- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00224601
CHROENDOHNPCC: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer Syndrome
February 17, 2011 updated by: Assistance Publique - Hôpitaux de Paris
Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Syndrome: Assessment of Coloscopy With Chromoscopy Benefit
The aim of the study is to test the hypothesis that a chromoscopy colonoscopy is able to increase by 50 % the number of pre-cancer lesions or early cancer detected in patients with HNPCC syndrome, compared to a routine colonoscopy without chromoscopy.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
Patient with HNPCC syndrome confirmed by a mutation (MLH1, MSH2, MHS1) are involved in the study.
Patient have 2 colonoscopy back to back.
The second coloscopy is associated to chromoscopy with carmin indigo.
Endoscopist are randomised for the colonoscopy with chromoscopy and are un-awarded of the result of the first colonoscopy.
Histopathology of the polyp are noted.
The follow up were 1 month.
Study Type
Interventional
Enrollment (Actual)
80
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Ile de France
-
Paris, Ile de France, France, 75015
- Hôpital Européen Georges Pompidou
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
25 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patients with MLH1, MSH2 or MSH6 mutation.
- Patients concerned by early detection colonoscopy.
Exclusion Criteria:
- Coloscopy of tracking since less 1an
- occlusive Syndrome contra-indicating the preparation for a total coloscopies
- Colectomies
- medical Conditions or serious illnesses contra-indicating a coloscopy of screening
- pregnant Woman or nursing
- Anomaly of coagulation contra-indicating the realization of biopsies and/or the exeresis of the lesion colorectal
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Number of pre-cancer lesions or early cancer detected.
Time Frame: during the procedure
|
during the procedure
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Anatomopathologic criteria (size of lesions, …).
Time Frame: during the procedure
|
during the procedure
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Christophe CELLIER, Pr,MD,PhD, Assistance Publique - Hôpitaux de Paris
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2005
Primary Completion (Actual)
January 1, 2008
Study Completion (Actual)
January 1, 2008
Study Registration Dates
First Submitted
September 16, 2005
First Submitted That Met QC Criteria
September 16, 2005
First Posted (Estimate)
September 23, 2005
Study Record Updates
Last Update Posted (Estimate)
February 18, 2011
Last Update Submitted That Met QC Criteria
February 17, 2011
Last Verified
July 1, 2007
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Digestive System Diseases
- Metabolic Diseases
- Neoplasms
- Neoplasms by Site
- Gastrointestinal Neoplasms
- Digestive System Neoplasms
- Gastrointestinal Diseases
- Genetic Diseases, Inborn
- Colonic Diseases
- Intestinal Diseases
- Intestinal Neoplasms
- Rectal Diseases
- Neoplastic Syndromes, Hereditary
- DNA Repair-Deficiency Disorders
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
Other Study ID Numbers
- P040423
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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