Clinical Trials Sponsored by ECRI Institute

Total 74772 results

Seattle Children's Research Institute (SCRI)

Completed

Safety, Attenuation and Immunogenicity of GAP3KO Administered Via A Stephensi Mosquitoes

Malaria

United States
Seattle Children's Research Institute (SCRI)

Completed

Malaria Challenge in Healthy Volunteers (ITV)

Malaria

United States
Seattle Children's Research Institute (SCRI)

Terminated

Phase 1/2a Trial of Pf GAP p52-/p36- Sporozoite Malaria Vaccine

Malaria

United States
ECRI bv
Boston Scientific Corporation

Active, not recruiting

Intravascular Ultrasound Guidance for Complex High-risk Indicated Procedures (IVUS-CHIP)

Complex Coronary Lesions

Spain, United Kingdom, Netherlands, France, Belgium, Germany, Italy
ECRI bv
Micell Technologies; Stentys

Completed

Study Comparing the MiStent SES Versus the XIENCE EES Stent (DESSOLVE III)

Coronary Stenosis

France, Germany, Netherlands, Poland
ECRI bv
Cardialysis BV; Balton Sp.zo.o.

Terminated

POLish Bifurcation Optimal Treatment Strategy Study for Left Main Bifurcation Percutaneous Coronary Intervention (PCI) (POLBOS LM)

Coronary Stenosis

France, Italy, Poland
ECRI bv
GE Healthcare; HeartFlow, Inc.

Withdrawn

A Multicentre, Pilot Study to Evaluate the Safety and the Feasibility of Planning and Execution of Surgical Revascularization in Patients With Complex Coronary Artery Disease, Based Solely on MSCT Imaging Utilizing GE Healthcare Revolution CT and HeartFlow FFRCT. (CABGRevolution)

Multivessel Coronary Artery Disease

Italy, Switzerland, Belgium, Germany
ECRI bv
GE Healthcare; HeartFlow, Inc.

Completed

SYNTAX III REVOLUTION Trial: A Randomized Study Investigating the Use of CT Scan and Angiography of the Heart to Help the Doctors Decide Which Method is the Best to Improve Blood Supply to the Heart in Patients With Complex Coronary Artery Disease (SYNTAX III)

Heart Diseases | Cardiovascular Diseases | Multivessel Coronary Artery Disease | Coronary Artery Diseases

Belgium, France, Germany, Italy, Switzerland
Icahn School of Medicine at Mount Sinai
Medtronic - MITG; ECRI Institute

Completed

Observational Analysis of the Cause of Leaks When Bowel is Cut and Reconnected

Anastomotic Leaks

United States
Contura
Regulatory and Clinical Research Institute (RCRI)

Completed

Bulking Agents for the Treatment of Stress Urinary Incontinence in Females

Stress Urinary Incontinence

Canada, France, United States
Physeon GmbH
Regulatory Clinical Research Institute (RCRI)

Terminated

Veinplicity for Improved Venous Access: The VIVA Trial

Difficult-to-access Veins for Intravenous Cannulation

United States
ECRI bv
Boston Scientific Corporation; Philips Healthcare

Active, not recruiting

The OPTIMAL Randomized Controlled Trial (OPTIMAL)

Left Main Coronary Artery Stenosis

Spain, United Kingdom, Italy
ECRI bv
Sahajanand Medical Technologies Pvt. Ltd.

Completed

Thin Strut Sirolimus-eluting Stent in All Comers Population vs Everolimus-eluting Stent (TALENT)

Coronary Stenosis

Bulgaria, Hungary, Italy, Netherlands, Poland, Spain, United Kingdom
ECRI bv
Bayer; Rigshospitalet, Denmark; Cardialysis BV

Completed

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) (GALILEO-4D)

Cardiovascular Diseases | Thrombosis | Aortic Valve Stenosis | Heart Valve Diseases | Ventricular Outflow Obstruction

Germany, United States, Denmark, Switzerland, Netherlands, Sweden, Canada
ECRI bv
GE Healthcare; Amgen; HeartFlow, Inc.

Withdrawn

Multislice Computed Tomography Assessment of PCSK9 Inhibition on Coronary Perfusion (MARKOV)

Coronary Artery Disease
ECRI bv
Boston Scientific Corporation; Volcano Corporation

Completed

Trial Evaluating New Strategy in the Functional Assessment of 3-vessel Disease Using SYNTAXII Score in Patients With PCI

Heart Diseases | Cardiovascular Diseases | 3 Vessel Coronary Artery Disease

Netherlands, Poland, Spain, United Kingdom
Balton Sp.zo.o.
KCRI

Completed

Clinical Study to Assess the Safety and Efficacy of Mechanochemical Ablation With Flebogrif in Patients With Great Saphenous Vein Insufficiency (POLFLEB)

Chronic Venous Insufficiency, CVI

Poland
Balton Sp.zo.o.
KCRI

Completed

Prospective, Single-arm, Multicenter Study for Evaluation the Safety and Effectiveness of the ALEX Stent in a Real-world Setting of Percutaneous Coronary Interventions in Patients With Coronary Heart Disease (ALEX OCT)

Myocardial Infarction | Stable Angina | Unstable Angina

Poland
KCRI
Spectranetics Corporation

Terminated

ThromboAblation in Acute Myocardial Infarction (TAAMI)

ST Elevation Acute Myocardial Infarction

Poland
PlasFree Ltd.
KCRI

Completed

Clinical Investigation of Safety and Performance of a Medical Device (ClearPlasma) for the Treatment of Patients With Acute Upper Gastrointestinal Hemorrhage.

Acute Upper Gastrointestinal Bleeding | Acute Upper Gastrointestinal Hemorrhage

Czechia, Israel, Italy
Balton Sp.zo.o.
KCRI

Completed

Safety and Efficacy of Peripheral, Cobalt-chromium Sirolimus Eluting Stent (PERS) Versus Cobalt-chromium Stent (Neptune C) (PERS)

Peripheral Arterial Disease

Poland
Balton Sp.zo.o.
KCRI

Completed

Clinical Study to Evaluate the Safety and Effectiveness of MER® Stents in Carotid Revascularisation. (MER)

Carotid Artery Stenosis

Poland
Balton Sp.zo.o.
KCRI

Completed

Evaluation of the Usefulness of Imaging Methods and 3D Reconstruction in Percutaneous Closure Procedures of PVL. (VALE)

PVL - Paravalvular Leak

Poland
ECRI bv
AstraZeneca; The Medicines Company; Biosensors International

Completed

GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation

Coronary Artery Disease (CAD)

Australia, Austria, Belgium, Brazil, Bulgaria, Canada, Denmark, France, Germany, Hungary, Italy, Netherlands, Poland, Portugal, Singapore, Spain, Switzerland, United Kingdom
ECRI bv
Siemens Healthineers AG; Pie Medical Imaging

Recruiting

Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization (FAST III)

Coronary Artery Disease

Germany, Ireland, Italy, Netherlands, Spain, United Kingdom, France
ECRI bv
Terumo Europe N.V.; Abbott Medical Devices

Completed

ABSORB STEMI: the TROFI II Study

Acute ST Segment Elevation Myocardial Infarction

Denmark, Netherlands, Spain, Switzerland
ResMed
CRI-The Clinical Research Institute GmbH

Recruiting

HomeVent ( Connect) Registry: EU COPD Home NIV Registry (HOmeVent)

Chronic Obstructive Pulmonary Disease

Germany
ResMed
CRI-The Clinical Research Institute GmbH

Completed

Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure (Serve-HF)

Heart Failure | Sleep Disordered Breathing

Germany, Netherlands, Australia, Denmark, France, United Kingdom, Switzerland, Norway, Finland, Sweden, Czechia
Ludwig Institute for Cancer Research
Cancer Research Institute (CRI)

Completed

NY-ESO-1 Protein Vaccine With Imiquimod in Melanoma (Adjuvant Setting)

Malignant Melanoma

United States
SCRI Development Innovations, LLC

Terminated

A Study of CPX-351 (Vyxeos™) With Quizartinib for the Treatment of FLT3-ITD Mutation-Positive Acute Myeloid Leukemia

Leukemia, Myeloid, Acute

United States
Eximo Medical Ltd.
KCRI

Completed

Safety and Effectiveness Study of Eximo's B-Laser™ Atherectomy Device for PAD Treatment

Peripheral Arterial Disease

Poland
SCRI Development Innovations, LLC

Completed

Utilization of the OncoCEE™ Platform to Evaluate Selected Biomarker Alterations in CTCs Isolated From Patients With MBC

Metastatic Breast Cancer

United States
KCRI
SIS Medical AG

Completed

Optimal Lesion Preparation With Non-compliant Balloons Before Implantation Of Bioresorbable Scaffolds (OPreNBiS)

Coronary Artery Disease | Angina, Stable | Angina, Unstable

Switzerland
Eclipse Medical Ltd.
KCRI

Recruiting

Evaluation od Safety and Performance of the Omega™ LAA (Left Atrial Appendage) Occluder and Omega™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk (Omega)

Non-Valvular Atrial Fibrillation

Denmark, Germany, Italy, Spain, United Kingdom
SCRI Development Innovations, LLC

Withdrawn

iCORE: Collaborative Orthopedics Outcomes Registry (iCORE)

Arthroplasty, Replacement, Knee | Arthroplasty, Replacement, Hip

United States
SCRI Development Innovations, LLC

Withdrawn

Sarah Cannon Outcomes Registry

Oncology

United States
SCRI Development Innovations, LLC

Terminated

SCRI Tissue Testing Registry

Melanoma | Lymphoma | Multiple Myeloma | Myelodysplastic Syndrome

United States
KCRI
Vascular Concepts Limited

Completed

A Clinical Evaluation of the ProNOVA XR Polymer Free Drug Eluting Coronary Stent System (EURONOVA)

Myocardial Ischemia

Poland
Maria Sklodowska-Curie National Research Institute...
KCRI

Not yet recruiting

Nivolumab in Nasopharyngeal Cancer With Progression During or After Platinum-based Treatment (NIVONASO-21)

Nasopharyngeal Cancer

Poland
Maria Sklodowska-Curie National Research Institute...
KCRI

Not yet recruiting

Obinutuzumab Versus Rituximab for Acute Lymphoblastic Leukemia/PALG ALL7 OVERALL (PALG ALL7)

CD20-positive Acute Lymphoblastic Leukemia

Poland
Maria Sklodowska-Curie National Research Institute...
KCRI

Not yet recruiting

Total Body Irradiation and Cladribine Before Allogeneic Hematopoietic Cell Transplantation in Patients With AML (Acute Myeloid Leukemia) and Myelodysplastic Syndromes (CLARA)

Acute Myeloid Leukemia Myelodysplastic Syndromes

Poland
keepMED Ltd.
CRI-The Clinical Research Institute GmbH

Not yet recruiting

Efficacy and Safety of keepMED Positive Airway Pressure Device in Patients With Obstructive Sleep Apnea (keePaOSA)

Obstructive Sleep Apnea
Lohmann & Rauscher
CRI-The Clinical Research Institute GmbH

Not yet recruiting

Suprasorb® CNPendo Used for Negative Pressure Therapy in the Oesophagus and Rectum to Support Defect and Wound Healing (Velox)

Esophagus Injury | Rectal Lesion
University of Vienna
CRI Collagen Research Institute GmbH

Completed

Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage

Recovery

Austria
Thubrikar Aortic Valve, Inc.
KCRI

Recruiting

Safety and Performance Study of the Optimum Transcatheter Aortic Valve

Severe Aortic Stenosis

Poland
SCRI Development Innovations, LLC
Amgen

Completed

Carfilzomib for the Treatment of Patients With Advanced Neuroendocrine Cancers

Neuroendocrine Cancer

United States
Xtrac O.S.
KCRI; Scopus Research

Active, not recruiting

Safety and Preliminary Performance of Xtrac O.S. System for Lead Extraction. (XTR)

Bradycardia

Israel
SCRI Development Innovations, LLC
Celgene

Completed

Trial of Amrubicin as Treatment for Patients With HER2-Negative Metastatic Breast Cancer

Metastatic Breast Cancer

United States
SCRI Development Innovations, LLC
Bayer

Completed

Sorafenib/Erlotinib Versus Erlotinib Alone in Previously Treated Advanced Non-Small-Cell Lung Cancer (NSCLC)

Non-Small Cell Lung Cancer

United States
SCRI Development Innovations, LLC
Novartis

Completed

LBH589 Treatment for Refractory Clear Cell Renal Carcinoma

Renal Cell Carcinoma

United States

Clinical Trials Sponsored by ECRI Institute

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