Clinical Trials Sponsored by Velindre NHS Trust

Total 5102 results

University of Cambridge
National Institute for Health Research, United Kingdom; Cambridgeshire and...

Completed

Technology-enhanced Therapy: the SilverCloud Study

Depression

United Kingdom
Pier Lambiase
University Hospital Southampton NHS Foundation Trust; The Royal Bournemouth...

Completed

Randomized Trial of Two Ablation Catheters in Paroxysmal Atrial Fibrillation

Atrial Fibrillation

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
Institute of Child Health, University College London, London, UK.

Completed

Mycophenolate Mofetil in Systemic Lupus Erythematosus (MISSILE) (MISSILE)

Systemic Lupus Erythematosus | Atherosclerosis

United Kingdom
University Hospital Birmingham
Brighton and Sussex University Hospitals NHS Trust; British Heart Foundation; University of Birmingham

Unknown

Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy (HYPER)

Myocardial Reperfusion Injury | Hypertrophy, Left Ventricular | Cardiac Output, Low

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
University of Nottingham; Imperial College London; University College, London; Cambridge... and other collaborators

Not yet recruiting

BEARS Training Package to Maximise Hearing Abilities in Older Children and Teenagers With Bilateral Cochlear Implants (BEARS)

Hearing Loss | Deafness | Hearing Loss, Sensorineural | Hearing Impaired Children and Adolescents
Cambridge University Hospitals NHS Foundation Trust
GlaxoSmithKline; National Institute for Health Research, United Kingdom; Kidney... and other collaborators

Recruiting

PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V (PROTECT-V)

Covid19

United Kingdom
St. Anna Kinderkrebsforschung
Centre Leon Berard; Medical University of Graz; Fondazione IRCCS Istituto Nazionale... and other collaborators

Unknown

Long Term Continuous Infusion ch14.18/CHO Plus s.c. Aldesleukin (IL-2) (LTI)

Neuroblastoma

France, Spain, Austria, Germany, Israel, Italy, United Kingdom
Fondazione Poliambulanza Istituto Ospedaliero
Assistance Publique - Hôpitaux de Paris; King's College Hospital NHS Trust; Fondazione... and other collaborators

Recruiting

LIVACOR Trial: Minimally Invasive LIVer And Simultaneous COlorectal Resection (LIVACOR)

Neoplasm Metastasis | Colorectal Neoplasms Malignant

Italy, Belgium, France, Germany, Luxembourg, Netherlands, Norway, Russian Federation, Spain, United Kingdom
Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Teenage/Young Adults (TYA) and Paediatric Patients With ALK Positive Cancers (DETERMINE)

Neoplasms by Histologic Type | Lymphoma | Lymphoproliferative Disorders | Neoplasms by Site | Renal Cell Carcinoma | Cancer | Solid Tumor | Anaplastic Large Cell Lymphoma | Neuroblastoma | Malignant Neoplasm | Haematological Malignancy

United Kingdom
Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition (DETERMINE)

Melanoma | Neoplasms by Histologic Type | Lymphoproliferative Disorders | Neoplasms by Site | Cancer | Colorectal Neoplasms | Endometrial Neoplasms | Malignant Neoplasm | Malignancy

United Kingdom
Imperial College Healthcare NHS Trust
Imperial College London; University College, London; patientMpower Ltd.; Action...

Recruiting

ILD: Health Outcomes in Remote Digital Monitoring Versus Usual Care (REMOTE-ILD)

Interstitial Lung Disease

United Kingdom
University of Manchester
National Institute for Health Research, United Kingdom; Greater Manchester...

Recruiting

Youth Metacognitive Therapy Feasibility Trial (YoMETA)

Depression | Anxiety Disorders | Child Mental Disorder

United Kingdom
Hull University Teaching Hospitals NHS Trust
Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University...

Recruiting

Endoscopic Severity Image Recognition to Advance Research and Training in Inflammatory Bowel Disease (EVEREST - IBD)

Inflammatory Bowel Disease 1

United Kingdom
King's College London
National Institute for Health Research, United Kingdom; South London and Maudsley...

Completed

Electronic Clinical Decision Support for Diabetes and Dysglycaemia in Secondary Mental Healthcare

Diabetes Mellitus | Dysglycemia | Severe Mental Disorder | Staff Attitude

United Kingdom
Keele University
Guy's and St Thomas' NHS Foundation Trust; University of Southampton; University... and other collaborators

Active, not recruiting

Work And Vocational advicE Study - Effectiveness of Adding a Brief Vocational Support Intervention to Usual Primary Care (WAVE)

Musculoskeletal Pain | Mental Health Disorder | Mental Health Issue | Absence | Other Physical Health Condition

United Kingdom
Brighton and Sussex University Hospitals NHS Trust
King's College London; European Society of Cataract and Refractive Surgeons

Completed

Monofocal Extended Range of Vision (MERoV) Study (MERoV)

Pseudophakia | Accomodation | Aberration, Corneal Wavefront

United Kingdom
Chelsea and Westminster NHS Foundation Trust
Imperial College London; NEAT ID Foundation; FUJIFILM Toyama Chemical Co., Ltd.

Completed

Early Intervention in COVID-19: Favipiravir Verses Standard Care (PIONEER)

Coronavirus Infection

United Kingdom, Brazil, Mexico
University of Birmingham
East Kent Hospitals University NHS Foundation Trust; National Institute for...

Active, not recruiting

Accuracy of Glomerular Filtration Rate (GFR) Estimation Using Creatinine and Cystatin C and Albuminuria (eGFR-C)

Chronic Kidney Diseases

United Kingdom
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge; Medical Research Council Cognition and Brain Sciences...

Enrolling by invitation

Minimizing Facial Nerve Stimulation in Cochlear Implants

Hearing Loss | Hearing Loss, Sensorineural | Cochlear Hearing Loss | Facial Nerve Injury | Nerve Disorders

United Kingdom
Imperial College London
Chelsea and Westminster NHS Foundation Trust; National Heart and Lung Institute and other collaborators

Completed

Defining the Intestinal Microbiota in Premature Neonates

Necrotizing Enterocolitis | Premature Intestinal Microbiota | Late Onset Bloodstream Infection

United Kingdom
Imperial College London
Cambridge University Hospitals NHS Foundation Trust; University of Manchester; Food Standards Agency, United Kingdom

Completed

Mechanisms Underlying Peanut Allergic Reactions in TRACE Peanut Study Participants: Extension Study (TRACEextension)

Food Hypersensitivity | Peanut Hypersensitivity
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield; Weston Park Hospital Cancer Charity; Sheffield Hospitals...

Completed

Lung HeXeRT: Helium, Xenon MRI for NSCLC Patients (HeXeRT)

NSCLC

United Kingdom
University of Leeds
University of Bologna; The Leeds Teaching Hospitals NHS Trust; European Union; AdWare...

Completed

Effect of Bioactive Enriched Food on Markers of Metabolic Syndrome (PATHWAY-27)

Metabolic Syndrome

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust
Imperial College London; British Lung Foundation; National Heart and Lung Institute

Completed

The Use of Inflammatory Markers to Guide Therapy in Children With Severe Asthma

Asthma

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
University of Oxford; Engineering and Physical Sciences Research Council, UK

Completed

Validation of Respiration Rate Algorithms

Respiratory Rate | Pulse Oximetry

United Kingdom
University of Surrey
European Foundation for the Study of Diabetes; Royal Surrey County Hospital...

Terminated

The Effect of Rimonabant on Energy Expenditure, Fat Metabolism and Body Composition

Obesity

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
Pontificia Universidad Catolica de Chile; University of Rotterdam, The Netherlands

Not yet recruiting

UK ANDROMEDA-Shock-2 RCT

Septic Shock
Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers. (DETERMINE)

Glioma | Melanoma | Neoplasms by Histologic Type | Lymphoproliferative Disorders | Neoplasms by Site | Cancer | Brain Neoplasms | Solid Tumor | Malignant Neoplasm | Malignancy | Haematological Malignancy

United Kingdom
Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol (DETERMINE)

Solid Tumor | Haematological Malignancy

United Kingdom
Cambridge University Hospitals NHS Foundation Trust
National Institute for Health Research, United Kingdom; Wolfson Brain Imaging...

Recruiting

Quantiative MRI and Myelin-PET for the Assessment of Degenerative Cervical Myelopathy (IMAGE-DCM)

Cervical Spondylosis With Myelopathy | Degenerative Cervical Myelopathy

United Kingdom
University of Sydney
Northern Care Alliance NHS Foundation Trust; Waitemata District Health Board; Australasian Kidney Trials Network

Recruiting

Better Evidence and Translation for Calciphylaxis (BEAT-Calci)

Calciphylaxis

Australia, New Zealand
Great Ormond Street Hospital for Children NHS Foundation...
Hospices Civils de Lyon; Heidelberg University; Istanbul University

Active, not recruiting

Comparison of Pre- vs Post-dilution Haemodiafiltration in Children

Haemodiafiltration

United Kingdom, France, Germany, Turkey
NHS Grampian
University of Aberdeen; Innovate UK; Industrial centre for Artificial intelligence... and other collaborators

Active, not recruiting

Radiomics in Rectal Cancer

Rectal Cancer

United Kingdom
Cambridge University Hospitals NHS Foundation Trust
University of Pennsylvania; Roche Pharma AG; Genentech, Inc.; Arthritis Research...

Completed

Rituximab Vasculitis Maintenance Study (RITAZAREM)

Microscopic Polyangiitis | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | Wegener Granulomatosis

United States, Canada, United Kingdom, Sweden, New Zealand, Ireland, Australia, Italy, Czechia, Japan
King's College London
National Institute for Health Research, United Kingdom; South London and Maudsley...

Completed

High Intensity Interval Training in Severe Mental Illness

Schizophrenia | Bipolar Disorder | Major Depressive Disorder

United Kingdom
Professor Christi Deaton
University of Oxford; University of Manchester; Keele University

Completed

Optimising Management of Patients With Heart Failure With Preserved Ejection Fraction in Primary Care (OPTIMISEHFpEF)

Heart Failure With Preserved Ejection Fraction

United Kingdom
Great Ormond Street Hospital for Children NHS Foundation...
Yale University; Flinders University; Swinburne University of Technology

Completed

Electroretinogram in Autistic Spectrum Disorders (ERG in ASD)

Autism Spectrum Disorder

United States, United Kingdom, Australia
Royal Brompton & Harefield NHS Foundation Trust
University College London Hospitals; Imperial College London; University of East...

Completed

Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD (RECITAL)

Interstitial Lung Disease | Scleroderma | Idiopathic Inflammatory Myositis | Mixed Connective Tissue Disease

United Kingdom
Julie Dawson
Medical Research Council; University of East Anglia

Completed

Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Healthy Volunteer Trial (CAVA)

Optokinetic Nystagmus

United Kingdom
King's College Hospital NHS Trust
Barts and the London School of Medicine and Dentistry; Fetal Medicine Foundation

Unknown

The BEET-BP Trial - Investigating the Effect of Dietary Nitrates on Hypertension in Pregnancy

Pre-Eclampsia | Hypertension in Pregnancy | Gestational Hypertension | Pregnancy Induced Hypertension

United Kingdom
Quadram Institute Bioscience
Norfolk and Norwich University Hospitals NHS Foundation Trust; University of... and other collaborators

Unknown

Microbial Dysbiosis in Rheumatoid Arthritis (MyRA)

Rheumatoid Arthritis

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
King's College London; National Institute for Health Research, United Kingdom

Completed

Role of Anti-IgE in Severe Childhood Eczema (ADAPT)

Child | Atopic Dermatitis | Atopic Eczema

United Kingdom
Royal Devon and Exeter NHS Foundation Trust
Merck Sharp & Dohme LLC; Pfizer; AbbVie; CORE; Napp Pharmaceuticals Limited

Unknown

Personalising Anti-TNF Therapy in Crohns Disease (PANTS) (PANTS)

Crohn Disease

United Kingdom
Royal Devon and Exeter NHS Foundation Trust
National Institute for Health Research, United Kingdom; University of Exeter

Completed

Predicting Response to Incretin Based Agents in Type 2 Diabetes (PRIBA)

Type2 Diabetes

United Kingdom
University of Edinburgh
Royal Brompton & Harefield NHS Foundation Trust; Royal Infirmary of Edinburgh; Golden Jubilee National Hospital

Completed

DEtection of Cellular Inflammation With FERumoxytol in the HEART (DECIFER)

Myocarditis | Healthy Volunteers | Cardiac Transplant | Cardiac Sarcoid

United Kingdom
University Hospital Schleswig-Holstein
Johannes Gutenberg University Mainz; Great Ormond Street Hospital for Children...

Completed

Endomicroscopy, IBS and Food Intolerance

Food Intolerance | Inflammatory Bowel Syndrome | Endomicroscopy

Germany
University of Southampton
Wyeth is now a wholly owned subsidiary of Pfizer; Hampshire Hospitals NHS Foundation...

Completed

Safety and Tolerability of Etanercept in Alzheimer's Disease (STEADI-09)

Alzheimer's Disease

United Kingdom
University of Oxford
University of Michigan; University of Southern California; Chelsea and Westminster... and other collaborators

Recruiting

Rescue for Emergency Surgery Patients Observed to uNdergo Acute Deterioration (RESPOND)

Emergencies | Failure to Rescue

United Kingdom
Kronikgune
Odense University Hospital; Assuta Ashdod Hospital; Maccabi Healthcare Services... and other collaborators

Recruiting

Assessment of the Effectiveness, Socio-economic Impact and Implementation of a Digital Solution for Severe Patients (ADLIFE)

Heart Failure NYHA Class III | Heart Failure NYHA Class IV | Chronic Obstructive Pulmonary Disease Severe

Denmark, Germany, Israel, Spain, Sweden, United Kingdom
East and North Hertfordshire NHS Trust
National Institute for Health Research, United Kingdom; Manuka Doctor UK Ltd

Recruiting

HONEY for the Treatment of POst-Tonsillectomy Pain (HONEY-POT)

Analgesia | Post Surgical Pain

United Kingdom

Clinical Trials Sponsored by Velindre NHS Trust

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