Search clinical trials for: CABG surgery requiring CPB and at increased risk of bleeding and blood transfusion

Total 494500 results

Bayer

No longer available

Aprotinin US Special Access Protocol

Postoperative Hemorrhage

United States
Ulrik Sartipy, MD, PhD
Karolinska Institutet

Active, not recruiting

HeAlth-data Register sTudies of Risk and Outcomes in Cardiac Surgery (HARTROCS)

Depression | Cardiovascular Diseases | Kidney Diseases | Diabetes Mellitus
University Hospital, Bordeaux

Completed

AProtinin Versus Tranexamic Acid in Cardiac Surgery Patients With High-risk for Excessive Bleeding (APACHE)

Cardiac Surgery | Cardiopulmonary Bypass | High Risk Bleeding

France
Cedars-Sinai Medical Center

Withdrawn

Platelet Function Testing Help and Intraoperative Bleeding Risk for Patients Who Are on Plavix Prior to Surgery

Perioperative Bleeding

United States
University Hospital, Montpellier

Completed

SvO2 Trigger in Transfusion Strategy After Cardiac Surgery (ReTSEACS)

Undergoing Nonemergent Cardiac Surgery | Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure) | Anemia (<9g/dL) Requiring Blood Transfusion | Hemodynamic and Respiratory Stability | Bleeding Graded as Insignificant, Mild, Moderate of Universal Definition of Perioperative...

France
Novo Nordisk A/S

Completed

Multi-national Study Investigating the Effect and Safety of rFXIII on Transfusion Needs in Patients Undergoing Heart Surgery

Acquired Bleeding Disorder | Cardiac Surgery Requiring Cardiopulmonary Bypass

United States, Israel, Germany, Canada, Sweden, United Kingdom, Spain, Italy, Denmark, Japan
University of Copenhagen
Plandent A/S

Not yet recruiting

A Danish Nationwide Longitudinal Study on Prevalence of Periodontitis and Its Co-morbidities (PlanPerioMed)

Cardiovascular Diseases | Diabetes Mellitus, Type 2 | Rheumatoid Arthritis | Periodontitis
John Paul II Hospital, Krakow

Recruiting

Simultaneous Cardiac Surgery and Micronet-covered Stent Carotid Revascularization in High Perioperative Stroke Risk Patients (SIM-GUARD)

Myocardial Infarction | Coronary Artery Disease | Carotid Stenosis | Valvular Heart Disease | Pulmonary Edema With Heart Failure

Poland
Sahlgrenska University Hospital, Sweden

Recruiting

Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery

Congenital Heart Disease

Sweden
Children's Hospital Medical Center, Cincinnati
Indiana University; Mallinckrodt

Recruiting

NO During CPB in Neonates to Reduce Risk of AKI

AKI | Surgery | CHD - Congenital Heart Disease

United States
Rush University Medical Center

Recruiting

Single Versus Multi-Dose Oral and Intravenous Tranexamic Acid Patients at High Risk for Blood Transfusion After Spine Surgery

Open Posterior Thoracolumbar Spinal Fusion Procedure

United States
Turku University Hospital
Vifor Pharma

Recruiting

Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Surgery (PREFER-CABG)

Coronary Artery Disease | Postoperative Complications | Aortic Valve Stenosis | Aortic Aneurysm, Thoracic | Mitral Valve Disease

Finland
Laval University
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie...

Recruiting

Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery

Obesity | Cardiopulmonary Bypass

Canada
University of Colorado, Denver

Recruiting

Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass

Cardiac Disease | Bleeding Postoperative

United States
Abiomed Inc.

Enrolling by invitation

IMpella-Protected cArdiaC Surgery Trial (IMPACT) (IMPACT)

Left Ventricular Dysfunction

United States
Pfizer

Active, not recruiting

Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B

Hemophilia A | Hemophilia B

United States, Spain, Canada, China, Korea, Republic of, Hong Kong, Serbia, Taiwan, Turkey, France, Oman, Saudi Arabia, Japan, India, South Africa, Mexico, Croatia, Italy, Bulgaria, Russian Federation
Indonesia University

Completed

Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery

Coronary Artery Disease | Valvular Heart Disease | Surgical Blood Loss

Indonesia
Nantes University Hospital

Completed

Performance Evaluation of Von Willebrand:Collagen-Binding Assays to Diagnose Von Willebrand Factor Deficiency in Patients With Increased Risk of Bleeding (PERICOLL)

Von Willebrand Disease

France
Catalyst Biosciences

Terminated

Study of Coagulation Factor VIIa Marzeptacog Alfa (Activated) in Subjects With Inherited Bleeding Disorders

Factor VII Deficiency | Hemophilia A With Inhibitor | Glanzmann Thrombasthenia

United States, India, Italy, Russian Federation, Ukraine
IRCCS Policlinico S. Donato

Terminated

ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery (ZEPLAST-PED)

Bleeding | Surgery--Complications | Congenital Heart Disease | Transfusion-Related Acute Lung Injury | Cardiac Defect | Fibrinogenopenia; Acquired | Transfusion-Associated Circulatory Overload

Italy
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Completed

BAX 855 Continuation

Hemophilia A

United States, Spain, Netherlands, Australia, Czechia, Korea, Republic of, Taiwan, Poland, Bulgaria, United Kingdom, Germany, Turkey, Israel, Malaysia, Ukraine, Russian Federation, Austria, Switzerland, Japan, Hong Kong, Lithuania, Roman... and more
Baxalta now part of Shire

Completed

Study Investigating a PEGylated Recombinant Factor VIII (BAX 855) for Hemophilia A (PROLONG-ATE Study)

Hemophilia A

United States, Spain, Netherlands, Australia, Czechia, Korea, Republic of, Poland, Germany, Taiwan, Israel, Ukraine, United Kingdom, Malaysia, Japan, Austria, Switzerland, Sweden, Bulgaria, Lithuania, Romania
Baxalta now part of Shire

Completed

Recombinant Factor VIIa BI (rFVIIa BI) Treatment of Acute Bleeding Episodes Per an On-demand Regimen

Hemophilia A | Hemophilia B

Japan, Russian Federation, Spain, United States, Poland, Romania, Serbia, Taiwan, Ukraine
Nova Scotia Health Authority

Completed

Prospective Double Blinded Randomized Control Study of the Use of Fibrinogen in High-Risk Cardiac Surgery

Cardiac Complication During Procedure

Canada
Novo Nordisk A/S

Terminated

Use of Activated Recombinant Human Factor VII in Cardiac Surgery

Acquired Bleeding Disorder | Cardiac Surgery Requiring Cardiopulmonary Bypass

United States, Spain, Germany, Sweden, United Kingdom, Argentina, Italy, Brazil, Denmark, France, India, Malaysia, Singapore, South Africa
Novo Nordisk A/S

Completed

Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease

Acquired Bleeding Disorder | Cardiac Surgery Requiring Cardiopulmonary Bypass

Australia
Scios, Inc.

Withdrawn

An Efficacy and Safety Study for Nesiritide in Heart Failure Patients With Reduced Kidney Function Undergoing Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass (CPB Pump or Heart Lung Machine)

Coronary Heart Disease | Ischemic Heart Disease | Cardiopulmonary Bypass | Heart Failure, Congestive | Coronary Artery Bypass Surgery | Coronary Artery Bypass Grafting
GlaxoSmithKline
Sanofi

Completed

A Study to Evaluate the Efficacy and Safety of Fondaparinux Sodium When Used With Intermittent Pneumatic Compression to Prevent Venous Thromboembolic (IPC) Versus IPC Alone for the Prevention of Venous Thromboembolic Events in Subjects at Increased Risk Undergoing Major Abdominal Surgery (APOLLO).

Thromboembolism
Rigshospitalet, Denmark
Danish Heart Foundation

Completed

Perfusion Pressure Cerebral Infarction Trial (PPCI) (PPCI)

Postoperative Cognitive Dysfunction | Embolic Stroke

Denmark
Samsung Medical Center

Completed

The Predictability of Intraoperative Rotational Thromboelastometry on Postoperative Bleeding and Transfusion Requirements

Pediatric Patients | Surgery for Congenital Heart Disease

Korea, Republic of
Cubist Pharmaceuticals LLC

Completed

Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery (CONSERV-2)

Surgical Procedures, Operative | Bloodloss

Germany, Poland, United States
US Department of Veterans Affairs

Completed

Does Prophylactic Coronary Artery Revascularization for High Risk Patients Reduce Long-term Risk of Mortality (CARP)

Cardiovascular Disease

United States
Hospital Universitari Vall d'Hebron Research Institute
Hospital Clinic of Barcelona; Hospital Universitari de Bellvitge; Hospital Vall... and other collaborators

Completed

Multicenter, Randomized Placebo-controlled Clinical Trial to Evaluate the Effect of Perioperative Use of Tranexamic Acid on Transfusion Requirements and Surgical Bleeding in Major Spine Surgery

Hemorrhage | Blood Transfusion | Spinal Fusion | Antifibrinolytic Agents

Spain
Green Cross Corporation
Atlantic Research Group

Unknown

Safety, Efficacy and Pharmacokinetics of GreenGene™ F to Previously Treated Patients With Severe Hemophilia A

Hemophilia A

United States, Canada, New Zealand, Poland, Russian Federation, Ukraine, United Kingdom
Massachusetts General Hospital
National Heart, Lung, and Blood Institute (NHLBI); Transfusion Medicine/Hemostasis...

Withdrawn

Fresh-Frozen Plasma Infusions to Reduce Risk of Bleeding Related to Invasive Procedures

Blood Coagulation Disorders

United States
City Hospital No 40, Saint Petersburg, Russia

Withdrawn

Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy (CSWTSPB40)

Coronary Heart Disease (CHD)
Medical University of Silesia

Completed

Clinical Effects of Eptifibatide Administration in High Risk Patients Presenting With Non-ST Segment Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Urgent Coronary Artery Bypass Graft Surgery in Short- and Long-Term Follow-up

Non ST Elevation Myocardial Infarction

United States, Poland
Baylor Research Institute

Completed

Comparing Blood Loss, RBC Transfusions and Inflammatory Marker Changes Among Methods of CPB

Coronary Artery Disease

United States
Alcon Research

Completed

Circadian Ocular Perfusion Pressure and Ocular Blood Flow

Glaucoma

United States
University of L'Aquila
TRIB s.r.l.

Completed

Treatment of Inherited Factor VII Deficiency (STER)

Factor VII Deficiency

Italy
Tribhuvan University Teaching Hospital, Institute...
Pfizer

Unknown

Study of Tranexamic Acid for Reducing Blood Requirement in Patients Undergoing Major Gastro-intestinal Surgery (TMGS)

Gastric Cancer | Pancreatic Cancer | Colon Cancer | Hepatocellular Cancer

Nepal
Cardiochirurgia E.H.

Terminated

Blood Sparing Strategies: Omni-stat Routinary Use in Cardiac Surgery. A Prospective Randomized Study.

Hemostasis

Italy
Icahn School of Medicine at Mount Sinai
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

The Epidemiology of Bleeding and Clotting in Patients Undergoing Heart Transplantation, Coronary Artery Bypass Graft Surgery,or Implantation of Left Ventricular Assist Devices

Congestive Heart Failure

United States
Octapharma

Not yet recruiting

Post Marketing Observational Study on Safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure

Significant Bleeding Risk | Vitamin K-Dependent Coagulation Defect
Peking University Third Hospital
Peking University; The First Affiliated Hospital of Anhui Medical University; First Affiliated Hospital, Sun Yat-Sen University and other collaborators

Recruiting

Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC)

Pre-Eclampsia | High Risk Pregnancy | Twin Pregnancy, Antepartum Condition or Complication | Pre-Term | Twin Dichorionic Diamniotic Placenta | Twin to Twin Transfusion as Antepartum Condition | Twin Placenta | Twin Monochorionic Diamniotic Placenta

China
University of Manchester

Not yet recruiting

Use of CPETarm for Risk Stratification of Patients With CLTI

Surgery-Complications | Chronic Limb-Threatening Ischemia

United Kingdom
Weill Medical College of Cornell University
Patient-Centered Outcomes Research Institute; Icahn School of Medicine at Mount...

Not yet recruiting

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial (RECHARGE:M)

Coronary Artery Disease
Weill Medical College of Cornell University
Patient-Centered Outcomes Research Institute; Icahn School of Medicine at Mount...

Not yet recruiting

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women (RECHARGE:W)

Coronary Artery Disease

United States
Eli Lilly and Company

Recruiting

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Overweight and Obesity

United States, Australia, Italy, Hungary, Spain, Canada, Germany, Argentina, Belgium, Czechia, Greece, Israel, Austria, Brazil, Mexico, Netherlands, Romania, India, United Kingdom, Slovakia, Poland, Turkey, Puerto Rico, France, Denmark
Schulthess Klinik

Not yet recruiting

Impact of Patient Blood Management (PBM) at the Schulthess Clinic (PBM)

Patient Blood Management

Search clinical trials for: CABG surgery requiring CPB and at increased risk of bleeding and blood transfusion

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Burkina Faso

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations