Clinical Trials Sponsored by USWM, LLC (dba US WorldMeds)

Total 23 results

USWM, LLC (dba US WorldMeds)

Completed

Study to Evaluate the Exposures of Lofexidine and Its Major Metabolites in Subjects Seeking Buprenorphine Dose Reduction

Substance Withdrawal Syndrome | Opiate Dependence | Opiate Addiction

United States
USWM, LLC (dba US WorldMeds)

Suspended

Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Taper in Treatment of Withdrawal (TAPER)

Opioid Withdrawal (Disorder)

United States
Solstice Neurosciences

Completed

A Multi-Center Study of MYOBLOC for the Treatment of Sialorrhea in Parkinson's Disease Patients

Drooling

United States
Mayo Clinic
USWM, LLC (dba US WorldMeds)

Completed

Lofexidine for Adults Undergoing Lumbar Spine Surgery

Opioid Withdrawal

United States
Solstice Neurosciences

Completed

An Open Label Safety and Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) Injectable Solution in Patients With Cervical Dystonia

Cervical Dystonia
New York State Psychiatric Institute
USWM, LLC (dba US WorldMeds)

Completed

Lofexidine for Management of Opioid Withdrawal With XR-NTX Treatment

Opioid-use Disorder

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal

Opioid Dependence | Acute Opioid Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine Food Effect Study in Healthy Volunteers

Healthy

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine Pharmacokinetics in the Presence of Paroxetine in Healthy Volunteers

Healthy

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients

Opioid Dependence | Buprenorphine Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

Liver Failure

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-dose Pharmacokinetics and Safety of Oral Lofexidine in Renally-Impaired Subjects

Renally Impaired Subjects

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

Opioid Dependence | Methadone Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine ADME & Mass Balance in Volunteers

Normal Healthy Volunteers Will be Treated With Lofexidine to Understand the Absolute Bioavailability and Mass Balance Recovery of the Product

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Recruiting

Pharmacokinetic and Safety Study of Oral Lofexidine in Neonates Experiencing Opioid Withdrawal Due to Intrauterine Exposure to Opioids

Opioid Withdrawal (Disorder)

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

A Study Evaluating the Relative Bioavailability of Lofexidine Granules for Reconstitution Compared to LUCEMYRA (Lofexidine) Tablets and the Effect of Food on the Bioavailability of the Lofexidine Granules for Reconstitution

Normal Healthy Volunteers

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Open-Label, Safety Study of Lofexidine (NU LEAF)

Opioid Withdrawal

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

Opioid Dependence | Methadone Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Assessment of the Effect of Naltrexone on Lofexidine Single Dose Pharmacokinetics in Healthy Subjects

Healthy

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine Mass Balance in Volunteers

Normal Healthy Volunteers

United States
US Department of Veterans Affairs
National Institute on Drug Abuse (NIDA); USWM, LLC (dba US WorldMeds)

Completed

Lofexidine for Inpatient Opiate Detox

Opiate Addiction

United States
Pharmacotherapies for Alcohol and Substance Use...
United States Department of Defense; Michael E. DeBakey VA Medical Center; RTI... and other collaborators

Recruiting

Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans

Post Traumatic Stress Disorder | Opioid-use Disorder

United States
University of Basel
Johns Hopkins University; Azienda Ospedaliero, Universitaria Pisana; Universitaire... and other collaborators

Unknown

Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation (BRIGHT)

Heart Transplantation

Belgium

Clinical Trials Sponsored by USWM, LLC (dba US WorldMeds)

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