Clinical Trials Sponsored by Aurum Institute

Total 74019 results

The Aurum Institute NPC

Unknown

TB Host Directed Therapy (TBHDT)

Tuberculosis

South Africa
The Aurum Institute NPC
London School of Hygiene and Tropical Medicine; Johns Hopkins University; Aurum...

Completed

Evaluation of the Effect of 3HP vs Periodic 3HP vs 6H in HIV-Positive Individuals (WHIP3TB)

HIV | Tuberculosis

South Africa
The Aurum Institute NPC
Johns Hopkins University

Recruiting

Rifapentine and Isoniazid TB Preventive Therapy (3HP) for Children Taking Dolutegravir-based Antiretroviral Treatment (DOLPHIN KIDS) (DOLPHIN KIDS)

HIV | Tuberculosis

South Africa
The Aurum Institute NPC
Johns Hopkins University

Recruiting

Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients (1 to 3)

Tuberculosis | HIV Seropositivity | Household Contact

South Africa, India, Indonesia, Mozambique
The Aurum Institute NPC
National Institute for Medical Research, Tanzania

Recruiting

Adjunctive NAC in Adult Patients With Pulmonary Tuberculosis (NAC-TB)

Tuberculosis, Pulmonary

Tanzania
The Aurum Institute NPC
Coalition for Epidemic Preparedness Innovations

Recruiting

Phase 2a Trial to Evaluate Safety and Immunogenicity of COVID-19 Vaccine Strategies in HIV-infected/Uninfected Adults. (AUR1-8-341)

COVID-19

South Africa
Johns Hopkins University
Aurum Institute; UNITAID; KNCV Tuberculosis Foundation

Completed

Community Initiated Preventive Therapy for TB (CHIP-TB)

Tuberculosis

Ethiopia
Johns Hopkins University
Aurum Institute; UNITAID; KNCV Tuberculosis Foundation

Completed

Qualitative Understanding of Community TB Services Pre and Post the CHIP-TB Trial

Tuberculosis Infection | Tuberculosis Prevention

Ethiopia, South Africa
University of Pennsylvania
Aurum Institute; University of Witwatersrand, South Africa

Completed

Behavioural Text Messages to Improve Retention in Care in South Africa

HIV/AIDS

South Africa
The Aurum Institute NPC
Johns Hopkins University; University of California

Completed

Safety Tolerability DDI Short Course Treatment of LTBI Infection With High-dose Rifapentine and Isoniazid or Standard Isoniazid Preventive Therapy in HIV+ Patients (DOLPHIN & DOLPHIN TOO) (IMPAACT4TB)

HIV Infections | Respiratory Tract Infections

South Africa
The Aurum Institute NPC
Centers for Disease Control and Prevention

Completed

An Implementation Science Study Investigating Profiles of Men Interested in MMC (Imbizo)

Medical Male Circumcision

South Africa
University of Washington
National Institute of Nursing Research (NINR); Aurum Institute

Completed

Two-way Texting for VMMC Follow-up in Republic of South Africa (2wT_RSA)

Voluntary Medical Male Circumcision

South Africa
Johns Hopkins University
National Institute of Mental Health (NIMH); Aurum Institute

Completed

Post-release Retention in HIV Care for Ex-inmates in South Africa

Hiv | Adherence, Patient

South Africa
Johns Hopkins University
National Institute of Mental Health (NIMH); Seoul National University; Aurum...

Not yet recruiting

Structured Peer-delivered ART and Reentry Community Strategy (SPARCS)

Retention in Care
Johns Hopkins University
Aurum Institute; KNCV Tuberculosis Foundation; Clinton Health Access Initiative...

Completed

Choice Architecture Based TB Preventive Therapy Prescribing (CAT)

HIV/AIDS | Tuberculosis

Malawi, Mozambique, Zimbabwe
The Aurum Institute NPC
Ludwig-Maximilians - University of Munich; Chris Hani Baragwanath Academic...

Completed

Tuberculosis as a Risk Factor for a Worse Outcome Post-Sars-CoV-2 Infection (Co-TB)

COVID-19 | Tuberculosis | Post-acute COVID-19 Syndrome

South Africa
Statens Serum Institut
Bill and Melinda Gates Foundation; Aurum Institute; Leiden University Medical... and other collaborators

Recruiting

First-in-Human Trial of the Novel Tuberculosis Vaccine Candidate, H107e/CAF®10b (nTB-01)

Healthy

South Africa
National Institute of Allergy and Infectious Diseases...
University of Pennsylvania; Emory University; University of Florida; Aurum Institute

Completed

A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults When Given With and Without Isoniazid and Rifabutin (IMPACT-TB)

Tuberculosis

United States
NHS Greater Glasgow and Clyde
University of Glasgow; Aurum Biosciences Ltd

Unknown

Perfluorocarbon (ABL-101) Oxygenation for Stroke: Trial With GOLD (Glasgow Oxygen Level Dependent Technology) Imaging Theranostic (POST-IT)

Acute Ischaemic Stroke
Osel, Inc.
University of California, San Francisco; Aurum Institute; Harvard University; University... and other collaborators

Completed

Phase 2 Trial of LACTIN-V in Women at High Risk of HIV Acquisition

HIV Infections | Bacterial Vaginosis

South Africa
The Aurum Institute NPC
Johns Hopkins University; Weill Medical College of Cornell University; University...

Recruiting

Safety and Tolerability of 1 Month Daily (1HP) and 3 Months Weekly (3HP) Isoniazid and Rifapentine With Pharmacokinetics of Dolutegravir (DTG) in Pregnant People With HIV (DOLPHIN Moms)

Pregnancy | HIV Seropositivity | Tuberculosis Infection

South Africa
Universiteit Antwerpen
Aurum Institute; University of Stellenbosch; University of the Free State; Free...

Recruiting

Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment Trial (SMARTT)

Drug-resistant Tuberculosis | Rifampicin Resistant Tuberculosis | Pulmonary Tuberculoses | Multidrug Resistant Tuberculosis

South Africa
Aeras
Oslo University Hospital; University of Copenhagen; University of Bergen; Aurum... and other collaborators

Withdrawn

A Phase II Study of H56:IC31 in Healthy Adolescents (A-043)

Tuberculosis Infection

South Africa, Tanzania
International AIDS Vaccine Initiative
ModernaTX, Inc.; AURUM Tembisa Clinical Research; Center for Family Health Research

Active, not recruiting

A Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644)

HIV-1-infection

Rwanda, South Africa
University of Massachusetts, Worcester
National Institute of Allergy and Infectious Diseases (NIAID); Aurum Institute and other collaborators

Recruiting

Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) (METHOD)

Tuberculosis | Pulmonary Tuberculosis | HIV Coinfection

South Africa
The Aurum Institute NPC
Karolinska Institutet; Ludwig-Maximilians - University of Munich; University... and other collaborators

Unknown

TB Sequel: Pathogenesis and Risk Factors of Long-term Sequelae of Pulmonary TB (TBSEQUEL)

Respiratory Tract Infections | Tuberculosis, Pulmonary

Mozambique, South Africa, Tanzania, Gambia
The Aurum Institute NPC
London School of Hygiene and Tropical Medicine; Johns Hopkins University; United... and other collaborators

Completed

Thol'Impilo: Bringing People Into Care

HIV

South Africa
The Aurum Institute NPC
Ludwig-Maximilians - University of Munich; Global Alliance for TB Drug Development and other collaborators

Recruiting

A Pan-TB Regimen Targeting Host and Microbe (panTB-HM)

Tuberculosis

South Africa, Mozambique, Tanzania
University of Cape Town
National Institutes of Health (NIH); Texas Tech University Health Sciences... and other collaborators

Terminated

Catalysing the Containment of COVID-19 (C3-RCT)

COVID-19

South Africa
International AIDS Vaccine Initiative
University of Cape Town Lung Institute; European and Developing Countries Clinical... and other collaborators

Active, not recruiting

Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence

Tuberculosis, Pulmonary

South Africa, Tanzania
Karolinska Institutet
The Swedish Institute

Recruiting

MIDWIZE - Strengthening Midwives

Midwifery

Uganda
University of Cape Town
London School of Hygiene and Tropical Medicine; Fred Hutchinson Cancer Center; Aurum Institute and other collaborators

Unknown

The Correlate of Risk Targeted Intervention Study (CORTIS)

Tuberculosis

South Africa
Karolinska Institutet
Children's National Research Institute

Completed

Resistance Exercise Reduces the Expression of Inflammation and Fibrosis Associated Genes in Autoimmune Myositis Patients

Exercise | Myositis

Sweden
Institut Curie
National Cancer Institute, France

Completed

ER-One: A Double-blind Trial of Erector Spinae Block (ESP) Versus Paravertebral Block (PVB) Before Breast Cancer Surgery (ER-One)

Breast Surgery

France
Institut Bergonié
National Cancer Institute, France

Completed

A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/Unresectable Soft-tissue Sarcoma (RADIOSARP)

Soft-tissue Sarcoma

France
Institut Curie

Completed

Blood Levels of Tumor Cells in Predicting Response in Patients Receiving First-Line Chemotherapy for Stage IV Breast Cancer

Breast Cancer

France
Institut Curie

Completed

Bone Marrow and Blood Samples From Patients With Metastatic Choroid Melanoma

Intraocular Melanoma
Institute of Rheumatology, Prague
Karolinska Institutet

Completed

Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM (Prometheus)

Dermatomyositis | Polymyositis

Czech Republic
Jules Bordet Institute
AstraZeneca; Institut Curie

Active, not recruiting

Neo-adjuvant Chemotherapy Combined With Stereotactic Body Radiotherapy to the Primary Tumour +/- Durvalumab, +/- Oleclumab in Luminal B Breast Cancer: (Neo-CheckRay)

Luminal B

France, Belgium
The Netherlands Cancer Institute
Institut Curie

Terminated

Pre- Versus Postoperative Accelerated Partial Breast Irradiation (PAPBI-2)

Breast Cancer | Neoplasms, Breast | Cancer of the Breast

France, Netherlands, Portugal, Spain
Institut Bergonié
National Cancer Institute, France

Completed

Validation of a Screening Tool in Geriatric Oncology (ONCODAGE)

Lymphoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Lung Cancer | Prostate Cancer

France
Institut Bergonié

Completed

Effect of Advertisements on Treatment Compliance in Women With Breast Cancer

Breast Cancer
Institut Curie

Completed

Sunitinib as Second-Line Therapy in Treating Patients With Locally Advanced or Metastatic Transitional Cell Cancer

Bladder Cancer | Transitional Cell Cancer of the Renal Pelvis and Ureter

France
Institut Bergonié

Completed

MRI in Evaluating Early Response to Chemotherapy in Women Receiving Chemotherapy for Infiltrating Breast Cancer

Breast Cancer

France
Institut Bergonié

Completed

Psychological and Social Factors That May Increase the Risk of Developing Chronic Pain After Surgery in Women With Breast Cancer

Pain | Breast Cancer | Psychosocial Effects of Cancer and Its Treatment
Institut Curie

Unknown

Study of Tumor and Blood Samples From Women With Breast Cancer

Breast Cancer

France
Institut Bergonié

Unknown

Efavirenz as Second-Line Therapy in Treating Patients With Metastatic Pancreatic Cancer

Pancreatic Cancer

France
Institut Curie

Unknown

Radiation Therapy With or Without Temozolomide in Treating Women With Brain Metastases and Breast Cancer

Breast Cancer | Metastatic Cancer

France
Institut Curie
National Cancer Institute, France

Recruiting

LOC-R01 Study of Lenalidomide and Ibrutinib in Association With Rituximab-Methotrexate Procarbazine Vincristin (R-MPV) (LOC-R01)

Lymphoma, Large B-Cell, Diffuse | Central Nervous System Neoplasms, Primary

France
Institut Bergonié
National Cancer Institute, France

Completed

Diffuse Large B Cell Non-Hodgkin's Lymphoma in the Vulnerable/Frail Elderly. A Multicentric Randomized Phase II Trial (FRAIL-06)

Lymphoma

France

Clinical Trials Sponsored by Aurum Institute

Sponsors and Collaborators

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