Clinical Trials Sponsored by California Institute for Regenerative Medicine (CIRM)

Total 162 results

ViaCyte
California Institute for Regenerative Medicine (CIRM)

Terminated

A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus

Type 1 Diabetes Mellitus

Canada, United States
Neurona Therapeutics
California Institute for Regenerative Medicine (CIRM)

Recruiting

FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy

Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis

United States
ExCellThera inc.
California Institute for Regenerative Medicine (CIRM)

Withdrawn

US Phase I Study of ECT-001-CB in Patients With Sickle-Cell Disease

Sickle Cell Disease | Umbilical Cord Blood | Hematopoietic Cell Proliferation

United States
Angiocrine Bioscience
California Institute for Regenerative Medicine (CIRM)

Completed

Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia in Remission | Other Acute Leukemias

United States
jCyte, Inc
California Institute for Regenerative Medicine (CIRM)

Completed

Safety of a Single, Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Retinitis Pigmentosa

Retinitis Pigmentosa (RP)

United States
jCyte, Inc
California Institute for Regenerative Medicine (CIRM)

Completed

Safety of Repeat Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects With Retinitis Pigmentosa

Retinitis Pigmentosa

United States
Gilead Sciences
California Institute for Regenerative Medicine (CIRM)

Completed

CAMELLIA: Anti-CD47 Antibody Therapy in Haematological Malignancies

Acute Myeloid Leukemia | Myelodysplastic Syndrome

United Kingdom
Genascence Corporation
California Institute for Regenerative Medicine (CIRM)

Active, not recruiting

Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis (DONATELLO)

Knee Osteoarthritis | Osteoarthritis, Knee | Osteo Arthritis Knee

United States
Aspen Neuroscience
California Institute for Regenerative Medicine (CIRM)

Enrolling by invitation

Phase 1/2a Study of ANPD001 in Parkinson Disease (ASPIRO)

Parkinson Disease

United States
Angiocrine Bioscience
California Institute for Regenerative Medicine (CIRM)

Terminated

A Study of the Effects of AB-205 in Patients With Lymphoma Undergoing Autologous Hematopoietic Cell Transplantation (E-CELERATE)

Hodgkin Lymphoma | Non Hodgkin Lymphoma

United States
jCyte, Inc
California Institute for Regenerative Medicine (CIRM)

Completed

Safety and Efficacy of Intravitreal Injection of Human Retinal Progenitor Cells in Adults With Retinitis Pigmentosa

Retinitis Pigmentosa

United States
Angiocrine Bioscience
California Institute for Regenerative Medicine (CIRM)

Completed

Trial of AB-205 in Adults With Lymphoma Undergoing High-Dose Therapy and Autologous Stem Cell Transplantation

Hodgkin Lymphoma | Non-hodgkin Lymphoma

United States
Gilead Sciences
California Institute for Regenerative Medicine (CIRM)

Completed

Study of Magrolimab (Hu5F9-G4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer

Colorectal Cancer | Solid Tumor

United States
Poseida Therapeutics, Inc.
California Institute for Regenerative Medicine (CIRM)

Active, not recruiting

Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101

Multiple Myeloma

United States
Immune-Onc Therapeutics
California Institute for Regenerative Medicine (CIRM)

Recruiting

IO-202 as Monotherapy and IO-202 Plus Azacitidine ± Venetoclax in Patients in AML and CMML

CMML | AML With Monocytic Differentiation

United States
Poseida Therapeutics, Inc.
California Institute for Regenerative Medicine (CIRM)

Terminated

P-BCMA-101 Tscm CAR-T Cells in the Treatment of Patients With Multiple Myeloma (MM)

Multiple Myeloma

United States
Rocket Pharmaceuticals Inc.
California Institute for Regenerative Medicine (CIRM)

Completed

A Clinical Trial to Evaluate the Safety and Efficacy of RP-L201 in Subjects With Leukocyte Adhesion Deficiency-I

Leukocyte Adhesion Defect - Type I

Spain, United States, United Kingdom
Rocket Pharmaceuticals Inc.
California Institute for Regenerative Medicine (CIRM)

Terminated

A Trial to Evaluate Safety and Efficacy of RP-L401-0120 in Subjects With Infantile Malignant Osteopetrosis

Infantile Malignant Osteopetrosis

United States
Brainstorm-Cell Therapeutics
California Institute for Regenerative Medicine (CIRM)

Completed

Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients

Amyotrophic Lateral Sclerosis (ALS)

United States
Medeor Therapeutics, Inc.
California Institute for Regenerative Medicine (CIRM)

Active, not recruiting

Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants

Kidney Transplant Rejection

United States, Canada
Cedars-Sinai Medical Center
California Institute for Regenerative Medicine (CIRM)

Recruiting

CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS

Amyotrophic Lateral Sclerosis

United States
Stanford University
Northwestern University; California Institute for Regenerative Medicine (CIRM)

Recruiting

TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation

Living Donor Kidney Transplantation

United States
Samuel Strober
California Institute for Regenerative Medicine (CIRM)

Recruiting

Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation (CIRM)

Immune Tolerance

United States
Jonsson Comprehensive Cancer Center
California Institute for Regenerative Medicine (CIRM)

Terminated

Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer (NYESO SCT)

Sarcoma | Unresectable Malignant Neoplasm | Locally Advanced Malignant Neoplasm | HLA-A*0201 Positive Cells Present | NY-ESO-1 Positive

United States
University of California, San Francisco
California Institute for Regenerative Medicine (CIRM)

Enrolling by invitation

In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)

Hemoglobinopathies | Alpha Thalassemia Major | Thalassemia Major | Fetal Hydrops | Hemoglobinopathy; With Thalassemia | Fetal Anemia | Alpha; Thalassemia | Thalassemia Alpha | A-Thalassemia

United States
Alice Bertaina
California Institute for Regenerative Medicine (CIRM)

Recruiting

Early Trial of Allogeneic Hematopoietic Stem Cell Transplantation for Patients Who Will Receive a Kidney Transplant From the Same Donor

CKD Stage 4 | Cystinosis | FSGS | SLE Nephritis | SIOD

United States
Cedars-Sinai Medical Center
California Institute for Regenerative Medicine (CIRM)

Recruiting

CNS10-NPC for the Treatment of RP

Retinitis Pigmentosa

United States
Cedars-Sinai Medical Center
California Institute for Regenerative Medicine (CIRM)

Completed

ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy (ALPHA)

Pulmonary Arterial Hypertension (PAH)

United States
Cedars-Sinai Medical Center
California Institute for Regenerative Medicine (CIRM)

Completed

CNS10-NPC-GDNF for the Treatment of ALS

Amyotrophic Lateral Sclerosis

United States
University of California, Davis
California Institute for Regenerative Medicine (CIRM); Cook MyoSite

Recruiting

Autologous Muscle Derived Cells for Treatment of Tongue Dysphagia

Oropharyngeal Dysphagia

United States
Porteus, Matthew, MD
California Institute for Regenerative Medicine (CIRM)

Recruiting

Stem Cell Transplant From Donors After Alpha Beta Cell Depletion in Children and Adults With T-allo10 Cells Addback

Hematologic Diseases

United States
ViaCyte
California Institute for Regenerative Medicine (CIRM); Horizon 2020 - European...

Completed

A Safety, Tolerability, and Efficacy Study of VC-02™ Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness

Type 1 Diabetes Mellitus With Hypoglycemia

United States, Canada, Belgium
Joseph C. Wu
California Institute for Regenerative Medicine (CIRM)

Recruiting

Human Embryonic Stem Cell-Derived Cardiomyocyte Therapy for Chronic Ischemic Left Ventricular Dysfunction (HECTOR)

Chronic Ischemic Left Ventricular Dysfunction

United States
City of Hope Medical Center
California Institute for Regenerative Medicine (CIRM)

Active, not recruiting

A Blood Stem Cell Transplant for Sickle Cell Disease

Sickle Cell Disease | Anemia, Sickle Cell | Hemoglobinopathies | Thalassemia | Sickle Cell Disorder

United States
Lisata Therapeutics, Inc.
California Institute for Regenerative Medicine (CIRM); Sanford Health

Completed

Safety and Efficacy of CLBS03 in Adolescents With Recent Onset Type 1 Diabetes (The Sanford Project T-Rex Study)

Diabetes Mellitus

United States
Crystal Mackall, MD
California Institute for Regenerative Medicine (CIRM)

Active, not recruiting

CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies

B Acute Lymphoblastic Leukemia | Philadelphia Chromosome Positive | Minimal Residual Disease | CD19 Positive

United States
University of California, Los Angeles
Orchard Therapeutics; California Institute for Regenerative Medicine (CIRM)

Completed

Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID

Severe Combined Immunodeficiency Due to ADA Deficiency

United States
Peter Stock
California Institute for Regenerative Medicine (CIRM)

Recruiting

Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes (PARADIGM)

Type 1 Diabetes

United States
Diana Lee Farmer
California Institute for Regenerative Medicine (CIRM)

Recruiting

Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial (CuRe)

Myelomeningocele

United States
Calibr, a division of Scripps Research
California Institute for Regenerative Medicine (CIRM)

Completed

A Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of KA34 in Subjects With Knee Osteoarthritis

Osteoarthritis, Knee

United States
Gary Steinberg, MD, PhD
California Institute for Regenerative Medicine (CIRM)

Recruiting

A Safety and Tolerability Study of Neural Stem Cells (NR1) in Subjects With Chronic Ischemic Subcortical Stroke (ISS)

Ischemic Stroke

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); California Institute for Regenerative Medicine...

Active, not recruiting

Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant

HIV Infection | Plasmablastic Lymphoma | Recurrent Adult Hodgkin Lymphoma | Recurrent Adult Non-Hodgkin Lymphoma | Stage III Mantle Cell Lymphoma | Stage IV Mantle Cell Lymphoma | Recurrent Burkitt Lymphoma | Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma | Recurrent Follicular Lymphoma | Stage III Follicular... and other conditions

United States
University of California, San Diego
California Institute for Regenerative Medicine (CIRM); Cystinosis Research...

Active, not recruiting

Stem Cell Gene Therapy for Cystinosis

Lysosomal Storage Diseases | Cystinosis

United States
Celularity Incorporated
Lung Biotechnology PBC; California Institute for Regenerative Medicine (CIRM); ID...

Active, not recruiting

Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19 (CYNKCOVID)

Coronaviridae Infections | Nidovirales Infections | RNA Virus Infections | Respiratory Tract Infections | Coronavirus Infection | Pneumonia, Viral | Pneumonia | Lung Diseases | ARDS | Coronavirus | Severe Acute Respiratory Syndrome Coronavirus 2 | Respiratory Tract Disease | Virus Disease | Physiological Effects of... and other conditions

United States
University of California, Los Angeles
National Eye Institute (NEI); California Institute for Regenerative Medicine...

Recruiting

Stem Cell Therapy for Limbal Stem Cell Deficiency

Limbal Stem-cell Deficiency

United States
University of California, San Diego
California Institute for Regenerative Medicine (CIRM); n-Lorem Foundation

Active, not recruiting

Personalized Antisense Oligonucleotide Therapy for Rare Pediatric Genetic Disease: SCN2A

Genetic Disease

United States
Nancy E. Lane, MD
California Institute for Regenerative Medicine (CIRM)

Completed

Safety and Tolerability of Intravenous LLP2A-Alendronate for Osteopenia Secondary to Glucocorticoids

Osteoporosis | Osteonecrosis | Osteopenia

United States
City of Hope Medical Center
Sangamo Therapeutics; California Institute for Regenerative Medicine (CIRM)

Active, not recruiting

Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients

HIV

United States
Brain Neurotherapy Bio, Inc.
California Institute for Regenerative Medicine (CIRM); Asklepios Biopharmaceutical...

Active, not recruiting

GDNF Gene Therapy for Parkinson's Disease

Parkinson's Disease

United States
Donald B. Kohn, M.D.
California Institute for Regenerative Medicine (CIRM)

Recruiting

Stem Cell Gene Therapy for Sickle Cell Disease

Sickle Cell Disease

United States

Clinical Trials Sponsored by California Institute for Regenerative Medicine (CIRM)

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