Clinical Trials Sponsored by Nuffield Trust

Total 6078 results

Portsmouth Hospitals NHS Trust

Completed

Study to Explore the Relationship Between the Level of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device Against Existing Measures of Lung Disease (EXHALE 1A)

Asthma | COPD Exacerbation

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

A Prospective Study Comparing the Accuracy of Olympus Lucera Spectrum Technology vs Olympus Lucera Elite Technology in the in Vivo Diagnosis of Barrett's Oesophagus and Colorectal Polyps: The ELITE Study (ELITE)

Polyps | Barrett Esophagus

United Kingdom
Bedford Hospital NHS Trust

Unknown

Finger-prick Autologous Blood (FAB) for Use in Dry Mouth

Xerostomia | Xerostomia Due to Radiotherapy | Xerostomia Due to Hyposecretion of Salivary Gland
Medway NHS Foundation Trust

Completed

A Long Term Follow up of Anterior Meshes for Recurrent Prolapse

Pelvic Organ Prolapse | Genital Diseases, Female

United Kingdom
St Stephens Aids Trust

Unknown

Targeted Clinical Strategies and Low Level Viraemia (LLV) in Boosted Protease Inhibitor Therapy

HIV

United Kingdom
St Stephens Aids Trust

Completed

A Pilot Study to Assess the Feasibility of Switching, Individuals Receiving Atripla With Continuing Central Nervous System (CNS) Toxicity, to a Fixed Dose Combination of Tenofovir/Emtricitabine/Rilpivirine

HIV

United Kingdom
St Stephens Aids Trust

Completed

The Pharmacology/Aging Clinic (SSAT041)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

A Phase IV, Open-label Single-arm Study Investigating the Pharmacokinetics and Pharmacodynamics of the Antiretroviral Combination of Rilpivirine and Ritonavirboosted Darunavir in Therapy-naive HIV-1 Infected Patients.

HIV

United Kingdom
Summit Therapeutics
Wellcome Trust

Completed

A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)

Clostridium Difficile Infection

United States, Canada
Vestre Viken Hospital Trust

Unknown

Maternal Metabolism and Pregnancy Outcomes in Obese Pregnant Women

Obesity | Pregnancy

Norway
Kingston Hospital NHS Trust

Unknown

The Effects of Serratus Plane Block Performed Under Direct Vision on Post-operative Pain in Breast Surgery

Breast Surgery | Post-operative Pain | Serratus Block
St Stephens Aids Trust

Completed

Atripla to Raltegravir Switch Study for CNS Toxicity (SSAT036)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

Men Who Have Sex With Men (MSM) Neurocog 1&2 Study (MSM Neurocog)

HIV Related Neurocognitive Impairment

United Kingdom
St Stephens Aids Trust

Unknown

Hydroxychloroquine for Discordant CD4 Responders on Highly Active Antiretroviral Therapy (HAART) (SSAT039)

HIV Infection

United Kingdom
St Stephens Aids Trust

Completed

Pharmacokinetics of Tenofovir and Tenofovir-diphosphate, Emtricitabine and Emtricitabine-triphosphate, and Rilpivirine Once Daily Over 14 Days Following Drug Intake Cessation in Healthy Volunteers

HIV

United Kingdom
St Stephens Aids Trust

Completed

PK Switch Efavirenz to Maraviroc in Patients Initially Suppressed on an Efavirenz-containing Regimen (SSAT033)

HIV Infection

United Kingdom
St Stephens Aids Trust

Terminated

Impact of Maraviroc on the Immune Function in HIV-1 Infected Subjects Receiving Immunisation With Novel Antigens

HIV Infections

United Kingdom
St Stephens Aids Trust

Completed

Raltegravir and Ezetimibe PK Study

HIV

United Kingdom
St Stephens Aids Trust

Completed

Abacavir Pharmacokinetic Study in the Absence/Presence of Darunavir/Ritonavir or Raltegravir in HIV-infected Subjects

HIV

United Kingdom
Medway NHS Foundation Trust

Completed

Tension Free Vaginal Tape (TVT) Versus the Miniarc Sling

Urodynamic Stress Incontinence

United Kingdom
Medway NHS Foundation Trust

Unknown

Cystoscopy Plus Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding

Overactive Bladder Syndrome | Voiding Dysfunction

United Kingdom
African Malaria Network Trust

Unknown

Safety and Immunogenicity of 30 and 100 µg of GMZ2 in Gabonese Children Aged 1-5 Years

Malaria

Gabon
African Malaria Network Trust

Unknown

Safety and Immunogenicity of Apical Membrane Antigen 1 (PfAMA-1-FVO[25-545])

Malaria

Mali
Vestre Viken Hospital Trust

Recruiting

Long vs Extended-short Nail When Treating Proximal Femur Fractures

Hip Fractures

Norway
Royal Cornwall Hospitals Trust

Recruiting

Virtual Reality Exercise Gaming in Patients Awaiting Bariatric Surgery

Bariatric Surgery | Prehabilitation

United Kingdom
Royal Cornwall Hospitals Trust

Enrolling by invitation

Simulation-based Stress Inoculation Training Study for UK Medical Professionals (SITS)

Stress | Stress, Psychological | Stress, Job

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Investigating Signal Change in Malignant and Non-malignant Pleural Effusions and asCitic Fluid Using fTiR Analysis (SPECTRA)

Ascites | Pleural Effusion

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Colonoscopy Outcome Database (COD)

Colonoscopy Procedures

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

The Effects of Changing Light Levels on Contrast Sensitivity in Patients With Glaucoma (ENLIGHTEN)

Glaucoma

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Investigation of Inflammacheck to Measure Exhaled Breath Condensate Hydrogen Peroxide in Respiratory Conditions (VICTORY)

Respiratory Disease

United Kingdom
Rett Syndrome Research Trust

Completed

ASSESSING EMERALD AND MC10 BIOSTAMP nPOINT BIOSENSORS FOR RETT SYNDROME

Rett Syndrome

United States
Vestre Viken Hospital Trust

Active, not recruiting

Functional Results With Attune Fixed Bearing Posterior Stabilized Knee Arthroplasty (A-16)

Knee Arthroplasty

Norway
Nottinghamshire Healthcare NHS Trust

Completed

QbTest Utility for Optimising Treatment in ADHD (QUOTA) (QUOTA)

ADHD

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

EXhaled Hydrogen Peroxide As a Marker of Lung Disease Study - Conformité Européenne (European Conformity) (EXHALE CE)

Point of Care Monitoring

United Kingdom
Kineta Inc.
Wellcome Trust

Completed

Multiple Ascending Oral Dose 14-Day Trial of LHF-535 in Healthy Participants

Healthy

Australia
Portsmouth Hospitals NHS Trust

Completed

The IUSS Crohn's Study: A Feasibility Study

Inflammatory Bowel Diseases | Crohn Disease

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

The Staff Stop Smoking Project (STOP)

Smoking Cessation

United Kingdom
GE Healthcare
Wellcome Trust

Terminated

Development of a MR Scanner Capable of Being Sited in a Neonatal Intensive Care Unit (Firefly)

Image Evaluation

United States
North Bristol NHS Trust

Completed

GDNF in ideopathicParkinsons Disease

Idiopathic Parkinson Disease
North Bristol NHS Trust

Terminated

Accelerated vs Non-Accelerated Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Pilot Study (AVON ACL)

Anterior Cruciate Ligament Reconstruction

United Kingdom
Bedford Hospital NHS Trust

Unknown

Aqueous Release to Treat IOP Spikes Post-cataract Surgery

Post-Op Complication | Raised Ocular Pressure
Portsmouth Hospitals NHS Trust

Completed

Purastat® vs Standard Therapy for Haemostasis During Endoscopic Submucosal Dissection

Gastrointestinal Haemorrhage

United Kingdom
Vestre Viken Hospital Trust

Completed

Quadratus Lumborum Block for Abdominoplasty

Pain, Postoperative | Abdominoplasty

Norway
St Stephens Aids Trust

Unknown

SSAT 054: Non Genetic Factors in the Pathogenesis of IBD in Twins

Crohn's Disease | Ulcerative Colitis | Inflammatory Bowel Disease

United Kingdom
Medway NHS Foundation Trust

Withdrawn

A Follow-net Investigation of a Randomised Study of Cystoscopy and Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding

Overactive Bladder | Urinary Incontinence | Voiding Dysfunction
Bedford Hospital NHS Trust

Unknown

Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. (OCT)

Epiphora | Dry Eye Syndrome | Sjögren's Syndrome
Portsmouth Hospitals NHS Trust

Completed

Endo-cuff Assisted Vs. Standard Colonoscopy for Polyp Detection in Bowel Cancer Screening (E-CAP)

Colonic Polyps | Colonic Neoplasms

United Kingdom
Royal Cornwall Hospitals Trust

Unknown

Exercise as an Intervention in Endometrial Cancer Survivors

Quality of Life | Endometrial Cancer

United Kingdom
Walsall Healthcare NHS Trust

Unknown

RCT Novasure Versus Novasure + Mirena IUS in the Treatment of Menorrhagia

Menorrhagia

United Kingdom
Buckinghamshire Healthcare NHS Trust

Unknown

Exoskeletons for Spinal Cord Injury: A Feasibility Study

Spinal Cord Injury

United Kingdom

3

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