Search clinical trials for: Long term safety

Total 114687 results

Abivax S.A.

Active, not recruiting

Long-term Safety and Efficacy Profile of ABX464 in Subjects With Moderate to Severe Active Ulcerative Colitis

Ulcerative Colitis

Belgium, Poland, Czechia, Hungary
Sumitomo Pharma America, Inc.

Completed

A Study of the Long-term Safety and Tolerability of an Investigational Drug in People With Schizophrenia.

Schizophrenia

United States, Romania, Russian Federation, Ukraine
Takeda

Completed

Vonoprazan Study in Patients With Erosive Esophagitis to Evaluate Long-term Safety

Erosive Esophagitis

Japan
Celgene

Active, not recruiting

A Study to Evaluate Long-term Safety of CC-486 (Oral Azacitidine) in Subjects With Hematological Disorders

Neoplasms | Hematologic Malignancies | Hematologic Neoplasm

United Kingdom, United States
LIB Therapeutics LLC
Medpace, Inc.

Active, not recruiting

Study of Long-Term Efficacy and Safety of LIB003 in CVD or High Risk for CVD Patients Needing Further LDL-C Reduction (LIBerate-HR)

Cardiovascular Diseases | Hypercholesterolemia | Cardiovascular Risk Factor | Cardiovascular Stroke

United States, Israel, India
Wyeth is now a wholly owned subsidiary of Pfizer

Terminated

Study Evaluating the Long-Term Safety of Desvenlafaxine Succinate Sustained-Release (DVS SR) in Subjects With Pain Associated With Diabetic Peripheral Neuropathy

Diabetic Neuropathy, Painful
BioMarin Pharmaceutical

Active, not recruiting

A Study to Evaluate Long-Term Safety, Tolerability, & Efficacy of BMN 111 in Children With Achondroplasia (ACH) (ACH)

Achondroplasia

United States, Australia, France, United Kingdom
Hoffmann-La Roche

Completed

An Extension Study of WA19926 of the Long-Term Safety of Tocilizumab (RoActemra/Actemra) in Patients With Early Moderate to Severe Rheumatoid Arthritis

Rheumatoid Arthritis

Russian Federation
Sumitomo Pharma America, Inc.

Terminated

A Clinical Trial to Determine the Long-term Safety and Tolerability of an Investigational Drug in People With Major Depressive Episode Associated With Bipolar I Disorder (Bipolar I Depression).

Depressive Episodes, Bipolar I Depression

United States, Bulgaria, Japan
UCB Biopharma SRL

Completed

A Study to Evaluate the Long-Term Safety and Efficacy of Bimekizumab in Subjects With Psoriatic Arthritis (BE ACTIVE 2)

Psoriatic Arthritis

United States, Czechia, Germany, Hungary, Poland, Russian Federation
PTC Therapeutics

Completed

Long-Term Safety and Efficacy Evaluation of EPI-743 in Children With Leigh Syndrome

Leigh Syndrome

United States
Catalyst Pharmaceuticals, Inc.

Terminated

Long Term Safety of Amifampridine Phosphate in Spinal Muscular Atrophy 3 (SMA3)

Spinal Muscular Atrophy Type 3

Italy
Karuna Therapeutics

Completed

An Extension Study to Assess Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-4)

Schizophrenia

United States, Ukraine
SCM Lifescience Co., LTD.

Active, not recruiting

A Long-term Safety Follow-up Study of SCM-AGH in Patients Who Completed SCM-APT2001 Study

Pancreatitis, Acute

Korea, Republic of
Galapagos NV
Gilead Sciences

Active, not recruiting

Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis (SELECTIONLTE)

Ulcerative Colitis

United States, Netherlands, Israel, Spain, Taiwan, Australia, Italy, Hong Kong, Singapore, Korea, Republic of, Canada, Germany, United Kingdom, New Zealand, Ireland, Poland, Romania, Croatia, Belgium, Japan, India, Malaysia, Sweden, F... and more
Zealand Pharma

Enrolling by invitation

Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS - Extension Trial (EASE SBS 3)

Short Bowel Syndrome

Germany, United States, Belgium, Denmark, France, United Kingdom, Netherlands, Poland
Sumitomo Pharma America, Inc.

Completed

Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease

Parkinson Disease

United States, Spain, United Kingdom, Italy, Canada, Austria, France, Germany
Merck Sharp & Dohme LLC

Active, not recruiting

Study of Doravirine/Islatravir (DOR/ISL 100 mg/0.75 mg) to Evaluate the Antiretroviral Activity, Safety, and Tolerability in Treatment-Naïve Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-020)

HIV-1 Infection

United States, Argentina, Canada, Chile, Colombia, France, Germany, Israel, Italy, Japan, South Africa, Spain, Taiwan
UNEEG Medical A/S

Completed

Safety and Performance of Short- and Long-term Baseplates for Attaching the Marco Recorder

Healthy Subjects

Denmark
Ionis Pharmaceuticals, Inc.

Completed

Extension Study Assessing Long Term Safety and Efficacy of IONIS-TTR Rx in Familial Amyloid Polyneuropathy (FAP)

Amyloidosis | Familial Amyloid Polyneuropathy | FAP | TTR | Transthyretin

United States, Spain, Argentina, Brazil, France, Germany, Italy, Portugal, United Kingdom
Qiang Shu

Completed

The Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months and Long-term Treatment

Arthritis, Rheumatoid

China
Biohaven Pharmaceuticals, Inc.

Enrolling by invitation

Long-term Safety Study of Adjunctive Troriluzole in Subjects With Obsessive Compulsive Disorder

Obsessive Compulsive Disorder

Canada, United States, Spain, United Kingdom, Italy, Netherlands
Merz Aesthetics GmbH
Merz Pharmaceuticals GmbH

Completed

Study to Investigate the Safety and Duration of Effect of Different Botulinum Toxin A (NT 201) Dose Groups Following the Treatment of Glabellar Frown Lines

Moderate to Severe Glabellar Frown Lines

United States, Germany
Centre hospitalier de l'Université de Montréal...
Recordati Rare Diseases

Active, not recruiting

Canadian Continuation of Roll-over Study in Patients With Endogenous Cushing's Syndrome (ISS-CA-2023)

Endogenous Cushing Syndrome

Canada
NuVasive

Enrolling by invitation

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

Degenerative Disc Disease | Cervical Disc Disease

United States
NuVasive

Enrolling by invitation

Long-Term Assessment of the Safety and Performance of the NuVasive Simplify Disc at Two Levels

Degenerative Disc Disease | Cervical Disc Disease

United States
Italfarmaco
Cromsource

Enrolling by invitation

Givinostat in Duchenne's Muscular Dystrophy Long-term Safety and Tolerability Study

Duchenne Muscular Dystrophy

Spain, United States, Canada, Belgium, France, Israel, Italy, Netherlands, Serbia, Germany, United Kingdom
AbbVie

Active, not recruiting

A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)

Ulcerative Colitis (UC)

United States, Argentina, Australia, Austria, Belarus, Belgium, Bosnia and Herzegovina, Brazil, Canada, Chile, China, Colombia, Croatia, Czechia, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Korea, Republic... and more
Novartis Pharmaceuticals

Completed

Study to Assess the Safety and Efficacy of Ribociclib (LEE011) in Combination With Letrozole for the Treatment of Men and Pre/Postmenopausal Women With HR+ HER2- aBC (COMPLEEMENT-1)

Breast Cancer

United States, Belgium, Canada, Italy, Spain, United Kingdom, Austria, Czechia, Hungary, Malaysia, Saudi Arabia, Taiwan, Argentina, France, Israel, Netherlands, Russian Federation, Hong Kong, Thailand, Lebanon, Bulgaria, Denmark, Po... and more
UCB Biopharma SRL

Completed

A Study to Evaluate the Long Term Safety and Efficacy of Bimekizumab in Subjects With Ankylosing Spondylitis (BE AGILE 2)

Ankylosing Spondylitis

United States, Bulgaria, Canada, Czechia, Germany, Hungary, Poland, Russian Federation, Spain, Ukraine
Mirum Pharmaceuticals, Inc.

Completed

Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis (INDIGO)

Progressive Familial Intrahepatic Cholestasis (PFIC)

United States, United Kingdom, Poland, France
Pfizer

Terminated

Long Term Safety Observation of Crizotinib in Chinese NSCLC Population

ALK or ROS1-positive NSCLC

China
Galapagos NV
Gilead Sciences

Active, not recruiting

Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Adults With Rheumatoid Arthritis (FINCH 4)

Rheumatoid Arthritis

Spain, United States, Japan, Korea, Republic of, Taiwan, Belgium, India, Malaysia, Argentina, Australia, Poland, Czechia, Serbia, Germany, New Zealand, Bulgaria, Canada, Chile, France, Hong Kong, Hungary, Ireland, Israel, Italy, Mexico, R... and more
Genentech, Inc.

Terminated

A Study Assessing the Long-Term Safety and Tolerability of Galegenimab (FHTR2163) in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Geographic Atrophy | Macular Degeneration, Age-Related

United States
Regeneron Pharmaceuticals
Teva Pharmaceutical Industries, Ltd.

Completed

Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip (FACT LTS & OA)

Osteoarthritis of the Knee or Hip

United States, Bulgaria, Chile, Colombia, Denmark, Estonia, Germany, Hong Kong, Hungary, Italy, Lithuania, Mexico, Peru, Poland, Romania, Russian Federation, South Africa, Spain, Sweden, Ukraine, United Kingdom
Actelion

Completed

Clinical Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Ponesimod in Patients With Relapsing-remitting Multiple Sclerosis

Multiple Sclerosis

Poland, Ukraine, United Kingdom, United States, Germany, Spain, Bulgaria, Romania, Serbia, Canada, Finland, Sweden, Russian Federation, Hungary, Czechia, Netherlands, Israel, Switzerland, Austria, France
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Safety And Efficacy In Long Term Use Of Lyrica (Regulatory Post Marketing Commitment Plan) (RAINBOW-L)

Neuropathic Pain
Sollis Therapeutics, Inc.

Completed

Long-Term Follow-up Safety of Clonidine Micropellets (RePRIEVE-CM-LT)

Lumbosacral Radiculopathy

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Long-term Safety and Efficacy of Deucravacitinib in Participants With Crohn's Disease or Ulcerative Colitis

Crohn Disease | Ulcerative Colitis

Romania, Italy, United States, Australia, Canada, China, Germany, Hungary, Japan, Netherlands, Poland, Portugal, Russian Federation, Spain, Taiwan, United Kingdom
Novartis Pharmaceuticals

Completed

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension (CONTRAIL I)

Liver Transplant Rejection

United States, Belgium, Germany, Spain, Argentina, Netherlands, Italy, Hungary, France, Czechia
Zealand Pharma

Completed

The Long-term Effect on Intestinal Absorption and Safety of Treatment With Glepaglutide in Patients With Short Bowel Syndrome (EASE SBS 4)

Short Bowel Syndrome

Denmark
Genentech, Inc.

Terminated

An Extension Study to Evaluate the Long-Term Safety and Tolerability of UTTR1147A in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease

Crohn's Disease | Ulcerative Colitis

Germany, Italy, Poland, Russian Federation, Serbia, United States, Ukraine, Bulgaria, Georgia, Greece, Ireland, Moldova, Republic of, Spain, United Kingdom
Novartis Pharmaceuticals

Completed

An Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of LOU064 in Subjects With CSU

Chronic Spontaneous Urticaria

United States, Belgium, United Kingdom, Hungary, Spain, France, Turkey, Canada, Czechia, Russian Federation, Poland, Japan, Argentina, Denmark, Slovakia
Bristol-Myers Squibb

Active, not recruiting

Long-Term Study That Measures the Safety and Efficacy of Deucravacitinib (BMS-986165) in Participants With Psoriasis (POETYK PSO-LTE)

Psoriasis

China, Taiwan, Spain, United States, Hungary, Canada, Germany, Japan, Australia, Poland, Czechia, United Kingdom, Korea, Republic of, Israel, New Zealand, Sweden, France, Finland, Russian Federation, Puerto Rico
Vertex Pharmaceuticals Incorporated

Completed

A Study to Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Participants With Cystic Fibrosis Who Have an F508del-CFTR Mutation

Cystic Fibrosis

United States, Australia, Canada, France, United Kingdom, Germany, Spain, Switzerland, Belgium, Israel, Netherlands, Denmark, Italy, Austria, Ireland, Sweden
AstraZeneca

Completed

Long-term Observational Study of the Safety of Roflumilast

COPD

Sweden, Germany, United States, Norway
Galderma R&D

Active, not recruiting

Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis

Moderate-to-Severe Atopic Dermatitis

United States, Australia, Austria, Belgium, Bulgaria, Canada, Czechia, Estonia, France, Georgia, Germany, Hungary, Italy, Korea, Republic of, Latvia, Lithuania, Netherlands, New Zealand, Poland, Singapore, Spain, United Kingdom
Zogenix International Limited, Inc., a subsidiary...

Completed

An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride HCl) Oral Solution in Children and Young Adults With Dravet Syndrome

Dravet Syndrome

United States, United Kingdom, Spain, Belgium, Italy, Australia, Denmark, Germany, Canada, Japan, Netherlands, France
Vertex Pharmaceuticals Incorporated

Completed

Long-term Safety of Lumacaftor/Ivacaftor in Subjects With Cystic Fibrosis Who Are Homozygous for F508del and 12 to <24 Months of Age at Treatment Initiation

Cystic Fibrosis

United States, Canada
UCB Pharma

Completed

Study Evaluating Long-term Safety and Efficacy of Lacosamide in Subjects With Painful Distal Diabetic Neuropathy.

Painful Diabetic Neuropathy

Russian Federation, Austria, Belgium, Bulgaria, Czechia, Finland, France, Germany, Hungary, Italy, Poland, Romania, Serbia, Spain, United Kingdom

Search clinical trials for: Long term safety

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