Clinical Trials Sponsored by Shire Development LLC

Total 1362 results

Janssen Research & Development, LLC

Active, not recruiting

A Study of JNJ-67856633 in Participants With Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

Lymphoma, Non-Hodgkin | Leukemia, Lymphocytic, Chronic, B-Cell

United States, Korea, Republic of, Israel, Japan, Germany, Spain, Australia, China, France, United Kingdom, Greece, Italy
Janssen Research & Development, LLC

Active, not recruiting

A Study of JNJ-75229414 for Metastatic Castration-resistant Prostate Cancer Participants

Prostatic Neoplasms

United States
Janssen Research & Development, LLC

Active, not recruiting

A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis (PURSUIT 2)

Colitis, Ulcerative

United States, Korea, Republic of, Taiwan, Israel, Spain, France, Brazil, Belgium, Poland, Italy, Netherlands
Janssen Research & Development, LLC

Completed

A Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn

Erythroblastosis, Fetal | Early Onset Severe Hemolytic Disease of the Fetus and Newborn (EOS-HDFN)

United States, Canada, Netherlands, Belgium, Australia, Germany, Spain, Sweden, United Kingdom
Janssen Research & Development, LLC

Active, not recruiting

A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy (PROTEUS)

Prostatic Neoplasms

United States, Italy, Czechia, Israel, Japan, Taiwan, Korea, Republic of, United Kingdom, France, Spain, Germany, Australia, Canada, Brazil, Netherlands, Russian Federation, Argentina, Poland
Janssen Research & Development, LLC

Active, not recruiting

A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease (Autonomy)

Cognitive Dysfunction | Dementia | Alzheimer Disease

United States, Belgium, France, Japan, United Kingdom, Spain, Canada, Australia, Sweden, Netherlands
Janssen Research & Development, LLC

Completed

A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma

Multiple Myeloma

United States, France, Spain
Janssen Research & Development, LLC

Completed

Addition of Daratumumab to Combination of Bortezomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma

United States, Australia, Poland, Ukraine, Germany, Spain, Turkey, Korea, Republic of, Brazil, Russian Federation, Netherlands, Hungary, Sweden, Czechia, Mexico
Janssen Research & Development, LLC

Completed

A Study of Subcutaneous Versus (vs.) Intravenous Administration of Daratumumab in Participants With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma

Canada, United States, Czechia, Israel, Italy, Korea, Republic of, Brazil, United Kingdom, Japan, Taiwan, Australia, Poland, Spain, France, Russian Federation, Sweden, Ukraine, Greece
Janssen Research & Development, LLC

Completed

A Study to Investigate JNJ-40411813 in Combination With Levetiracetam or Brivaracetam in Epilepsy

Focal Onset Seizures

Germany, Korea, Republic of, Belgium, United States, Russian Federation, Poland, Ukraine, Spain
Janssen Research & Development, LLC

Completed

A Study to Assess Intrahepatic and Peripheral Changes of Immunologic and Virologic Markers in Chronic Hepatitis B Virus Infection (INSIGHT)

Hepatitis B

France, United States, Belgium, United Kingdom, Poland, New Zealand, Germany, Italy, Canada
Janssen Research & Development, LLC

Suspended

A Study of JNJ-64281802 Against Dengue Serotype 1 Infection in a Dengue Human Challenge Model in Healthy Adult Participants

Healthy

United States, United Kingdom
Janssen Research & Development, LLC

Terminated

A Study of Ustekinumab in Participants With Active Systemic Lupus Erythematosus

Lupus Erythematosus, Systemic

United States, Japan, Korea, Republic of, Canada, Taiwan, Thailand, Germany, China, Serbia, Spain, Portugal, Russian Federation, Poland, Ukraine, Lithuania, South Africa, Hungary, Argentina, Bulgaria, Colombia
Janssen Research & Development, LLC

Completed

A Study of Efficacy and Safety of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis (VEGA)

Colitis, Ulcerative

United States, Russian Federation, Australia, Poland, Germany, Brazil, Ukraine, Argentina, Mexico
Janssen Research & Development, LLC

Completed

A Study of JNJ-63733657 in Healthy Chinese Participants

Healthy

China
SCRI Development Innovations, LLC

Withdrawn

iCORE: Collaborative Orthopedics Outcomes Registry (iCORE)

Arthroplasty, Replacement, Knee | Arthroplasty, Replacement, Hip

United States
SCRI Development Innovations, LLC

Withdrawn

Sarah Cannon Outcomes Registry

Oncology

United States
Janssen Research & Development, LLC

Completed

A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

Depressive Disorder, Major

United States, Belgium, Czechia, Ukraine, Poland, Malaysia, Serbia, Bulgaria, Argentina, Lithuania, Slovakia, Russian Federation, Canada, United Kingdom, Latvia
Janssen Research & Development, LLC

Completed

A Study of JNJ-73763989 in Adult Participants With Renal Impairment

Renal Impairment

Germany
Janssen Research & Development, LLC

Completed

A Study to Investigate the Efficacy and Safety of Canagliflozin in Children and Adolescents (>=10 to <18 Years) With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

United States, India, China, Brazil, Greece, Malaysia, Mexico, Philippines, Poland, Russian Federation
Janssen Research & Development, LLC

Completed

A Study to Investigate the Efficacy, Safety, and Tolerability of JNJ-42165279 in Adolescent and Adult Participants With Autism Spectrum Disorder (Envision)

Autism Spectrum Disorder

United States
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on Lazertinib (JNJ-73841937)

Healthy | Hepatic Impairment

Germany
Janssen Research & Development, LLC

Completed

A Thorough QT Study of Aticaprant (JNJ-67953964) in Healthy Adult Participants

Healthy

Belgium
Janssen Research & Development, LLC

Terminated

Study to Evaluate Safety and Antiviral Activity of Doses of JNJ-53718678 in Children (>=28 Days to <=3 Years) With Respiratory Syncytial Virus Infection

Respiratory Syncytial Virus Infections

United States, Taiwan, Belgium, Hungary, Thailand, United Kingdom, Germany, Korea, Republic of, Bulgaria, Turkey, France, Italy, Poland, Spain, Brazil, Russian Federation, Japan, Argentina, Malaysia, Mexico, Sweden, South Africa
Janssen Research & Development, LLC

Active, not recruiting

An Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resistant Prostate Cancer and DNA-Repair Anomalies (Galahad)

Prostatic Neoplasms

United States, Australia, France, United Kingdom, Belgium, Taiwan, Spain, Israel, Netherlands, Sweden, Korea, Republic of, Canada, Russian Federation, Brazil, Denmark
Janssen Research & Development, LLC

Completed

A Study of Cetrelimab in Participants With Chronic Hepatitis B Virus Infection

Hepatitis B, Chronic

France, Germany, Spain, Poland, Belgium
Janssen Research & Development, LLC

Completed

A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem

Healthy Non-dependent, Recreational Sedative Users | Abuse Potential

United States
Janssen Research & Development, LLC

Terminated

A Study of Rivaroxaban to Reduce the Risk of Major Venous and Arterial Thrombotic Events, Hospitalization and Death in Medically Ill Outpatients With Acute, Symptomatic Coronavirus Disease 2019 (COVID-19) Infection (PREVENT-HD)

Coronavirus Disease 2019 (COVID-19)

United States
Janssen Research & Development, LLC

Completed

A Study of JNJ-77474462 in Healthy Participants

Healthy

Australia
Janssen Research & Development, LLC

Completed

A Study of Paliperidone Palmitate 6-Month Formulation

Schizophrenia

Hong Kong, Poland, Argentina, Russian Federation, Ukraine, Italy
Janssen Research & Development, LLC

Completed

A Study of JNJ-73763989, JNJ-56136379, Nucleos(t)Ide Analogs, and Pegylated Interferon Alpha-2a in Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection (PENGUIN)

Hepatitis B, Chronic

Taiwan, Poland, Japan, New Zealand
Janssen Research & Development, LLC

Terminated

A Study of EPI-7386 in Combination With Abiraterone Acetate Plus Prednisone, or Apalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC)

Prostatic Neoplasms

United States, Canada
Janssen Research & Development, LLC

Completed

A Pharmacokinetic Study of Ustekinumab in Pediatric Subjects With Moderately to Severely Active Crohn's Disease (STELARA)

Crohn Disease

United States, Belgium, Canada, France, Poland, Germany
Janssen Research & Development, LLC

Completed

A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy

Epilepsy

United States, France, Poland, Taiwan, Argentina, South Africa, Belgium, Germany, Russian Federation, Austria, Hungary, Canada, Philippines, Australia
Janssen Research & Development, LLC

Completed

A Phase 1b Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of JNJ-64565111 in Participants With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

United States
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on JNJ-42847922 in Adult Participants

Healthy | Hepatic Impairment

Germany
Janssen Research & Development, LLC

Completed

A Study to Identify Participants With Urothelial Cancer and Fibroblast Growth Factor Receptor Gene Aberrations

Urothelial Cancer | Receptors, Fibroblast Growth Factor

United States, Italy, Belgium, United Kingdom, Japan, Turkey, Brazil, Ukraine, Spain, Russian Federation, Israel, France, Germany, Argentina
Janssen Research & Development, LLC

Completed

Safety and Efficacy Study of JNJ-64304500 in Participants With Moderately to Severely Active Crohn's Disease (TRIDENT)

Crohn Disease

United States, France, Poland, Ukraine, Germany, Belgium, Bulgaria, Romania, Japan, Canada, Korea, Republic of, Russian Federation, Hungary, United Kingdom
Janssen Research & Development, LLC

Completed

A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes (T1GER)

Diabetes Mellitus, Type 1

United States
Janssen Research & Development, LLC

Terminated

A Study Evaluating Participants With Moderately to Severely Active Crohn's Disease (PRISM)

Crohn Disease

United States, Italy, Ukraine, Poland, Germany, Russian Federation, Argentina
Janssen Research & Development, LLC

Completed

A Study of JNJ-64251330 in Healthy Participants

Healthy

Belgium
Janssen Research & Development, LLC

Completed

A Study Validating the Use of Candin as a Challenge Agent in Healthy Participants - Intervention Specific Appendix 4

Healthy

Belgium
Janssen Research & Development, LLC

Completed

A Study of TAR-200 in Participants With Muscle-Invasive Urothelial Carcinoma of the Bladder Who Are Ineligible for or Refuse Cisplatin-based Chemotherapy and Who Are Unfit for Radical Cystectomy

Urinary Bladder Neoplasms

United States, Spain
Janssen Research & Development, LLC

Completed

A Study of JNJ-80202135 in Healthy Chinese Adult Participants

Healthy

China
Janssen Research & Development, LLC

Completed

A Study Validating the Use of Candin as a Challenge Agent in Healthy Participants - Intervention Specific Appendix 3

Healthy

Belgium
Janssen Research & Development, LLC

Completed

A Study of Safety, Pharmacokinetics and Pharmacodynamics of JNJ-64457107 in Participants With Advanced Stage Tumors

Advanced Solid Neoplasms

Spain, Israel
Janssen Research & Development, LLC

Withdrawn

A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression

Depression

United States
Janssen Research & Development, LLC

Completed

Evaluation of Tau Protein in the Brain of Participants With Alzheimer's Disease Compared to Healthy Participants

Alzheimer Disease

United States
Janssen Research & Development, LLC

No longer available

Pre-approval Access Single Patient Request for Teclistamab (JNJ-64007957)

Multiple Myeloma
Janssen Research & Development, LLC

Terminated

A Study of Guselkumab and Risankizumab in Healthy Participants and Participants With Psoriatic Arthritis

Healthy | Arthritis, Psoriatic

Austria

Clinical Trials Sponsored by Shire Development LLC

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