Search clinical trials for: DNA Repair

Total 11224 results

Assistance Publique - Hôpitaux de Paris

Unknown

Consequences of DNA Repair and Telomere Defects on the Function of the Immune System: Application to CVID and Immune Deficiencies With Dysmorphic Syndromes (IMMUNEREP)

Immune Deficiency and Early BMF in Childhood

France
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cord Blood Stem Cell Transplantation Study (COBLT)

Neoplasms | Myelodysplastic Syndromes | Hematologic Diseases | Leukemia | Severe Combined Immunodeficiency | Fanconi Anemia | Anemia, Aplastic | Hematopoietic Stem Cell Transplantation
National Health Research Institutes, Taiwan
Chang Gung Memorial Hospital

Unknown

Hereditary Nonpolyposis Colorectal Cancer in Taiwan-Related Genetic Study and Clinical Applications

Hereditary Nonpolyposis Colorectal Cancer

Taiwan
National Taiwan University Hospital

Unknown

Comparisons of Clinical Outcomes Between Novel Tailored Transvaginal Mesh Surgery and Vaginal Native Tissue Repair Surgery for Pelvic Organ Prolapse

Pelvic Organ Prolapse

Taiwan
Coloplast A/S

Terminated

Exair® Versus Native Tissue Repair for Prolapse

Pelvic Organ Prolapse

United States, Canada
University of California, San Francisco

Withdrawn

Sirolimus Prophylaxis for aGVHD in TME SCID

Severe Combined Immunodeficiency | Stem Cell Transplant | Transplacental Maternal Engraftment

United States
Russian Academy of Medical Sciences

Completed

BRCA1-associated DNA Repair Dysfunction in Patients With Early Triple Negative Breast Cancer Treated With Neoadjuvant Platinum-based Chemotherapy

Early Triple Negative Breast Cancer

Russian Federation
Great Ormond Street Hospital for Children NHS Foundation...

Completed

Gene Therapy ADA Deficiency

Adenosine Deaminase Deficiency

United Kingdom
Vejle Hospital

Completed

Molecular Screening for Lynch Syndrome in Southern Denmark

Colorectal Cancer | Lynch Syndrome | HNPCC

Denmark
St. Jude Children's Research Hospital
National Cancer Institute (NCI); Children's Hospital of Philadelphia

Completed

Study for Treatment of Cancer in Children With Ataxia-telangiectasia

Ataxia-Telangiectasia

United States
National Institute of Allergy and Infectious Diseases...

Terminated

Treatment for Growth Failure in Patients With X-Linked Severe Combined Immunodeficiency: Phase 2 Study of Insulin-Like Growth Factor-1

Growth Failure | X-linked Severe Combined Immunodeficiency (XSCID) | Growth Hormone Resistence

United States
Johann Wolfgang Goethe University Hospital

Completed

Body Composition and Hormonal Status in Ataxia Telangiectasia

Ataxia Telangiectasia
University Hospital Freiburg

Completed

Assessing Immune Function in Young Patients With Cytopenia That Did Not Respond to Treatment

Myelodysplastic Syndromes | Fanconi Anemia | Dyskeratosis Congenita | Pearson Marrow-pancreas Syndrome | Shwachman-diamond Syndrome

Spain, Germany, Switzerland, Austria, Netherlands, Italy, Czech Republic, Belgium, Denmark, Ireland
Erydel

Completed

International Ataxia Rating Scale in Younger Patients

Ataxia Telangiectasia

Italy, United States, India, Israel
University Medical Center Groningen
Maastricht University Medical Center; Erasmus Medical Center; Medtronic - MITG; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) and other collaborators

Completed

Capsule Endoscopy to Screen for Small Bowel Neoplasia in Lynch Syndrome (CELSIUS)

Lynch Syndrome | Small Bowel Neoplasia

Netherlands
Fox Chase Cancer Center
National Cancer Institute (NCI)

Completed

Educational CD-ROM Compared With Standard Informed Consent for Patients With Colorectal Cancer or a Family History of Colorectal Cancer

Colorectal Cancer | Hereditary Non-polyposis Colon Cancer

United States
Shanghai Children's Medical Center

Unknown

Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China

Severe Combined Immunodeficiency

China
French National Agency for Research on AIDS and...
Celgene Corporation

Terminated

Lenalidomide in Kaposi Disease Associated With HIV Infection (LENAKAP)

HIV Infection Associated Kaposi Disease

France
Ethicon, Inc.

Completed

Clinical Performance of the GYNECARE PROLIFT + M* Pelvic Floor Repair System as a Device for Pelvic Organ Prolapse

Cystocele | Rectocele | Enterocele

Netherlands, France, Belgium, Germany
Gilead Sciences

Completed

Fanconi Syndrome Due to ARVs in HIV-Infected Persons

HIV Infections | Renal Impairment | Fanconi Syndrome | Kidney Disease

Canada, United States
Cystinosis Research Foundation

Unknown

Cure Cystinosis International Registry (CCIR)

Cystinosis | Nephropathic Cystinosis | Renal Fanconi Syndrome

United States
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine; University of...

Terminated

Use of Rft5-Dga to Deplete Alloreactive Cells for Pts With Fanconi Anemia After Haploidentical SCT (RAFHAS)

FANCONI ANEMIA

United States
Milton S. Hershey Medical Center

Unknown

Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases

Sarcoma | Lymphoma | Unspecified Childhood Solid Tumor, Protocol Specific | Myelodysplastic Syndromes | Leukemia | Fanconi Anemia | Neuroblastoma | Childhood Langerhans Cell Histiocytosis

United States
Xiaofan Zhu

Available

Use Massive Parallel Sequencing and Exome Capture Technology to Sequence the Exome of Fanconi Anemia Children and Their Patents

Fanconi Anemia | Autosomal or Sex Linked Recessive Genetic Disease | Bone Marrow Hematopoiesis Failure, Multiple Congenital Abnormalities, and Susceptibility to Neoplastic Diseases. | Hematopoiesis Maintainance.

China
Applied Genetics

Unknown

T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With Xeroderma Pigmentosum

Precancerous Condition

United States, Germany, United Kingdom
St George's, University of London

Terminated

Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome

Endometrial Cancer | Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)

United Kingdom
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine

Terminated

Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders (MASCI)

Severe Combined Immunodeficiency Disease | Severe Primary Immunodeficiency Disorder | Undefined T Cell Deficiency Disorder | Wiskott-Aldrick Syndrome

United States
Peking Union Medical College Hospital

Unknown

Clinical Performance of GYNECARE PROSIMA* Pelvic Floor Repair System for Symptomatic Pelvic Organ Prolapse

Pelvic Organ Prolapse | Stage II-III

China
Peking Union Medical College Hospital

Unknown

GYNECARE PROSIMA* Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Uterine Prolapse Stage III

Uterine Prolapse | Stage III

China
University of California, San Francisco
National Cancer Institute (NCI)

Completed

Busulfan, Antithymocyte Globulin, and Fludarabine Followed By a Donor Stem Cell Transplant in Treating Young Patients With Blood Disorders, Bone Marrow Disorders, Chronic Myelogenous Leukemia in First Chronic Phase, or Acute Myeloid Leukemia in First Remission

Leukemia | Thrombocytopenia | Fanconi Anemia | Congenital Amegakaryocytic Thrombocytopenia | Severe Congenital Neutropenia | Diamond-blackfan Anemia

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Longitudinal Study of Multiple Symptoms in Advanced Lung Cancer

Lung Cancer

United States
University of California, San Francisco

Completed

Newborn Screening for Severe Combined Immunodeficiency (SCID) in a High-Risk Population

Severe Combined Immunodeficiency | T Cell Lymphocytopenia

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Cyclophosphamide in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Fanconi's Anemia

Fanconi Anemia

United States, Brazil
Duke University
Susan G. Komen Breast Cancer Foundation

Completed

Telemedicine vs. Face-to-Face Cancer Genetic Counseling

Lynch Syndrome | Hereditary Breast and Ovarian Cancer Syndrome

United States
Columbia University

Unknown

Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases

Severe Combined Immunodeficiency | Fanconi Anemia | Bone Marrow Failure | Osteopetrosis

United States
Mid-Atlantic Retina Consultations, Inc.
West Virginia University

Unknown

Supplemental Adjuvants for Intracellular Nutrition and Treatment (SAINTS)

Diabetic Macular Edema | Neovascular Age-related Macular Degeneration

United States
Children's Hospital Medical Center, Cincinnati
FDA Office of Orphan Products Development

Completed

Oxandrolone for the Treatment of Bone Marrow Aplasia in Fanconi Anemia

Fanconi Anemia

United States
Sheba Medical Center

Completed

Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia

Fatigue | Ataxia | Dystonia | Parkinsonism | Chorea

Israel
DNage B.V.

Completed

Pharmacokinetics and Safety Study of Single and Multiple Oral Doses Prodarsan™ in Patients With Cockayne Syndrome

Cockayne Syndrome

United States
DNage B.V.

Terminated

Observational Study to Assess Natural History in Cockayne Syndrome Patients

Cockayne Syndrome

United States, France, United Kingdom
Samsung Medical Center

Unknown

Genetic Predictive Model Based on Single Nucleotide Polymorphisms in the DNA Repair Pathway and Drug Metabolis/Transport Pharmacogenetics in the Prediction of Response and Treatment Outcomes in Acute Myeloid Leukemia

Patients With Acute Myeloid Leukemia | Patients Receiving Induction/Consolidation Chemotherapy

Korea, Republic of
Memorial Sloan Kettering Cancer Center
Yale University; University of New Mexico

Completed

Differential Risks for Melanoma: p16 and DNA Repair

Melanoma | Skin Melanoma

United States
Assistance Publique - Hôpitaux de Paris

Completed

CHROENDOHNPCC: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer Syndrome

Colorectal Neoplasms, Hereditary Nonpolyposis

France
China Medical University Hospital
National Science Council, Taiwan

Completed

The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis

Rheumatoid Arthritis

Taiwan
National Taiwan University Hospital
National Science Council, Taiwan

Unknown

DNA Repair Genes and Outcomes in Patients With Stage III NSCLC

Carcinoma, Non-Small-Cell Lung | Chemotherapy

Taiwan
Johann Wolfgang Goethe University Hospital

Unknown

Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT) (GHAT)

Growth Failure | Ataxia Telangiectasia

Germany
Henry Ford Health System

Unknown

Xeroderma Pigmentosum Patient Experiences

Xeroderma Pigmentosum

United States
Sheba Medical Center

Unknown

Immunogenicity of Pneumococcal Vaccines in Ataxia-telangiectasia Patients

Ataxia Telangiectasia

Israel
University of New Mexico

Completed

Phase I Study of Capecitabine in Combination With Cisplatin and Irinotecan

Cancer | Solid Tumors

United States
Fairview University Medical Center

Terminated

Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies

Immunologic Deficiency Syndromes | Common Variable Immunodeficiency | Severe Combined Immunodeficiency | Chronic Granulomatous Disease | Hemophagocytic Lymphohistiocytosis | Wiskott-Aldrich Syndrome | Graft Versus Host Disease | X-linked Agammaglobulinemia | Chediak-Higashi Syndrome | Virus-Associated... and other conditions

United States

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