Search clinical trials for: Calcineurine free

Total 9791 results

Instituto Nacional de Cancer, Brazil

Recruiting

PTCy and ATG for MSD and MUD Transplants

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Hodgkin Lymphoma | Acute Lymphoblastic Leukemia | Non-hodgkin Lymphoma

Brazil
Sanofi

Recruiting

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor (AQUA)

Dermatitis Atopic

Argentina, Chile, Germany, Japan, Spain, United Kingdom, Canada, United States, Brazil, France, Turkey, Israel, Korea, Republic of, China
Sanofi

Recruiting

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis on Background Topical Corticosteroids (SHORE)

Dermatitis Atopic

Japan, Chile, Canada, Argentina, Brazil, France, United States, Turkey, China
Sanofi

Recruiting

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis (COAST 1)

Dermatitis Atopic

Israel, Chile, Australia, United States, France, Canada, Germany, Korea, Republic of, Taiwan, China
Sanofi

Recruiting

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials (RIVER-AD)

Dermatitis Atopic

Canada, United States, Australia, Bulgaria, Czechia, Germany, Hungary, Japan, Poland, Spain, Taiwan, United Kingdom
CareDx

Not yet recruiting

HeartCare Immuno-optimization in Cardiac Allografts (MOSAIC) (MOSAIC)

Immunosuppression | Allograft | Heart Transplant
Sanofi

Recruiting

BIVV020 (SAR445088) n Prevention and Treatment of Antibody-mediated Rejection (AMR)

Transplant Rejection

Germany, Italy, Spain, United States, Canada, France, Sweden
The First Affiliated Hospital of Soochow University

Not yet recruiting

Outcomes of Patients After Allo-HSCT With Decitabine and NAC

GVHD | Relapse | Engraft Failure
University of Birmingham
IMPACT (funded by NHS Blood & Transplant, Anthony Nolan and Leukaemia UK)

Recruiting

Methods of T Cell Depletion Trial (MoTD) (MoTD)

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Multiple Myeloma | Hodgkin Lymphoma | Myelofibrosis | Chronic Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Non Hodgkin Lymphoma | Chronic Myelogenous Leukemia

United Kingdom
National Science Centre, Poland
Medical University of Warsaw

Recruiting

The New LC-MS/MS Method for Determination of Unbound Tacrolimus in Plasma (FreeTAC)

Kidney Transplant Rejection | Liver Transplant; Complications | Immunosuppression | Metabolism Medication Toxicity | Genetic Predisposition | Kidney Transplant; Complications | Liver Transplant Rejection

Poland
Southern Medical University, China
First Affiliated Hospital, Sun Yat-Sen University; Nanfang Hospital of Southern...

Not yet recruiting

Sirolimus-based Immunosuppression Treatment Regimen for Liver Transplantation

Liver Transplantation

China
King's College London
King's College Hospital NHS Trust; National Institute for Health Research,...

Terminated

Liver Immunosuppression Free Trial (LIFT)

Transplantation, Liver

United Kingdom
Boston Children's Hospital
Massachusetts General Hospital; Mayo Clinic; Karolinska University Hospital; Baylor... and other collaborators

Active, not recruiting

Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita

Aplastic Anemia | Dyskeratosis Congenita | Hoyeraal Hreidarsson Syndrome | Revesz Syndrome

United States, Norway, Sweden
Vishal Jhanji
Sun Pharmaceutical Industries Limited

Withdrawn

Tear Film Markers in Dry Eye Syndrome

Dry Eye

United States
Novartis Pharmaceuticals

Completed

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension (CONTRAIL I)

Liver Transplant Rejection

United States, Belgium, Germany, Spain, Argentina, Netherlands, Italy, Hungary, France, Czechia
Masonic Cancer Center, University of Minnesota

Completed

Allo HSCT Using RIC for Hematological Diseases

Follicular Lymphoma | Myelodysplastic Syndromes | Multiple Myeloma | Non-Hodgkin's Lymphoma | Lymphoblastic Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia | Mantle-Cell Lymphoma | Chronic Myelogenous Leukemia | Prolymphocytic Leukemia and other conditions

United States
CareDx

Withdrawn

KidneyCare Immuno-optimization in Renal Allografts (KIRA)

Immunosuppression | Kidney Transplant | Allograft
AstraZeneca
Parexel

Completed

Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy Volunteers

Chronic Kidney Disease

Germany
National Heart, Lung, and Blood Institute (NHLBI)
National Cancer Institute (NCI); Blood and Marrow Transplant Clinical Trials...

Completed

Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

Acute Leukemia | Myelodysplasia

United States
Novartis Pharmaceuticals

Completed

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients (CIRRUS I)

Kidney Transplant Rejection

United States, Hungary, Japan, United Kingdom, Belgium, Spain, Netherlands, Germany, Australia, France, Korea, Republic of, Switzerland, Norway, Italy, Latvia, Sweden, Argentina, Brazil, Canada, Czechia
University Medical Center Groningen
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Leiden University...

Completed

Steroid Free Immunosuppression or Calcineurin Inhibitor Minimization After Basiliximab Induction Therapy in Kidney Transplantation: Comparison With a Standard Quadruple Immunosuppressive Regimen (Allegro)

Renal Insufficiency | Kidney Transplantation

Netherlands
M.D. Anderson Cancer Center
Sanofi

Completed

Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Leukemia | Transplantation Infection | Disorder Related to Bone Marrow Transplantation

United States
Masonic Cancer Center, University of Minnesota

Terminated

Busulfan and Cyclophosphamide Followed By ALLO BMT

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome

United States
National Institute of Allergy and Infectious Diseases...
Clinical Trials in Organ Transplantation

Terminated

Open-Label Phase 2 Trial of a Steroid-Free, CNI-Free, Belatacept-Based Immunosuppressive Regimen

Kidney Transplantation | Primary Renal Allograft Candidate

United States
University of Oxford
Novartis; Pfizer; National Health Service, United Kingdom

Completed

Campath, Calcineurin Inhibitor Reduction and Chronic Allograft Nephropathy (3C)

Kidney Transplantation

United Kingdom
Astellas Pharma Europe Ltd.

Completed

Study to Ascertain if Prolonged Release Tacrolimus (FK506E - MR4) is Safe and Effective When Used in the Long Term and in Combination With Other Immunosuppressive Drugs in Patients Who Have Received a Transplant

Liver Transplantation | Kidney Transplantation | Heart Transplantation

Spain, Australia, France, Germany, Canada, Italy, United Kingdom, Belgium, South Africa, Switzerland, Sweden, United States, Austria, Brazil, Czechia, Denmark, Finland, Hungary, Ireland, Mexico, Netherlands, New Zealand, Poland
Centre Hospitalier Universitaire, Amiens
Novartis

Unknown

Comparison of Efficacy and Safety of Treatment With a Calcineurin Inhibitor (CNI)Versus a CNI-free Treatment in Renal Transplantation (CIME) (CIME)

Kidney Failure

France
Novartis

Completed

Everolimus in a Cyclosporine Microemulsion-free Regimen Compared to a Low-dose Cyclosporine Microemulsion Regimen, in de Novo Kidney Transplant Patients (CERTES02)

Organ Transplantation, Renal Transplantation
Novartis Pharmaceuticals

Completed

A Study Investigating the Renal Tolerability, Efficacy, and Safety of a CNI-free Versus a Standard Regimen in de Novo Heart Transplant (HTx) Recipients (MANDELA)

Heart Transplantation

Germany
National Institute of Allergy and Infectious Diseases...
Clinical Trials in Organ Transplantation

Terminated

Optimization of NULOJIX® Usage As A Means of Avoiding CNI and Steroids in Renal Transplantation

Kidney Transplantation | Renal Transplantation

United States
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Evolution of Cardiovascular Parameters in Renal Transplant Recipients (ELEVATE)

Kidney Transplantation

Germany, Belgium, Netherlands, Australia, Austria, Italy, Spain, Thailand, Estonia, Norway, Lithuania, Turkey, Mexico, Argentina, Greece, Russian Federation, Portugal, France, India, Latvia, Romania
Massachusetts General Hospital

Completed

Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Graft Versus Host Disease | Myelodysplastic/Myeloproliferative Neoplasms

United States
Novartis Pharmaceuticals

Completed

Study Investigating a Standard Regimen in de Novo Kidney Transplant Patients Versus a Calcineurin Inhibitor (CNI)-Free Regimen and a CNI-low Dose Regimen

Kidney Transplantation

Germany, Switzerland
National Institute of Allergy and Infectious Diseases...
Hoffmann-La Roche; Astellas Pharma Inc

Completed

Steroid-Free Versus Steroid-Based Immunosuppression in Pediatric Renal (Kidney) Transplantation

Kidney Diseases | Kidney Transplantation | Renal Transplant | Renal Transplantation | Kidney Transplant

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Multiple Myeloma | Plasma Cell Neoplasm | Myeloproliferative Neoplasms

United States
Seoul National University Hospital

Completed

Efficacy of Sirolimus In Liver Transplantation for Hepatocellular Carcinoma (HCC) (Sirolimus)

Hepatocellular Carcinoma

Korea, Republic of
Novartis Pharmaceuticals

Completed

24 Months Follow-up, Two Arm Study to Compare the Cardiovascular Profile in a Regimen With Everolimus + Mycophenolic Acid (MPA) Versus (vs.) a Regimen of CNI+MPA in Maintenance Renal Transplant Recipients (EVITA)

Renal Transplant

Spain
Northwestern University
Roche Pharma AG

Terminated

A Trial of Two Steroid-Free Approaches Toward Mycophenolate Mofetil-Based Monotherapy Immunosuppression (Cell220)

Kidney Transplant Failure and Rejection

United States
Karolinska Institutet

Completed

Randomized Trial Comparing Sirolimus and Tacrolimus Versus Cyclosporine and Methotrexate as Graft-versus-host Disease (GVHD) Prophylaxis After Allogeneic Stem Cell Transplantation

Survival | Graft-versus-host Disease

Sweden
University of Cincinnati
Roche Pharma AG

Completed

Pilot Study for HLA Identical Living Donor Renal Transplant Recipients

Renal Transplant

United States
University Hospital Freiburg
Roche Pharma AG; Genzyme, a Sanofi Company; Astellas Pharma GmbH

Completed

Phase IV Study to Evaluate Calcineurin Inhibitor Reduced, Steroid Free Immunosuppression After Renal Transplantation (Harmony)

Disorder Related to Renal Transplantation

Germany
Novartis Pharmaceuticals

Terminated

Comparison of CNI-based Regimen Versus CNI-free Regimen in Kidney Transplant Recipients.

Renal Transplantation

Germany
NeuroVive Pharmaceutical AB

Completed

A Study to Compare the Bioavailability and Pharmacokinetics of Cyclosporine After Intravenous Administration of NEUROSTAT®, a CREMOPHOR® EL-free Lipid Emulsion, and SANDIMMUNE® Injection (a Suspension of Cyclosporine in CREMOPHOR® EL) in Healthy Volunteers

Healthy

South Africa
University of Regensburg

Completed

Immunosuppression in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma

Hepatocellular Carcinoma

Germany
Novartis Pharmaceuticals

Completed

Pharmacodynamics, Efficacy and Safety of Basiliximab 40 or 80 mg in Combination With Ciclosporine Microemulsion or Everolimus, in Adult Low Risk de Novo Renal Transplant Recipients (IDEALE Study) (IDEALE)

Renal Transplantation

France
National Institute of Allergy and Infectious Diseases...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

No longer available

B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft Failure

Type 1 Diabetes Mellitus

United States
Bristol-Myers Squibb

Completed

A Phase II Study of Belatacept (BMS-224818) With a Steroid-free Regimen in Subjects Undergoing Kidney Transplantation

Disorder Related to Renal Transplantation

Italy, United States, Spain
Novartis

Completed

Efficacy and Safety of Everolimus With Enteric-Coated Mycophenolate Sodium (EC-MPS) in a Cyclosporine Microemulsion-free Regimen Compared to Standard Therapy in de Novo Renal Transplant Patients

Renal Transplantation

Switzerland, Germany
National Institute of Diabetes and Digestive and...

Completed

Combination Drug Therapy Followed by Single Drug Steroid Free Therapy to Prevent Organ Rejection in Kidney Transplantation

Kidney Transplantation

United States
Thomas Jefferson University
Novartis Pharmaceuticals

Completed

Steroid Free Immunosuppression in Liver Transplantation

Liver Cirrhosis | Liver Transplant Disorder

United States

Search clinical trials for: Calcineurine free

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