- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02410642
NAG-excretion During Cardiopulmonary Bypass (CPBNAG)
Effects of Cardiopulmonary Bypass on Urinary Secretion of NAG
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The standard biomarker of AKI, serum creatinine, has poor specificity and sensitivity in the early phases of renal injury. Since the therapeutic window is likely to be in the earlier stages before renal injury is manifest, there is a need for novel diagnostic methods. In the recent years, several new biomarkers of kidney injury have been introduced. To date, none has proven outstanding regarding precision in early detection of AKI. NAG (N-acetyl-b-D-glucosaminidase) is a lysosomal enzyme with high molecular weight. Due to its size, NAG does not normally pass the glomerulus apparatus, but urine levels are elevated after tubulus damage. NAG excretion in urine is seen in AKI after cardiac surgery, exposure to nephrotoxic agents and after renal transplantation. However, its role in clinical decision-making is yet to be established.
We aim to study the excretion pattern of urinary NAG during and after cardiac surgery with cardiopulmonary bypass. Association with perioperative variables will be explored.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
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Gothenburg, Sweden, 41345
- Department of thoracic anesthesia, Sahlgrenska University Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Expected cardiopulmonary bypass time exceeding 60 minutes
- Elective surgery
Exclusion Criteria:
- End-stage kidney disease with dialysis
- Ongoing treatment with nephrotoxic antibiotic agent
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Urinary NAG secretion
Time Frame: 24 hours
|
Secretion pattern of NAG
|
24 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Development of AKI (acute kidney injury) according to AKIN criteria
Time Frame: 72 hours
|
Development of AKI (acute kidney injury) according to AKIN criteria
|
72 hours
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Perioperative factors influencing NAG-secretion
Time Frame: 24 hours
|
Multivariate analysis of factors that might influence NAG-excretion
|
24 hours
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- SahlgrenskaUHThoraxLL2
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