Search clinical trials for: Carriers

Total 192 results

Anhui Medical University

Not yet recruiting

Establishment of Reproductive Cohort and Prediction Model of Genetic Counseling for Mitochondrial Genetic Diseases

Mitochondrial Diseases
Shanghai University of Traditional Chinese Medicine
Shanghai Minimally Invasive Surgery Center

Not yet recruiting

Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers

Cognitive Impairment | Alzheimer Disease

China
Assistance Publique - Hôpitaux de Paris
Centre Leon Berard; Institut National de la Santé Et de la Recherche Médicale... and other collaborators

Not yet recruiting

Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers (PGLEXPO2)

Environmental Exposure | SDH Gene Mutation | SDH-Related Familial Paraganglioma | SDHx-Related Syndromes

France
Azienda Ospedaliero-Universitaria di Modena

Recruiting

Assessing Clinical Features and Outcome of Breast Cancer in PALB2 Mutation Carriers: the Palbreast Study (PALBREAST)

Breast Cancer

Italy
University of Minnesota

Recruiting

Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients

Surgical Site Infections | Healthcare Associated Infections | Staphylococcus Aureus Colonization

United States
Alnylam Pharmaceuticals

Recruiting

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Hereditary Amyloidosis, Transthyretin-Related | Asymptomatic Carrier State

France
University of Guelph
McMaster University; Laval University

Not yet recruiting

Phe for Me? The Effects of L-Phe on PKU Carriers and Non-carriers (Phe for Me)

Autosomal Recessive Disorder (Genetic Carriers of PKU)

Canada
Maastricht University

Recruiting

Effect and Safety MABs Administration m.3243A>G Mutation Carriers

Mitochondrial Myopathies

Netherlands
University of Guelph
McMaster University

Recruiting

PKU Carriers Trial (Pilot Study): Impact on Cognition, Mental Health, Blood Pressure and Metabolism

Autosomal Recessive Disorder (Genetic Carriers of PKU)

Canada
Zydus Lifesciences Limited

Not yet recruiting

A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers

Asymptomatic Condition | Falciparum Malaria | Uncomplicated Malaria
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Identification of Clinically Significant Markers of ATTRv in Pre-symptomatic Mutation Carriers.

Amyloidosis

Italy
Hvidovre University Hospital
Odense University Hospital; Zealand University Hospital; Aarhus University Hospital

Recruiting

The Effect of Faecal Microbiota Transplantation (FMT) on Eradication of Multidrug Resistant Organisms (MRO) in Intestinal Carriers (FEMRO)

Faecal Microbiota Transplantation | Multidrug Resistant Organisms

Denmark
Rigshospitalet, Denmark

Not yet recruiting

Follow-up Study on Female Carriers With DMD Gene Variants

Muscular Dystrophy | Duchenne Muscular Dystrophy | Becker Muscular Dystrophy

Denmark
Vanderbilt University Medical Center

Recruiting

Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals (RARE-PAH)

Idiopathic Pulmonary Arterial Hypertension | Heritable Pulmonary Arterial Hypertension | Unaffected Mutation Carriers: Healthy Participants With a Known BMPR2 Gene Mutation and Normal Pulmonary Pressure and RV Function on Echo | Healthy Individuals With no Cardiopulmonary Disease

United States
Western Sydney Local Health District
Monash University; University of Sydney; University of Melbourne; The University... and other collaborators

Not yet recruiting

A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers (NAC-preHD)

Huntington Disease

Australia
University of Texas Southwestern Medical Center
National Heart, Lung, and Blood Institute (NHLBI); Columbia University; The Cleveland... and other collaborators

Recruiting

Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers

Amyloidosis, Familial | Amyloidosis, Hereditary | Amyloidosis Cardiac | Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy | Transthyretin Gene Mutation

United States
Henan Provincial People's Hospital

Recruiting

Study on Clinical Program Optimization of Inactive Hepatitis B Surface Antigen (HBsAg) Carriers (IHCs)

Chronic Hepatitis B

China
Fundació Institut de Recerca de l'Hospital de la...

Recruiting

Study of Quality of Life Post Salpingo-oophorectomy in BRCA1/2 & PALB2 Mutation Carriers (BRCA-HRT) (BRCA-HRT)

Hereditary Breast and Ovarian Cancer

Spain
Shaare Zedek Medical Center

Not yet recruiting

Acupuncture With/Without Self-acupressure for Post-oophorectomy Hot Flashes in BRCA Carriers (BRCA)

Hot Flashes | Menopause Surgical

Israel
Cristina Avendaño Solá

Recruiting

Early Treatment With Candesartan vs Placebo in Genetic Carriers of Dilated Cardiomyopathy (EARLY-GENE Trial) (EARLY-GENE)

Cardiomyopathy, Dilated

Spain
Shaare Zedek Medical Center

Recruiting

Prodromal Parkinsonian Features in GBA1 Mutation Carriers

Healthy | Gaucher Disease, Type 1

Israel
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

PARP-inhibitor on Advanced Metastatic Breast Cancer in Germline PALB2 Mutations Carriers (PALB2-PARPi-01)

Metastatic Breast Cancer in Germline-PALB2 Mutations Carriers
National Cancer Institute (NCI)

Recruiting

Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers

Gastric Cancer | Gastric Adenocarcinoma | Gastric Neoplasms

United States
Shaare Zedek Medical Center

Recruiting

World Data on Ambroxol for Patients With GD and GBA Related PD

Parkinson Disease | Gaucher Disease | GBA Gene Mutation

Israel
University of Pennsylvania
Inovio Pharmaceuticals

Recruiting

INO 5401 Vaccination in BRCA1/2 Mutation Carriers

BRCA1/2 Mutation

United States
Université de Sherbrooke

Not yet recruiting

Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Determining the Blood-to-brain Link

Healthy

Canada
University Hospital, Bordeaux

Recruiting

Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers. (PROBATAZO)

Enterobacteriaceae Infections

France
Hvidovre University Hospital

Recruiting

Optimal Treatment of MRSA Throat Carriers

MRSA Colonization | MRSA

Denmark
Translational Research Center for Medical Innovation...
Okayama University; Japanese Gynecologic Oncology Group (JGOG)

Recruiting

Prospective Cohort Study of Germline Variant Carriers With BRCA1 or BRCA2

Fallopian Tube Carcinoma | Peritoneal Carcinoma | Ovarian Carcinoma | BRCA1 and/or BRCA2 Variant Carriers

Japan
Rutgers, The State University of New Jersey
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Recruiting

Parkinson Disease and DBS: Cognitive Effects in GBA Mutation Carriers

Parkinson Disease | Cognitive Decline | Parkinson | Genetic Predisposition | GBA Gene Mutation

United States
University Hospital Tuebingen

Recruiting

The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4

Hereditary Spastic Paraplegia | Hereditary, Spastic Paraplegia, Autosomal Dominant

Germany
Nationwide Children's Hospital
Parent Project Muscular Dystrophy

Recruiting

Characterization of Clinical Skeletal and Cardiac Impairment in Carriers of DMD and BMD

Duchenne Muscular Dystrophy | Becker Muscular Dystrophy

United States
Centre Hospitalier Universitaire de Saint Etienne
Ministry of Health, France

Recruiting

Study of the Impact of a Targeted Decolonization of S. Aureus Persistent Carriers (CIBERSTAPH)

Hemodialysis Patients

France
Institute of Cancer Research, United Kingdom

Recruiting

Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations (GENPROS)

Prostate Cancer

United Kingdom
Technical University of Munich
University of Cologne; University of Leipzig; University Hospital Schleswig-Holstein and other collaborators

Recruiting

Efficacy of Lifestyle Intervention in BRCA1/2 Mutation Carriers (LIBRE-2)

Hereditary Breast and Ovarian Cancer

Germany
Toronto Sunnybrook Regional Cancer Centre
Sunnybrook Health Sciences Centre; Women's College Hospital

Recruiting

Prostate Screening Study Using MRI in BRCA Carriers

Prostate Cancer

Canada
Memorial Sloan Kettering Cancer Center
Johns Hopkins University; Dana-Farber Cancer Institute; Sheba Medical Center; Shaare... and other collaborators

Recruiting

A Registry for BRCA Mutation Carriers With Pancreatic Ductal Adenocarcinoma

Pancreatic Ductal Adenocarcinoma

United States, Israel
University of Wisconsin, Madison
National Institute of Allergy and Infectious Diseases (NIAID)

Recruiting

GRoup A StrePtococcus (GRASP)

Streptococcal Pharyngitis

United States
Assaf-Harofeh Medical Center
Rambam Health Care Campus; Rabin Medical Center; Tel-Aviv Sourasky Medical Center and other collaborators

Recruiting

Prophylactic Irradiation to the Contralateral Breast for BRCA Mutation Carriers Undergoing Treatment for Breast Cancer

Breast Cancer

Israel
University of Rochester
Michael J. Fox Foundation for Parkinson's Research; Emerald Innovations

Completed

Objective, Passive Assessment of LRRK2 Carriers (OPAL)

Parkinson Disease

United States
AstraZeneca
AstraZeneca K.K.

Active, not recruiting

A Study to Evaluate AZD2693 in Participants Who Are Carriers of the PNPLA3 148M Risk Allele With Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis (FORTUNA)

Nonalcoholic Steatohepatitis

United States, Italy, Thailand, Germany, Korea, Republic of, Turkey, Vietnam, China, Malaysia, Taiwan, Hong Kong, Chile, Spain, Japan, Mexico, Brazil, Argentina, India, Singapore, Philippines, Peru, Colombia
M.D. Anderson Cancer Center

Active, not recruiting

Prophylactic Salpingectomy With Delayed Oophorectomy

Ovarian Carcinoma

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Rapid Pancreatic and Ovarian Screening MR Imaging With Motion Corrected T1, T2, and Advanced Diffusion Weighted Imaging for Patients With BRCA Mutation Who Undergo Screening Breast MRI

Screening Breast MRI in Patients Who Are BRCA Mutation Carriers

United States
Technical University of Munich

Completed

Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers (LIBRE)

Hereditary Breast and Ovarian Cancer

Germany
Hoffmann-La Roche
National Institute on Aging (NIA); Banner Alzheimer's Institute

Completed

Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's Disease

Alzheimer Disease

Colombia
Parc de Salut Mar
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation; Hospital...

Completed

Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention ((PENSA))

Alzheimer Disease | Cognitive Decline

Spain
Leipzig University Medical Center
European Leukodystrophy Association

Completed

SMART-ALD - A New Lifestyle Intervention to Improve Quality of Life in Women With X-linked Adrenoleukodystrophy (X-ALD)

X-linked Adrenoleukodystrophy

Germany
Tammie L. S. Benzinger, MD, PhD

Withdrawn

Imaging of Brain Structural/Functional Connectivity and Amyloid and Tau Lesions in APOE4 Carriers. (Protocol_Z)

Alzheimer Disease

United States
Joslin Diabetes Center

Enrolling by invitation

Oral Hypoglycemic Therapy for Monogenic Variant Carriers of the Joslin Medalist Study

Type 1 Diabetes | Monogenic Diabetes

United States
Centre Georges Francois Leclerc
AstraZeneca

Active, not recruiting

Study Evaluating the Efficacy of a Double Immunotherapy Combined With Olaparib in Patients With Solid Cancers and Carriers of Homologous Recombination Repair Genes After Olaparib Treatment (GUIDE2REPAIR)

Immunotherapy

France

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