Search clinical trials for: DNA Repair

Total 11183 results

Attikon Hospital

Unknown

Predictive Biomarkers for Response to Nivolumab in Head and Neck Squamous Cell Carcinoma

DNA Damage | HNSCC | DNA Double Strand Break

Greece
University of California, San Francisco

Terminated

Hematopoietic Stem Cell Transplantation (HSCT) for Children With SCID Utilizing Alemtuzumab, Plerixafor & Filgrastim

Severe Combined Immunodeficiency

United States
Nantes University Hospital

Completed

Generalized Neonatal Screening of Severe Combined Immunodeficiencies (DEPISTREC)

Severe Combined Immunodeficiency, Atypical

France
Hospital Universitario de Valme
Instituto de Salud Carlos III

Completed

Role of Rehabilitation for the Repair of Pelvic Floor Injuries Associated to Vaginal Delivery Identified by 3/4D Transperineal Ultrasound

Obstetric Labor Complications | Pelvic Floor Disorders | Ultrasound Therapy; Complications | Physical Disorder

Spain
Memorial Sloan Kettering Cancer Center
Boston Children's Hospital; Fred Hutchinson Cancer Center; Children's Hospital... and other collaborators

Completed

Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine

Leukemia | Myelodysplastic Syndrome | Aplastic Anemia

United States
Ohio State University Comprehensive Cancer Center

Completed

Ohio Colorectal Cancer Prevention Initiative (OCCPI)

Colorectal Cancer | Lynch Syndrome

United States
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Terminated

Antibody Conditioning Regimen For Allogeneic Donor Stem Cell Transplantation Of Patients With Fanconi Anemia (Mafia)

Fanconi Anemia | Severe Aplastic Anemia

United States
University of Florida
National Institute on Aging (NIA)

Completed

Skeletal Muscle Inflammation, Oxidative Stress and DNA Repair in Age-Related Sarcopenia

Sarcopenia

United States
Assistance Publique - Hôpitaux de Paris

Completed

Microcephaly Genetic Deficiency in Neural Progenitors (MICROFANC)

Microcephaly

France
Hospital Clinic of Barcelona
Fundacion Clinic per a la Recerca Biomédica

Completed

High Definition White-Light Colonoscopy vs. Chromoendoscopy for Surveillance of Lynch Syndrome. (EndoLynch)

Lynch Syndrome

Spain
University of Pittsburgh

Completed

Hereditary Colorectal and Associated Tumor Registry Study

Lynch Syndrome | Hereditary Diffuse Gastric Cancer | FAP | Peutz-Jeghers Syndrome | Juvenile Polyposis Syndrome

United States
Fatih Sultan Mehmet Training and Research Hospital

Completed

Laparoscopic Lateral Mesh Suspension for Pelvic Organ Prolapse

Pelvic Organ Prolapse | Pelvic Floor Prolapse
Loyola University

Withdrawn

Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream

Actinic Cheilitis

United States
Johns Hopkins University

Completed

Baclofen Treatment of Ataxia Telangiectasia

Ataxia Telangiectasia

United States
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Terminated

Gene Function in Bone Marrow Cells From Patients With Fanconi Anemia and From Healthy Participants

Fanconi Anemia

United States
NHS Tayside
University of Dundee

Completed

Response of Individuals With Ataxia-Telangiectasia to Metformin and Pioglitazone (RAMP)

Ataxia-Telangiectasia

United Kingdom
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Completed

Tissue Sample Collection From Patients With Fanconi Anemia

Unspecified Childhood Solid Tumor, Protocol Specific | Unspecified Adult Solid Tumor, Protocol Specific | Fanconi Anemia

United States
Johann Wolfgang Goethe University Hospital
CSL Behring

Completed

Susceptibility to Infections in Ataxia Telangiectasia

Infections | Lung Disease | Immunodeficiency | Ataxia Telangiectasia
Johann Wolfgang Goethe University Hospital

Unknown

Susceptibility to Infections, Tumor Risk and Liver Disease in Patients With Ataxia Telangiectasia

Ataxia Telangiectasia

Germany
Masonic Cancer Center, University of Minnesota
National Cancer Institute (NCI)

Terminated

Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Fanconi Anemia | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Diseases | Graft Versus Host Disease | Diamond-blackfan Anemia

United States
Premier Specialists, Australia

Unknown

Using Topical Sirolimus 2% for Patients With Epidermolysis Bullous Simplex (EBS) Study

Epidermolysis Bullosa Simplex | Epidermolysis Bullosa Simplex Kobner | Weber-Cockayne Syndrome

Australia
Rabin Medical Center

Unknown

Prostate Cancer Screening Among Men With High Risk Genetic Predisposition

Lynch Syndrome | BRCA1 Syndrome | BRCA2 Syndrome

Israel
Neena Kapoor, M.D.

Terminated

SCID Bu/Flu/ATG Study With T Cell Depletion

Severe Combined Immunodeficiency

United States
Novartis Pharmaceuticals

Completed

Study of Deferasirox in Iron Overload From Beta-thalassemia Unable to be Treated With Deferoxamine or Chronic Anemias

Myelodysplastic Syndromes | Fanconi Syndrome | Anemia, Aplastic | Beta-thalassemia | Anemia, Diamond-Blackfan

United States
Vanderbilt University Medical Center
National Cancer Institute (NCI)

Completed

Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer

Colorectal Cancer | Precancerous Condition | Hereditary Non-polyposis Colon Cancer

United States
Great Ormond Street Hospital for Children NHS Foundation...

Unknown

Gene Therapy for X-linked Severe Combined Immunodeficiency (SCID-X1)

X-linked Severe Combined Immunodeficiency

United Kingdom
Emory University
Children's Healthcare of Atlanta

Terminated

Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation

Sickle Cell Disease | Fanconi Anemia | Thalassemia | Severe Congenital Neutropenia | Wiskott-Aldrich Syndrome | Diamond-Blackfan Anemia | Severe Aplastic Anemia | Glanzmann Thrombasthenia | Leukocyte Adhesion Deficiency | Dyskeratosis-congenita | Chediak-Higashi Syndrome | Chronic-granulomatous Disease | Schwachman-Diamond...

United States
Universitaire Ziekenhuizen KU Leuven

Completed

I-Scan For Colon Polyp Detection In HNPCC

Lynch Syndrome | Hereditary Non-polyposis Colon Carcinoma | HNPCC

Belgium
Nahla Mahmoud Awad

Unknown

Efficacy of Endoscopic Transantral Surgical Approach in the Repair of Orbital Blow-Out Fractures

Orbital Floor Fracture
Neena Kapoor, M.D.

Withdrawn

Unrelated HSCT in Patients With Fanconi Anemia

Fanconi Anemia

United States
Prof. Evelien Dekker, MD, PhD
Dutch Digestive Diseases Foundation

Completed

Identifying Patients With Hereditary and Familial Colorectal Cancer by Using an Online Risk Tool (FR-QUENT)

Colorectal Cancer | Lynch Syndrome | Familial Colorectal Cancer
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Gene Therapy for the Treatment of Fanconi's Anemia Type C

Pancytopenia | Fanconi's Anemia

United States
National Cancer Institute (NCI)

Completed

Tabectedin to Treat Children and Adolescents With Cancer

Solid Tumors

United States
National Cancer Institute (NCI)

Completed

Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas

Solid Tumors | Lymphomas

United States
National Human Genome Research Institute (NHGRI)

Completed

Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCID

Severe Combined Immunodeficiency

United States
National Human Genome Research Institute (NHGRI)

Completed

Psychosocial Aspects of Genetic Testing for Hereditary Nonpolyposis Colon Cancer

HNPCC | Hereditary Nonpolyposis Colon Cancer

United States
National Institute of Allergy and Infectious Diseases...

Completed

Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID)

Severe Combined Immunodeficiency

United States
Boston Children's Hospital
National Heart, Lung, and Blood Institute (NHLBI); Children's Hospital Medical...

Completed

Bone Marrow Cell Gene Transfer in Individuals With Fanconi Anemia

Fanconi Anemia

United States
Atlantic Health System
Reproductive Medicine Associates of New Jersey

Completed

Do Patients With Early Post Operative Recurrence of Pelvic Organ Prolapse Have a Genetic Predisposition?

Pelvic Organ Prolapse

United States
National Cancer Institute (NCI)

Completed

Phase II ABT-888 With Cyclophosphamide

Ovarian Cancer | Fallopian Tube Cancer | Primary Peritoneal Cancer | Triple-Negative Breast Cancer | Serous Carcinoma Cancer

United States, Canada
NextGen Company Limited
Moscow State University of Medicine and Dentistry; Burnasyan Federal Medical...

Unknown

Gene-activated Matrix for Bone Tissue Repair in Maxillofacial Surgery

Jaw Fractures | Alveolar Bone Atrophy | Maxillofacial Bone Defects | Maxillofacial Bone Deformities | Bone Neoplasm, Benign | Disorders of Teeth and Jaw

Russian Federation
University of Surrey
Ashford and St. Peter's NHS Trust

Completed

DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease (DECODE)

Coronary Atherosclerosis

United Kingdom
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Low-Dose Total-Body Irradiation and Fludarabine Phosphate Followed by Unrelated Donor Stem Cell Transplant in Treating Patients With Fanconi Anemia

Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) | Fanconi Anemia | Adult Acute... and other conditions

United States
University of Florida
National Institute on Aging (NIA)

Completed

Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle

Sarcopenia

United States
ASTORA Women's Health

Completed

Pelvic Floor Repair Systems for Prolapse Repair (PROPEL)

Pelvic Organ Prolapse

United States, Belgium, France, Germany, Netherlands, Spain, United Kingdom
University of Calgary
Alberta Health services; Cook Group Incorporated

Completed

Trial of Small Intestine Submucosa (SIS) Mesh for Anterior Repair: A Pilot Study (Anterior SIS)

Anterior Pelvic Organ Prolapse

Canada
Kaiser Permanente
M.D. Anderson Cancer Center; Dana-Farber Cancer Institute; Vanderbilt University and other collaborators

Completed

Integrating Genetic Testing for Lynch Syndrome in a Managed Care Setting (HNPCC)

Lynch Syndrome | Colon Cancer

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI); Miltenyi Biotec, Inc.

Completed

Hematopoietic Stem Cell Transplantation for Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using Total Body Irradiation, Cyclophosphamide and Fludarabine

Fanconi Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)
Children's Hospital Medical Center, Cincinnati

Completed

Blood Cell Collection for Future Use in Individuals With Fanconi Anemia

Fanconi Anemia

United States
DNA Therapeutics

Completed

DNA Repair Inhibitor & Irradiation on Melanoma (DRIIM)

Local Metastatic Melanoma

France

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