Search clinical trials for: Aldose Reductase Inhibition

Total 3591 results

Applied Therapeutics, Inc.

Completed

Safety and Pharmacokinetics of AT-007 in Healthy Subjects and in Adult Subjects With Classic Galactosemia

Classic Galactosemia

United States
Fundación para la Investigación Biosanitaria del...

Recruiting

Cross-over Study of Coronary Risk Factors With a Polypill (POLICROSS)

Coronary Artery Disease

Spain
Khanh Nguyen

Recruiting

Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis

Deep Vein Thrombosis Leg | Post-thrombotic Syndrome

United States
Organon and Co

Completed

Begin With The Right Patients With Dual-Inhibition Action Therapy Through Vytorin for Newly Diagnosed Dyslipidemia Patients (0653A-172)(COMPLETED) (BRAVO)

Hypercholesterolemia
Applied Therapeutics, Inc.

Active, not recruiting

Clinical Benefit, Safety, PK and PD Study of AT-007 in Pediatric Subjects With Classic Galactosemia

Classic Galactosemia

United States
Applied Therapeutics, Inc.

Active, not recruiting

Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy

Diabetic Cardiomyopathies

United States, France, Spain, Australia, Canada, United Kingdom, Germany, Czechia, Hong Kong, Poland
Amgen

Completed

LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2 (LAPLACE-2)

Hyperlipidemia

United States, Denmark, France, Italy, Czechia, Taiwan, Switzerland, Korea, Republic of, Germany, Hong Kong, Netherlands, Australia, Belgium, Canada, Hungary, South Africa, Russian Federation, Spain, United Kingdom, Sweden, Mexico
Dr. med. Mahir Karakas

Terminated

Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive Troponin (GRAY-ZONE)

Acute Chest Syndrome

Germany
University of Coimbra

Completed

From Molecules to Cognition: Inhibitory Mechanisms in ASD and NF1 (ASD/NF1inhib)

Autism Spectrum Disorder | Neurofibromatosis 1

Portugal
Galmed Pharmaceuticals Ltd
Hammersmith Medicines Research; Diamond Pharma Services Regulatory Affairs... and other collaborators

Completed

Study of Potential for Drug Interactions Mediated by CYP3A4 Inhibition With Aramchol in Healthy Volunteers

Healthy

United Kingdom
Amgen

Completed

Effects on Lipoprotein Metabolism From PCSK9 Inhibition Utilizing a Monoclonal Antibody (FLOREY)

Primary Hyperlipidemia and Mixed Dyslipidemia

Australia
University of Washington
National Institute of General Medical Sciences (NIGMS)

Completed

The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity (FLUOXETINE)

Healthy Volunteers | Drug-Drug Interaction
University Hospital, Gentofte, Copenhagen

Completed

The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion

Diabetes Mellitus, Type 2 | Hydroxymethylglutaryl-CoA Reductase Inhibitors

Denmark
Indiana University School of Medicine
National Center for Research Resources (NCRR)

Terminated

Effects of Short Term, High Dose Atorvastatin Therapy on Periprocedural Myonecrosis and Platelet Inhibition After Percutaneous Coronary Intervention (PCI) (ESTATE)

Coronary Artery Disease

United States
Shenyang Northern Hospital

Completed

Effects of Atorvastatin Versus Pravastatin on Platelet Inhibition by Clopidogrel

Ischemic Heart Disease | Acute Coronary Syndromes

China
Franklin D. Gaylis, MD Inc.

Completed

Treatment of Refractory Urinary Retention Secondary to Benign Prostatic Hyperplasia (BPH) With Dual Five Alpha Reductase Inhibition Combined With an Alpha Blocker (AUR)

Benign Prostatic Hyperplasia | Urinary Retention
Regional Hospital Holstebro

Completed

Short Term Effects of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Healthy

Denmark
Regional Hospital Holstebro

Completed

Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Healthy

Denmark
National Center for Research Resources (NCRR)

Unknown

The Inhibition of Platelet Antiaggregating Activity of Clopidogrel by Atorvastatin Detected by Erythromycin Breath Test: a Metabolic Inhibition of Hepatic Cytochrome P450-3A

Thrombosis | Hypercholesterolemia

United States
University of Utah
Kaiser Permanente

Not yet recruiting

A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.

Cardiovascular Diseases | Hypercholesterolemia | Placebo Effect | Pharmacists | Hydroxymethylglutaryl-CoA Reductase Inhibitors
Vertex Pharmaceuticals Incorporated

Not yet recruiting

A Microneurography Study of NaV1.8 Inhibition in Healthy Adults

Pain
Incyte Corporation

Recruiting

A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics When Administered Orally to Healthy Adult Participants

Healthy Participants

United States
University of Reading
INNOPURE

Recruiting

The Effects of Vitamin B6 Supplementation on Pain Thresholds and Tolerance

Pain

United Kingdom
Riphah International University

Recruiting

Effect of Superficial Back Line Relaxation Technique on Hamstring Flexibility in Non Specific Low Back Pain Patients

Low Back Pain, Mechanical | Hamstring Flexibility

Pakistan
Riphah International University

Recruiting

Effects of Sub Occipital Muscle Inhibition Technique in Mechanical Low Back Pain

Mechanical Low Back Pain

Pakistan
Assiut University

Not yet recruiting

Topical Simvastatin Versus Topical Steroid in Treatment of Alopecia Areata

Alopecia Areata

Egypt
Chulalongkorn University

Not yet recruiting

"Quick-starting" of a Quadriphasic Contraceptive Pills, 1 - 3 mg Estradiol Valerate/ 2 - 3 mg Dienogest VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition

Ultrasound Finding: Ovulation Inhibition, Ovarian Activities | Cervical Mucus | Serum Hormonal Profile
Chulalongkorn University

Not yet recruiting

"Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition

Ultrasound Finding: Ovulation Inhibition, Ovarian Activities | Cervical Mucus | Serum Hormonal Profile
Fundació Sant Joan de Déu
Instituto de Salud Carlos III

Recruiting

Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity (PREC-BED)

Obesity | Binge-Eating Disorder | Emotion Regulation | Eating Disorders | Food Addiction | Other Specified Feeding or Eating Disorder | Eating Disorder Nos | BED

Spain
Amsterdam UMC, location VUmc
Maastricht University Medical Center; Erasmus Medical Center; St. Antonius Hospital

Not yet recruiting

Neoadjuvant Triple Treatment for Borderline Resectable Pancreatic Cancer (PREOPANC-5) (PREOPANC-5)

Borderline Resectable Pancreatic Cancer
University of Minnesota

Not yet recruiting

How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time?

Stroke
Jord Vink

Not yet recruiting

Interaction Between the Brain Hemispheres - Key to Motor Recovery After Stroke (InterAct)

Stroke

Netherlands
Modern Biosciences Ltd

Recruiting

Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects

Pharmacokinetics

United Kingdom
Novartis Pharmaceuticals

Not yet recruiting

Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial Infarction (V-ACCELERATE)

Plaque, Atherosclerotic
Assiut University

Not yet recruiting

Statins Role in Acute Ischemic Stroke (observation)

Stroke, Acute
Johns Hopkins University
American Heart Association

Not yet recruiting

Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet

Epilepsy | Dyslipidemia
University of Bologna

Not yet recruiting

Middle Term Effect of Red Yeast Rice on Plasma Lipids and Proteoma in Individuals With Suboptimal Cholesterolemia

Hypercholesterolemia

Italy
Haaglanden Medical Centre
Takeda; Leiden University Medical Center

Not yet recruiting

Complement Inhibition: Attacking the Overshooting Inflammation @Fter Subarachnoid Hemorrhage (CIAO@SAH) (CIAO@SAH)

Subarachnoid Hemorrhage, Aneurysmal
Kafrelsheikh University

Recruiting

Combining Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Large-vessel Ischemic Stroke

Ischemic Stroke

Egypt
Kafrelsheikh University

Recruiting

Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Minor Stroke or TIA

Ischemic Stroke

Egypt
Ann & Robert H Lurie Children's Hospital of Chicago

Not yet recruiting

Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease (SHIELD)

Non-Alcoholic Fatty Liver Disease
Jemincare

Not yet recruiting

Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects

Solid Tumor, Adult
Nanjing First Hospital, Nanjing Medical University

Not yet recruiting

Effects of Inclisiran Combined With Statins on the Morphology of Coronary Vulnerable Plaques (EItoCVP)

Coronary Artery Disease
Mario Pérez Sayáns
Universidad de Murcia

Recruiting

Osteogenic Action of a Biphasic Bioceramic With Statin in a Third Molar Extraction Model (Galibone)

Bone Loss | Regenerative Inflammation

Spain
Hangzhou Sciwind Biosciences Co., Ltd.

Recruiting

A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin

Healthy Volunteers

China
Anhui Medical University

Recruiting

Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort Study

Cognitive Impairment | Intracranial Atherosclerosis | Cerebrovascular Event

China
Bayer

Recruiting

A Study to Learn About How BAY2927088 Affects the Level of Dabigatran or Rosuvastatin in the Blood When These Drugs Are Taken Together in Healthy Participants

Healthy Volunteers | Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

United Kingdom
GRI Bio Operations, Inc.

Recruiting

Biomarker Modulation and the Inhibition of NKT1 Cells by Oral GRI-0621 in Patients With IPF

Idiopathic Pulmonary Fibrosis

United States
Tianjin Medical University General Hospital

Recruiting

Evaluate the Efficacy and Safety of Atorvastatin Combined With Temozolomide in the Treatment of Glioblastoma

Glioblastoma, IDH-wildtype

China
Children's Mercy Hospital Kansas City
Indiana Clinical and Translational Sciences Institute

Recruiting

IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease (IMPROVE-FALD)

Fontan Circulation

United States

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