Search clinical trials for: Area under the curve (AUC)

Total 236982 results

AstraZeneca

Completed

Study to Investigate the Safety Profile of AZD4721 After Single Doses at Different Dose Levels

Safety,Plasma AUC and Cmax, Plasma AUC 0-t, t1/2λz, and Tmax

United Kingdom
Chulalongkorn University
Ratchadapiseksompotch Research Fund

Completed

Pharmacokinetic of Everolimus and Atorvastatin Co-administration

Difference of 12-hour AUC

Thailand
AstraZeneca

Completed

Prilosec Bioequivalence Study in Healthy Volunteers

Bioequivalence, AUC, Cmax, Pharmacokinetics

United States
AstraZeneca

Completed

Study in Healthy Subjects to Compare the Concentrations of the Omega-3 Fatty Acids EPA and DHA in Blood When Delivered as Three New Capsules in Relation to the Epanova® Capsule Under Fasting and Fed Conditions

Pharmacokinetics | Relative Bioavailability | AUC | Cmax

United States
Geropharm

Completed

Fasting Bioequivalence Study of Memantinol 20 mg Tablets Versus Akatinol Memantine® 20 mg Tablets In Normal Healthy Subjects

Bioequivalence, AUC, Cmax, Pharmacokinetics

Russian Federation
AstraZeneca

Completed

Clopidogrel Bioequivalence Study in Healthy Subjects

Bioequivalence, AUC, Cmax, Pharmacokinetics

Germany
Eisai Inc.

Completed

A Dose-Finding Study of E7389 in Combination With Carboplatin in Patients With Solid Tumors

Cancer

United States, Austria, India
Pfizer

Completed

A Study To Establish The Equivalence Of 2 Palbociclib (PD-0332991) Formulations To The Intended Final Market Product

Healthy

United States
Norwegian University of Science and Technology
St. Olavs Hospital; Liverpool John Moores University; Australian Catholic University

Completed

Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome (HIT-FAT)

Polycystic Ovary Syndrome

Australia, Norway
Norwegian University of Science and Technology
St. Olavs Hospital; Liverpool John Moores University; Australian Catholic University

Completed

Improving Reproductive Function in Women With Polycystic Ovary Syndrome by High Intensity Interval Training (IMPROV-IT)

Polycystic Ovary Syndrome

Australia, Norway
Irmandade Santa Casa de Misericórdia de Porto Alegre
Novartis

Completed

A Prospective Study to Investigate Mycophenolic Acid (MPA) Exposure Through Area Under the Curve (AUC) in Renal Transplants Recipients Treated With Mycophenolate Mofetil (MMF) and After Conversion to Mycophenolate Sodium (EC-MPS) (AUC-MPA)

Renal Transplantation

Brazil
Northwestern University
National Institute of Allergy and Infectious Diseases (NIAID); National Jewish...

Completed

Pre-SunBeam TEWL AUC

Atopic Dermatitis

United States
McMaster University
The Physicians' Services Incorporated Foundation

Recruiting

Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC

MRSA

Canada
National Taiwan University Hospital

Completed

The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?

Methicillin-resistant Staphylococcus Aureus Septicemia

Taiwan
MedImmune LLC

Completed

A Study to Evaluate the Safety and Tolerability of Multiple Intravenous Doses of MEDI 545 in Patients With Systemic Lupus Erythematosus

Lupus

Brazil, United States, Chile, Argentina
AstraZeneca

Completed

Phase I Study to Assess the Effect on Healthy Male Volunteers of Ketoconazole on the Pharmacokinetics of a Single Dose of AZD5069 Administered Orally.

Asthma, | Pharmacokinetics, | Cmax, | Tmax, | λz, | AUC, | Ketoconazole, | Metabolite

United Kingdom
Samyang Biopharmaceuticals Corporation

Completed

A Trial to Evaluate Efficacy and Safety of the Combination Therapy of Genexol®-PM Plus Carboplatin® Compared to Genexol® Plus Carboplatin® as a Firstline Treatment in Subjects With Ovarian Cancer (GPMOC202)

Ovarian Cancer

Korea, Republic of
Barts & The London NHS Trust
University College London Hospitals

Completed

Carboplatin AUC-10 With Early PET Scanning in Metastatic Seminoma (Car-PET)

Metastatic Seminoma

United Kingdom
Pfizer

Completed

Bioavailability of Bosutinib Administered as Capsule Contents Mixed With Applesauce or Yogurt Relative to Intact Capsules Under Fed Condition

Healthy Participants

Belgium
AstraZeneca

Completed

A Study in Healthy Subjects to Investigate Pharmacokinetics of AZD5423 When Administered in Different Ways

Bioavailability and AUC

United Kingdom
Pfizer

Completed

Bioequivalence Study of Bosutinib Pediatric Capsule Relative to Commercial Tablet Under Fed Condition

Healthy Participants

Netherlands
AstraZeneca

Completed

A Randomized, Open Label Study to Compare the Current Phase II and Planned Phase III Capsule Formulation of AZD6244 (AZD6244Formula)

Healthy Volunteers

United States
Pfizer

Completed

Evaluation of the Relative Bioavailability of Bosutinib Capsules Under Fed Condition and Estimation of Food Effect on Orally Administered Bosutinib Capsule

Healthy Participants

Belgium
University of Aberdeen

Completed

A Single Supplement of a Standardised Bilberry Extract Modifies Glycaemic Response

Type 2 Diabetes

United Kingdom
AZ Sint-Jan AV
Onze Lieve Vrouw Hospital

Completed

Dose-finding of Rivaroxaban in Hemodialysis

Chronic Renal Failure

Belgium
Pari Pharma GmbH

Completed

Bioequivalence and Safety of Vantobra and TOBI in Healthy Subjects

Cystic Fibrosis

Germany
Pfizer

Completed

Relative Bioavailability Of Palbociclib (PD-0332991) Under Fed And Fasted Conditions

Healthy

United States
University Hospital, Limoges
Hoffmann-La Roche

Unknown

Concentration Controlled Versus Fixed Dose of MMF in Kidney Transplant Recipients

Kidney Transplant Recipients

France
Assistance Publique - Hôpitaux de Paris

Recruiting

MPA AUC Monitoring in Patients Receiving MMF for Diffuse Cutaneous or Pulmonary Involvement in Systemic Sclerosis (SCLERAMAC)

Systemic Sclerosis

France
RWTH Aachen University

Unknown

European Calciphylaxis Registry Network (EuCalNet)

Calciphylaxis | Calcific Uremic Arteriolopathy (CUA)

Germany
CR-CSSS Champlain-Charles-Le Moyne

Completed

Vancomycin Dose Adjustments Comparing Trough Levels to The AUC/MIC Method Using a Bayesian Approach in a Hospitalized Adult Population (VancoDATABayes)

Adult | Vancomycin | Area Under Curve

Canada
Geropharm

Completed

Bioequivalence Study of Metformin 750 mg Tablets XR Versus Glucophage® Long 750 mg Tablets XR In Normal Healthy Subjects Under Fasting and Fed Conditions

Bioequivalence

Russian Federation
Leiden University Medical Center

Completed

VIP: Vascular Imaging Project. Study on the Progression of Cardiovascular Disease in Renal Transplant Recipients

Cardiovascular Disease

Netherlands
Institut Claudius Regaud

Completed

Determination of Carboplatin's Optimal Plasmatic Exposure

Neoplasms

France
Per Damkier

Completed

Interaction Between Paracetamol and Lamotrigine: A Clinical Interaction Study

Healthy

Denmark
Geropharm

Completed

Bioequivalence Study of Bosentan 125 mg Tablets Immediate Release (IR) Versus Tracleer® 125 mg Tablets IR In Healthy Subjects

Bioequivalence

Russian Federation
AstraZeneca
Bristol-Myers Squibb

Completed

To Compare the Similarity of a Combination Dapagliflozin/Metformin Tablet With the Two Drugs Administered Separately

Type 2 Diabetes Mellitus

United Kingdom
Universidade Federal Fluminense

Completed

Different Application Strategies When Using Ambar Universal in Class V Cavities (AUC)

Dental Restoration Failure of Marginal Integrity

Brazil
Hamad Medical Corporation

Not yet recruiting

Appropriateness of Carpal Tunnel Syndrome Management Compared With the AAOS Appropriate Use Criteria (CTS)

Carpal Tunnel Syndrome
Merck Sharp & Dohme LLC

Completed

Study of Epacadostat (INCB024360) Alone and In Combination With Pembrolizumab (MK-3475) With Chemotherapy and Pembrolizumab Without Chemotherapy in Participants With Advanced Solid Tumors (MK-3475-434)

Neoplasms | Carcinoma, Non-Small-Cell Lung
Pfizer

Completed

Study Of Palbociclib (PD-0332991) In Renal Impairment

Renal Impairment

United States
R-Pharm

Completed

A Randomized Phase 2 Study of Ixabepilone Plus Carboplatin and Paclitaxel Plus Carboplatin in Advanced Nonsmall-Cell Lung Cancer

Advanced/Metastatic Non-Small Cell Lung Cancer

Germany, Korea, Republic of, Russian Federation, Taiwan, Australia, Italy, France, United States, Argentina, Spain
Hospital General de México Dr. Eduardo Liceaga

Completed

Serum Insulin Response After Acute and Chronic Sucralose Ingestion in Healthy Volunteers With Variable Body Mass Index

Healthy
Hospices Civils de Lyon

Unknown

RIBAJUSTE Clinical Trial Investigating the Efficacy and Safety of Dose Adaptation of Ribavirin (RIBAJUSTE)

Chronic Hepatitis C

France
Eli Lilly and Company

Completed

A Study of Pemetrexed and Carboplatin/Cisplatin or Gemcitabine and Carboplatin/Cisplatin With or Without IMC-1121B in Participants Previously Untreated With Recurrent or Advanced Non-Small Cell Lung Cancer (NSCLC)

Carcinoma, Non-Small-Cell Lung

United States, Germany, Poland, Belgium, Canada, United Kingdom
Heidelberg University
Roche Pharma AG

Active, not recruiting

Gazyvaro and Low Dose Radiotherapy in Early Stage Follicular Lymphoma (GAZAI)

Stage II Grade 1 Follicular Lymphoma | Stage II Grade 2 Follicular Lymphoma | Stage I Follicular Lymphoma Grade 1 | Stage II Follicular Lymphoma Grade 2

Germany
Geropharm

Completed

Bioequivalence Study of Metformin 1000 mg Tablets Immediate Release (IR) Versus Glucophage® 1000 mg Tablets IR In Healthy Subjects

Bioequivalence

Russian Federation
AstraZeneca

Completed

Assessing the Pharmacokinetics of NKTR-118 in Subjects With Renal Impairment Compared to That in Subjects With Normal Renal Function

Renal Impairment

United States
AstraZeneca

Withdrawn

A Study in Healthy Subjects to Investigate Pharmacokinetics of AZD8683 When Administered in Different Ways

Healthy
Pfizer

Completed

A Study to Assess Safety, Tolerability and Pharmacokinetics of Ceftaroline in Healthy Subjects

Healthy Volunteers

United Kingdom

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