Clinical Trials Sponsored by Leonard Appleman

Total 221 results

Weill Medical College of Cornell University
The Leona M. and Harry B. Helmsley Charitable Trust

Not yet recruiting

Testing the Role for Anti-fungal Therapy in Improving the Response to Medicine for Crohn's Disease

Inflammatory Bowel Diseases | Crohn's Disease

United States
Susan Harkema PhD
The Leona M. and Harry B. Helmsley Charitable Trust

Active, not recruiting

Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation

Spinal Cord Injuries

United States
University of Oxford
Oxford Brookes University; The Leona M. and Harry B. Helmsley Charitable Trust

Terminated

Dapagliflozin During Exercise for the PrevenTion of Hypoglycaemia (DEPTH)

Diabetes Mellitus, Type 1

United Kingdom
Julia Blanchette
The Leona M. and Harry B. Helmsley Charitable Trust

Not yet recruiting

iHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults With Type 1 Diabetes

Type 1 Diabetes

United States
University of Florida
Genzyme, a Sanofi Company; The Leona M. and Harry B. Helmsley Charitable Trust

Completed

Reversing Type 1 Diabetes After it is Established

Diabetes Mellitus, Type 1

United States
Centre Hospitalier Universitaire de Saint Etienne
Claude Bernard University; Laboratoire de Physiologie de l'Exercice; Centre de...

Completed

Evaluation of a Training Program for Homozygous Sickle Cell Disease Patients (EXDRE)

Hemoglobin S Disease | Sickle Cell Hemoglobin C Disease

France
Stanford University
University of Virginia; DexCom, Inc.; The Leona M. and Harry B. Helmsley Charitable...

Completed

Testing State of the Art Remote Glucose Monitoring at Diabetes Camp

Type 1 Diabetes

United States
Centre Leon Berard
Hospices Civils de Lyon; Claude Bernard University; Lyon Cancer Research Centre; Inter-university Laboratory of Human Movement Biology

Completed

Feasibility of an Acute Physical Exercise Before Treatment Infusion for Metastatic Lung Cancer Patients (ERICA)

Carcinoma, Non-Small-Cell Lung

France
University of Colorado, Denver
The Leona M. and Harry B. Helmsley Charitable Trust; Nova Immunotherapeutics...

Recruiting

MER3101: MAS-1 Adjuvanted Antigen-specific Immunotherapeutic for Prevention and Treatment of Type 1 Diabetes (MER3101)

Type 1 Diabetes Mellitus

United States
Universidad del Desarrollo
Clinica Alemana de Santiago; Clínica INDISA; Clínica BUPA; Hospital del Salvador; Hospital Regional Dr. Leonardo Guzmán de Antofagasta and other collaborators

Recruiting

Impact on Mental, Physical, And Cognitive Functioning of a Critical Care sTay During the COVID-19 Pandemic (IMPACCT)

Covid19 | Critical Care | Postintensive Care Syndrome

Chile
University of Massachusetts, Worcester
University of Puerto Rico; The Leona M. and Harry B. Helmsley Charitable Trust

Recruiting

A Culturally Tailored Dietary Intervention to Treat Crohn's Disease (DAIN)

Crohn Disease

United States, Puerto Rico
University of Colorado, Denver
Juvenile Diabetes Research Foundation; The Leona M. and Harry B. Helmsley Charitable...

Completed

Assessment of Sleep and Sleep Disruptors in Adolescents With Type 1 Diabetes

Type 1 Diabetes | Insufficient Sleep

United States
University of Sao Paulo
LEONARDO ALFONSO BUSTAMANTE L; MARIANNY NAZARETH SULBARAN N; PAULO SAKAI; EDUARDO... and other collaborators

Completed

Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy (EACC)

Rectal Neoplasms | Colonic Neoplasms | Fecal Incontinence

Brazil
Jaeb Center for Health Research
Juvenile Diabetes Research Foundation; The Leona M. and Harry B. Helmsley Charitable...

Completed

Wireless Innovation for Seniors With Diabetes Mellitus (WISDM)

Type 1 Diabetes Mellitus

United States
Sanford Health
University of Exeter; The Leona M. and Harry B. Helmsley Charitable Trust; Pacific...

Recruiting

General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery (PLEDGE)

Type 1 Diabetes | Celiac Disease

United States
Oregon Health and Science University
Juvenile Diabetes Research Foundation; The Leona M. and Harry B. Helmsley Charitable...

Completed

Two Way Crossover Closed Loop Study MPC vs FMPD

Type 1 Diabetes

United States
Jaeb Center for Health Research
The Leona M. and Harry B. Helmsley Charitable Trust; Indiana University School...

Completed

Strategies to Enhance New CGM Use in Early Childhood (SENCE) (SENCE)

Type 1 Diabetes Mellitus

United States
Hasselt University
Jessa Hospital; University of Warwick; University of Zagreb; Claude Bernard University and other collaborators

Completed

Fast Assay for Pathogen Identification and Characterization (FAPIC)

Sepsis | Septic Shock | Bacteremia

Belgium
Soroka University Medical Center
The Leona M. and Harry B. Helmsley Charitable Trust; Ben-Gurion University...

Recruiting

A Smartphone Application for Added Psychological Wellbeing in Crohn's Disease (COBMINDEX)

Crohn Disease

Israel
University of Cambridge
Juvenile Diabetes Research Foundation; The Leona M. and Harry B. Helmsley Charitable... and other collaborators

Unknown

An Innovative Approach Towards Understanding and Arresting Type 1 Diabetes (INNODIA) (INNODIA)

Type 1 Diabetes Mellitus

Austria, Italy, Finland, Denmark, Germany, Belgium, United Kingdom, France, Luxembourg, Norway, Poland, Slovenia, Sweden
University of Edinburgh
NHS Lothian; DexCom, Inc.; Tandem Diabetes Care, Inc.; The Leona M. and Harry B...

Active, not recruiting

Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes

Hypoglycemia | Type 1 Diabetes | Type 1 Diabetes Mellitus With Hypoglycemia | Hypoglycemia Unawareness | Glucagon Deficiency | Insulin Hypoglycemia

United Kingdom
Icahn School of Medicine at Mount Sinai
University of Massachusetts, Worcester; The Leona M. and Harry B. Helmsley...

Active, not recruiting

Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease

Pregnancy | Crohn Disease

United States
Beth Israel Deaconess Medical Center
Icahn School of Medicine at Mount Sinai; The Leona M. and Harry B. Helmsley...

Enrolling by invitation

Proactive Infliximab Optimization Using a Pharmacokinetic Dashboard Versus Standard of Care in Patients With Inflammatory Bowel Disease: The OPTIMIZE Trial

Inflammatory Bowel Diseases | Crohn Disease | Ulcerative Colitis

United States, Canada
University of California, San Diego
Juvenile Diabetes Research Foundation; The Leona M. and Harry B. Helmsley Charitable... and other collaborators

Completed

Combination GRA and SGLT-2i Treatment in Type 1 Diabetes

Type 1 Diabetes

United States
Hasselt University
Jessa Hospital; University of Warwick; Claude Bernard University; AIT Austrian... and other collaborators

Completed

Fast Assay for Pathogen Identification - Quasi-Experimental Intervention Study (FAPIC-QE)

Sepsis | Septic Shock | Bacteremia

Belgium
Foundation for Innovative New Diagnostics, Switzerland
The Leona M. and Harry B. Helmsley Charitable Trust; Kenya Diabetes Management...

Not yet recruiting

Use of Continuous Glucose Monitoring Devices Among People Living With Type 1 Diabetes in Kenya. (ACCEDE)

Type 1 Diabetes
Foundation for Innovative New Diagnostics, Switzerland
University of Cape Town; The Leona M. and Harry B. Helmsley Charitable Trust; University of Pretoria

Recruiting

Use of Continuous Glucose Monitoring Devices Among People Living With Type 1 Diabetes in South Africa (ACCEDE)

Type 1 Diabetes

South Africa
Center for Sleep Medicine - Clinique André Renard
PIRON Alain, Osteopath - physiotherapist; LACROIX Alain, neurologist, MD, PhD; CHAKAR Bassam, neurologist, MD, PhD and other collaborators

Enrolling by invitation

Predictability of OSA With a Subjective Screening Scale (OSASSS1) (OSASSS1)

Obstructive Sleep Apnea | OSA

Belgium
Vanderbilt University Medical Center
University of Utah; Children's Hospital Los Angeles; The Leona M. and Harry B... and other collaborators

Enrolling by invitation

Adapting FAMS to Optimize CGM Use Among Emerging Adults With Type 1 Diabetes

Type 1 Diabetes

United States
Instituto Fernandes Figueira
Hospital de Clinicas de Porto Alegre; University of Campinas, Brazil; UPECLIN... and other collaborators

Completed

PREPARE, Prematurity Reduction by Pre-eclampsia Care (PREPARE)

Premature Birth | Pre-Eclampsia

Brazil
Erasmus Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development; Stichting... and other collaborators

Recruiting

Generation R Next - Optimaal Opgroeien

Pregnancy Complications | Pregnancy Outcome | Risk Reduction Behavior | Pregnancy Early | Lifestyle Factors | Preconception Care | Outcome, Adverse Birth

Netherlands
Uriach Consumer Healthcare
Hospital General Universitario Gregorio Marañon; Hospital Universitario 12... and other collaborators

Not yet recruiting

Efficacy of Intravaginal Carboxymethyl-β-glucan and Polycarbophil on Low-grade Cervical Lesions (GLUCANCIN) (GLUCANCIN)

Human Papilloma Virus

Spain
Buchinger Wilhelmi Development & Holding GmbH
King's College London; Leiden University Medical Center; ETH Zurich; Claude Bernard... and other collaborators

Completed

Long-term Fasting: Multi-system Adaptations in Humans

Fasting

Germany
Pedro Abizanda
Puerta de Hierro University Hospital; Hospital Universitario Infanta Leonor; Hospital... and other collaborators

Completed

Sarcopenia Measured by Ultrasound in Hospitalized Older Adults (ECOSARC)

Sarcopenia

Spain
Universidade Federal do Ceará
São José Hospital for Infectious Diseases - HSJ; Central Laboratory of Public... and other collaborators

Not yet recruiting

Clinical Trial With N-acetylcysteine and Bromhexine for COVID-19

COVID-19

Brazil
University Hospital, Clermont-Ferrand
UMR 1019, Unité de Nutrition Humaine, INRA, Centre Auvergne-Rhône Alpes; UMR...

Completed

Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers (ProVegOmics) (ProVegOmics)

Metabolic Syndrome | Hypertriglyceridemia | Fasting Blood Sugar Above Normal | Lower Than Standard HDL-cholesterol Level | Slightly Elevated Blood Pressure

France
Jaeb Center for Health Research
Juvenile Diabetes Research Foundation; Roche Pharma AG; National Eye Institute... and other collaborators

Recruiting

Fenofibrate for Prevention of DR Worsening (Protocol AF)

Diabetic Retinopathy

United States
Sociedad Española de Anestesiología, Reanimación...
Hospital Clinic of Barcelona; Hospital Universitario La Fe; Hospital Universitario... and other collaborators

Unknown

Fluid Day Spanish Observational Study (Fluid Day)

Fluid Therapy

Spain
Barcelona Institute for Global Health
Hospital del Mar; Hospital Universitario Infanta Leonor; Eduardo Mondlane University and other collaborators

Active, not recruiting

SARS-CoV-2 and Acetylsalicylic Acid (SARA) (SARA)

Covid19 | SARS-CoV2 Infection

Spain, Mozambique
University of Louisville
University of California, Los Angeles; National Institute for Biomedical Imaging... and other collaborators

Completed

Epi Stim to Facilitate Standing and Stepping

Spinal Cord Injury

United States
Boston University Charles River Campus
Massachusetts General Hospital; National Institute of Diabetes and Digestive... and other collaborators

Completed

Integration of Continuous Glucose Monitoring Into a BiHormonal Closed-Loop Artificial Pancreas (CL2)

Diabetes Mellitus

United States
Centre Hospitalier Universitaire de Nīmes
Saint-Louis Hospital, Paris, France; Institut Paoli-Calmettes; Center Eugene... and other collaborators

Recruiting

Safety & Efficacy of Durvalumab+Neoadjuvant Chemotherapy for High-risk Urothelial Carcinoma of the Upper Urinary Tract (iNDUCT)

Cancer | Urothelial Carcinoma

France
Johns Hopkins University
National Institute of Mental Health (NIMH); National Institute on Aging (NIA); Leonard & Helen R. Stulman Charitable Foundation and other collaborators

Completed

Maximizing Independence at Home (MIND at Home)

Dementia | Memory Disorders

United States
Riitta Veijola
Turku University Hospital; Juvenile Diabetes Research Foundation; University... and other collaborators

Recruiting

Type 1 Diabetes Prediction and Prevention (DIPP) Study (DIPP)

Type 1 Diabetes Mellitus

Finland
Hospices Civils de Lyon
Institut National de la Santé Et de la Recherche Médicale, France; Centre National... and other collaborators

Recruiting

Prismatic Adaptation for Rehabilitation of Postural Imbalance After Stroke (PEQUIE)

Chronic Right Supratensorial Stroke Patients

France
University of Chicago
University of California, Los Angeles; Oak Foundation; UBS Optimus Foundation; Trickle... and other collaborators

Completed

Child Protective Outcomes Among Ultra-poor Families in Burkina Faso

Child Abuse | Child Maltreatment

Burkina Faso
Hospital Universitario Fundación Alcorcón
Hospital General Universitario Gregorio Marañon; Hospital Universitario Ramon... and other collaborators

Not yet recruiting

Predicting ROtator Cuff Tears Outcomes After Physical Therapy Treatment (PROTO)

Rotator Cuff Injuries
Hospital Universitario Fundación Alcorcón
Hospital General Universitario Gregorio Marañon; Hospital Universitario Ramon... and other collaborators

Not yet recruiting

Effectiveness of TheRApeutic ExercIse aNd EDucation on Patients With Massive Rotator Cuff Tears (TRAINED)

Rotator Cuff Injuries
Hospital Universitario Fundación Alcorcón
Hospital General Universitario Gregorio Marañon; Hospital Universitario Ramon... and other collaborators

Not yet recruiting

PRedIcting MEniscal Tears Outcomes After Physical Therapy Treatment (PRIME)

Meniscus Tear
STADA, Spain
Hospital Universitario Virgen Macarena; Alpha Bioresearch S.L.; Hospital Universitario... and other collaborators

Active, not recruiting

Study and Follow-up of the Clinical Effectiveness and Comparative Safety of Biosimilar Teriparatide in the Management of Postmenopausal or Senile. (ESECTO)

Osteoporosis

Spain

Clinical Trials Sponsored by Leonard Appleman

Sponsors and Collaborators

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CROs in Mozambique

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