Search clinical trials for: Absorption, distribution, metabolism, and excretion (ADME)

Total 473663 results

Janssen Research & Development, LLC

Completed

A Study to Investigate the Absorption, Distribution, Metabolism, and Excretion of 14C-JNJ-42847922 After a Single Oral Dose of 40 mg in Healthy Subjects

Healthy

United States
University of Hohenheim
German Federal Ministry of Economics and Technology

Completed

Absorption and Excretion Kinetics of the Bioactive Ingredients of Rice Bran Extract

Safety After Oral Intake | Pharmacokinetics After Oral Intake

Germany
Sanwa Kagaku Kenkyusho Co., Ltd.
Fuji Yakuhin Co., Ltd.

Completed

Effect of Topiroxostat on Urinary Albumin Excretion Early Stage Diabetic Nephropathy and Hyperuricemia With or Without Gout (UPWARD)

Diabetic Nephropathy

Japan
Global Blood Therapeutics

Completed

A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male Subjects

Anemia, Sickle Cell

United States
Novo Nordisk A/S

Completed

Trial Investigating the Absorption, Metabolism and Excretion After a Single Subcutaneous Dose of [3H]-Semaglutide in Healthy Male Subjects

Healthy | Diabetes

Netherlands
Innovaderm Research Inc.

Completed

Exploratory Study of Intra and Inter-subject Variability in Sebum Excretion Rate

Oily Skin

Canada
University of Copenhagen
The Danish Dairy Research Foundation, Denmark; The Ministry of Science, Technology... and other collaborators

Completed

Calcium Intake and Fat Excretion (KIFU/B266)

Fat Excretion | Energy Excretion

Denmark
Medical Research Council

Completed

Effect of the Consumption of Ferric Hydroxide Adipate on Urinary Phosphorus Excretion.

Healthy | Chronic Kidney Diseases

United Kingdom
Verastem, Inc.

Completed

A Phase I, Open-label Study of Absorption, Metabolism, and Excretion of Defactinib (VS-6063) in Healthy Male Subjects

Healthy Subjects
Celgene

Completed

A Single Dose Oral Excretion Balance Study of [14C]-RPC1063 in Healthy Male Adults

Healthy Volunteers

United Kingdom
Novo Nordisk A/S

Completed

Metabolism and Excretion of Liraglutide in Healthy Male Volunteers

Healthy | Diabetes

Netherlands
Eli Lilly and Company

Completed

A Study of the Absorption, Distribution, Metabolism and Excretion of LY3039478 in Healthy Participants

Healthy

United States
Brigham and Women's Hospital

Withdrawn

The Effect of Vitamin D on Urinary Calcium Excretion in Kidney Stone Formers With High Urinary Calcium

Nephrolithiasis | Vitamin D Deficiency

United States
Bial - Portela C S.A.

Completed

Absorption, Distribution, Metabolism and Excretion of [14C]- Labeled BIA 5-453 and Metabolites

Hypertension | Congestive Heart Failure

Switzerland
Genentech, Inc.

Completed

Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-GDC-0941 Following Single Oral Dose Administration in Healthy Male Subjects

Healthy Volunteer

United States
Hoffmann-La Roche

Completed

A Study of The Excretion Balance, Pharmacokinetics and Metabolism of A Single Oral Dose of [14C]-Labeled RO4917523 in Healthy Male Volunteers

Healthy Volunteer

Netherlands
Genentech, Inc.

Completed

Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-GDC-0980 Following Single Oral Dose Administration in Healthy Postmenopausal Female Subjects

Healthy Volunteer

United States
GlaxoSmithKline

Completed

Parkinson's Disease Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole

Parkinson Disease

Germany, South Africa
Takeda

Completed

TAK-385 Phase I Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability Study

Healthy Volunteers

United Kingdom
Otsuka Pharmaceutical Co., Ltd.

Completed

A Phase 1,Open -Label Study to Assess the Absorption, Metabolism and Excretion of 14C-OPS-2071 Following a Single Oral Dose to Healthy Male Japanese Subjects

Bacterial Enteritis

United Kingdom
Aerpio Therapeutics

Completed

Study to Assess the Absorption, Metabolism, Excretion and Pharmacokinetics of [14C]-AKB-9778

Healthy
Hoffmann-La Roche
Trophos SA

Completed

A Study of the Excretion Balance of Radiocarbon and the Pharmacokinetics and Metabolic Profile of TRO19622 (Olesoxime)

Healthy Volunteer
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Investigate the Absorption, Metabolism, and Excretion of Canagliflozin (JNJ-28431754) in Healthy Male Volunteers

Healthy

Belgium
Biogen

Completed

Absorption, Metabolism, and Excretion Study of BIIB074

Neuropathic Pain

United States
Supernus Pharmaceuticals, Inc.

Completed

Phase I Study to Assess the Absorption, Metabolism, and Excretion of [14C] Labeled SPN-810M

Impulsive Aggression Comorbid With ADHD

United Kingdom
Bial - Portela C S.A.

Completed

Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 3-202 and Metabolites

Parkinson's Disease

Switzerland
Richard E. Ostlund Jr., MD
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Physiological Study of Human Cholesterol Metabolism and Excretion

Cardiovascular Disease | Dyslipidemia | Coronary Heart Disease | Disorder of Cholesterol Metabolism

United States
Pennington Biomedical Research Center
Quest Nutrition LLC

Withdrawn

The Effect of Oral Alpha-Cyclodextrin on Fecal Fat Excretion (FAT ABSORBER)

Obesity | Cardiovascular Disease

United States
Kissei Pharmaceutical Co., Ltd.

Completed

Study of Absorption, Metabolism and Excretion Following a Single Oral Dose of [14C]KWA-0711 to Healthy Male Subjects

Healthy Male Subject

United Kingdom
University of Utah

Completed

Study of Sodium Bicarbonate in Kidney Transplant Recipients

Kidney Transplantation

United States
Prana Biotechnology Limited

Completed

Absorption, Metabolism and Excretion Study of [14C]PBT2 and Absolute Bioavailability of PBT2

Healthy Volunteers

United Kingdom
Merck Sharp & Dohme LLC
Pfizer

Completed

A Radiolabeled Mass Balance Study of [14C]-Ertugliflozin (PF04971729, MK-8835) In Healthy Male Participants (MK-8835-038)

Type 2 Diabetes Mellitus (T2DM)
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Blood Pressure and Diurnal Variation in Sodium, Potassium, and Water Excretion

Heart Diseases | Cardiovascular Diseases | Hypertension
Sahlgrenska University Hospital, Sweden

Completed

NAG-excretion During Cardiopulmonary Bypass (CPBNAG)

Renal Impairment

Sweden
Kowa Research Institute, Inc.

Completed

Evaluation of Absorption, Metabolism, and Excretion and Estimation of the Absolute Bioavailability of K-312

Dyslipidemia

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...

Completed

Reperfusion-induced Self-antigen Excretion Following Major Liver Surgery (RISE)

Warm Hepatic Ischemia-reperfusion Injury

Netherlands
Zhiming Zhu

Completed

Spicy Diet on Salty Taste and Salt Intake

Salty Taste | Spicy Diet

China
Clinical Hospital Centre Zagreb
Merck Sharp & Dohme LLC

Completed

Natriuretic Effect of GLP-1in Healthy Non Obese Subjects

Sodium Excretion by Urination

Croatia
Agios Pharmaceuticals, Inc.

Completed

Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-AG-120

Healthy Volunteers

United States
Southwest Regional Wound Care Center

Withdrawn

A Multi-Center Protocol for Obtaining and Storing Human Samples for Immediate or Future Microbial, Immune, or Host Microbe Scientific Study

Infection

United States
Southwest Regional Wound Care Center

Completed

A Multi-Center Protocol for Obtaining and Storing Human Samples for Immediate or Future Microbial, Immune, or Host-Microbe Scientific Study

Infections

United States
Novartis Pharmaceuticals

Completed

Sodium Excretion of LCZ696 in Patients With Hypertension; Heart Failure and Healthy Volunteers

Hypertension

Russian Federation
Trevena Inc.

Completed

A Study to Investigate the Metabolism and Excretion of [14C]-TRV130 in Healthy Male Subjects

Healthy

United States
Showa Inan General Hospital

Withdrawn

Elemental Diets vs. Semi-solid Diets on Gastric Excretion and Gastroesophageal Regurgitation

Gastro-oesophageal Reflux

Japan
Eisai Inc.

Completed

An Open-label, Single-dose Study to Determine the Metabolism and Excretion of [14C]E2006 in Healthy Male Subjects

Metabolism and Excretion

United States
Tufts University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Completed

Musculoskeletal Effects of Bicarbonate

Fall Injury | Muscle Loss | Fractures | Osteoporosis, Age Related

United States
Kasr El Aini Hospital

Unknown

Cardiovascular Risks and Urinary Albumin Excretion(UAE) in Polycystic Ovarian Syndrome (PCO)

Urinary Albumin Excretion
Ardelyx

Completed

AZD1722 Open Label, Absorption Distribution Metabolism and Excretion Study

Healthy Volunteers

United Kingdom
Hormozgan University of Medical Sciences

Completed

Minirin Versus Oxybutynin for Nocturnal Enuresis in Children

Nocturnal Enuresis

Iran, Islamic Republic of
Astellas Pharma Inc

Completed

A Study of ASP1585 to Evaluate the Bioequivalence Between ASP1585 Granules and ASP1585 Capsules

Healthy | Urine Phosphorus Excretion

Japan

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