Search clinical trials for: Placebo + Methotrexate

Total 54914 results

Ablynx

Completed

Study Evaluating Multiple Doses Of ATN-103 In Subjects With Active Rheumatoid Arthritis

Active Rheumatoid Arthritis

United States, Russian Federation, South Africa, Canada, Serbia, Switzerland, Hungary, Belgium, Germany
Lexicon Pharmaceuticals

Completed

Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis

Rheumatoid Arthritis

United States
National Heart, Lung, and Blood Institute (NHLBI)
National Cancer Institute (NCI); Blood and Marrow Transplant Clinical Trials...

Completed

Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

Lymphoma, Follicular | Lymphoma, B-Cell | Lymphoma, Large B-Cell, Diffuse | Hodgkin's Lymphoma | Chronic Lymphocytic Leukemia | Acute Leukemia | Chronic Myelogenous Leukemia | Myelodysplasia | Small Lymphocytic Lymphoma

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Methotrexate Combined With Tofacitinib in Rheumatoid Arthritis

Rheumatoid Arthritis
University of Alabama at Birmingham

Not yet recruiting

Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant

Myeloproliferative Disorders | Acute Leukemia | Myelodysplastic Syndrome

United States
PETHEMA Foundation

Recruiting

Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years)

Acute Lymphoblastic Leukemia

Spain
Tufts Medical Center

Completed

Mechanism of Action Study for Psoriasis (MOA)

Psoriasis

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S9716: Combination Chemotherapy in Treating Patients With Merkel Cell Cancer

Neuroendocrine Carcinoma of the Skin

United States
Fred Hutchinson Cancer Center

Completed

Graft-Versus-Host Disease Prevention in Treating Patients Who Are Undergoing Bone Marrow Transplantation

Lymphoma | Leukemia | Graft Versus Host Disease

United States
University of Parma

Unknown

Methotrexate as a Steroid-sparing Agent in Idiopathic Retroperitoneal Fibrosis: a Randomised, Multicenter Trial (FIPREDEX)

Idiopathic Retroperitoneal Fibrosis | Perianeurysmal Retroperitoneal Fibrosis | Chronic Periaortitis

Italy
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Filgrastim-Treated Donor Peripheral Stem Cell Transplantation in Treating Patients With Acute Leukemia</p>

Leukemia

United States
Fred Hutchinson Cancer Center

Completed

Monoclonal Antibody Followed by Bone Marrow Transplantation in Treating Patients With Acute Myelogenous Leukemia in Remission or First Relapse

Leukemia
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Completed

Chemotherapy and Bone Marrow Transplantation in Treating Patients Acute Myeloid With Leukemia or Myelodysplastic Syndrome

Myelodysplastic Syndromes | Leukemia

United States
Contera Pharma
Bukwang Pharmaceutical

Active, not recruiting

A Study in Parkinson's Disease in Patients With Moderate to Severe Dyskinesia (ASTORIA)

Dyskinesias

France, Germany, Italy, Korea, Republic of, Spain
University of California, San Diego

Terminated

Phase 2 RCT of Alvimopan vs. Placebo After CRS/HIPEC (ILEUS)

Ileus

United States
Novartis

Completed

Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects With Acute Blunt Trauma Injuries

Acute Blunt Soft Tissue Injuries/Contusions

United States
William Beaumont Hospitals

Terminated

Effect of Probiotics in Non-alcoholic Fatty Liver Disease and Steatohepatitis (PRONE)

Fibrosis, Liver | Cirrhosis, Liver | Steatohepatitis, Nonalcoholic | Fatty Liver Disease

United States
Vanderbilt University
Merck Sharp & Dohme LLC

Withdrawn

Vorapaxar and Lower Extremity Bypass Grafts

Peripheral Artery Disease
European Organisation for Research and Treatment...

Completed

Combination Chemotherapy With Trastuzumab in Treating Women With Metastatic Breast Cancer

Breast Cancer

Belgium, Netherlands, France, Egypt, South Africa, United Kingdom, Denmark, Serbia, Poland
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Prevention of Graft-Versus-Host Disease in Patients With Hematologic Malignancies Who Are Receiving a Bone Marrow Transplant

Myelodysplastic Syndromes | Leukemia | Graft Versus Host Disease
University of Chicago
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Patients With Stage IV Locally Advanced or Metastatic Bladder Cancer

Bladder Cancer

United States
Taiho Pharmaceutical Co., Ltd.

Completed

A Randomized Controlled Study of Postoperative Adjuvant Therapy of Uracil-tegafur (UFT) Compared With Cyclophosphamide/Methotrexate/5-fluorouracil (CMF) in Breast Cancer (NSAS-BC)

Breast Cancer

Japan
Pacira Pharmaceuticals, Inc

Completed

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

Meningeal Neoplasms

United States, Canada
Genentech, Inc.
Roche Pharma AG

Terminated

A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Continuing Methotrexate Treatment (STAGE) (STAGE)

Rheumatoid Arthritis

United States
UCB Pharma SA, Belgium
Parexel

Completed

A Study of Certolizumab Pegol as Additional Therapy in Chinese Patients With Active Rheumatoid Arthritis (RAPID-C)

Rheumatoid Arthritis

China
University of North Carolina, Chapel Hill
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Methotrexate in Induction and Maintenance of Steroid Free Remission in Ulcerative Colitis (Merit-UC)

Ulcerative Colitis

United States
Astellas Pharma Inc
Biogen

Completed

A Placebo-controlled Study With an Extension Examining the Safety and Efficacy of Alefacept in Psoriatic Arthritis

Psoriatic Arthritis

Poland, Canada, United States, Russian Federation, Germany
Stanford University
AstraZeneca

Terminated

Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant Histology Bladder Cancer

Bladder Adenocarcinoma | Bladder Mixed Adenocarcinoma | Bladder Squamous Cell Carcinoma | Infiltrating Bladder Urothelial Carcinoma With Giant Cells | Infiltrating Bladder Urothelial Carcinoma, Nested Variant | Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant | Bladder Urothelial... and other conditions

United States
Fengmei Lian
Peking Union Medical College Hospital; Huashan Hospital; Chengdu University of... and other collaborators

Unknown

Post-marketing Evaluation of Mudan Granule Intervention on Type 2 Diabetic Peripheral Neuropathy

Diabetic Peripheral Neuropathy Type 2

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Allogeneic Stem Cell Transplant for CLL

Chronic Lymphocytic Leukemia | Prolymphocytic Leukemia | Richter Syndrome | Allogeneic Hematopoietic Stem Cell Transplantation Recipient

United States
Fred Hutchinson Cancer Center

Completed

Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated... and other conditions

United States
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI); Otsuka America Pharmaceutical

Completed

Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based Regimen (LCCC0510)

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm

United States
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Reduced-Intensity Busulfan and Fludarabine With or Without Antithymocyte Globulin Followed by Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm

United States
Singapore National Eye Centre
International Stem Cell Forum

Completed

Thyroid Treatment Trial

Graves Ophthalmopathy

Singapore
Gustave Roussy, Cancer Campus, Grand Paris
Children's Oncology Group

Unknown

Intergroup Randomized Trial for Children or Adolescents With B-Cell Non Hodgkin Lymphoma or B-Acute Leukemia: Rituximab Evaluation in High Risk Patients

B-cell Non Hodgkin Lymphoma | Mature B-cell Leukemia Burkitt-type

Belgium, France, United Kingdom, Netherlands, Canada, Hungary, Italy, Poland, Spain, China
Sun Yat-sen University

Unknown

The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia

China
George Washington University

Enrolling by invitation

Methotrexate Treatment of Arthritis Caused by Chikungunya Virus (MARCH)

Investigate the Effect(s) of Methotrexate Treatment on Arthritis Disease Severity

Colombia
Aclaris Therapeutics, Inc.

Completed

Study of ATI-450 Plus Methotrexate (MTX) vs MTX Alone in Patients With Moderate to Severe RA

Rheumatoid Arthritis

United States
GlaxoSmithKline

Withdrawn

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Proof of Mechanism of GSK2618960 in Primary Sjögren's Syndrome (pSS)

Autoimmune Diseases

United Kingdom
Philogen S.p.A.

Terminated

A Randomized, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of F8IL10 (Dekavil) in Patients With Active RA Receiving MTX

Rheumatoid Arthritis

Switzerland, Germany, Italy
Hoffmann-La Roche

Terminated

A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha Therapy

Rheumatoid Arthritis

Spain, United Kingdom, United States, Italy, Peru, Argentina, Colombia, Mexico, Germany, Austria, Guatemala
Hoffmann-La Roche

Completed

A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis

Rheumatoid Arthritis

France, Israel, Italy, Switzerland, Germany, Mexico, Canada, Austria, Thailand, Singapore, Bulgaria, Australia, Argentina, Brazil, Slovakia, Hungary, China
Children's Cancer Group, China
Xiangya Hospital of Central South University; Tongji Hospital; Qilu Hospital... and other collaborators

Active, not recruiting

LBL-2016 for Children or Adolescents in China

Lymphoblastic Lymphoma

China
Won Seog Kim
Celltrion

Recruiting

[CREMA]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma

Primary CNS Lymphoma

Korea, Republic of
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia

Leukemia

United States
University Hospital, Montpellier

Completed

Topical Steroids Alone or Associated With Methotrexate in Bullous Pemphigoid (BP/MTX)

Bullous Pemphigoid

France
Children's Hospital of Philadelphia
Gateway for Cancer Research

Completed

Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy

Osteosarcoma | Nephrotoxicity | Ototoxicity

United States
UCB Pharma SA
Parexel

Completed

Study to Assess the Short- and Long-term Efficacy of Certolizumab Pegol Plus Methotrexate Compared to Adalimumab Plus Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis (RA) Inadequately Responding to Methotrexate

Rheumatoid Arthritis

Romania, United States, Australia, Austria, Bulgaria, Canada, Czechia, France, Germany, Greece, Hungary, Ireland, Italy, Mexico, Monaco, Poland, Portugal, Spain, Switzerland, United Kingdom
Ohio State University Comprehensive Cancer Center

Completed

Safety & Efficacy of Atorvastatin for Prophylaxis of Acute Graft Versus Host Disease in Patients With Hematological Malignancies HLA- Donor Hematopoietic Stem Cell Transplantation

Myelodysplastic Syndrome | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia

United States
University Health Network, Toronto
Bayer

Completed

Alemtuzumab and Cyclosporine for the Prevention of Graft vs Host Disease After Stem Cell Transplants

Bone Marrow Transplantation | Graft Versus Host Disease

Canada

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