Search clinical trials for: severe bone defects

Total 39991 results

Amgen

Withdrawn

Efficacy of Romiplostim in Treatment of SAA in Adults Previously Untreated With or Refractory to Immunosuppressive Therapy

Severe Aplastic Anemia (SAA)
R-Pharm International, LLC
Quintiles, Inc.; OCT Clinical Trials; Mene Research

Completed

Evaluation of the Efficacy and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Were Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Had Active Disease (CREDO 3)

Rheumatoid Arthritis

United States, Korea, Republic of, Germany, Czechia, Mexico, Hungary, Poland, Argentina, Brazil, Colombia, Russian Federation
R-Pharm International, LLC
Quintiles, Inc.; OCT Clinical Trials

Completed

Evaluation of the Efficacy and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo and Adalimumab, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease (CREDO 2)

Rheumatoid Arthritis

United States, Germany, Korea, Republic of, Bulgaria, Poland, Taiwan, Mexico, Hungary, Czechia, United Kingdom, Lithuania, Argentina, Brazil, Colombia, Estonia, Latvia, Russian Federation, Romania
Ross Leighton
Biocomposites Ltd

Completed

Management of Traumatic Bone Defects in Tibial Plateau Fractures With Antibiotic-Impregnated Biodegradable Calcium Sulfate Beads: A Prospective Clinical Trial

Tibial Fractures | Intra-Articular Fractures | Fracture Fixation, Internal

Canada
University of Florida
Live Like Bella Pediatric Cancer Research

Completed

Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

Common Variable Immunodeficiency | Severe Combined Immunodeficiency | Sickle Cell Disease | Hurler Syndrome | Chronic Granulomatous Disease | Thalassemia | Wiskott-Aldrich Syndrome | Adrenoleukodystrophy | X-linked Lymphoproliferative Disease | Diamond Blackfan Anemia | Bone Marrow Failure Syndrome | Hemophagocytic... and other conditions

United States
Pfizer

Completed

A Study to Learn About the Study Medicine Called Nirmatrelvir/Ritonavir in People Who Are Healthy Volunteers Co-administered the Medicine Rosuvastatin

Healthy Volunteers | Pharmacokinetics

Belgium
Icahn School of Medicine at Mount Sinai
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones

Craniosynostosis

United States, Germany, France, Spain, United Kingdom
Centre Hospitalier Intercommunal Creteil
Association Clinique Thérapeutique Infantile du val de Marne; Keocyt

Active, not recruiting

HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell Disease (DREPHAPLO)

Sickle Cell Disease

France
University of Missouri-Columbia

Withdrawn

Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee (LongTermOC)

Outcomes of Allograft

United States
University of New Mexico
Thrasher Research Fund

Completed

Prevention of Post Operative Bone Loss in Children

Cerebral Palsy | Osteoporosis | Osteopenia | Osteogenesis Imperfecta | Spina Bifida

United States
St. Jude Children's Research Hospital

Active, not recruiting

Haploidentical HCT for Severe Aplastic Anemia

Aplastic Anemia | Bone Marrow Failure Syndrome

United States
Cairo University

Completed

Amnion Chorion Membrane Combined With Allograft Bone Putty for the Management of Intrabony Defects

Periodontal Regeneration

Egypt
Baylor College of Medicine
The Marfan Foundation

Completed

Marfan Syndrome Moderate Exercise Pilot

Marfan Syndrome

United States
AbbVie

Terminated

Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)

Rheumatoid Arthritis (RA)

United States, Australia, Canada, Czechia, Germany, Greece, Hungary, Israel, Italy, Japan, Korea, Republic of, Netherlands, New Zealand, Poland, Puerto Rico, Russian Federation, Slovakia, Spain, Taiwan, Turkey, Ukraine
Masonic Cancer Center, University of Minnesota

Completed

MT2015-20: Biochemical Correction of Severe EB by Allo HSCT and Serial Donor MSCs

Epidermolysis Bullosa

United States
Ohio State University

Completed

Nifedipine XL Versus Placebo for the Treatment of Preeclampsia With Severe Features During Induction of Labor

Preeclampsia Severe

United States
AbbVie

Completed

A Study to Investigate the Safety and Efficacy of Elsubrutinib and Upadacitinib Given Alone or in Combination in Participants With Moderately to Severely Active Systemic Lupus Erythematosus (SLE) (SLEek)

Systemic Lupus Erythematosus (SLE)

United States, Argentina, Australia, Bulgaria, Canada, China, Colombia, France, Germany, Hungary, Italy, Japan, Korea, Republic of, Mexico, Netherlands, New Zealand, Poland, Puerto Rico, Spain, Taiwan, United Kingdom
Centre Hospitalier Universitaire, Amiens

Withdrawn

Influence of Verticalization on Bone Mineral Density and Biological Parameters of Bone Remodeling in Children With Severe Cerebral Palsy (CPABONE)

Cerebral Palsy | Osteoporosis | Bone Mineral Density | Fracture | Bone Remodeling Disorder

France
Near East University, Turkey

Completed

Myoinositol Treatment and Asprosin Levels in PCOS

Insulin Resistance | PCOS

Cyprus
Dr. Aslan Private Perio Center

Completed

Entire Papilla Preservation Technique With and Without Biomaterials in the Treatment of Isolated Intrabony Defects

Periodontal Diseases
Abbott Medical Devices

Completed

Multi-center Prospective Study to Evaluate Outcomes of the Moderate to Severely Calcified Coronary Lesions (MACE) (MACE)

Coronary Artery Disease

United States
Near East University, Turkey

Completed

Myoinositol Effect on Asprosin Levels

Pregnancy Related

Cyprus
Yuzuncu Yıl University

Completed

Different Autologous Products in The Treatment of Intrabony Defects

Periodontal Pocket

Turkey
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Active, not recruiting

CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene (CASPALLO)

Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia | Myelodysplastic Syndrome

United States
The University of Texas Medical Branch, Galveston
National Institute of General Medical Sciences (NIGMS)

Completed

Assessment of Mechanisms of Improved Wound Healing

Burns

United States
The Cleveland Clinic

Completed

Anti-thymocyte Globulin and Cyclosporine as First-Line Therapy in Treating Patients With Severe Aplastic Anemia

Aplastic Anemia

United States
Amira ragab

Enrolling by invitation

Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects

Bone Loss in Jaw

Egypt
Government Dental College and Hospital, India

Completed

Comparison of PRP & DFDBA vs. DFDBA in Intrabony Periodontal Defects

Chronic Periodontitis

India
University of Alabama at Birmingham
Medical University of South Carolina; Johns Hopkins University; University of... and other collaborators

Completed

Chronic Hypertension and Pregnancy (CHAP) Project (CHAP)

Hypertension

United States
University Hospital, Toulouse

Completed

Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome (RASTAT)

Noonan Syndrome

France
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Extended Dosing With Eltrombopag for Severe Aplastic Anemia

Severe Aplastic Anemia (SAA)

United States
Assistance Publique Hopitaux De Marseille

Completed

Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot

Tetralogy of Fallot With Pulmonary Stenosis

France
Zimmer Biomet

Terminated

Post-market Surveillance Study With the HYPERION Hip Endoprosthesis System in Defect Reconstruction

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Femur Fracture | Trochanteric Fractures | Pseudarthrosis | Pseudoarthrosis | Functional Deformities | Revision of Endoprosthesis-treated Hips | Fracture, Proximal Humeral | Provision of Non-endoprosthetic Previous Operations of the Hip Joint (e.g... and other conditions

Germany
University of Bonn
Universidad Complutense de Madrid

Completed

Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration

Periodontitis | Intrabony Periodontal Defect | Tooth Migration

Germany, Spain
University of Pecs

Completed

Rod Shape Changing After Scoliosis Correction Surgery

Scoliosis Idiopathic | Scoliosis, Severe

Hungary
Shanghai General Hospital, Shanghai Jiao Tong University...
Ruijin Hospital; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine and other collaborators

Completed

The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia

Severe Aplastic Anemia

China
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy

Severe Aplastic Anemia

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

Bone Marrow Failure Syndromes | Severe Aplastic Anemia

United States
Queen Mary University of London
University College, London; University of the Punjab

Active, not recruiting

Trial of High-Dose Vitamin D in the Treatment of Complicated Severe Acute Malnutrition (ViDiSAM)

Severe Acute Malnutrition

Pakistan
Maimónides Biomedical Research Institute of Córdoba
Dynamic Solutions; Faes Farma, S.A.; Junta de Andalucía - Consejería de Salud...

Completed

Prevention and Treatment With Calcifediol of COVID-19 Induced Acute Respiratory Syndrome (COVIDIOL)

SARS-CoV 2 | COVID19 | Cytokine Storm | Cytokine Release Syndrome | SARS (Severe Acute Respiratory Syndrome)

Spain
Hams Hamed Abdelrahman

Completed

Bone Marrow Aspirate Concentrate in Treating Mandibular Cystic Defects

Mandible Cyst

Egypt
Prof. Dr. Jörg Leuppi

Completed

High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study (VitCov)

Covid19 | Vitamin D Deficiency | Corona Virus Infection | ARDS | SARS-CoV Infection | Coronavirus

Switzerland
Yang I. Pachankis

Completed

Medicine-induced Cardiac Hemodialysis on COVID-19

Renal Dialysis | Vaccines | Infection Viral | Severe Acute Respiratory Syndrome-related Coronavirus | Myocarditis Allergic

China
University of Ljubljana

Completed

Papillae Tunneling Techniques in the Treatment of Isolated Intrabony Defects (PTT)

Xenograft Model | Periodontitis Complex

Slovenia
Merz North America, Inc.

Completed

Evaluation of the Effectiveness and Safety of Radiesse for the Correction of Moderate to Severe Nasolabial Folds

Correction of Moderate to Severe Nasolabial Folds (NLFs)

China
Indonesia University

Completed

Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery

Myocardial Injury | Cardiac Surgery

Indonesia
Ain Shams University

Active, not recruiting

Bone Transport Through Induced Membrane vs Conventional Bone Transport in Management of Bone Defects of Lower Limbs

Bone Loss

Egypt
Assistance Publique - Hôpitaux de Paris

Completed

Clinical Signs and Activity Limitations Associated With Dural Ectasia in Patients With Marfan Disease (MARFANLOMB)

Marfan Syndrome

France
University Hospital, Ghent
Agentschap voor Innovatie door Wetenschap en Technologie

Completed

Randomized, Double-blind Study for the Evaluation of the Effect of Losartan Versus Placebo on Aortic Root Dilatation in Patients With Marfan Syndrome Under Treatment With Beta-blockers

Marfan Syndrome

Belgium
King Abdullah International Medical Research Center

Completed

Efficacy and Safety for Different Regimen of VTE Pharmacoprophylaxis Among Severely Burn Patients

Burns

Saudi Arabia

Search clinical trials for: severe bone defects

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