Search clinical trials for: Asfotase alfa

Total 10565 results

Alexion Pharmaceuticals, Inc.

Recruiting

Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa (CHESTNUT)

Hypophosphatasia

Australia, United States, Japan, Germany, Turkey, Italy, India, France, United Kingdom, Argentina, Canada
Alexion Pharmaceuticals, Inc.

Recruiting

Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa (HICKORY)

Hypophosphatasia

Italy, Spain, Israel, Korea, Republic of, Belgium, Germany, United States, China, France, Taiwan, Austria, Japan, India, Australia, Argentina, Poland, Turkey, Brazil, Canada, Thailand, United Kingdom, Slovakia, Czechia
Alexion Pharmaceuticals, Inc.

Not yet recruiting

Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia (RESTORE)

Hypophosphatasia
Alexion

Recruiting

A Prospective Sub-Study of the Global Hypophosphatasia Registry

Hypophosphatasia

United States
Alexion Pharmaceuticals, Inc.
Xcenda, LLC

Active, not recruiting

Patient Reported Outcomes in Adults With Pediatric-onset Hypophosphatasia Treated With Strensiq® (Asfotase Alfa)

Hypophosphatasia

United States
Dr. Lothar Seefried
Alexion Pharmaceuticals

Completed

Evaluate and Monitor Physical Performance of Adults Treated With Asfotase Alfa for Hypophosphatasia (EmPATHY)

Hypophosphatasia

Germany
Alexion Pharmaceuticals

Withdrawn

Relieving Burden of Hypophosphatasia in Adults With Functional Impairment Due to Chronic Disease (REBUILD)

Hypophosphatasia
Alexion Pharmaceuticals

Completed

Pharmacokinetic and Dose Response Study of Asfotase Alfa in Adult Patients With Pediatric-Onset Hypophosphatasia (HPP)

Hypophosphatasia

United States, Germany
Alexion Pharmaceuticals

Completed

Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada, United Arab Emirates, United Kingdom
Alexion Pharmaceuticals

Completed

Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
Alexion Pharmaceuticals

Completed

Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
Alexion Pharmaceuticals

Approved for marketing

Expanded Access Program for Asfotase Alfa Treatment for Patients With Infantile- or Juvenile-onset Hypophosphatasia (HPP)

Hypophosphatasia

United States, France
Alexion Pharmaceuticals

Completed

Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)

Hypophosphatasia

United States, Spain, Australia, United Kingdom, Italy, France, Canada, Germany, Japan, Russian Federation, Saudi Arabia, Turkey
Alexion Pharmaceuticals

Completed

Safety and Efficacy Study of Asfotase Alfa in Adolescents and Adults With Hypophosphatasia (HPP)

Hypophosphatasia

United States, Canada
Alexion Pharmaceuticals

Completed

Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP)

Hypophosphatasia

United States, United Arab Emirates, United Kingdom
Alexion Pharmaceuticals

Completed

Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
GlaxoSmithKline

Completed

Fracture Risk With Thiazolidinediones

Fractures, Bone | Type II Diabetes
Alexion Pharmaceuticals

Completed

Post-approval Clinical Study of Asfotase Alfa Treatment for Patients With Hypophosphatasia (HPP) in Japan

Hypophosphatasia
Translational Research Center for Medical Innovation...
Osaka University Graduate School of Medicine

Completed

Safety and Efficacy of Asfotase Alfa in Patients With Hypophosphatasia (HPP)

Hypophosphatasia

Japan
Aretaieion University Hospital

Recruiting

Opioid-based Versus Opioid-free Endotracheal Intubation

Anesthesia | Opioid Use | Fentanyl | Analgesic Non-narcotic | Anesthesia Intubation

Greece
Egymedicalpedia

Recruiting

Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation

Valvular Cardiac Surgeries

Egypt
Gazi University

Not yet recruiting

Health Literacy's Impact on Exercise Habits and Medication Adherence in Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal
First Affiliated Hospital of Zhejiang University
The Second Hospital of Hebei Medical University; Shenzhen Second People's Hospital and other collaborators

Not yet recruiting

Dobutamine for Management of Surgical Patients With Septic Shock

General Anesthesia | Surgical Patients | Patients With Septic Shock
Takeda

Recruiting

A Survey of Susoctocog Alfa (Genetical Recombination) in Participants With Acquired Haemophilia A

Acquired Hemophilia A

Japan
Aveiro University
Fundação para a Ciência e a Tecnologia

Not yet recruiting

Shedding Light on a Forgotten Workforce: Loved Ones of People With Chronic Respiratory Diseases

Chronic Respiratory Disease

Portugal
Istanbul University

Not yet recruiting

Intraosseous Local Anesthesia System in Children With Molar Incisor Hypomineralization

Molar Incisor Hypomineralization | Intraosseous Anesthesia

Turkey
Beijing 302 Hospital

Recruiting

Sequential Combination Therapy With PD-1 Antibody and Peg-IFNα in CHB Patients

Chronic Hepatitis B

China
Amin Javer

Not yet recruiting

Bupivacaine and Epinephrine Injection Study

Bleeding | Anesthesia | Sinus Disease
Vanderbilt University Medical Center
National Institute of Mental Health (NIMH)

Not yet recruiting

Text-messaging Intervention to Support Parents After Their Child's Psychiatric Emergency (iPEACE)

Parents | Self Efficacy | Psychiatric Emergency | Mental Health Literacy
Anastasia Vishnevetsky, MD, MPH
argenx

Not yet recruiting

Efgartigimod for the Treatment of Acute Optic Neuritis (PET-AON)

Optic Neuritis

United States
Kasr El Aini Hospital

Recruiting

Dexmedetomidine as an Adjuvant to Bupivacaine in Bilateral PECs for Pain Control After Cardiac Surgeries (PECs)

Post Operative Pain

Egypt
University of Aarhus
Aarhus University Hospital; University of Copenhagen; Gødstrup Hospital; Statens... and other collaborators

Not yet recruiting

The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial (BEGIN)

Healthy | Healthy Nutrition
Boston Children's Hospital

Not yet recruiting

Lidocaine Versus Bupivacaine in Orthognathic Surgery

Pain, Postoperative | Numbness | Temperature Sensation | Perception of Touch
Westlake Eye Specialists
Sengi

Recruiting

Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost

Normal Tension Glaucoma

United States
Chinese University of Hong Kong
University of Palermo; University of Malaya; Singapore General Hospital; University... and other collaborators

Not yet recruiting

Non-selective Beta-blocker in Compensated Advanced Chronic Liver Disease (BB_cACLD)

Portal Hypertension | Advanced Chronic Liver Disease | Hepatic Decompensation
University of Maryland, Baltimore

Not yet recruiting

Effect of RECK in Posterior Spinal Fusion

Degenerative Disc Disease | Degenerative Spondylolisthesis | Degenerative Lumbar Spinal Stenosis | Degenerative Disease

United States
University of Milan
Kolfarma s.r.l. - Italy; Fondazione Telethon

Recruiting

Targeting the Gut to Improve Seizure Control in CDKL5 Deficiency Disorder (CDD) (NUTRIENT)

CDKL5

Italy
Merck Sharp & Dohme LLC

Not yet recruiting

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

Esophageal Cancer | Esophageal Neoplasms | Gastroesophageal Adenocarcinoma | Gastroesophageal Junction
Dr. George Luciuk

Recruiting

Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral Challenges

Hypersensitivity | Anaphylaxis

Canada
Jun Tao

Recruiting

α-ketoglutarate in Patients With Hypertension (AKGHTN)

Hypertension

China
Alcon Research

Not yet recruiting

A Double-Masked Comparison of FID 123320 Ophthalmic Solution to Vehicle for the Reduction of Ocular Redness

Ocular Redness

United States
Osaka University
Japan Agency for Medical Research and Development

Recruiting

Clinical Trial of Targeted Alpha Therapy for Prostate Cancer (Alpha-PS1)

Prostate Cancer

Japan
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation

Thyroid Gland Follicular Carcinoma | Thyroid Gland Papillary Carcinoma | Thyroid Gland Oncocytic Carcinoma

United States
Yale-NUS College

Recruiting

Taylor Swift and Mental Health Outcomes

Stress | Depression, Anxiety | Psych | Social Stigma

Singapore
San Diego State University

Recruiting

Camp SMART Speech to Print Summer Literacy Camp

Reading Disorder, Developmental

United States
Massachusetts General Hospital
Patient-Centered Outcomes Research Institute

Not yet recruiting

Sequential Multiple Assignment Randomized Trial for Bipolar Depression (SMART-BD)

Depression | Bipolar I Disorder

United States, Canada
Post Graduate Institute of Medical Education and...
Indian Council of Medical Research

Not yet recruiting

Carvedilol + Simvastatin vs. Carvedilol Alone for Chronic Liver Disease and Cirrhotic Cardiomyopathy and Its Impact on Hepatic Decompensation and Survival; a Double-blind Randomized Controlled Trial (CIRROSTAT)

Decompensated Cirrhosis | Acute Kidney Injury | Cirrhosis, Liver | Left Ventricular Diastolic Dysfunction | Cirrhotic Cardiomyopathy
Washington University School of Medicine

Recruiting

Local Anesthesia for Facial Fractures (LAFF)

Pain Management

United States
Auburn University
National Institute on Drug Abuse (NIDA); Wayne State University

Not yet recruiting

Cannabinoids and Biological Reactivity to Stress (COBRAS)

Cannabis Use Disorder
Zhongshan Hospital Xiamen University

Not yet recruiting

Efficacy of Self vs. Physician Application of Triamcinolone-Econazole in Otomycosis

Otomycosis

China

Search clinical trials for: Asfotase alfa

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