Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage

Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage

The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.

Study Overview

• Status: Completed
• Conditions: Recovery
• Intervention / Treatment: Dietary supplement: Collagen; Other: Concurrent training

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Austria
  • Vienna, Austria, 1150
    • University of Vienna, Institute of Sport Science

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• No subjective symptoms during physical exertion
• Stable weight and dietary behaviour
• Body Mass Index (BMI) between 18.5 and 24.9
• No extensive strength/endurance sports so far (less than 3 h/week)
• No complaints during strenuous physical activity

Exclusion Criteria:

• Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)
• Intolerance/aversion to animal protein
• Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest
• Presence of insulin-dependent diabetes mellitus
• Liver and/or kidney disease that precludes a high protein load
• Collagen supplementation or regular intake of other dietary supplements in the last 6 months.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Collagen; 15g of collagen peptides ingested daily	Dietary supplement: Collagen; Participants ingest 15 grams of either specific collagen peptides or Placebo daily; Other: Concurrent training; Both arms undergo a 12-week trainingintervention 3x/week
Placebo Comparator: Placebo; 15g of Placebo ingested daily	Other: Concurrent training; Both arms undergo a 12-week trainingintervention 3x/week

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in maximal voluntary contraction (MVC)	Measured by isokinetic dynamometer	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in rate of force development (RFD)	Measured by isokinetic dynamometer	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in countermovement jump height (CMJ)	Measured by force plate	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in subjective pain score	Measured by visual analogue scale	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in Achilles tendon cross-sectional area	Measured by ultrasound	Baseline and after 12 weeks
Change in Vastus Lateralis fibre length	Measured by ultrasound	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in collagen related blood markers	Measured by blood analysis	Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)
Change in Achilles tendon echo intensity	Measured by ultrasound	Baseline and after 12 weeks
Change in Vastus Lateralis echo intensity	Measured by ultrasound	Baseline and after 12 weeks
Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)	Measured by bioelectrical impedance analysis	Baseline and after 12 weeks

Collaborators and Investigators

• Sponsor: University of Vienna
• Collaborators: CRI Collagen Research Institute GmbH
• Investigators: Principal Investigator: Daniel Koenig, Prof. Dr., University of Vienna, Institute of Sport Science

Study record dates

Study Major Dates

• Study Start (Actual): January 28, 2022
• Primary Completion (Actual): June 30, 2023
• Study Completion (Actual): June 30, 2023

Study Registration Dates

• First Submitted: January 28, 2022
• First Submitted That Met QC Criteria: January 28, 2022
• First Posted (Actual): February 2, 2022

Study Record Updates

• Last Update Posted (Actual): August 28, 2023
• Last Update Submitted That Met QC Criteria: August 23, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Keywords: Ultrasound; Collagen peptides; Concurrent training; MVC; RFD
• Other Study ID Numbers: 00765

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No