Search clinical trials for: Area Under Curve

Total 38816 results

Novartis Pharmaceuticals

Not yet recruiting

Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease

Rheumatoid Arthritis | Systemic Lupus Erythematosus | Sjögrens Disease
Radboud University Medical Center

Not yet recruiting

Model Informed preciSion doSIng tO iNdividualise and Optimize Pharmacotherapeutic Treatment (MISSION)

Pharmacokinetics | Tacrolimus | Area Under Curve | Immunosuppressive Agents | Mycophenolic Acid
Changhai Hospital

Not yet recruiting

DV Combined With PD-1 and Platinum-based First-line Treatment in Patients With HER2 IHC2+/3+ ESCC

HER-2 Protein Overexpression | Esophageal Squamous Carcinoma
University Hospital, Clermont-Ferrand

Recruiting

ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure (I-SWEAR)

Ultrasonography | Airway Extubation | Predictive Value of Tests | Critical Care | Ventilator Weaning | Echocardiography, Transthoracic | Mechanical Ventilator Weaning | Prospective Studies | Area Under Curve | Care Unit, Intensive | Sensitivity and Specificity | Logistic Models | Biomarkers / Blood

France
First Affiliated Hospital Xi'an Jiaotong University

Recruiting

Risk Factors of Chinese Kidney Transplant Recipients DSA Based on MPA Immunosuppressive Regimen

Kidney Transplant Recipients

China
MU-JHU CARE

Recruiting

BONE: STAR (Switching to TAF Based Anti-Retroviral Therapy) Study (BONE:STAR)

Bone Loss

Uganda
Dr. Negrin University Hospital

Active, not recruiting

Machine Learning Model to Predict Outcome and Duration of Mechanical Ventilation in Acute Hypoxemic Respiratory Failure (MEMORIAL)

Acute Hypoxemic Respiratory Failure

Spain
Dr. Negrin University Hospital
Cardiff University; Unity Health Toronto; Leiden University Medical Center

Completed

Prediction of Duration of Mechanical Ventilation in ARDS (PIONEER)

Acute Respiratory Distress Syndrome

Spain, United Kingdom
University Hospital, Basel, Switzerland

Completed

Probability of Optimal Target Attainment of Amikacin in Patients With Febrile Neutropenia During Treatment for a Hematological Disorder

Febrile Neutropenia (FN)

Switzerland
Prof. Franca Fagioli

Suspended

Qarziba for Patients in Relapsed/Refractory High-grade Osteosarcoma

Osteosarcoma in Children

Italy
Medical University of Warsaw
Human Biome Institute S.A.

Active, not recruiting

Effect of Fecal Microbiota Transfer on Progression of Parkinson Disease (EFFACE-PD)

Parkinson Disease

Poland
AstraZeneca

Completed

To Determine the Effect of Food on the Pharmacokinetics of Olaparib and the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet Formulation in Patients With Advanced Solid Tumours

Solid Tumours

Denmark, Belgium, United Kingdom, Netherlands
Merck Sharp & Dohme LLC

Completed

Study of Epacadostat (INCB024360) Alone and In Combination With Pembrolizumab (MK-3475) With Chemotherapy and Pembrolizumab Without Chemotherapy in Participants With Advanced Solid Tumors (MK-3475-434)

Neoplasms | Carcinoma, Non-Small-Cell Lung
Pfizer

Completed

Evaluation of the Relative Bioavailability of Bosutinib Capsules Under Fed Condition and Estimation of Food Effect on Orally Administered Bosutinib Capsule

Healthy Participants

Belgium
Pfizer

Completed

Bioavailability of Bosutinib Administered as Capsule Contents Mixed With Applesauce or Yogurt Relative to Intact Capsules Under Fed Condition

Healthy Participants

Belgium
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Safety, Tolerability, and Anti-HIV Activity of DMP 266 (Efavirenz) in Combination With Nelfinavir in HIV-Positive Children

HIV Infections

United States, Puerto Rico
Luxembourg Institute of Health
Université Catholique de Louvain; Laboratoires Réunis; Luxembourg Institute of...

Completed

Influence of Proteins on the Bioavailability of Carotenoids (CAROPROT)

Absorption; Chemicals | Healthy Diet | Metabolism

Luxembourg
CR-CSSS Champlain-Charles-Le Moyne

Completed

Vancomycin Dose Adjustments Comparing Trough Levels to The AUC/MIC Method Using a Bayesian Approach in a Hospitalized Adult Population (VancoDATABayes)

Adult | Vancomycin | Area Under Curve

Canada
R-Pharm

Completed

A Randomized Phase 2 Study of Ixabepilone Plus Carboplatin and Paclitaxel Plus Carboplatin in Advanced Nonsmall-Cell Lung Cancer

Advanced/Metastatic Non-Small Cell Lung Cancer

Germany, Korea, Republic of, Russian Federation, Taiwan, Australia, Italy, France, United States, Argentina, Spain
Peking University Third Hospital

Completed

Novel Method for Diagnosing Lateral Patellar Compression Syndrome Using X-ray: a Retrospective Case-Control Study

Lateral Patellar Compression Syndrome

China
Ultragenyx Pharmaceutical Inc

Completed

A Study to Assess Plasma Ammonia Time-Normalized Area Under the Curve and Rate of Ureagenesis in Healthy Adult Subjects

Ornithine Transcarbamylase Deficiency

United States
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Solid Tumours

France, United Kingdom, Czechia, Korea, Republic of, Netherlands
IVFarma LLC
NADIM LLC

Completed

The Safety and Pharmacokinetics of Primapur and Gonal-f

Pharmacokinetics | Absorption | Area Under Curve

Russian Federation
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of AZD9291 in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Solid Tumours

United States, Spain, Belgium, France, Korea, Republic of, United Kingdom
Millennium Pharmaceuticals, Inc.

Completed

Pharmacokinetics Study of Oral IXAZOMIB in Participants With Advanced Nonhematologic Malignancies or Lymphoma

Lymphoma | Nonhematologic Malignancies

United States
AstraZeneca

Completed

D081AC00001 Food Interaction With Olaparib Capsule in Patients With Solid Tumours

Solid Tumours

Belgium, United Kingdom, Netherlands
American British Cowdray Medical Center

Completed

Meta-Analysis of Stress Myocardial Perfusion Imaging

Coronary Disease | Magnetic Resonance Imaging | Predictive Value of Tests | Hemodynamics | Positron Emission Tomography | Echocardiography | Coronary Angiography | Multidetector Computed Tomography | Echocardiography, Stress | Fractional Flow Reserve, Myocardial | Myocardial Perfusion Imaging | Humans | Perfusion | Single Photon Emission Computed Tomography

Mexico
Charleston Laboratories, Inc

Completed

A Four-Period, Four-Treatment, Four-Way Relative Bioavailability Study of CL-108 Under Fed and Fasted Conditions

Healthy
Hospital de Clinicas de Porto Alegre
Federal University of Rio Grande do Sul; Coordenação de Aperfeiçoamento de...

Completed

Glycemic and Insulinemic Response With Different Sources of Soluble Fiber in Patients Type 2 Diabetes Mellitus

Diabetes Mellitus Type 2 | Dietary Modification | Insulin Tolerance | Diabetic Blood Glucose Monitoring

Brazil
University of Miami

Completed

Obesity/Overweight in Persons With Early and Chronic Spinal Cord Injury (SCI)

Overweight | Obese | Spinal Cord Injury

United States
AcelRx Pharmaceuticals, Inc.

Completed

Effect of Ketoconazole on Sufentanil NanoTab Pharmacokinetics

Pharmacokinetics

United States
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal or Impaired Kidney Function

Solid Tumours

Belgium, France, Netherlands, United Kingdom, Denmark
Cantonal Hospital of St. Gallen
University of Bern

Completed

Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients (FLOXTOX2)

Colorectal Cancer

Switzerland
AcelRx Pharmaceuticals, Inc.

Completed

Effect of Delivery Route on PK of Sufentanil NanoTab

Pharmacokinetics

United States
National Institute of Allergy and Infectious Diseases...

Terminated

Hormone Replacement Therapy and Anti-HIV Drugs in HIV-Infected, Postmenopausal Women

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Effects of Ribavirin on Zidovudine or Stavudine

HIV Infections | Hepatitis C

United States
Peking Union Medical College Hospital

Completed

The Normal Reference Values of Pulse Oximetry Plethymographic Waveform Parameters

Pulse Oximetry Plethymographic Waveform | Area Under Curve | Amplitude

China
Irmandade Santa Casa de Misericórdia de Porto Alegre
Novartis

Completed

A Prospective Study to Investigate Mycophenolic Acid (MPA) Exposure Through Area Under the Curve (AUC) in Renal Transplants Recipients Treated With Mycophenolate Mofetil (MMF) and After Conversion to Mycophenolate Sodium (EC-MPS) (AUC-MPA)

Renal Transplantation

Brazil
National Taiwan University Hospital

Completed

The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?

Methicillin-resistant Staphylococcus Aureus Septicemia

Taiwan
Northumbria University

Suspended

Effect of Timing of a Post-exercise Oral Glucose Tolerance Test on Glycaemic Control.

Area Under Curve [N06.850.520.830.200]

United Kingdom
National Institute of Allergy and Infectious Diseases...

Completed

Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities

HIV Infections | Hyperinsulinemia | Lipodystrophy

United States
Lundbeck LLC

Withdrawn

An Open-Label, Single and Multiple Oral Dose Pharmacokinetic Study of Vigabatrin in Infants With Infantile Spasms

Infantile Spasms
MedImmune LLC

Completed

A Study to Evaluate the Safety and Tolerability of Multiple Intravenous Doses of MEDI 545 in Patients With Systemic Lupus Erythematosus

Lupus

Brazil, United States, Chile, Argentina
University of Pittsburgh
American Society for Metabolic and Bariatric Surgery

Completed

The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors

Depression | Anxiety Disorder | Gastric Bypass

United States
University Hospital Freiburg
Novartis

Completed

Pharmacokinetics of Two Extended-Release Formulations of Methylphenidate in Children With Attention Deficit Hyperactivity Disorder (ADHD) (MPH-Kinetics)

Attention Deficit Hyperactivity Disorder

Germany
University Hospital, Limoges
Hoffmann-La Roche

Unknown

Concentration Controlled Versus Fixed Dose of MMF in Kidney Transplant Recipients

Kidney Transplant Recipients

France
Risk Factor Modification Centre
Canadian Institutes of Health Research (CIHR); Ontario Ginseng Growers Association

Completed

The Effect of American Ginseng Root and Its Components on Glycemia in Healthy Individuals

Hyperglycemia

Canada
Erasmus Medical Center
Massachusetts General Hospital; Universitaire Ziekenhuizen KU Leuven; University... and other collaborators

Recruiting

The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma (RECMAP)

Glioblastoma | Brain Neoplasms | Recurrent Glioblastoma | Recurrent Adult Brain Tumor | Glioblastoma, IDH-wildtype | Glioblastoma Multiforme of Brain | Brain Neoplasms, Adult, Malignant | Astrocytoma, Malignant | Brain Neoplasms, Adult

United States, Germany, Switzerland, Belgium, Netherlands
University Hospital, Bordeaux

Recruiting

Remote Programming of Cardiac Implantable Electronic Devices 2 (REACT 2)

Pacemaker | Defibrillator | Telemedecine

France
Innovaderm Research Inc.

Recruiting

Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects With Discoid Lupus Erythematosus

Discoid Lupus Erythematosus

Canada

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