Search clinical trials for: APO E4

Total 6673 results

Estetra
Quotient Clinical

Completed

Study Conducted to Further Understand the Elimination Pathways, Metabolite Profile and PK Profile of 14C-estetrol

Menopause | Contraception

United Kingdom
Estetra

Recruiting

Estetrol for the Treatment of Female Sexual Arousal Disorder in Postmenopausal Women

Sexual Dysfunction, Physiological

United States
Donesta Bioscience
SynteractHCR

Completed

E4Relief (Response to Estetrol in Life Improvement for MEnopausal-associated Hot Flushes)

Hot Flushes

Belgium
NEURALIS s.a.

Recruiting

Single and Multiple Intravenous Administrations of Estetrol (E4) in Healthy Adult Volunteers

Pharmacokinetics | Safety

Bulgaria
Estetra

Completed

Safety, Tolerability and Pharmacokinetics of Estetrol (E4) After Single and Multiple Oral Doses in Healthy Female Volunteers

Menopause | Contraception

Bulgaria
Mayo Clinic

Enrolling by invitation

Development of a Practical, Minimally Invasive Seizure Gauge

Epilepsy

United States
Columbia University

Terminated

Detection of Gastrointestinal Bleeding in Intensive Care Patients Via Biosensor Watch

Gastro Intestinal Bleeding

United States
Donesta Bioscience

Completed

Effect of Food on the Bioavailability of 30 mg Estetrol (E4) Tablet in Healthy Postmenopausal Female Volunteers

Food-effect

Bulgaria
Seer Medical Pty Ltd

Enrolling by invitation

Development of a Minimally Invasive Seizure Gauge

Epilepsy

Australia
Estetra
ICON Clinical Research

Completed

Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort)

Vasomotor Symptoms | Menopausal Symptoms

United States, Canada
NEURALIS s.a.

Active, not recruiting

Estetrol (E4) for the Treatment of Patients With Confirmed SARS-COV-2 Infection

Covid19

Belgium, Hungary, Russian Federation, Poland
University of Southern California
National Institute on Aging (NIA); Alzheimer's Drug Discovery Foundation; Huntington...

Completed

DHA Brain Delivery Trial (PreventE4)

Brain DHA Delivery and Alzheimer's Disease Risk

United States
Ain Shams University

Completed

Human Epididymis Protein 4 in Endometrial Carcinoma

Endometrial Cancer

Egypt
University of Washington

Completed

APOE Genotype and Diet Influences on Alzheimer's Biomarkers

Alzheimer's Disease; Dementia

United States
Turku University Hospital

Unknown

Serum Biomarker HE4 During IVF Treatment (FHE4)

IVF Treatment | Human Epididymal Secretory Protein E4

Finland
King's College London
Guy's and St Thomas' NHS Foundation Trust

Unknown

The CEDiD Study (COVID-19 Early Diagnosis in Doctors and Healthcare Workers) (CEDiD)

Covid19

United Kingdom
Zeno Pharmaceuticals, Inc.

Completed

A Study of ZN-e4 in Subjects With Epidermal Growth Factor Receptor Mutated Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

United States, Bosnia and Herzegovina
University of Aarhus
National Cancer Institute (NCI); University of Virginia; University of Cambridge and other collaborators

Active, not recruiting

Biomarkers Predictive for Cervical Intraepithelial Neoplasia Grade 2 (CIN2) Evolvement

Cervical Intraepithelial Neoplasia Grade 2 (CIN2)

Denmark
Estetra

Completed

E4/DRSP Single and Multiple Dose PK and Early QT Study

Contraception
Ottawa Hospital Research Institute
University of Ottawa; Canadian Anesthesiologists' Society

Completed

Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

Delirium | Postoperative Cognitive Dysfunction

Canada
Mayo Clinic
Alzheimer's Association

Completed

Does Zumba Improve Cognition in Healthy APOE e4 Carriers and Noncarriers

Cognitive Impairment

United States
Avera McKennan Hospital & University Health Center

Completed

A Study to Compare Genetic Variations of IGF-I and IGF-II

Dementia

United States
Estetra

Completed

E4/DRSP Ovarian Function Inhibition Study

Prevention of Pregnancy

Netherlands
University Hospital, Caen
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Multi-modal Neuroimaging in Alzheimer's Disease (IMAP+)

Alzheimer's Disease

France
Scott and White Hospital & Clinic
Anodyne Therapy, LLC

Completed

Anodyne Therapy in Diabetic Sensory Neuropathy

Diabetes Mellitus | Diabetic Neuropathy

United States
Mayo Clinic
National Institute of Mental Health (NIMH)

Completed

The Impact of Lorazepam on Cognition in APOE e4 Carriers

Alzheimer's Disease

United States
Eastern Virginia Medical School
Medarva

Completed

Urinary Leukotriene E4 Levels in Children With Obstructive Sleep Apnea

Obstructive Sleep Apnea

United States
Estetra

Completed

Effect of Estetrol Monohydrate (E4) on QTc Interval

Prolonged QTc Interval

United States
Shanghai University of Traditional Chinese Medicine
Shanghai Minimally Invasive Surgery Center

Not yet recruiting

Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers

Cognitive Impairment | Alzheimer Disease

China
Estetra
Quotient Sciences

Completed

Estetrol (E4)/Drospirenone (DRSP) Drug-drug Interaction (DDI) Study

Contraception

United Kingdom
Estetra

Completed

"E4/DRSP Endocrine Function, Metabolic Control and Hemostasis Study"

Contraception | Liver Metabolism | Hemostasis Parameter

Netherlands
Millennium Magnetic Technologies, LLC

Unknown

Pre-Clinical (Alzheimers) Diagnosis PCD = Optimum Outcomes OO (PCD=OOALZ)

Alzheimer Disease

United States
Avera McKennan Hospital & University Health Center

Completed

The Occurrence of the ApoE4 Allele in Agitated In-Patients With Late-Onset Alzheimer's Disease

Alzheimer's Disease | Agitation

United States
University of Aarhus
Aarhus University Hospital; Innovation Fund Denmark; Brain+ ApS; Eurostars EUREKA

Completed

Simultaneous tDCS and Computerised Gamified Short-term Memory Task Feasibility (ACTTDCS-FG)

Genetic Predisposition

Denmark
Center for Epidemiology and Health Research, Germany
Estetra SRL

Recruiting

International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety Study (INAS-NEES)

Contraception | Birth Control

Germany
Mental Health Services in the Capital Region, Denmark
University of Copenhagen; Technical University of Denmark

Recruiting

A Wearable AI Feedback Tool for Pediatric OCD

Obsessive-Compulsive Disorder

Denmark
Genexine, Inc.
PT Kalbe Genexine Biologics

Recruiting

A Phase 3 Study of Efepoetin Alfa for Treatment of Anemia in Patients With Chronic Kidney Disease on Dialysis

Anemia of Chronic Kidney Disease

Korea, Republic of, Georgia
Randy Kardon

Recruiting

Objectively Diagnose and Monitor Treatment of Light Sensitivity

Migraine | Traumatic Brain Injury | Photophobia

United States
KK Women's and Children's Hospital

Recruiting

Pain Detection Through Automated Video Analysis

Pain, Postoperative

Singapore
Mayo Clinic
Spark Neuro Inc.

Enrolling by invitation

Development of an EEG Diagnostic for Alzheimer's Disease

Alzheimer Disease | Mild Cognitive Impairment | Dementia With Lewy Bodies | Normal Control APOE e4 Carriers and Noncarriers

United States
The Cleveland Clinic
National Institutes of Health (NIH); National Institute on Aging (NIA); University...

Recruiting

CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease) (CYCLE-AD)

Normal Cognition | High Intensity Exercise | Exercise Intervention

United States
Center for Epidemiology and Health Research, Germany
Estetra

Not yet recruiting

International Active Surveillance Study: Safety of Estrogen Estetrol (E4) Contraceptive Study (INAS-SEECS) (INAS-SEECS)

Contraception
Sahlgrenska University Hospital, Sweden
The Swedish Research Council; Swedish National Quality Registries; The Swedish...

Completed

Smoking Cessation Prior to Gynecological Surgery

Smoking Cessation | Surgery--Complications

Sweden
Estetra
PRA Health Sciences

Completed

E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - EU/Russia Study

Contraception

Belgium
Parc de Salut Mar
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation; Hospital...

Completed

Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention ((PENSA))

Alzheimer Disease | Cognitive Decline

Spain
Estetra
PRA Health Sciences

Completed

E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - United States/Canada Study

Contraception

United States, Canada
Estetra

Completed

Effect of Food on the Bioavailability of 15 mg Estetrol/3 mg Drospirenone Tablets in Healthy Female Volunteers

Contraception
National Cancer Institute (NCI)

Suspended

Testing the Use of Nilotinib and Paclitaxel as a Treatment for Patients With Prior Taxane Treatment, A ComboMATCH Treatment Trial

Refractory Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Karolinska University Hospital
Karolinska Institutet

Unknown

A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma (E-Type)

Asthma

Sweden
Estetra

Completed

Safety, Compliance and Pharmacokinetics of Estetrol Monohydrate/Drospirenone 15/3 mg in Post-menarchal Female Adolescents

Safety

Estonia, Finland, Georgia, Latvia, Poland, Sweden

Search clinical trials for: APO E4

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