, Belgium, Canada, Australia, France, Italy, Greece, Germany, Portugal, Argentina, Israel, Russian Federation, Turkey, Mexico, Finland, Netherlands
University Hospital, Strasbourg, France

Terminated

Personalized rTMS for Resistant Depression

Depressive Disorder | Treatment-Resistant

France
Terumo Europe N.V.

Completed

Prospective Single Arm CAS - ROADSAVER Study (ROADSAVER)

Carotid Artery Stenosis

Belgium, Spain, Czechia, France, Serbia, Netherlands, Germany, Hungary, North Macedonia, Latvia, Poland, Portugal, Slovakia
BioSight Ltd.

Active, not recruiting

Phase 2, Open-Label, Single Arm Study, With BST-236 in Adults With R/R AML or Higher-Risk MDS

Refractory Acute Myeloid Leukemia | MDS | AML, Adult | Relapse/Recurrence

United States
Biocad

Active, not recruiting

A Double-Blind, Comparative, Randomized Clinical Study of the Pharmacokinetics, Safety, and Immunogenicity of a Single Intravenous Infusion of BCD-178 or Perjeta® in Healthy Volunteers

Breast Cancer

Russian Federation
Ohio State University

Completed

Physiological Brain Atlas Development

Depression | Parkinson Disease | Obsessive Compulsive Disorder | Dystonia | Tremors

United States
Nordsjaellands Hospital

Active, not recruiting

What is the Rate of Surgical Treatment in Adult Patients With Displaced Distal Radius Fractures Managed According to the Danish National Clinical Practice Guidelines? - A Single Center Retrospective Cohort Study

Distal Radius Fracture

Denmark
University of California, Los Angeles
National Cancer Institute (NCI); Children's Hospital of Philadelphia; University... and other collaborators

Withdrawn

The STOP-HPV Trial 6: Single Arm Evaluation of the Maintenance of the STOP-HPV Bundle (STOP-HPV)

Vaccination | Immunization

United States
Memorial Sloan Kettering Cancer Center
Rockefeller University

Completed

Immune Responses to Autologous Langerhans-type Dendritic Cells Electroporated With mRNA Encoding a Tumor-associated Antigen in Patients With Malignancy: A Single-arm Phase I Trial in Melanoma

Melanoma

United States
Memorial Sloan Kettering Cancer Center

Terminated

A Single-Arm Pilot Study of Adjuvant Pembrolizumab Plus Trastuzumab in HER2+ Esophagogastric Tumors With Persistent Circulating Tumor DNA Following Curative Resection

Gastric Cancer | Esophageal Cancer | Esophageal Neoplasms | Gastroesophageal Junction Cancer | Gastric Tumor | Gastroesophageal Junction Adenocarcinoma | GastroEsophageal Cancer | Esophageal Tumor | Esophagogastric Tumors | Gastroesophageal Junction Tumor

United States
Tianjin Eye Hospital

Active, not recruiting

Evaluate the Safety and Efficacy of Two Types of Circular Column Modulated Lenses for Delaying the Progression of Myopia

Myopia

China
Institut du Cancer de Montpellier - Val d'Aurelle
Fondazione IRCCS ISTITUTO NAZIONALE TUMORI

Withdrawn

Quantifying Systemic Immunosuppression to Personalize Cancer Therapy (SERPENTINE)

Healthy | Non-small Cell Lung Cancer Stage III | Squamous Cell Carcinoma of Head and Neck | Metastatic Breast Cancer | Metastatic Melanoma | Advanced Renal Cell Carcinoma
Millennium Pharmaceuticals, Inc.

Completed

A Study of Ixazomib, Given With Dexamethasone in Adults With Multiple Myeloma

Relapsed and/or Refractory Multiple Myeloma

United States, France, Norway, Spain, Israel, United Kingdom, Italy, Australia, Germany, Greece, Canada, Czechia, Turkey, Russian Federation, Denmark, Sweden, Belgium, Netherlands
Jennifer Marler, MD

Completed

Assessment of the Pivot Breath Sensor: Single-Arm Cohort Study

Smoking Cessation | Smoking Reduction | Smoking, Tobacco | Smoking Behaviors

United States
biotx.ai GmbH

Withdrawn

Phase II Safety Single-arm Study of CDK4/6 Inhibition With Palbociclib in Hospitalized, Moderate COVID-19 Cases to Prevent Thromboinflammation (CDK6COV)

COVID-19

Germany
NSABP Foundation Inc
Novartis Pharmaceuticals; Natera, Inc.

Withdrawn

A Single Arm Phase II Study to Evaluate Treatment With Gevokizumab in Patients With Stage II/III Colon Cancer Who Are ctDNA-positive After Curative Surgery and Adjuvant Chemotherapy

Colon Cancer

United States
CytoDyn, Inc.

Completed

Randomized, Double-Blind, Placebo-Controlled Trial, Followed by Single-Arm Treatment of PRO 140 (PRO140)

HIV

United States, Puerto Rico
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI); National Institutes of Health (NIH); Fogarty...

Completed

Rituximab Plus CHOP Chemotherapy for Diffuse Large B-cell Lymphoma

HIV | Diffuse Large B-cell Lymphoma

Malawi
AstraZeneca

Active, not recruiting

Phase II Single Arm Study of AZD9291 to Treat NSCLC Patients in Asia Pacific (AURA17)

Non-Small Cell Lung Cancer

Korea, Republic of, China, Australia
Celgene

Completed

A Post Authorisation Registry of IMNOVID (Pomalidomide) for Patients With Relapsed and Refractory Multiple Myeloma.

Multiple Myeloma

Belgium, United Kingdom, Italy, Germany, Sweden, Denmark, Norway, Spain
Zhejiang Zylox Medical Device Co., Ltd.

Active, not recruiting

A Single-Arm Trial of Neurovascular Drug-Eluting Balloon Dilatation Catheter Treating Symptomatic Intracranial Atherosclerotic Stenosis

Intracranial Atherosclerosis

China
Hanmi Pharmaceutical Company Limited

Completed

An Observational Study to Evaluate the Treatment of Newvast® Tab(Atorvastatin) in Korean Patients With Dyslipidemia

Dyslipidemia

Korea, Republic of
Tesaro, Inc.
Gynecologic Oncology Group

Terminated

Study to Evaluate the Efficacy and Safety of the Combination of Niraparib and Dostarlimab (TSR-042) in Participants With Platinum Resistant Ovarian Cancer (MOONSTONE)

Ovarian Neoplasms

United States
National Cancer Institute (NCI)

Terminated

A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer

Breast Cancer | Ovarian Cancer | Prostate Cancer

United States

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