Clinical Trials Sponsored by National Pediatric Myoclonus Center

Total 115 results

Nationwide Children's Hospital
National Pediatric Cancer Foundation

Recruiting

A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue (TINKS)

Pediatric Sarcoma, Refractory | Pediatric Sarcoma, Relapsed

United States
Salarius Pharmaceuticals, LLC
National Pediatric Cancer Foundation

Active, not recruiting

Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas

Ewing Sarcoma | Myxoid Liposarcoma | Fibromyxoid Tumor | Sarcoma,Soft Tissue | Desmoplastic Small Round Cell Tumor | Angiomatoid Fibrous Histiocytoma | Extraskeletal Myxoid Chondrosarcoma | Clear Cell Sarcoma | Primary Pulmonary Myxoid Sarcoma | Myoepithelial Tumor | Sclerosing Epithelioid Fibrosarcoma

United States
H. Lee Moffitt Cancer Center and Research Institute
National Pediatric Cancer Foundation

Recruiting

Evolutionary Therapy for Rhabdomyosarcoma

Rhabdomyosarcoma

United States
H. Lee Moffitt Cancer Center and Research Institute
National Pediatric Cancer Foundation

Active, not recruiting

Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma

Soft Tissue Sarcoma | Osteosarcoma | Ewing Sarcoma | Rhabdomyosarcoma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors

Recurrent Childhood Medulloblastoma | Childhood Choroid Plexus Tumor | Childhood Ependymoblastoma | Childhood Grade III Meningioma | Childhood High-grade Cerebellar Astrocytoma | Childhood High-grade Cerebral Astrocytoma | Childhood Medulloepithelioma | Recurrent Childhood Anaplastic Astrocytoma | Recurrent... and other conditions

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Withdrawn

Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiation Therapy and Chemotherapy

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Removed By Surgery

Recurrent Childhood Anaplastic Astrocytoma | Recurrent Childhood Anaplastic Oligoastrocytoma | Recurrent Childhood Anaplastic Oligodendroglioma | Recurrent Childhood Giant Cell Glioblastoma | Recurrent Childhood Glioblastoma | Recurrent Childhood Gliomatosis Cerebri | Recurrent Childhood Gliosarcoma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Withdrawn

Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children

Central Nervous System Embryonal Neoplasm

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Withdrawn

Immunotoxin Therapy in Treating Children With Recurrent Malignant Gliomas

Brain and Central Nervous System Tumors
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

SU5416 in Treating Children With Recurrent or Progressive Brain Tumors

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors

Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Atypical Teratoid/Rhabdoid Tumor | Refractory Diffuse Intrinsic Pontine Glioma | CNS Embryonal Tumor, Not Otherwise Specified

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors

Glioblastoma | Gliosarcoma | Medulloblastoma | Anaplastic Astrocytoma | Choroid Plexus Neoplasms | Anaplastic Oligodendroglioma | Giant Cell Glioblastoma | Neuroectodermal Tumor, Primitive | Brainstem Tumors | Teratoid Tumor, Atypical

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Capecitabine and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Nonmetastatic Brain Stem Glioma or High-Grade Glioma

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Lymphoma | Unspecified Childhood Solid Tumor, Protocol Specific | Leukemia | Brain and Central Nervous System Tumors | Carcinoma of Unknown Primary

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer

Sarcoma | Lymphoma | Leukemia | Brain and Central Nervous System Tumors | Metastatic Cancer | Retinoblastoma | Childhood Germ Cell Tumor

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma (PBTC-047)

Glioma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Peginterferon Alfa-2b in Younger Patients With Craniopharyngioma That is Recurrent or Cannot Be Removed By Surgery

Childhood Craniopharyngioma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors

Glioblastoma | Gliosarcoma | Ependymoma | Anaplastic Astrocytoma | Oligodendroglioma | Anaplastic Ependymoma | Giant Cell Glioblastoma | Astrocytoma, Grade II | Brainstem Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors

Brain and Central Nervous System Tumors | Neuroblastoma

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Genetic Study of Brain Tumors in Young Children

Central Nervous System Tumor, Pediatric

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

TP-38 Toxin in Treating Young Patients With Recurrent or Progressive Supratentorial High-Grade Glioma

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Carmustine Implants and O(6)-Benzylguanine in Treating Children With Recurrent Malignant Glioma

Brain and Central Nervous System Tumors

United States
National Cancer Institute (NCI)
Children's Cancer Group; Pediatric Oncology Group

Completed

Health-Related Outcomes in Patients Who Were Previously Treated for Rhabdomyosarcoma

Sarcoma | Long-term Effects Secondary to Cancer Therapy in Children
American Academy of Pediatrics
National Cancer Institute (NCI)

Completed

Adolescent Smoking Cessation in Pediatric Primary Care (Smokebusters)

Tobacco Cessation | Media Use

United States
National Center for Research Resources (NCRR)
Elizabeth Glaser Pediatric AIDS Foundation

Completed

The Metabolic Effects of Protease Inhibitors in HIV Infected Children

HIV Infections

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); PTC Therapeutics

Completed

PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors

Brain and Central Nervous System Tumors

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; Y-mAbs...

Active, not recruiting

131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma

Recurrent Ependymoma | Recurrent Medulloblastoma

United States
Children's Oncology Group
National Cancer Institute (NCI); Pediatric Oncology Group

Completed

Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma

Brain Tumors | Central Nervous System Tumors

United States, Puerto Rico, Switzerland, Australia, Canada
Yale University
National Center for Advancing Translational Sciences (NCATS); Academic Pediatric...

Completed

Implementing and Evaluating a Social-Emotional Learning Program for Refugee Children During the COVID-19 Pandemic

Social Emotional Wellness

United States
Children's Oncology Group
National Cancer Institute (NCI); Pediatric Brain Tumor Consortium

Active, not recruiting

Pilot Study to Enable Electronic Laboratory Data Transfer From Participating Institutions to MediData/RAVE

Accurate and Complete Data Acquisition for Clinical Trials

United States
European Paediatric Soft Tissue Sarcoma Study Group
Children's Cancer and Leukaemia Group; Dutch Childhood Oncology Group; Italian...

Unknown

Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

Sarcoma

Ireland, United Kingdom, Spain, Belgium, Austria, Denmark, Sweden, Switzerland
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Not yet recruiting

Bifocal Spectacles vs. Single Vision Spectacles for Esotropia Greater at Near (ETS3)

Esotropia
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Recruiting

Bevacizumab Treatment For Type 1 ROP (ROP4)

Retinopathy of Prematurity

United States, Canada
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia (IXT1)

Exotropia

United States
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Terminated

A Randomized Trial of Low-Dose Bevacizumab vs Laser for Type 1 ROP (ROP3)

Retinopathy of Prematurity

United States, Canada
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

Base-in Prism Spectacles for Intermittent Exotropia (IXT6)

Exotropia Intermittent

United States
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

Low-Dose Atropine for Treatment of Myopia (MTS1)

Myopia

United States
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity (ROP1)

Retinopathy of Prematurity

United States
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Withdrawn

Excimer Laser Surgery for Anisometropic Amblyopia (ATS19)

Refractive Errors | Anisometropic Amblyopia
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

Convergence Insufficiency Treatment Study (CITS)

Convergence Insufficiency

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; American...

Active, not recruiting

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

Glioblastoma Multiforme | Medulloblastoma | Low-Grade Astrocytoma, Nos | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | Pilocytic Astrocytoma | Pineoblastoma | Supratentorial Primitive Neuroectodermal Tumor | Atypical Teratoid/Rhabdoid Tumor | Choroid Plexus Carcinoma | High-grade Astrocytoma NOS | CNS... and other conditions

United States
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Not yet recruiting

Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age (ATS23)

Amblyopia
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Recruiting

A Randomized Trial to Evaluate Sequential vs Simultaneous Patching (ATS22)

Amblyopia

United States
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

A Prospective Observational Study of Adult Strabismus (SAS1)

Convergence Insufficiency | Divergence Insufficiency | Hypertropia

United States
Jaeb Center for Health Research
National Eye Institute (NEI); Pediatric Eye Disease Investigator Group

Completed

Binocular Dig Rush Game Treatment for Amblyopia (ATS20)

Amblyopia

United States, Canada

Clinical Trials Sponsored by National Pediatric Myoclonus Center

Sponsors and Collaborators

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