Search clinical trials for: Single Oral Doses

Total 27713 results

Fochon Pharmaceuticals, Ltd.

Recruiting

A Safety and Tolerability Study of FCN-207 in Healthy Volunteers

Hyperuricemia

China
Carilion Clinic

Recruiting

Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery

Surgical Site Infection

United States
Aligos Therapeutics

Recruiting

A Study of ALG-000184 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single and Multiple Doses in Healthy Volunteers and CHB Subjects

Chronic Hepatitis B

Hong Kong, China, United Kingdom, Moldova, Republic of, New Zealand, Australia, Mauritius
University of Malaya

Recruiting

Single Dose Intravenous Iron Isomaltoside in Combination With Oral Iron vs Oral Iron Monotherapy in Patients With Anemia After Postpartum Haemorrhage (IVIronPPH)

Anemia | Post Partum Hemorrhage

Malaysia
University of Leipzig

Recruiting

Leipzig Childhood Obesity Study

Childhood Obesity

Germany
Second Affiliated Hospital, School of Medicine,...
Zhejiang Provincial Hospital of TCM; Guiyang Hospital of Stomatology

Recruiting

Head Yuanshi Dian Therapy in Burning Mouth Syndrome

Burning Mouth Syndrome | Oral Mucosa Disease

China
Beijing Tongren Hospital

Recruiting

Human Placental Mesenchymal Stem Cells Treatment on Diabetic Foot Ulcer

Diabetic Foot Ulcer

China
National Cancer Institute (NCI)

Recruiting

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Anal Canal Cloacogenic Carcinoma | Metastatic Anal Squamous Cell Carcinoma | Recurrent Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IV Anal Cancer AJCC v8 | Unresectable Anal Squamous Cell Carcinoma | Anal Basaloid Squamous Cell Carcinoma

United States
University of Alabama at Birmingham

Recruiting

Renal Metabolism of Glycolate to Oxalate

Healthy

United States
Yonsei University

Recruiting

The Efficacy and Safety of Non-vItamiN K antaGonist oraL Anticoagulants for intermEdiate Stroke Risk in Patients With Atrial Fibrillation (SINGLE-AF)

Atrial Fibrillation Patients With Intermediate Stroke Risk

Korea, Republic of
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Oral Cavity Squamous Cell Carcinoma | Stage I Lip and Oral Cavity Cancer AJCC v8 | Stage II Lip and Oral Cavity Cancer AJCC v8 | Buccal Mucosa Squamous Cell Carcinoma | Floor of Mouth Squamous Cell Carcinoma | Gingival Squamous Cell Carcinoma | Hard Palate Squamous Cell Carcinoma | Lip Squamous Cell... and other conditions

United States, Canada
Palatin Technologies, Inc

Recruiting

Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects

Heart Failure With Preserved Ejection Fraction

United States
Beijing Tongren Hospital

Recruiting

The Phase I Study of Recombinant Human Nerve Growth Factor Injection

Injury of Optic Nerve

China
University of Nottingham
Sanofi

Recruiting

MRI Assessment of Mode of Action of Bisacodyl, Single Dose (MODS)

Constipation

United Kingdom
University of Nottingham
Sanofi

Recruiting

MRI Assessment of Mode of Action of Bisacodyl, Multiple Doses (MODEM)

Constipation

United Kingdom
Cecilia Soderberg-Naucler
Karolinska University Hospital; Karolinska Institutet

Recruiting

A Clinical Trial Evaluating the Efficacy of Valganciclovir in Glioblastoma Patients (VIGAS2)

Glioblastoma Multiforme

Sweden
Institut Paoli-Calmettes
INATHERYS

Recruiting

Study of Escalating Doses of INA03 Administered Intravenously as Single Agent in Adult Patients With Relapse/Refractory Acute Leukemia (INA03)

Acute Lymphoblastic Leukemia, in Relapse | Acute Myeloid Leukemia, in Relapse | Mixed Phenotype Acute Leukemia | Acute Lymphoblastic Leukemia Recurrent | Acute Myeloid Leukaemia Recurrent

France
Rush University Medical Center

Recruiting

Single Versus Multi-Dose Oral and Intravenous Tranexamic Acid Patients at High Risk for Blood Transfusion After Spine Surgery

Open Posterior Thoracolumbar Spinal Fusion Procedure

United States
Viramal Limited
Simbec Research

Recruiting

Study to Investigate the Pharmacokinetics & Safety Following One Application of 3 Different Doses 0.5,0.75,& 1.25 gm,a Transdermal Estradiol Cream (VML-0203), in Comparison to a Single Dose of EstroGel 1.25 gm to Healthy Post-menopausal Women.

Menopause

United Kingdom
Southern California Institute for Research and...

Recruiting

A Prospective, Randomized, Open Label Trial of Two Doses of Oral Betaine

Non-Alcoholic Fatty Liver Disease | Non Insulin Dependent Diabetes | ALT

United States
Cellectar Biosciences, Inc.

Recruiting

Study of Iopofosine I 131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia (CLOVER-WaM)

Multiple Myeloma | Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Diffuse Large B Cell Lymphoma | Small Lymphocytic Lymphoma | Central Nervous System Lymphoma

United States, Australia, Czechia, Greece, Israel, Brazil, Finland, France, Spain, Turkey, United Kingdom
EMS

Recruiting

Efficacy and Safety of Three Doses of Florence Oral Suspension in Adults With Eosinophilic Esophagitis

Eosinophilic Esophagitis

Brazil
Hamad Medical Corporation

Recruiting

Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.

Bronchial Asthma

Qatar
Mansoura University

Recruiting

Dual Trigger Versus GnRHa Trigger Combined With Luteal HCG Administration

Infertility

Egypt
Transdermal Delivery Solutions Corp
Advanced Therapies Centre, The London Clinic

Not yet recruiting

A Dose Ranging Study to Examine TDS-Testosterone 5% (PARC-T-D)

Hypogonadotropism

United Kingdom
Kyowa Kirin Co., Ltd.
Kyowa Hakko Kirin Pharma, Inc.

Completed

A Study of Single and Multiple Doses of KHK6640 in Subjects With Prodromal or Mild to Moderate Alzheimer's Disease

Alzheimer's Disease

Belgium, Finland, Netherlands, Serbia, Sweden
National Cancer Institute (NCI)

Active, not recruiting

Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer

Stage IV Lung Cancer AJCC v8 | Lung Non-Squamous Non-Small Cell Carcinoma | Stage IIIB Lung Cancer AJCC v8 | Stage IIIC Lung Cancer AJCC v8

United States, Canada, Guam
Incyte Corporation

Completed

A Study Assessing the Mass Balance, Pharmacokinetics, and Metabolite Profiles of a Single Oral Dose of [14C]INCB099280 in Healthy Male Participants

Healthy Participants

United Kingdom
National Cancer Institute (NCI)

Active, not recruiting

Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Olaparib) for Men With Advanced Prostate Cancer

Castration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Stage IV Prostate Adenocarcinoma AJCC v7 | Advanced Prostate Adenocarcinoma With Neuroendocrine Differentiation | Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation | Prostate Adenocarcinoma With Neuroendocrine...

United States
Alexion Pharmaceuticals, Inc.
Celerion

Completed

Safety and Tolerability, PK, and PD Study of Single and Multiple ALXN2080 Doses in Healthy Participants

Healthy

United Kingdom
Memorial Sloan Kettering Cancer Center
Y-mAbs Therapeutics

Active, not recruiting

Bivalent Vaccine With Escalating Doses of the Immunological Adjuvant OPT-821, in Combination With Oral β-glucan for High-Risk Neuroblastoma

Neuroblastoma

United States
Washington University School of Medicine
Case Western Reserve University; University of Health and Allied Sciences

Completed

Safety and Efficacy of IDA for Onchocerciasis (DOLF IDA/Oncho)

Onchocerciasis

Ghana
Ottawa Hospital Research Institute
The Ottawa Hospital Academic Medical Association; Network of Canadian Emergency...

Enrolling by invitation

High-dose Cephalexin for Cellulitis (HI-DOCC) (HI-DOCC)

Cellulitis

Canada
Nuvamid SA
Medpace, Inc.; Anapharm; LGD

Completed

Study of the Safety, Tolerability, and Pharmacokinetics of NUV001 Administered Orally to Healthy Adult Participants

Healthy Volunteers

United States
Hoffmann-La Roche

Active, not recruiting

A Study to Evaluate Single Subcutaneous Doses of NXT007 Among Injection Sites Abdomen, Upper Arm, and Thigh in Healthy Male Participants

Healthy Male Participants

New Zealand
AstraZeneca

Active, not recruiting

A Study to Assess the Safety and Tolerability of Single Doses of AZD4076 in Healthy Male Subjects

Non-alcoholic Steatohepatitis (NASH)

United States
Arcus Biosciences, Inc.

Completed

Study to Investigate the Safety, Tolerability, and Pharmacokinetic Profile With Oral AB521 in Healthy Volunteers (ARC-14)

Healthy Participants

Netherlands
Genentech, Inc.

Active, not recruiting

Safety and Pharmacokinetics (PK) of Escalating Doses of Tiragolumab as a Single Agent and in Combination With Atezolizumab and/or Other Anti-Cancer Therapies in Locally Advanced or Metastatic Tumors

Advanced/Metastatic Tumors

Spain, United States, Korea, Republic of, Australia, France, Japan, Canada
Biogen

Completed

A Study to Look at How a Single Oral Dose of Carbon-14-Labelled [14C] BIIB091 Moves Through and is Processed by the Body in Healthy Male Participants (Mass Balance)

Healthy Volunteer

United States
Eli Lilly and Company

Completed

A Study of Two Doses of Dulaglutide (LY2189265) in Japanese Patients With Type 2 Diabetes (AWARD-JPN)

Glucose Metabolism Disorders | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Endocrine System Diseases | Metabolic Disease | Type 2 Diabetes Mellitus (T2DM) | Hypoglycemic Agents

Japan
OrsoBio, Inc

Completed

A Study to Evaluate Single and Multiple Doses of TLC-2716 in Healthy Participants

Healthy Subjects

New Zealand
Boston Scientific Corporation

Active, not recruiting

Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation (ASAP-TOO)

Stroke

United States, Denmark, Germany, Netherlands, United Kingdom, Belgium, Canada, Czechia, Italy
Organon and Co

Completed

Performance and Safety of Vaginal Ring Applicator in Healthy Females (MK-8342A-063)

Contraception: Optional Applicator for Insertion of Vaginal Ring
University of Oxford
Malaria Research and Training Center, Bamako, Mali

Active, not recruiting

Assessment of Safety and Immunogenicity of a Single Vial Presentation of R21/Matrix-M and Co-Administration With EPI Vaccines

Malaria

Mali, United Kingdom
Amgen

Active, not recruiting

Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke (VESALIUS-CV)

Coronary Heart Disease (CHD)

Canada, France, United States, Spain, United Kingdom, Korea, Republic of, Netherlands, Austria, Australia, Czechia, Taiwan, Finland, Hungary, Italy, Poland, Greece, Germany, Brazil, Latvia, Denmark, Mexico, Russian Federation, Bulgaria and more
Medicines for Malaria Venture
Q-Pharm Pty Limited; Clinical Network Services (CNS) Pty Ltd; QIMR Berghofer...

Completed

Safety, Tolerability and Antimalarial Activity of Single Doses of OZ439 and PQP

Malaria

Australia
Madrigal Pharmaceuticals, Inc.

Enrolling by invitation

A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Multiple Oral Doses (6 Days) of 100 mg Resmetirom in Subjects With Severe Renal Impairment and in Matched Healthy Control Subjects With Normal Renal Function

Renal Impairment

United States
Oxford Cannabinoid Technologies Holdings PLC
Simbec-Orion Group

Completed

Single Ascending Oral Dose Study to Investigate the Effects of OCT461201 in Healthy Volunteers

Healthy

United Kingdom
University Medical Center Groningen
Netherlands Heart Foundation

Completed

Effects of a Single Oral Dose of KETone Ester ON Exercise Performance in Patients With Chronic Heart Failure (KETONE-HF)

Heart Failure | Heart Failure With Reduced Ejection Fraction

Netherlands
GlaxoSmithKline

Terminated

A First Time in Human (FTIH) Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of GSK3884464 in Healthy Participants

Heart Failure

United Kingdom

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