Search clinical trials for: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic)

Total 37943 results

University Hospital, Rouen

Completed

Simultaneaous Detection of Quantitative Somatic Alterations Using the Qantitative Multiplex Pcr of Short Fluorescent Fragments Method (QMPSF) in Stage II-III Colon Cancer: a Prospective Study (Code Barre)

Colorectal Cancer | Stage II and III

France
Centre Hospitalier Universitaire Dijon

Unknown

Study of the Telomere-telomerase System and the Expression of Candidate Genes in the Leukocytes of Patients With Depressive Disorder: Search for Peripheral Markers of Somatic Stress

Depressive Disorder

France
pharmaand GmbH
Foundation Medicine

Active, not recruiting

A Study of Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency (TRITON3)

Metastatic Castration Resistant Prostate Cancer

United States, Canada, Spain, France, Australia, Ireland, Belgium, Denmark, United Kingdom, Germany, Israel, Italy
Novartis Pharmaceuticals

Completed

An Open-label, Multi-center, Expanded Access Study of Everolimus in Participants With Advanced Neuroendocrine Tumors (NETs) (Core Study) and an Extension Study to the Open-label, Multi-center, Expanded Access Study of Everolimus in Patients With Advanced NETs (E1)

Neuroendocrine Tumors

Germany
zr Pharma & GmbH

Completed

A Study of Rucaparib in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation

Pancreatic Cancer | Pancreatic Ductal Adenocarcinoma

United States, Israel
First Affiliated Hospital Xi'an Jiaotong University
Second Affiliated Hospital of Wenzhou Medical University

Completed

Imaging Biomarkers of Mild Traumatic Brain Injury: a Longitudinal Cohort Study

Posttraumatic Stress Disorder | Mild Traumatic Brain Injury | Cognitive Impairments | Affective and Somatic Complaints

China
Memorial Sloan Kettering Cancer Center
Pfizer

Terminated

Pharmacological Penile Rehabilitation in the Preservation of Erectile Function Following Bilateral Nerve-Sparing Radical Prostatectomy

Erectile Dysfunction | Penile Cancer | Radical Prostatectomy

United States
University of Geneva, Switzerland
All India Institute of Medical Sciences, New Delhi; Swiss National Science... and other collaborators

Recruiting

Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia (MPGx-INDALL)

Drug Effect | Pediatric Cancer | Adverse Drug Event | Drug Interaction | ALL, Childhood | Drug Toxicity | Toxicity, Drug | Relapse Leukemia

India
Cairo University

Completed

Letrozole in Induction of Abortion of Anembryonic Pregnancy

Anembryonic Pregnancy

Egypt
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Completed

Allogeneic ABCB5-positive Stem Cells for Treatment of Epidermolysis Bullosa

Recessive Dystrophic Epidermolysis Bullosa

United States, Austria, France, Germany, United Kingdom
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Completed

Allogeneic ABCB5-positive Stem Cells for Treatment of CVU

Skin Ulcer Venous Stasis Chronic

Germany
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH

Recruiting

Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of CVU (Phase IIb)

Skin Ulcer Venous Stasis Chronic

Germany
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Terminated

Allogeneic ABCB5-positive Stem Cells for Treatment of PAOD

Peripheral Arterial Occlusive Disease

Germany, Austria, Czechia, Poland, United Kingdom
Organon and Co
CRS Mannheim GmbH

Completed

A Trial to Assess the Pharmacokinetic Profile (e.g., Uptake, Distribution and Excretion of a Substance in the Body) of Nomegestrol Acetate (NOMAC), Estradiol (E2) and Estrone (E1) After Multiple and Single Dose Administration of the Combined Oral Contraception NOMAC-E2 (COMPLETED)(P05822)

Healthy
Glaxo Wellcome

Unknown

Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment

HIV Infections

United States
Mansoura University

Not yet recruiting

Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI Cycles

PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
German Breast Group
AstraZeneca

Completed

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency (GeparOla)

Breast Cancer | Triple Negative Breast Neoplasms | HRpos Breast Neoplasms | BRCA 1 /2 and / or HRD

Germany
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Completed

Allogeneic ABCB5-positive Stem Cells for Treatment of DFU "Malum Perforans"

Diabetic Neuropathic Ulcer

Germany
Medtronic - MITG

Completed

ADVANCE: Assessment for Defining Variability in Anesthesia Through Novel Clinical EEG (CVI)

Pain

United States, Spain
MEDA Pharma GmbH & Co. KG
ClinResearch, GmbH; Prolytic GmbH

Completed

Single Dose Pharmacokinetics of Intranasal Azelastine Delivered by a Fixed Combination With Fluticasone in Comparison to Azelastine Nasal Sprays

Allergic Rhinitis

Germany
Lei Li

Recruiting

Chromosomal Instability in Ovarian Cancer

Epithelial Ovarian Cancer | High-grade Serous Ovarian Carcinoma | Survival Outcomes | Overall Survival | Progression-free Survival | Chromosomal Instability | Somatic Copy Number Distortion | Minimal Residual Lesions

China
Seagen Inc.

Active, not recruiting

Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

Urologic Neoplasms | Uterine Cervical Neoplasms | Uterine Neoplasms | Carcinoma, Non-Small-Cell Lung | Biliary Tract Neoplasms | HER2 Mutations Breast Neoplasms

United States, United Kingdom, Spain, Korea, Republic of, Italy, Belgium, Germany, Japan, Netherlands, Poland
Yonsei University

Withdrawn

Efficacy of Triplet Combination With Pembrolizumab, Neratinib, and Paclitaxel as a Second Line Treatment in Recurrent/Advanced Gastric Cancer Having Somatic Human Epidermal Growth Factor Receptor Family (EGFR, HER2, HER3, HER4) Mutations or HER2 Amplification/Overexpression

Recurrent/Advanced Gastric Cancer

Korea, Republic of
zr Pharma & GmbH
Foundation Medicine

Completed

A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cancer | Advanced Solid Tumor With Evidence of Germline or Somatic BRCA

United States, Israel, Spain, Canada, United Kingdom
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Terminated

Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers

Skin Ulcer Venous Stasis Chronic

Germany
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH

Terminated

Allogeneic ABCB5-positive Stem Cells for Treatment of Acute-on-Chronic Liver Failure

Acute-On-Chronic Liver Failure

Germany
Janssen Research & Development, LLC

Active, not recruiting

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) (AMPLITUDE)

Metastatic Castration-sensitive Prostate Cancer

United States, Italy, China, Korea, Republic of, Canada, Australia, United Kingdom, Hungary, France, Taiwan, Thailand, Germany, Malaysia, Denmark, Russian Federation, New Zealand, Ukraine, Bulgaria, Israel, Spain, Turkey, Sweden, Cz... and more
National Institute of Allergy and Infectious Diseases...

Completed

Cyclosporine A in Combination With Abacavir Sulfate, Lamivudine, and Zidovudine and Lopinavir/Ritonavir in HIV

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Changing to Nonprotease Inhibitor Treatment to Improve Side Effects

HIV Infections | Lipodystrophy

United States
MedImmune LLC

Withdrawn

Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC

Microsatellite-stable Colorectal Cancer
Incyte Corporation

Recruiting

Study of INCB123667 in Subjects With Advanced Solid Tumors

Solid Tumors

United States, Japan, France, Italy, United Kingdom, Netherlands, Switzerland
National Institutes of Health Clinical Center (CC)

Completed

Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)

Healthy Volunteers

United States
zr Pharma & GmbH
Foundation Medicine

Completed

A Study of Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency (TRITON2)

Metastatic Castration Resistant Prostate Cancer

United States, Spain, United Kingdom, France, Australia, Belgium, Denmark, Israel, Germany, Ireland, Canada, Italy
Fudan University

Active, not recruiting

An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC. (FUTURE-SUPER)

TNBC - Triple-Negative Breast Cancer

China
Universitätsklinikum Hamburg-Eppendorf
Deutsche Kinderkrebsstiftung

Active, not recruiting

International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

Brain Tumors

Germany, Denmark, United Kingdom, Belgium, Poland, Ireland, Austria, Italy, Czechia, France, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland
National Center for Complementary and Integrative...

Completed

Efficacy of Osteopathic Manipulation in Chronic Obstructive Pulmonary Disease

Emphysema

United States
Masonic Cancer Center, University of Minnesota

Recruiting

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | AML | Acute Leukemia | Neurofibromatosis 1 | Hematologic Malignancy | Myelodysplasia | Minimal Residual Disease | Chromosome Abnormality | Monosomy 7 | Remission | Somatic Mutation | Cytogenetic Abnormality | TP53 | Fetal Hemoglobin | Intrachromosomal Amplification of Chromosome... and other conditions

United States
Novartis Pharmaceuticals

Active, not recruiting

Management of LDL-cholesterol With Inclisiran + Usual Care Compared to Usual Care Alone in Participants With a Recent Acute Coronary Syndrome (V-INCEPTION)

Acute Coronary Syndrome

United States
Activartis Biotech

Completed

Dendritic Cell Cancer Vaccine for High-grade Glioma (GBM-Vax)

Glioblastoma Multiforme

Austria
pharmaand GmbH

Terminated

A Study to Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes (LODESTAR)

Solid Tumor

United States
Technische Universität Dresden
Bristol-Myers Squibb; University Hospital Munich

Recruiting

Multicenter, Interdisciplinary National VEXAS Registry With Accompanying Biomaterial Collection

VEXAS Syndrome

Germany
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France; Sorbonne... and other collaborators

Not yet recruiting

Clonal Hematopoiesis of Immunological Significance (CHIS)

Immune System Diseases | Lymphoma | Lymphoproliferative Disorders | Autoimmune Diseases | Inflammation | Myelodysplastic Syndromes | Hematologic Diseases | Leukemia | Myeloproliferative Disorders | Myelodysplastic-Myeloproliferative Diseases | Monoclonal Gammopathy of Undetermined Significance | Autoinflammatory... and other conditions
University of Siena

Recruiting

AutoInflammatory Disease Alliance Registry (AIDA) (AIDA)

Behcet Syndrome | Uveitis | Hereditary Autoinflammatory Diseases | Schnitzler Syndrome | Scleritis | PFAPA Syndrome | Still Disease | Autoinflammatory Syndrome, Unspecified | Vexas Syndrome

Egypt, Spain, Turkey, Italy, Saudi Arabia, Greece, Belgium, United States, Algeria, Brazil, Germany, Ghana, Iran, Islamic Republic of, Lebanon, Morocco, Poland, Portugal, Romania, Taiwan
Takeda

Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis

United States, France, Hungary, Korea, Republic of, Belgium, Japan, Germany, Canada, Italy, Poland, Czechia, Denmark, Greece, Norway, Romania, Slovakia, United Kingdom
Takeda

Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Crohn's Disease

United States, Australia, France, Taiwan, Hungary, Korea, Republic of, Spain, Switzerland, China, Japan, Belgium, Canada, Germany, Italy, Poland, Romania, United Kingdom, Czechia, Denmark, Greece, Norway, Slovakia, Netherlands
Firat University

Recruiting

Ozone Therapy in Patients With Carpal Tunnel Syndrome

Carpal Tunnel Syndrome

Turkey
Azienda Usl di Bologna

Recruiting

Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock (EVSS)

Septic Shock | Renal Function Replacement

Italy
Seoul National University

Not yet recruiting

Thoracic Sympathetic Ganglion Block With Botulinum Toxin Type A

Complex Regional Pain Syndromes
Firat University

Recruiting

Effects of Connective Tissue Massage in Patients With Fibromyalgia

Fibromyalgia

Turkey
Bitlis Eren University

Not yet recruiting

Effectiveness of Cervical Stabilization Exercises in Individuals With Temporomandibular Joint Disorder

Temporomandibular Joint Disorders

Search clinical trials for: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic)

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