Search clinical trials for: First in class

Total 460302 results

Shanghai Ninth People's Hospital Affiliated to...

Recruiting

A Retrospective Study on Epidemiological Characteristics of Chinese NF1 Patients in Real World (PROMISE)

Neurofibromatosis 1 | Plexiform Neurofibroma

China
The First Affiliated Hospital of Zhejiang Chinese...

Recruiting

Peripheral Mechanisms of Humoral Immune Effector-mediated Tourette's Syndrome and the Role of Tuina Intervention

Inflammatory Response | Tourette Syndrome in Children | Food Intolerance

China
Chongqing Medical University

Recruiting

Effect of Bilirubin on Prognosis in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction | Prognathism

China
The First Affiliated Hospital of Soochow University

Recruiting

Maintenance Therapy of Hypomethylating Agent (HMA) in Favorable Risk Acute Myeloid Leukemia (AML) Patients

Acute Myeloid Leukemia

China
The First Hospital of Jilin University

Not yet recruiting

The Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced Coagulopathy

Sepsis-induced Coagulopathy
NuvoAir Medical PC
Optum, Inc.

Not yet recruiting

The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events

COPD | COPD Exacerbation | Cardio/Pulm: Heart Failure
Université Paris-Sud

Not yet recruiting

3D Model - Classification of Thoracic and Lumbar Spinal Fractures.

Lumbar Spine Disease
Beijing InnoCare Pharma Tech Co., Ltd.

Not yet recruiting

ICP-248 in Combination With Orelabrutinib in Treatment-naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Hematologic Malignancies

China
Masonic Cancer Center, University of Minnesota

Not yet recruiting

MT2022-60: Ph 2 Study of Pembro+ BEAM With ASCT for Relapsed Hodgkin Lymphoma

Classic Hodgkin Lymphoma | Autologous Stem Cell Transplant
RemeGen Co., Ltd.

Not yet recruiting

To Evaluate the Safety, Efficacy, and Pharmacokinetics of Intravesical Instiliations of Disitamab Vedotin in Patients With High-risk Non-muscular Invasive Bladder Cancer (NMIBC) That Express HER2

High-risk Non-muscle Invasive Bladder Cancer

China
Akeso

Recruiting

A Phase III Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis

Ankylosing Spondylitis

China
Guangzhou Medical University
Ningbo SensCure Biotechnology Co., Ltd.

Recruiting

Single-center Clinical Study on the Safety and Effect of Bronchoscopic Cryotherapy in Patients With Chronic Cough (ColdCough)

Chronic Cough

China
Hangzhou GluBio Pharmaceutical Co., Ltd.

Recruiting

A Study of GLB-001 in Patients With Myeloid Malignancies

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Polycythemia Vera | Essential Thrombocythemia | Myelofibrosis | Myeloid Malignancy

China
The First Affiliated Hospital of Xiamen University

Recruiting

Clinical Evaluation of 177Lu-DansyI-PSMA (LNC1011) in Patients With Metastatic Castration-Resistant Prostate Cancer

Metastatic Castration-resistant Prostate Cancer, mCRPC

China
Hospital Universitari de Bellvitge
Hospital Universitario Ramon y Cajal; Complejo Hospitalario de Navarra; University... and other collaborators

Not yet recruiting

EUS-Gallbladder vs CDS as First Line in MBDO- Palliative (CARPEGIEM Trial) (CARPEGIEM)

Biliary Tract Neoplasms | Malignant Biliary Obstruction | Pancreatic Cancer Non-resectable

Spain
Hull University Teaching Hospitals NHS Trust

Recruiting

An Observational Study Using Novel Questionnaire to Characterize Cough Phenotypes in Patients With Chronic Cough

Chronic Cough

United Kingdom
AstraZeneca

Not yet recruiting

Osimertinib With Chemotherapy as First-line Therapy for EGFR Mutation-positive NSCLC (FOREFRONT)

Neoplasms | Respiratory Tract Diseases | Lung Diseases | Neoplasms by Site | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms

China
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Efficacy and Safety of Telitacicept in the Treatment of Systemic Sclerosis

Diffuse Cutaneous Systemic Sclerosis

China
Hospital Universitari de Bellvitge
Hospital Universitario Ramon y Cajal; Complejo Hospitalario de Navarra; University... and other collaborators

Not yet recruiting

EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction in Resectable Disease (CARPEDIEM-1 Trial)

Biliary Tract Neoplasms | Pancreatic Cancer Resectable | Malignant Biliary Obstruction

Spain
Xuanwu Hospital, Beijing
Beijing Tiantan Hospital; West China Hospital; Second Affiliated Hospital of... and other collaborators

Recruiting

Intelligent Diagnosis and Treatment Model for Insomnia Disorder

Insomnia

China
Hospital Universitari de Bellvitge
Hospital Universitario Ramon y Cajal; Complejo Hospitalario de Navarra; University... and other collaborators

Not yet recruiting

EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial)

Pancreatic Cancer | Biliary Tract Neoplasms | Malignant Biliary Obstruction

Spain
The First Affiliated Hospital of Xiamen University

Recruiting

Clinical Evaluation of 177Lu-AB-3PRGD2 in Various Solid Tumors With Integrin αvβ3 Positive Expression

Refractory Solid Tumor

China
The First Affiliated Hospital with Nanjing Medical...
Zhejiang Cancer Hospital

Recruiting

Efficacy and Safety of Ribociclib in Combination With NSAI Versus Physician's Choice of Chemotherapy Sequential Endocrine Therapy in HR+/HER2- Advanced Breast Cancer

Advanced Breast Cancer

China
Henan University of Traditional Chinese Medicine
West China Hospital; The First Affiliated Hospital of Zhejiang Chinese Medical...

Not yet recruiting

Bufei Recipe Reduces the Incidence Rate of COPD

Preserved Ratio Impaired Spirometry
Istinye University

Not yet recruiting

Effect of Virtual Reality in Patients With Long Covid-19

COVID-19
University Hospital, Essen
German Cancer Aid

Not yet recruiting

Exercise in Patients With Advanced Non-small Cell Lung Cancer (BREATH)

Advanced Lung Carcinoma | NSCLC Stage IV | NSCLC Stage IIIB | First Line Treatment | Second Line Treatment | Palliative Treatment | NSCLC Stage IIIC

Germany
Henan University of Traditional Chinese Medicine
Peking University People's Hospital; The First Affiliated Hospital of Zhengzhou... and other collaborators

Not yet recruiting

REspiratory diSEAse cohoRt Studies of CHinese Medicine for Asthma (RESEARCH- Asthma)

Bronchial Asthma

China
Suez Canal University

Recruiting

Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study

Dental Caries in Children | Vital Pulp Therapy

Egypt
yilong Wang

Recruiting

The Efficacy and Safety of Y-3 Intracalvariosseous Injection Versus Intravenous Injection in the Treatment of Acute Large Hemispheric Infarction (SOLUTION-2)

Stroke, Acute Ischemic | Blood-Brain Barrier

China
EdiGene Inc.
The First Affiliated Hospital of Henan University of Science and Technology; Changping Laboratory

Not yet recruiting

A Study to Evaluate the Safety and Efficacy of ATHENA CAR-T in Subjects With Systemic Lupus Erythematosus

Lupus Erythematosus, Systemic

China
Ivoclar Vivadent AG

Recruiting

Clinical Evaluation of a New Flowable and a New Sculptable Universal Bulk-fill Composite for Direct Restorative Treatment

Insufficient Dental Filling or Primary Caries (Class I or II Cavities in Premolars or Molars)

Liechtenstein
Shandong Cancer Hospital and Institute

Recruiting

First-line Treatment for Unresectable Locally Advanced Distal Cholangiocarcinoma Combining Radiotherapy and HAIC

Intrahepatic Cholangiocarcinoma

China
Qilu Pharmaceutical Co., Ltd.

Not yet recruiting

A Study Comparing Pharmacokinetic and Safety of QL2109 and DARZALEX FASPRO® in Healthy Adults

Tumor

China
First Affiliated Hospital of Zhejiang University
Shanghai Longfine Biotechnology Co., Ltd.; TopAlliance

Not yet recruiting

A Study on the Efficacy and Safety of Oral All-trans Retinoic Acid Combined With Toripalimab in TNBC.

Triple-negative Breast Cancer

China
Zheng Liu ENT
Peking Union Medical College; First Affiliated Hospital of Xinjiang Medical... and other collaborators

Recruiting

The Epidemiological and Intrinsic Characteristics of Chronic Rhinitis

Chronic Rhinitis

China
Zhejiang University
Hangzhou Qihanjiyin Biotech Co.,Ltd.

Recruiting

Natural Killer(NK) Cell Therapy Targeting CLL1 or CD33 in Acute Myeloid Leukemia

AML, Adult

China
Shanghai Unicar-Therapy Bio-medicine Technology...
Peking University People's Hospital; The First Affiliated Hospital of Soochow...

Not yet recruiting

Clinical Trial of ssCART-19 Cell Injection in the Treatment of Relapsed or Refractory Acute Lymphoblastic Leukemia (Including Central Nervous System Infiltration)

Relapsed or Refractory Acute Lymphoblastic Leukemia

China
Indonesia University

Recruiting

The Role of Manual Twirling Acupuncture in Reducing Muscle Pain and Stiffness After Biceps Curling in Healthy Untrained Individuals

Muscle Soreness | Stiffness of Elbow, Not Elsewhere Classified

Indonesia
Obstetrics & Gynecology Hospital of Fudan University
Peking Union Medical College Hospital; First Affiliated Hospital of Xinjiang... and other collaborators

Not yet recruiting

Role of Methylation Test Triage in HPV Positive Women (MTTRIHPW)

Precancerous Cervical Lesion

China
Versa Vascular, Inc

Not yet recruiting

A First in Human Study for the Versa Device for Tricuspid Regurgitation

Tricuspid Regurgitation

New Zealand
RenJi Hospital

Recruiting

Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations

End Stage Renal Disease | Kidney Transplantation | Delayed Graft Function

China
First Affiliated Hospital of Wenzhou Medical University

Recruiting

Efficacy and Safety of Antiviral Therapy With Peg-interferon for Chronic Hepatitis B Complicated With Nonalcoholic Fatty Liver Disease（OCEAN PROJECT）

Chronic Hepatitis b | Nonalcoholic Fatty Liver Disease

China
Seattle Children's Hospital

Recruiting

Examining the Feasibility, Acceptability, and Fidelity of Utilizing Parent Training Graduates as Peer Supports

Child Behavior Problems | Child Disruptive Behavior Disorders | Peer Support | Challenging Behavior | Parent Child Relationship | Positive Parenting | Parent Management Training

United States
Wuhan Union Hospital, China
Xiangya Hospital of Central South University; Sun Yat-sen University; The Affiliated... and other collaborators

Not yet recruiting

A Trial of Cadonilimab With Adriamycin in Patients With Advanced Soft Tissue Sarcoma

Advanced Soft-tissue Sarcoma
Wuhan Union Hospital, China

Recruiting

Cadonilimab Combined With Chemotherapy as First or Second Line Treatment in Recurrent or Metastatic Triple Negative Breast Cancer

Triple-negative Breast Cancer | Cadonilimab

China
Salubris Biotherapeutics Inc

Recruiting

Study of JK07 in Patients With Chronic Heart Failure (RENEU-HF)

Heart Failure With Reduced Ejection Fraction | Heart Failure With Preserved Ejection Fraction

United States
The Central Hospital of Lishui City

Not yet recruiting

Efficacy and Safety of DEB-BACE Combined With Serplulimab in First-line Treatment of SCLC

Carcinoma | Small Cell Lung Cancer

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

An Phase III Study, Multicenter，Randomized Controlled Trail to Determine the Safety and Efficacy of the Combination of Tislelizumab With Cisplatin and Gemcitabine, With or Without Trilaciclib for Patients With Untreated Unresectable and Metastatic Urothelial Carcinoma.

Bladder Cancer

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Phase Ib/II Trail of Neoadjuvant of Tislelizumab Combined With Palbociclib in Patients With Platinum-refractory Bladder Urothelial Carcinoma

Bladder Cancer

China
Changhai Hospital
First People's Hospital of Hangzhou; Peking Union Medical College Hospital

Not yet recruiting

Efficacy of ERCP in the Diagnosis and Treatment of Idiopathic Recurrent Acute Pancreatitis (ESPRIT)

Recurrent Acute Pancreatitis

China

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