Clinical Trials Sponsored by Rion LLC

Total 11761 results

Christopher J. McLeod
Rion LLC

Enrolling by invitation

Safety Evaluation of Intracoronary Infusion of Extracellular Vesicles in Patients Following Coronary Stent Implantation

Percutaneous Coronary Intervention

United States
Merck Sharp & Dohme LLC
Orion Corporation, Orion Pharma

Recruiting

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

Prostate Cancer Metastatic

Canada, Germany, United States, Israel, Puerto Rico, Taiwan, Korea, Republic of, Australia, Chile, China, France, Norway, Czechia, Finland, Hong Kong, Netherlands, Poland, Spain, Sweden, Turkey
Merck Sharp & Dohme LLC
Orion Corporation, Orion Pharma

Recruiting

A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001)

Prostatic Neoplasms | Metastatic Castration-Resistant Prostate Cancer

China
Merck Sharp & Dohme LLC
Orion Corporation, Orion Pharma

Not yet recruiting

Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

Prostatic Neoplasms, Castration-Resistant
Merck Sharp & Dohme LLC
Orion Corporation, Orion Pharma

Recruiting

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

Prostatic Neoplasms | Metastatic Castration-resistant Prostate Cancer (mCRPC)

Germany, United States, Puerto Rico, Israel, Australia, Korea, Republic of, Taiwan, China, Costa Rica, Guatemala, Spain, France, Hong Kong, Portugal, Romania
Merck Sharp & Dohme LLC
Orion Corporation, Orion Pharma

Recruiting

A Study of Opevesostat (MK-568)4 in Japanese Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-005)

Prostatic Neoplasms | Metastatic Castration-Resistant Prostate Cancer

Japan
Jason Ahee, M.D.

Not yet recruiting

Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery

Endophthalmitis

United States
Rion Inc.
ProPharma

Active, not recruiting

PEP on a Skin Graft Donor Site Wound

Skin Graft

United States
Orion Corporation, Orion Pharma

Completed

Safety and Pharmacokinetics of ODM-209 (STESIDES)

Advanced Breast Cancer | Metastatic Breast Cancer | Castration-resistant Prostate Cancer | Prostate Cancer Metastatic

Finland, France, Denmark
Orion Corporation, Orion Pharma

Completed

Use of Buventol Easyhaler and Bufomix Easyhaler in Methacoline Challenge Testing (EASYRELIEF)

Asthma

Finland
Orion Corporation, Orion Pharma

Completed

Comparison of Tiotropium Absorption From Tiotropium Easyhaler and Spiriva HandiHaler (TEMPO)

Healthy Volunteers

Finland
Orion Corporation, Orion Pharma

Completed

Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS (REFALS)

Amyotrophic Lateral Sclerosis

Canada, United States, Australia, Austria, United Kingdom, Germany, Finland, Spain, France, Italy, Sweden, Netherlands, Belgium, Ireland
Orion Corporation, Orion Pharma

Completed

Absorption of Indacaterol and Glycopyrronium From Ultibro Breezhaler (FINDA)

Healthy Volunteers

Finland
Orion Corporation, Orion Pharma

Terminated

Switch of Budesonide-formoterol Dry Powder Inhalers at Pharmacy in Norway (BufoSwitch)

Asthma | COPD

Norway
Orion Corporation, Orion Pharma

Completed

Blood-Brain Barrier Penetration of Therapeutic Agents in Human (BRIAN)

CNS Disease

Finland
Orion Corporation, Orion Pharma

Completed

Inspiratory Flow Parameters With Placebo Easyhaler and Placebo HandiHaler (TIOPIF)

Healthy Volunteer | COPD

Estonia
Orion Corporation, Orion Pharma

Completed

Comparing Salmeterol/Fluticasone Easyhaler and Seretide Diskus (SAIMI)

Asthma

Finland
Orion Corporation, Orion Pharma

Completed

Safety and Tolerability of ODM-201 in Castrate Resistant Prostate Cancer; Extension Study to Study 3104001

Prostate Cancer

United States, United Kingdom, Finland, France, Estonia, Czech Republic
Orion Corporation, Orion Pharma

Completed

To Confirm Equivalent Bronchodilator Efficacy of the Test Product Compared to the Reference Product (BUFODIL)

Asthma

Bulgaria
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study of Single Doses of ORM-12741 (Nebula PK 1)

Healthy

Finland
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study in Healthy Males (NOCOF)

Parkinson's Disease

Finland
Orion Corporation, Orion Pharma

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ODM-103 in Healthy Volunteers (NOCOS)

Healthy

Germany
Orion Corporation, Orion Pharma

Completed

Comparison of Salmeterol and Fluticasone Propionate Absorption From Salmeterol/Fluticasone Easyhaler With Seretide Diskus

Asthma

Finland
Orion Corporation, Orion Pharma

Completed

Efficacy and Safety Proof of Concept Study in Patients With Parkinson's Disease and End-of-dose Motor Fluctuations (PARPOC)

Parkinson's Disease
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Pilot Study on Budesonide/Formoterol

Healthy

Germany
Orion Corporation, Orion Pharma

Completed

Safety and Pharmacokinetic Study With Multiple Ascending Doses of ORM-12741

Healthy

France
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study of Spironolactone 25 mg, 50 mg and 100 mg Tablets

Healthy

India
Orion Corporation, Orion Pharma

Completed

Bioequivalence Study Comparing Two Alprazolam 1 mg Tablets Under Fed Conditions

Healthy

Finland
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Pilot Study on Budesonide/Formoterol Device-metered Dry Powder Inhaler

Healthy

Finland
Orion Corporation, Orion Pharma

Completed

Comparison of PEG Solutions With and Without Electrolytes in the Treatment of Constipation (PEGorion)

Constipation

Finland
Orion Corporation, Orion Pharma

Terminated

PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding

Parkinson´s Disease

Finland
Orion Corporation, Orion Pharma

Recruiting

Effect of Electronic Monitoring and Feedback on Adherence to Easyhaler Controller Medication in Patients With Asthma (eMOFEE)

Asthma

Germany
Orion Corporation, Orion Pharma

Completed

Digital Therapeutics (DTx) for Pain: Pilot Study of a Virtual Reality Software for Chronic Pain (VIRPI)

Chronic Low Back Pain

Finland
Orion Corporation, Orion Pharma

Completed

Efficacy and Safety of Remo-Wax® Oil (RWO) in Subjects With Isolated Itching of the External Ear Canal (Remo_Itch)

Itching

Lithuania
Orion Corporation, Orion Pharma

Completed

Dose-finding Pharmacokinetic Study in Healthy Males (COMDOS1)

Healthy Volunteers

Germany
Orion Corporation, Orion Pharma

Completed

Safety and Efficacy of ORM-12741 in Patients With Alzheimer's Disease (ALPO)

Alzheimer's Disease

Finland
Orion Corporation, Orion Pharma

Completed

Salmeterol/Fluticasone Easyhaler in the Treatment of Asthma and COPD (SUNNY)

Chronic Obstructive Pulmonary Disease | Asthma

Germany
Orion Corporation, Orion Pharma

Completed

Safety and Pharmacokinetics of ODM-204 in Patients With Metastatic Castration-Resistant Prostate Cancer (DUALIDES)

Prostate Cancer

Finland, France, United Kingdom, Latvia
Orion Corporation, Orion Pharma

Completed

ODM-207 in Patients With Advance Solid Tumours (BETIDES)

Solid Tumors

Finland
Orion Corporation, Orion Pharma

Completed

Effect of Charcoal on Gastrointestinal Absorption of Tiotropium (TIOBLOCK)

Healthy Volunteer Study

Finland
Orion Corporation, Orion Pharma

Terminated

Non-interventional Comparison of Sedatives on Weaning From Mechanical Ventilation in Intensive Care Patients (NICEWEAN)

Critical Illness

Sweden
Orion Corporation, Orion Pharma

Completed

Safety, Tolerability and Efficacy of DEXDOR in Pediatric Patients in ICU (Pedrux)

ICU Sedation

Russian Federation
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study Comparing Tiotropium Easyhaler and Spiriva Handihaler

Healthy Subjects

Finland
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study Comparing Salmeterol/Fluticasone Easyhaler and Seretide Diskus

Asthma

Finland
Orion Corporation, Orion Pharma

Completed

Safety, Tolerability,Pharmacokinetics and Pharmacodynamics of ODM-106 in Healthy Volunteers (FIMPAM)

Healthy Volunteer Study

Germany
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study in Healthy Volunteers (NOCOFPK2)

Parkinson's Disease

Finland
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study Comparing Salmeterol/Fluticasone Easyhaler Products and Seretide Diskus

Asthma

Finland
Orion Corporation, Orion Pharma

Completed

Pharmacokinetic Study of Multiple Doses of ORM-12741 (Nebula PK 2)

Healthy

Finland
Orion Corporation, Orion Pharma

Completed

Prospective Multicentre Non-interventional Study of VANTAS® for the Treatment of Patients With Advanced Prostate Cancer (Vantas)

Prostate Cancer

Sweden
Orion Corporation, Orion Pharma

Terminated

Efficacy of ORM-12741 for Prevention of Raynaud's Phenomenon (REINO)

Raynaud's Phenomenon

United Kingdom

Clinical Trials Sponsored by Rion LLC

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