Search clinical trials for: assess optimal renoprotective dose of Aliskiren

Total 431808 results

Longeveron Inc.

Completed

Lomecel-B on Vaccine-Specific Antibody- Response in Subjects With Aging Frailty (HERA)

Aging Frailty

United States
Pfizer

Completed

A Trial To Assess The Safety, Tolerability, And Immunogenicity Of Rlp2086 Vaccine When Administered In Either 2- Or 3-Dose Regimens In Healthy Subjects Aged ≥11 To <19 Years

Meningococcal Vaccine

Spain, Germany, Finland, Czechia, Poland, Denmark, Sweden
MetroHealth Medical Center

Completed

Symptom Control Satisfaction With Proton Pump Inhibitor Regimen

Heartburn

United States
Ain Shams University

Completed

High-dose L-Carnitine and Diaphragmatic Function Assessed by Ultrasonography in Patients With Respiratory Failure.

Respiratory Failure

Egypt
iOnctura

Completed

A Study to Assess an ATX Inhibitor (IOA-289) in Healthy Volunteers

Healthy

Italy
Centers for Disease Control and Prevention
International Centre for Diarrhoeal Disease Research, Bangladesh; World Health... and other collaborators

Enrolling by invitation

Assessing Immunogenicity of Intramuscular Sabin Inactivated Poliovirus Vaccine and Non-inferiority of Intradermal Fractional Inactivated Poliovirus Vaccine

Poliomyelitis

Bangladesh
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of AZD5462 Following Single and Multiple Ascending Dose Administration to Healthy Volunteers

Healthy Participants

United States
Bond Avillion 2 Development LP

Completed

A Study to Assess the Efficacy and Safety of Budesonide/Albuterol Metered-dose Inhaler (BDA MDI/PT027) in Adults and Children 4 Years of Age or Older With Asthma (MANDALA)

Asthma

United States, Canada, Germany, Spain, South Africa, United Kingdom, Slovakia, Argentina, Ukraine, Serbia, Czechia
Ionis Pharmaceuticals, Inc.

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of ION547

Healthy Volunteers

Canada
AstraZeneca
Syneos Health

Completed

Study to Assess the Safety and Preliminary Efficacy of AZD0156 at Increasing Doses Alone or in Combination With Other Anti-cancer Treatment in Patients With Advanced Cancer (AToM)

Advanced Solid Tumours

United States, Spain, Korea, Republic of, United Kingdom
Hoffmann-La Roche

Completed

A Study To Assess Distribution Of RO7248824 In The Central Nervous System Following Single Intrathecal Doses Of [89zr] Labeled RO7248824 In Healthy Male Participants

Angelman Syndrome

Netherlands
Minervax ApS

Completed

Study to Assess a Booster Dose of GBS-NN/NN2 Vaccine

Group B Streptococcus Infection

United Kingdom
Otsuka Pharmaceutical Development & Commercialization...

Completed

A Single-blind, Placebo-controlled, Outpatient Trial to Assess the Effects of Single Oral Tablet Dose of OPC-214870

Epilepsy

United States
Ipsen

Withdrawn

Study to Assess the Safety and Efficacy of Intravenous Injection of the Imaging Agent 111In-IPN01087 in Patients With Locally Advanced or Metastatic Pancreatic or Colorectal Cancer.

Colorectal Cancer | Pancreatic Ductal Adenocarcinoma

Belgium, France
Mackay Memorial Hospital

Completed

An Observation Study to Assess the Efficacy and Safety of Proportional Doses of Painkyl® in Patients With Breakthrough Cancer Pain

Cancer Pain

Taiwan
Bellerophon

Completed

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis

Pulmonary Fibrosis | Pulmonary Hypertension | Sarcoidosis, Pulmonary

United States
GlaxoSmithKline

Completed

A Study to Assess the Safety, Reactogenicity and Immune Response of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3844766A) in Older Adults

Respiratory Syncytial Virus Infections

United States, Belgium
Mayo Clinic
National Cancer Institute (NCI)

Completed

Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery

Breast Cancer | Cardiac Toxicity

United States
Brigham and Women's Hospital

Completed

Optimal Bupivacaine Dose for Initiation of Labor Epidural Techniques

Analgesia | Labor Pain

United States
AbbVie
KU Leuven; Syndesi Therapeutics

Completed

A Single Ascending Oral Dose Study of SDI-118 in Healthy Male Subjects Including an Assessment of Receptor Occupancy and Food Effect

Cognitive Disorders

Belgium
Janssen Research & Development, LLC

Completed

A Study in Healthy Participants to Assess the Effect of Darunavir, Emtricitabine, and Tenofovir Alafenamide in the Presence of Cobicistat as Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared With Co-administration of the Separate Agents

Healthy

Netherlands
State University of New York at Buffalo
National Center for Advancing Translational Sciences (NCATS)

Withdrawn

Dose-Ranging Study to Assess the Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19

COVID-19

United States
Oregon Health and Science University

Completed

Assessment of a Decision Support Tool in Participants With Type 1 Diabetes

Type 1 Diabetes

United States
Hanmi Pharmaceutical Company Limited

Completed

A Phase 2 Study to Assess Dose-response Relationship of HCP1803 in Patients With Essential Hypertension (HM_APOLLO)

Hypertension

Korea, Republic of
Reistone Biopharma Company Limited

Terminated

Assess the Efficacy and Safety of SHR0302 Ointment in Adult Patients With Vitiligo

Vitiligo

China
Arena Pharmaceuticals

Completed

A Multiple-Dose Study to Assess the Safety, Tolerability, and Steady State Pharmacokinetics of APD791 in Healthy Volunteers

Healthy

United States
Wake Network, Inc.
Professor Roger Gibson Section of Psychiatry Faculty of Medical Sciences UWI

Withdrawn

Assessing the Efficacy of Micro-dosed Psilocybin on Reducing Anxiety & Depression Levels in Adults

Anxiety and Depression

Jamaica
Pfizer

Completed

Dose Ranging Study To Assess Efficacy, Safety and Tolerability Of PF-06700841 Topical Cream In Psoriasis

Psoriasis

United States, Germany, Canada, Denmark, Hungary, Australia, Latvia, Poland, Bulgaria, Japan
Abbott Medical Devices
Thoratec Corporation

Completed

Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device (LVAD) and Medical Management (ROADMAP)

Heart Failure

United States
Incyte Corporation

Completed

A Study Assessing the Mass Balance, Pharmacokinetics, and Metabolite Profiles of a Single Oral Dose of [14C]-INCB086550

Healthy Volunteers

United Kingdom
Henry Ford Health System

Terminated

Will Hydroxychloroquine Impede or Prevent COVID-19 (WHIP COVID-19)

Coronavirus Infections | COVID-19 | SARS-CoV 2 | Coronavirus

United States
Emory University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Terminated

The Energy Dose Study

Critical Illness

United States
Sanofi Pasteur, a Sanofi Company

Completed

Surveillance Study to Assess the Safety of Flublok Quadrivalent (Influenza Vaccine) in Pregnant Women and Their Offspring (VAP00007)

Influenza

United States
Craig Portell, MD
AbbVie

Completed

Optimal Dose Finding Study ABT-199 and Ibrutinib in MCL

Lymphoma, Mantle-Cell | Recurrent Lymphoma, Mantle-Cell

United States
AstraZeneca
Parexel

Completed

Study to Assess Efficacy and Safety of Aclidinium Bromide and Aclidinium Bromide/Formoterol Fumarate in Stabile COPD Patients (AVANT)

COPD

Philippines, Vietnam, China, Taiwan, India
Medical University of Warsaw

Completed

Optimal Type of Inhaler in Cough Variant- or Cough Predominant Asthma

Asthma | Cough Variant Asthma

Poland
State University of New York - Upstate Medical...

Completed

Participant(s) With Autism and High Pain Tolerance Treated With High Dose Naltrexone

Autism Spectrum Disorder

United States
Pfizer

Completed

A Double-blind Study to Assess 2 Doses of an Investigational Product for 16 Weeks in Participants With Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

Non-alcoholic Steatohepatitis

United States, Canada
Faron Pharmaceuticals Ltd

Withdrawn

A Phase I/II Open Label Single Centre Trial to Assess the Safety, Tolerability and Efficacy of Single Dose Neoadjuvant Anti-CLEVER-1 Antibody Bexmarilimab in Localised Renal Cell and Colon Carcinoma (RENACOL)

Carcinoma, Renal Cell | Carcinoma Colon

Finland
Astellas Pharma Global Development, Inc.

Completed

A Study to Assess the Safety and Efficacy of ASP4345 as Add-on Treatment for Cognitive Impairment in Subjects With Schizophrenia on Stable Doses of Antipsychotic Medication

Schizophrenia

United States
Sanofi Pasteur, a Sanofi Company

Completed

Study to Assess the Safety and Immunogenicity of a Single Dose of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) in Older Adults in Turkey and Lebanon (MEQ00063)

Healthy Volunteers (Meningococcal Infection)

Lebanon, Turkey
AbbVie

Completed

A Study of Oral Venetoclax Tablet in Combination With Subcutaneous Low-Dose Cytarabine (LDAC) Injection to Assess Adverse Events in Adult Japanese Participants With Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia (AML)

Japan
AstraZeneca

Completed

A Study to Assess the Bioequivalence of Fixed Dose Combination of Dapagliflozin/Metformin XR Relative to Co-administration of the Individual Components in Healthy Chinese Subjects.

Healthy Volunteer

China
Sanofi

Completed

First-in-human Study to Assess Safety and Tolerability of a Single Subcutaneous Dose of SAR441255 in Lean to Overweight Subjects

Overweight | Healthy Subjects

United States
The First Affiliated Hospital of Dalian Medical...
LanZhou University; Fudan University; Beijing Friendship Hospital; Chinese PLA... and other collaborators

Active, not recruiting

Assessment of Dialysis Initiation by a Fuzzy Mathematics Equation (ADIFE)

Chronic Kidney Disease

China
Synthetic Biologics Inc.
Spaulding Clinical Research LLC

Completed

Multiple Ascending Dose Study to Assess the Pharmacokinetics, Safety, and Tolerability of Orally Administered SYN 020

Enteritis Caused by Radiation

United States
The Netherlands Cancer Institute

Completed

Optimal Sequencing of Treatment Options for Poor Risk mCRPC Previously Treated With Docetaxel (OSTRICh)

Metastasis | Prostate Cancer Metastatic

Netherlands
Arbor Pharmaceuticals, Inc.

Terminated

Phase I Rising-dose Study to Assess Tolerability, Safety, Pharmacokinetics, Pharmacodynamics of AR09

Anesthesia

United States
Genzyme, a Sanofi Company

Completed

Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee

Osteoarthritis

Germany
Regeneron Pharmaceuticals

Completed

COVID-19 Study Assessing the Virologic Efficacy of REGN10933+REGN10987 Across Different Dose Regimens in Adult Outpatients With SARS-CoV-2 Infection

COVID-19

United States

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