Effect of Timing of a Post-exercise Oral Glucose Tolerance Test on Glycaemic Control.

August 28, 2014 updated by: Javier Gonzalez, PhD, Northumbria University

Postprandial glycaemic control is an important risk factor for the development of type 2 diabetes, cardiovascular disease and all-cause mortality.

Previous research has demonstrated that exercise performed in the postprandial state paradoxically results in a deterioration in glucose tolerance in the immediate post-exercise period (Gonzalez et a. 2013; Gonzalez and Stevenson 2013). This study aims to assess the timecourse of this post-exercise effect.

Study Overview

Status

Suspended

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

12

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
    • Tyne and Wear
      • Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 8ST
        • Northumbria University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Normal weight (18-25 kg/m2)
  • Physically active (>or= 3 times per week)
  • Male

Exclusion Criteria:

  • Contraindications to exercise
  • Food intolerances
  • Food allergies

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Rest
Breakfast followed by a rest period prior to OGTT.
Behavioral: Rest
Rest for 30 min
Experimental: Exercise-immediate
Breakfast followed by exercise and an immediate OGTT
Behavioral: Exercise
Exercise at 55% of maximum power output for 30 min.
Experimental: Exercise-delay
Breakfast followed by exercise and a delayed (1 h) OGTT.
Behavioral: Exercise
Exercise at 55% of maximum power output for 30 min.
Behavioral: Delay
Delay between exercise and OGTT

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Postprandial glucose concentration area under the curve
Time Frame: 90 min
Blood glucose concentrations will be sampled every 15 min following an oral glucose tolerance test.
90 min

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Postprandial insulin concentration area under the curve
Time Frame: 90 min
Insulin concentrations will be determine every 15 min following an oral glucose tolerance test.
90 min

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Northumbria University

Investigators

  • Principal Investigator: Javier T Gonzalez, PhD, Northumbria University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2016

Primary Completion (Anticipated)

February 1, 2017

Study Completion (Anticipated)

April 1, 2017

Study Registration Dates

First Submitted

November 13, 2013

First Submitted That Met QC Criteria

November 13, 2013

First Posted (Estimate)

November 19, 2013

Study Record Updates

Last Update Posted (Estimate)

August 29, 2014

Last Update Submitted That Met QC Criteria

August 28, 2014

Last Verified

August 1, 2014

More Information

Terms related to this study

Other Study ID Numbers

  • 32W7

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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