Clinical Trials Sponsored by Triple-Gene, LLC

Total 141 results

Triple-Gene, LLC
Intrexon Corporation; Precigen, Inc

Completed

Novel INXN-4001 Triple Effector Plasmid in Heart Failure

Cardiovascular Diseases | Heart Failure | Heart-Assist Device

United States
Gene Surgery LLC

Recruiting

Safety, Tolerability and Pharmacokinetics Investigation of Stimotimagene Copolymerplasmid

Melanoma | Sarcoma | Uterine Cervical Neoplasms | Breast Neoplasms | Squamous Cell Carcinoma of Head and Neck | Vulvar Neoplasms | Anus Neoplasms | Penile Neoplasms

Russian Federation
Geno LLC

Completed

Study in Subjects With PAH and PH Secondary to IPF Using Inhaled GeNOsyl. (PHiano)

Idiopathic Pulmonary Fibrosis | Pulmonary Arterial Hypertension

United States
Geno LLC

Withdrawn

Study to Assess Acute Vasodilation Response of Inhaled Nitric Oxide (EAGLE)

Pulmonary Arterial Hypertension

United States
Geno LLC

Completed

Pilot Study Evaluating the Safety and Performance of the GeNO NITROsyl Delivery System for Inhaled Nitric Oxide (PILOT)

Pulmonary Arterial Hypertension

United States
R-Pharm International, LLC
Quintiles, Inc.; OCT Clinical Trials; Mene Research

Completed

Evaluation of the Efficacy and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Were Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Had Active Disease (CREDO 3)

Rheumatoid Arthritis

United States, Korea, Republic of, Germany, Czechia, Mexico, Hungary, Poland, Argentina, Brazil, Colombia, Russian Federation
R-Pharm International, LLC
Quintiles, Inc.; OCT Clinical Trials; Mene Research

Completed

Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease (CREDO 1)

Rheumatoid Arthritis

Belarus, Bulgaria, Russian Federation
AgNovos Healthcare, LLC
KCR S.A.; genae Group

Completed

CONFIRM - Study of AGN1 LOEP in Patients With Osteoporosis

Osteoporosis

Belgium, Netherlands
Alliance Foundation Trials, LLC.
Pharmacyclics LLC.

Active, not recruiting

Study of Ibrutinib in Combination With Revlimid/Dexamethasone in Relapsed/Refractory Multiple Myeloma

Multiple Myeloma | Refractory Multiple Myeloma | Multiple Myeloma in Relapse

United States
Alliance Foundation Trials, LLC.

Completed

Atezolizumab Immunotherapy in Patients With Advanced NSCLC

Carcinoma, Non-Small-Cell Lung

United States
Alliance Foundation Trials, LLC.
Merck Sharp & Dohme LLC

Terminated

Pembrolizumab vs Topotecan in Patients With Small Cell Lung Cancer

Small Cell Lung Cancer

United States
Alliance Foundation Trials, LLC.
Merck Sharp & Dohme LLC

Completed

Optimal Sequencing of Pembrolizumab (MK-3475) and Standard Platinum-based Chemotherapy in First-Line NSCLC

Non-Small Cell Lung Cancer

United States
Alliance Foundation Trials, LLC.
Bayer

Recruiting

Androgen Receptor Directed Therapy on Cognitive Function in Patients Treated With Darolutamide or Enzalutamide (ARACOG)

Prostate Cancer | Metastatic Prostate Cancer | Prostate Cancer Metastatic | Castrate Resistant Prostate Cancer

United States
Alliance Foundation Trials, LLC.
AstraZeneca

Active, not recruiting

CHIO3 Trial: CHemotherapy Combined With Immune Checkpoint Inhibitor for Operable Stage IIIA/B Non-Small Cell Lung Cancer

Stage IIIA Non-small Cell Lung Cancer | Stage IIIB Non-small Cell Lung Cancer

United States
Temple University
Janssen Services, LLC

Completed

Undiagnosed Hepatitis C Infection in an Urban Hospital

Hepatitis C

United States
Alliance Foundation Trials, LLC.
Janssen Research & Development, LLC

Active, not recruiting

A Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer

Prostate Cancer

United States
Alliance Foundation Trials, LLC.
Pfizer

Active, not recruiting

Phase II Palbociclib +Ibrutinib in Mantle Cell Lymphoma

B Cell Lymphoma | Mantle Cell Lymphoma

United States
Betaliq, Inc.
Trial Runners, LLC; Summit Analytical, LLC

Completed

Nebivolol 0.5, 1.0, or Timolol 0.5 Suspension Compared to Timolol 0.5 Solution to Treat Glaucoma/Ocular Hypertension

Ocular Hypertension | Open-Angle Glaucoma

United States
Allegro Ophthalmics, LLC
Duke University; Trial Runners, LLC

Completed

A Clinical Trial Designed to Evaluate the Safety and Efficacy Study of Luminate® in Inducing PVD (Posterior Vitreous Detachment) in Non-Proliferative Diabetic Retinopathy

Non-Proliferative Diabetic Retinopathy

United States
Allegro Ophthalmics, LLC
Duke University; Trial Runners, LLC

Completed

Phase 2 Randomized Clinical Trial of Luminate® as Compared to Avastin® in the Treatment of Diabetic Macular Edema

Diabetic Macular Edema

United States
Temple University
Merck Sharp & Dohme LLC

Completed

Comparison of Time to Extubation Using Sugammadex or Neostigmine

Chronic Obstructive Pulmonary Disease | Neuromuscular Blockade

United States
Temple University
Merck Sharp & Dohme LLC

Completed

Telephone Based Management of Hyperlipidemia

Hyperlipidemia

United States
Pharmavite LLC
Atlantia Food Clinical Trials

Recruiting

Effect of a Nutritional Supplement on Mental Wellness in Adults

Low Mood

United States
Cerebral Therapeutics LLC
Neuroscience Trials Australia

Completed

A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures

Epilepsy

Australia
Alliance Foundation Trials, LLC.
Genentech, Inc.

Recruiting

Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC

NSCLC

United States
Corium, Inc.
Worldwide Clinical Trials; Premier Research Group plc; Almac; Prometrika, LLC

Recruiting

A Safety/Tolerability and PK Study With Azstarys® in Children With ADHD (KP415P02)

Attention Deficit/Hyperactivity Disorder

United States
Olix Pharmaceuticals, Inc.
Trial Runners, LLC

Recruiting

Evaluation of OLX10212 in Patients With Neovascular Age-related Macular Degeneration

Neovascular Age-related Macular Degeneration

United States
Alliance Foundation Trials, LLC.
Takeda; Janssen Scientific Affairs, LLC; Celgene Corporation

Active, not recruiting

Study of Lenalidomide/Ixazomib/Dexamethasone/Daratumumab in Transplant-Ineligible Patients With Newly Diagnosed MM

Myeloma, Multiple

United States
Alliance Foundation Trials, LLC.
Bristol-Myers Squibb

Terminated

Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease

Multiple Sclerosis | Autoimmune Diseases | Rheumatoid Arthritis | Systemic Lupus Erythematosus | Psoriasis | Crohn Disease | Ulcerative Colitis | Non-small Cell Lung Cancer | Giant Cell Arteritis | Polymyalgia Rheumatica

United States
Alliance Foundation Trials, LLC.
Celgene; Janssen, LP

Withdrawn

Study of Combination POM, BTZ, Low-Dose DEX, and DARA (PVD-DARA) in Patients With RRMM

Relapsed or Refractory Multiple Myeloma
Xemed LLC
University of Pennsylvania; Temple University

Not yet recruiting

Hyperpolarized Xenon Functional Lung Imaging in COPD Patients Undergoing Targeted Lung Denervation

COPD
Biomat USA, Inc.
Axio Research. LLC; Hammond Clinical Trial Consulting, LLC

Completed

Safety and Efficacy of Two Tetanus-Diphtheria Vaccines for a Donor Hyper Immunization Program

Healthy

United States
Canadian Cancer Trials Group
Merck Sharp & Dohme LLC

Terminated

Response to Pembrolizumab in Metastatic Melanoma: Computed Tomography Texture Analysis as a Predictive Biomarker

Metastatic Melanoma

Canada
PhenoSolve, LLC
Jacobi Medical Center; Boston Clinical Trials

Completed

Prevalence of Lidocaine Ineffectiveness in Adults With and Without ADHD

ADHD | PMS

United States
Merck Sharp & Dohme LLC
HIV Vaccine Trials Network

Terminated

Investigation of V520 in an HIV Vaccine Proof-of-Concept Study (V520-023)

HIV Infections | AIDS
VBI Vaccines Inc.
Clinical Trial Data Services, LLC

Completed

Study to Evaluate Safety, Tolerability, and Immunogenicity of Candidate Human Cytomegalovirus Vaccine in Healthy Adults

Cytomegalovirus Infections

Canada
Alliance Foundation Trials, LLC.
Patient-Centered Outcomes Research Institute

Completed

Direct Oral Anticoagulants (DOACs) Versus LMWH +/- Warfarin for VTE in Cancer (CANVAS)

Cancer | Venous Thromboembolism | Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE) | Blood Clot

United States
Gilead Sciences
Alliance Foundation Trials, LLC.; NSABP Foundation Inc

Recruiting

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/NSABP B-63) (ASCENT-05)

Triple Negative Breast Cancer

United States
Alliance Foundation Trials, LLC.
Bristol-Myers Squibb; Celgene Corporation

Terminated

A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancer

Nonsmall Cell Lung Cancer | Non Small Cell Lung Cancer Recurrent | Non-Small Cell Carcinoma of Lung, TNM Stage 4 | Non-Small-Cell Lung Cancer Metastatic

United States
Alliance Foundation Trials, LLC.
Patient-Centered Outcomes Research Institute

Completed

Optimizing the Effectiveness of Routine Post-treatment Surveillance in Prostate Cancer Survivors

Prostate Cancer | Cancer of the Prostate | Prostatic Cancer | Cancer of Prostate
Olatec Therapeutics LLC
CTI Clinical Trial and Consulting Services

Terminated

Safety and Efficacy of Dapansutrile for Treatment of Moderate COVID-19 Symptoms and Evidence of Early Cytokine Release Syndrome

Covid19 | Cytokine Release Syndrome

United States, Switzerland
Collaborative Care Initiative, LLC
Dauten Family Center for Bipolar Treatment Innovation, Massachusetts Gen...

Unknown

Comparison of Two Forms of Oxcarbazepine for the Treatment of Bipolar Depression

Bipolar Depression | Treatment Effectiveness | Measure-based Guidance

United States
Canadian Cancer Trials Group
Merck Sharp & Dohme LLC; Seagen Inc.

Recruiting

Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma

Hodgkin Lymphoma

Canada
Merck Sharp & Dohme LLC

Completed

The Effectiveness of Indinavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients With No Symptoms of Infection

HIV Infections

United States, Canada
Merck Sharp & Dohme LLC

Completed

A Comparison of Two Dose Levels of Indinavir Combined With Two Nucleoside Analogue Reverse Transcriptase Inhibitors (NRTIs) in HIV-Infected Patients

HIV Infections

United States
Merck Sharp & Dohme LLC

Completed

Safety and Effectiveness of an Anti-HIV Drug Combination in HIV-Positive Patients Who Have Failed Previous Treatment With Protease Inhibitors

HIV Infections

United States
Merck Sharp & Dohme LLC

Completed

Effect of Indinavir Plus Two Other Anti-HIV Drugs on Blood Clotting in HIV-Positive Males With Hemophilia

HIV Infections | Hemophilia A

Canada, United States
Merck Sharp & Dohme LLC

Completed

A Study of Indinavir Sulfate Given Together With Stavudine to HIV-Positive Patients

HIV Infections

United States
Novartis Pharmaceuticals
Alliance Foundation Trials, LLC.; RTOG Foundation, Inc.

Active, not recruiting

An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With SoC, Versus SoC Alone, in Adult Male Patients With mHSPC (PSMAddition)

Prostatic Neoplasms

United States, China, Canada, Spain, United Kingdom, Belgium, Japan, Taiwan, Germany, Singapore, Austria, Netherlands, Korea, Republic of, France, Switzerland, Denmark, Sweden, Poland, Czechia
Merck Sharp & Dohme LLC

Completed

Indinavir Plus Efavirenz Plus Adefovir Dipivoxil in HIV-Infected Patients Who Have Not Had Success With Nelfinavir

HIV Infections

United States

Clinical Trials Sponsored by Triple-Gene, LLC

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