Study of the Telomere-telomerase System and the Expression of Candidate Genes in the Leukocytes of Patients With Depressive Disorder: Search for Peripheral Markers of Somatic Stress

February 5, 2026 updated by: Centre Hospitalier Universitaire Dijon
The mechanisms of oxidative stress and inflammation involved in mood disorders are factors of chronicity and severity. These mechanisms induce a phenomenon of accelerated cellular senescence and are reflected by alterations in systemic gene expression detectable in leukocytes in peripheral blood. The genetic markers of these mechanisms are clinically significant markers. The identification of new genetic markers will make it possible to improve evaluations of the severity and somatic consequences of depressive syndromes.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

300

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Dijon, France, 21079
        • CHU de Dijon

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Persons who have given their written informed consent
  • absence of a diagnosis of major depressive disorder throughout the study and no history of psychiatric disorders
  • diagnosis of a first episode of a major depressive disorder
  • diagnosis of a recurrent major depressive disorder (at least three episodes) with or without resistance to therapy

Remarks:

  • the diagnosis of major depressive disorder with characteristics of melancholy must be clearly mentioned in the case report form but is not a reason for not being included in the study
  • the presence of a recent or older attempted suicide must lead to a careful clinical assessment of the diagnosis of depressive disorder and must be clearly mentioned in the case report form.

Exclusion Criteria:

  • Persons not covered by the national Health Insurance Agency
  • Psychotic or bipolar disorders
  • Severe personality disorders
  • cardiovascular disease, proven inflammatory disease and cancer
  • persons unable to give their consent personally,
  • persons in emergency situations,
  • pregnant women,
  • breast-feeding women

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: patients with a first episode of major depressive disorder
a group of patients with a first episode of major depressive disorder according to DSM-IV-TR including depressive episodes with melancholic features
Other: telomere length
Other: patients with recurrent depressive disorder
a group of patients with recurrent depressive disorder according to DSM-IV-TR including depressive episodes with melancholic features (at least three episodes of depression)
Other: telomere length
Other: control group
patient with no depressive disorder during the study period and no psychiatric history
Other: telomere length

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Telomere length
Time Frame: participants will be followed for the duration of hospital stay, an expected average of 6 months
participants will be followed for the duration of hospital stay, an expected average of 6 months

Secondary Outcome Measures

Outcome Measure
Time Frame
level of oxidative stress.
Time Frame: participants will be followed for the duration of hospital stay, an expected average of 6 months
participants will be followed for the duration of hospital stay, an expected average of 6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire Dijon

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 1, 2010

Primary Completion (Actual)

November 1, 2012

Study Completion (Actual)

November 1, 2012

Study Registration Dates

First Submitted

July 17, 2013

First Submitted That Met QC Criteria

July 18, 2013

First Posted (Estimated)

July 19, 2013

Study Record Updates

Last Update Posted (Actual)

February 9, 2026

Last Update Submitted That Met QC Criteria

February 5, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Chauvet PHRC IR 2009

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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