Search clinical trials for: Dermal open flow microperfusion

Total 14009 results

Joanneum Research Forschungsgesellschaft mbH

Completed

An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques

Healthy | Dermal Pharmacokinetic Measurement

Austria
Joanneum Research Forschungsgesellschaft mbH

Completed

Evaluate the Ability of dOFM for BE Testing of Topically Applied Diclofenac Sodium Products in Healthy Subjects

Healthy

Austria
Novartis Pharmaceuticals

Completed

Distribution of Secukinumab (AIN457) Into Dermal Interstitial Fluid After a Single Subcutaneous Administration of 300 mg (OFM ISF)

Healthy | Psoriasis

Austria
Joanneum Research Forschungsgesellschaft mbH

Completed

An Exploratory Study in Healthy Volunteers to Identify Factors Influencing Bioequivalence Studies on Moderately Lipophilic Drugs Using Dermal Open Flow Microperfusion (dOFM)

Healthy | Dermal Pharmacokinetic Measurements

Austria
Joanneum Research Forschungsgesellschaft mbH

Completed

An Exploratory Pilot Study in Healthy Volunteers to Assess the Parameters for the Design of Bioequivalence Studies on Moderately Lipophilic, Moderately to Highly Protein Bound Drugs Using Dermal Open Flow Microperfusion (dOFM)

Dermal Pharmacokinetic Measurements | Dermatology/Skin - Other

Austria
Medical University of Graz
Joanneum Research Forschungsgesellschaft mbH

Completed

Bioequivalence of Topical Acyclovir in Healthy Volunteers (FDA_BE1)

Dermatologic Disorders

Austria
GI Windows, Inc.

Not yet recruiting

Functional Lumen Opening With Self-Forming Magnetic Anastomosis (FLOWS)

Small Bowel Anastomosis
Southeast University, China

Not yet recruiting

Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients

Critical Illness | Mechanical Ventilation Pressure High

China
First Hospital of China Medical University

Not yet recruiting

Normal Reference Values in Han Adults of Skin Thickness and Blood Flow by High-frequency Ultrasound (NOVAS-HFUS)

Healthy Volunteer | Skin
Wang xingang

Not yet recruiting

Double-layer Artificial Dermal Repair Material Combined With Growth Factors is Used for Exposed Tendon Wounds

Open Wound of Hip With Tendon Involvement
New World Medical, Inc.

Recruiting

STREAMLINE®SURGICAL SYSTEM Compared to iStent Inject W® in Patients With Open-Angle Glaucoma (VENICE)

Open Angle Glaucoma

United States, Costa Rica
Poitiers University Hospital

Recruiting

Avalanche Phenomenon During Airways Opening in Acute Respiratory Distress Syndrome (AVALANCHE)

Acute Respiratory Distress Syndrome

France
JOTEC GmbH

Recruiting

A Post-Market Clinical Follow-up Study in Patients Treated With Vascular Grafts (FLOWGRAFT)

Vascular Diseases

Germany
Madrigal Pharmaceuticals, Inc.

Recruiting

A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)

Non-Alcoholic Fatty Liver Disease

United States, Puerto Rico
University Hospital Hradec Kralove

Recruiting

Evaluation of the Severity of Right to Left Shunt in PFO Patients After Systemic Embolism

Embolism | Patent Foramen Ovale

Czechia
Medical University of Vienna

Recruiting

The Effect of Dronabinol on Ocular Hemodynamics in Patients With Primary Open Angle Glaucoma

Retinal Blood Flow

Austria
Universitaire Ziekenhuizen KU Leuven

Recruiting

The Role of TRP Channels in CIPN

Chemotherapy-induced Peripheral Neuropathy

Belgium
Pfizer
Arena is a wholly owned subsidiary of Pfizer

Recruiting

An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis (ELEVATE UC OLE)

Ulcerative Colitis

Poland, Japan, Georgia, Estonia, United States, Australia, Korea, Republic of, Lithuania, Italy, Turkey, Spain, Romania, Serbia, Germany, France, Bulgaria, Austria, Belarus, Canada, Croatia, Czechia, Denmark, Hungary, Israel, Latvia, Lebanon and more
Dufresne, Craig, MD, PC

Not yet recruiting

Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds (FTFDT3)

Wounds and Injuries | Soft Tissue Injuries | Surgical Wound | Surgical Wound Infection | Wound Infection | Wounds, Nonpenetrating | Skull Fractures | Wound Healing | Wounds | Wounds, Penetrating | Wound Complication | Wound of Skin | Wound Open | Wound Dehiscence | Facial Bones Fracture | Disturbance of Wound Healing | Wound... and other conditions

United States
Medical University of Vienna

Recruiting

Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects

Ocular Hypertension | Glaucoma, Open-Angle | Normal Tension Glaucoma

Austria
Wills Eye

Recruiting

Caffeine Consumption in Glaucoma Patients and Healthy Subjects

Glaucoma, Primary Open Angle

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)

Stage IB Non-Small Cell Lung Carcinoma AJCC v7 | Stage II Non-Small Cell Lung Cancer AJCC v7 | Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 | Stage IIB Non-Small Cell Lung Carcinoma AJCC v7 | Stage IIIA Non-Small Cell Lung Cancer AJCC v7 | ALK Gene Rearrangement | ALK Gene Translocation | ALK...

United States, Guam, Puerto Rico
National Cancer Institute (NCI)

Active, not recruiting

Lenalidomide and Dexamethasone With or Without Thalidomide in Treating Patients With Multiple Myeloma

DS Stage I Multiple Myeloma | DS Stage II Multiple Myeloma | DS Stage III Multiple Myeloma

United States
Pfizer
Arena is a wholly owned subsidiary of Pfizer

Active, not recruiting

Etrasimod Versus Placebo for the Treatment of Moderately Active Ulcerative Colitis (GLADIATOR UC)

Ulcerative Colitis

United States, Israel, Spain, Korea, Republic of, Poland, Australia, Canada, Germany, Belarus, Russian Federation, Belgium, Czechia, Hungary, Georgia, Bulgaria, France, Italy, Portugal, Ukraine
Suven Life Sciences Limited

Active, not recruiting

Study Evaluating Safety and Efficacy of Ropanicant in MDD Patients

Major Depressive Disorder

United States
Nova Southeastern University

Completed

Weightlessness Associated Cephalad Fluid Shifts; The Potential to Evaluate Venous and Lymphatic Dysfunction (NIID)

Perfusion; Complications | Fluid Retention Tissue

United States
Teva Branded Pharmaceutical Products R&D, Inc.

Active, not recruiting

A Randomized, Double-Blind, Placebo-Controlled Study With an Open-Label, Long-Term Safety Phase to Evaluate the Efficacy and Safety of TV-44749 in Adults With Schizophrenia (SOLARIS)

Schizophrenia

United States, Bulgaria, China, Romania, Turkey
Zhengzhou Gensciences Inc
Haimen Gensciences lnc

Completed

An Open Label Study to Determine the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A.

Hemophilia A

China
Occlutech International AB

Active, not recruiting

Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study (FROST-HF)

Heart Failure With Preserved Ejection Fraction (HFpEF) | Heart Failure With Reduced Ejection Fraction (HFrEF)

United States
Merck Sharp & Dohme LLC

Completed

Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-Small Cell Lung Cancer (NSCLC) (MK-3475-598/KEYNOTE-598)

Carcinoma, Non-Small-Cell Lung

United States, Ireland, Argentina, Australia, Brazil, Canada, Chile, Colombia, France, Germany, Hungary, Italy, Korea, Republic of, Latvia, Mexico, Peru, Poland, South Africa, Spain, Taiwan, Thailand, Turkey, Ukraine, United Kingdom
Merck Sharp & Dohme LLC
Eisai Inc.

Active, not recruiting

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Carcinoma, Hepatocellular

Colombia, Israel, Taiwan, United States, Australia, Brazil, Chile, China, Denmark, France, Germany, Hong Kong, Hungary, Ireland, Italy, Japan, Korea, Republic of, Netherlands, New Zealand, Norway, Portugal, Puerto Rico, Spain, Thailand, Turke... and more
Merck Sharp & Dohme LLC

Active, not recruiting

Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)

Hepatocellular Carcinoma

United States, Argentina, Australia, Belgium, Brazil, Bulgaria, Canada, China, Denmark, France, Germany, Hong Kong, Hungary, Ireland, Israel, Italy, Japan, Korea, Republic of, Malaysia, New Zealand, Norway, Poland, Russian Federation, Spai... and more
Novartis Pharmaceuticals

Completed

A Phase I/II, Multicenter, Open-label Study of EGFRmut-TKI EGF816, Administered Orally in Adult Patients With EGFRmut Solid Malignancies

Advanced Non-small Cell Lung Cancer

Spain, Canada, Germany, Korea, Republic of, Taiwan, United States, Japan, Netherlands, Singapore
Karuna Therapeutics

Active, not recruiting

An Open-label Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-5)

Schizophrenia

United States
Intra-Cellular Therapies, Inc.

Enrolling by invitation

An Open-label Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

Major Depressive Disorder

United States, Bulgaria, Czechia, Slovakia, Germany, Hungary, Poland, Finland, India, Korea, Republic of, Sweden
University of Zurich
Cantonal Hosptial Aarau, Department of Ophthalmology, Aarau, Switzerland

Completed

Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System (LSFG Repro)

Healthy | Open Angle Glaucoma | Normal Tension Glaucoma

Switzerland
Universitaire Ziekenhuizen KU Leuven

Completed

Influence of Ubrogepant and Sumatriptan on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin

Migraine

Belgium
Galderma R&D

Completed

Pan Facial Volume Restoration (EVE)

Volume Loss (Soft Tissue Ptosis or Atrophy )

Brazil
University Health Network, Toronto
Sunnybrook Health Sciences Centre; University of British Columbia; University... and other collaborators

Completed

Fluoxetine Opens Window to Improve Motor Recovery After Stroke (FLOW)

Vascular Diseases | Stroke | Cerebrovascular Disorders | Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Brain Ischemia | Cerebral Infarction | Brain Infarction | Cerebrovascular Accident

Canada
University of the Incarnate Word
Guardion Health Sciences, Inc.

Withdrawn

Augmented Macular Pigment-containing Nutraceutical and Central Visual Function

Glaucoma | Glaucoma, Open-Angle | Glaucoma Eye

United States
Fayoum University

Completed

The Effect of Topical Brimonidine on the Ocular Hemodynamics in Patients of POAG Using OCTA

Glaucoma, Primary Open Angle | Ocular Blood Flow | Optical Coherence Tomography Angiography

Egypt
Dufresne, Craig, MD, PC

Enrolling by invitation

Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds (FTFDT2)

Wounds and Injuries | Soft Tissue Injuries | Surgical Wound | Surgical Wound Infection | Wound Infection | Wounds, Nonpenetrating | Skull Fractures | Wound Healing | Wounds | Wounds, Penetrating | Wound Complication | Wound of Skin | Wound Open | Wound Dehiscence | Facial Bones Fracture | Disturbance of Wound Healing | Wound... and other conditions

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal

Opioid Dependence | Acute Opioid Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Open-Label, Safety Study of Lofexidine (NU LEAF)

Opioid Withdrawal

United States
Icahn School of Medicine at Mount Sinai

Completed

Nailfold Capillary Blood Flow With Latanoprost Bunod

Glaucoma, Open-Angle

United States
Bristol-Myers Squibb

Completed

A Study of Nivolumab in Advanced Non-Small Cell Lung Cancer (NSCLC) (CheckMate370)

Non-Small Cell Lung Cancer

United States
Seoul National University Hospital

Terminated

High-flow Nasal Oxygenation for Open Mouth

Apnea | Anesthesia, General

Korea, Republic of
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Extension Study Of Long-Term Safety And Efficacy Of Pregabalin As Monotherapy (Lyrica) In Patients With Partial Seizures

Epilepsy

United States, Ukraine, Hong Kong, Czechia
University Hospital, Montpellier

Active, not recruiting

Effect of Vocal Exercises With Straw on Aerodynamic Parameters of Voice (Pressure, Flow) in Dysodic Singers With Nodules (DYSODIE)

Dysodia | Vocal Disorders

France
Southwest Oncology Group
National Cancer Institute (NCI); NCIC Clinical Trials Group

Completed

S0226 Anastrozole With or Without Fulvestrant as First-Line Therapy in Postmenopausal Women With Metastatic Breast Cancer

Breast Cancer

Canada, United States

Search clinical trials for: Dermal open flow microperfusion

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