Search clinical trials for: Fc fusion protein

Total 25324 results

Guy's and St Thomas' NHS Foundation Trust
Gilead Sciences; ViiV Healthcare

Completed

The Role of Home Packs of HIV PEPSE in High Risk Individuals (Home PEPSE)

HIV-1-infection

United Kingdom
Shire

Terminated

SPD489 Low Dose and High Dose Ranges When Added to Stable Doses of Antipsychotic Medications in Clinically Stable Adults With Negative Symptoms of Schizophrenia

Schizophrenia

United States
Novartis Pharmaceuticals

Completed

Pazopanib Versus Sunitinib in the Treatment of Locally Advanced and/or Metastatic Renal Cell Carcinoma (COMPARZ)

Carcinoma, Renal Cell

United States, Canada, Spain, United Kingdom, Taiwan, Netherlands, Australia, Germany, Italy, Japan, Sweden, China, Ireland, Korea, Republic of
University of Maryland, Baltimore

Completed

A Study to Evaluate of the Efficacy of Enfuvirtide During the Induction Phase of Therapy

HIV Infections

United States
University of British Columbia
Biogen

Completed

Factor Product Utilization and Health Outcomes in Patients With Hemophilia

Hemophilia A, Congenital | Hemophilia B, Congenital

Canada
RemeGen Co., Ltd.

Completed

Evaluation the Pharmacokinetics,Safety,Tolerability of Single Intravitreal Injection RC28-E in Subjects With Wet Age-Related Macular Degeneration

Neovascular Age-related Macular Degeneration

China
Tianjin SinoBiotech Ltd.

Completed

Study of Recombinant Human Serum Albumin/Interferon alpha2b Fusion Protein in Hepatitis B Patient

Hepatitis B Virus

China
IRCCS Azienda Ospedaliero-Universitaria di Bologna
University of Bologna

Completed

5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients

Inflammation | Mortality | Hyperhomocysteinemia

Italy
Fox Chase Cancer Center
National Cancer Institute (NCI)

Terminated

Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

United States
University of California, San Francisco
Pfizer; ViiV Healthcare

Completed

Effects of Maraviroc (MVC) on HIV-related Kaposi's Sarcoma (KS)

Kaposi's Sarcoma

United States
Shire

Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Ascending, Subcutaneous, Single and Multiple Doses of SHP681 (Glucagon-like Peptide-2 [GLP-2] Analog-Fc Fusion) in Healthy Adult Participants

Healthy Volunteers

United States
Oncoethix GmbH

Completed

A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003)

Triple Negative Breast Cancer | Pancreatic Ductal Adenocarcinoma | Castrate-resistant Prostate Cancer | CRPC | NUT Midline Carcinoma | Non-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation
Abramson Cancer Center of the University of Pennsylvania

Completed

Phase II Maraviroc for GVHD Prevention

Hematologic Malignancy

United States
Bioverativ Therapeutics Inc.
Swedish Orphan Biovitrum; Syntonix Pharmaceuticals, Inc.

Completed

Phase I/IIa Study of FIXFc in Hemophilia B Patients

Hemophilia B

United States
Fondazione Italiana Linfomi ONLUS

Completed

Fase II Study With BRB for Non-Hodgkin Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia's (FIL_BRB)

Waldenstrom's Macroglobulinemia

Italy
Shahid Beheshti University

Completed

Trial of Protein Supplement on Vertebral Fusion in Posterior Spine Fusion Surgery

Spine Surgery

Iran, Islamic Republic of
Mayo Clinic
National Cancer Institute (NCI)

Completed

Ponatinib Hydrochloride in Treating Patients With Advanced Biliary Cancer With FGFR2 Fusions

Malignant Hepatobiliary Neoplasm

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

Anti-CD20 Radioimmunotherapy Before Chemotherapy and Stem Cell Transplant in Treating Patients With High-Risk B-Cell Malignancies

Diffuse Large B-Cell Lymphoma | Burkitt Lymphoma | Mantle Cell Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma | Indolent Non-Hodgkin Lymphoma | CD20-Positive Neoplastic Cells Present | Refractory Mature B-Cell Non-Hodgkin Lymphoma

United States
University of Turin, Italy

Withdrawn

Pharmacokinetics of Maraviroc and Boosted Atazanavir Dual Regimen in Stable HIV-infected Patients

HIV Infection

Italy
Giovanni Di Perri

Terminated

Using Less Neurotoxic Drugs in Patients With HAND (MARAND-X) ((MARAND-X))

Hiv | Neurocognitive Dysfunction

Italy
Temple University
Pfizer; Abbott

Terminated

Kaletra and Maraviroc in Antiretroviral Therapy (ART)-Naive Patients (KALMAR Study) (KALMAR)

HIV Infections

United States
Tianjin SinoBiotech Ltd.

Completed

Study on Single Administration and Dose Increment of Recombinant Human Serum Albumin/Erythrocyte Fusion Protein for Injection

Healthy Subjects

China
Weill Medical College of Cornell University

Withdrawn

CIMER: Combined Immunotherapies in Metastatic ER+ Breast Cancer (CIMER)

Breast Cancer
University of Texas Southwestern Medical Center
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Instant Total Contact Cast to Heal Diabetic Foot Ulcers (ITCC)

Diabetic Foot Ulcers

United States
University of California, San Diego
University of California, Los Angeles; Pfizer; University of Southern California and other collaborators

Completed

CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery

HIV Infections

United States
University of California, San Francisco
Pfizer; Stanford University; amfAR, The Foundation for AIDS Research; Case Western... and other collaborators

Completed

Maraviroc as an Immunomodulatory Drug for Antiretroviral-treated HIV Infected Patients Exhibiting Immunologic Failure

HIV Infection

United States
OncoMed Pharmaceuticals, Inc.

Completed

Dose Escalation Study of OMP-54F28 in Combination With Sorafenib in Patients With Hepatocellular Cancer

Liver Cancer | Hepatocellular Cancer

United States
Federal University of São Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo; Conselho Nacional de... and other collaborators

Completed

Multi Interventional Study Exploring HIV-1 Residual Replication: a Step Towards HIV-1 Eradication and Sterilizing Cure

HIV | Chronic Infection

Brazil
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Brain and Central Nervous System Tumors | Unspecified Adult Solid Tumor, Protocol Specific | Multiple Myeloma and Plasma Cell Neoplasm | Lymphoproliferative Disorder | Myelodysplastic/Myeloproliferative Neoplasms

United States
ViiV Healthcare
Pfizer

Active, not recruiting

An Open Label Pharmacokinetic, Safety And Efficacy Study Of Maraviroc In Combination With Background Therapy For The Treatment Of HIV-1 Infected, CCR5 -Tropic Children

Human Immunodeficiency Virus

Spain, United States, Italy, South Africa, Brazil, Mexico, Portugal, Puerto Rico, Thailand
Pharmacyclics Switzerland GmbH
Janssen Research & Development, LLC

Completed

Study of Ibrutinib in Combination With Bortezomib and Dexamethasone in Subjects With Relapsed/Relapsed and Refractory Multiple Myeloma

Multiple Myeloma

Spain, Germany, Turkey, Greece, Italy, Czechia
Ottawa Hospital Research Institute
Pfizer

Completed

A Drug Interaction Study Investigating the Effect of Rifabutin on the Pharmacokinetics of Maraviroc (RIFAMARA)

HIV Infection | HIV-1 Infection | Mycobacterium Avium Complex (MAC)

Canada
Children's Hospital Medical Center, Cincinnati

Terminated

Maraviroc as GVHD Prophylaxis in Transplant Recipients

Graft Versus Host Disease (GVHD) | Diagnoses That Require Stem Cell Transplant

United States
Novartis Pharmaceuticals

Terminated

A Safety and Efficacy Study of INC280 Alone, and in Combination With Erlotinib, Compared to Chemotherapy, in Advanced/Metastatic Non-small Cell Lung Cancer Patients With EGFR Mutation and cMET Amplification

Non-Small Cell Lung Cancer

Italy, Singapore, Spain, Germany, Korea, Republic of, United States, Belgium, France, Netherlands, Japan
Germans Trias i Pujol Hospital

Completed

Efficacy of Treatment Intensification With Maraviroc on HIV-1 Viral Latency in Recently Infected Hiv-1 naïve Patients Starting Raltegravir Plus Tenofovir/Emtricitabine

HIV Infections

Spain
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant

Acute Myeloid Leukemia | Hodgkin Lymphoma | Waldenstrom Macroglobulinemia | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Non-Hodgkin Lymphoma | Plasma Cell Myeloma | Myelodysplastic/Myeloproliferative Neoplasm | Graft Versus Host Disease | Chronic Myelogenous Leukemia, BCR-ABL1 Positive

United States, Italy
Maimónides Biomedical Research Institute of Córdoba

Terminated

Study of Pomalidomide, Oral Dexamethasone and Very Low-dose Cyclophosphamide in Patients With Refractory Multiple Myeloma Who Have Received Lenalidomide and Bortezomib (POCODEX)

Multiple Myeloma

Spain
University of California, San Francisco

Terminated

Capmatinib, Ceritinib, Regorafenib, or Entrectinib in Treating Patients With BRAF/NRAS Wild-Type Stage III-IV Melanoma

ALK Fusion Protein Expression | Stage III Cutaneous Melanoma | Stage IIIA Cutaneous Melanoma | Stage IIIB Cutaneous Melanoma | Stage IIIC Cutaneous Melanoma | Stage IV Cutaneous Melanoma | ROS1 Fusion Positive | BRAF wt Allele | Invasive Skin Melanoma | MET Fusion Gene Positive | NRAS wt Allele | NTRK1 Fusion... and other conditions

United States
RemeGen Co., Ltd.

Completed

A Phase I Study of TACI-antibody Fusion Protein Injection (RC18) in Healthy Adult Chinese Subjects

Healthy

China
Mayo Clinic
National Cancer Institute (NCI)

Completed

Vaccine Therapy With or Without Cryosurgery in Treating Patients With Residual, Relapsed, or Refractory B-Cell Non-Hodgkin Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Splenic Marginal Zone Lymphoma | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Cutaneous B-cell Non-Hodgkin Lymphoma | Small Lymphocytic Lymphoma | Adult Grade III Lymphomatoid... and other conditions

United States
ViiV Healthcare
GlaxoSmithKline

Completed

Pharmacodynamics, Safety and Pharmacokinetics of BMS-663068, an HIV Attachment Inhibitor, in HIV-1

HIV Infections

Germany
ViiV Healthcare
Pfizer

Completed

Safety And Efficacy Of Maraviroc In Patients For HIV Patients (Regulatory Post Marketing Commitment Plan)

CCR5-tropic HIV-1 Infection
University of Maryland, Baltimore

Withdrawn

Impact of Sirolimus and Maraviroc on CCR5 Expression and the HIV-1 Reservoir in HIV-infected Kidney Transplant Recipients

Hiv | Kidney Transplant | HIV Reservoir | CCR5

United States
National Cancer Institute (NCI)

Completed

A Pilot Study of Tumor-Specific Peptide Vaccination and IL-2 With or Without Autologous T Cell Transplantation in Recurrent Pediatric Sarcomas

Rhabdomyosarcoma | Ewing's Sarcoma

United States
University of North Carolina, Chapel Hill
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

ENLIGHTEN: Establishing Novel Antiretroviral (ARV) Imaging for Hair to Elucidate Non-Adherence (ENLIGHTEN)

HIV/AIDS

United States
University of Wisconsin, Madison
National Cancer Institute (NCI)

Completed

Hu14.18-Interleukin-2 Fusion Protein in Treating Patients With Advanced Melanoma

Melanoma (Skin)

United States
Pfizer

Completed

Study Of Letrozole With Or Without Palbociclib (PD-0332991) For The First-Line Treatment Of Hormone-Receptor Positive Advanced Breast Cancer

Breast Cancer

Korea, Republic of, United States, Spain, Germany, Ireland, Hungary, Canada, France, Italy, Russian Federation, South Africa, Ukraine
Imperial College London
Pfizer

Completed

The Maraviroc Central Nervous System (CNS) Study

HIV Infections

United Kingdom
Imperial College London

Completed

The Maraviroc Darunavir/Ritonavir Once Daily Pharmacokinetic Study

HIV

United Kingdom
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory Neuroblastoma

Recurrent Neuroblastoma

United States, Canada

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