Search clinical trials for: Familial high risk

Total 33050 results

AOP Orphan Pharmaceuticals AG
GCP-Service International Ltd. & Co. KG; ANOVA CRO s.r.o.; PharmaLex Belgium; Aixial...

Recruiting

Initial Triple Therapy Including Parenteral Treprostinil vs Initial Double Oral Therapy in PAH Group I Patients (TripleTRE)

Pulmonary Arterial Hypertension

Austria, Spain, France, Germany, Italy, Czechia, Hungary, Poland, Portugal, Romania
Mental Health Services in the Capital Region, Denmark
Novo Nordisk A/S; Lundbeck Foundation; TrygFonden, Denmark; Aalborg Psychiatric... and other collaborators

Not yet recruiting

The VIA Family 2.0 - a Family Based Intervention for Families With Parental Mental Illness

Child | Parents | Mental Disorder | Child of Impaired Parents | Preventive Health Services
Gee-Chen Chang
AstraZeneca

Recruiting

Taiwan Real-world LDCT Screening Behavior and Outcome Research for High Risk Subjects Based on Health Promotion Administration (TRIO)

Smoking | Lung Cancer | Pollution; Exposure | Family Relations | High-Risk Cancer

Taiwan
Gia Mudd
National Institute of Nursing Research (NINR)

Recruiting

Heart of the Family: A Cardiovascular Disease and Type 2 Diabetes Risk Reduction Intervention in High-Risk Rural Families

Cardiovascular Diseases | Diabetes Mellitus, Type 2

United States
Acceleron Pharma, Inc., a wholly-owned subsidiary...

Recruiting

Study of Sotatercept in Newly Diagnosed Intermediate- and High-Risk PAH Participants (MK-7962-005/A011-13) (HYPERION)

Pulmonary Arterial Hypertension

United States, Belgium, France, Germany, Spain, Argentina, Australia, Austria, Colombia, Croatia, Denmark, Greece, Israel, Korea, Republic of, Netherlands, Portugal, Serbia, Taiwan, Brazil, Canada, Czechia, Italy, New Zealand, Sweden, S... and more
Changhai Hospital

Recruiting

Artificial Intelligence-based Early Screening of Pancreatic Cancer and High Risk Tracing (ESPRIT-AI) (ESPRIT-AI)

Diabetes | Pancreatic Cancer | Chronic Pancreatitis | Familial Pancreatic Cancer | Pancreatic Cystic Neoplasm | Hereditary Pancreatitis

China
University of California, Los Angeles
National Institute of Mental Health (NIMH)

Recruiting

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial

Psychotic Disorders | Psychosis | Prodromal Schizophrenia | Prodromal Symptoms | Family

United States, Canada
Rhode Island Hospital

Recruiting

A Treatment Engagement Protocol for Psychiatrically Hospitalized Adolescents at Clinical High Risk for Psychosis

Psychosis Nos/Other

United States
National Cancer Institute (NCI)

Completed

Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer

Familial Ovarian Cancer | Familial Breast Cancer | BRCA1-associate Malignancies | BRCA2-associated Malignancies

United States
Mental Health Services in the Capital Region, Denmark
TrygFonden, Denmark; Child and Adolescent Mental Health Services, Research...

Completed

VIA Family 4 Year Follow-up of a Family-based Preventive Intervention (VIA Family)

Mental Disorder

Denmark
Acceleron Pharma, Inc., a wholly-owned subsidiary...

Active, not recruiting

A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH) (ZENITH)

Pulmonary Arterial Hypertension

France, Germany, United States, Australia, Belgium, Canada, Israel, Italy, Mexico, Netherlands, Spain, United Kingdom
New York Medical College
Washington University School of Medicine; University of California, Los Angeles and other collaborators

Active, not recruiting

Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease (HaploSCD)

Sickle Cell Disease

United States
Novartis Pharmaceuticals

Completed

Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C (ORION-8)

Elevated Cholesterol | Homozygous Familial Hypercholesterolemia | Heterozygous Familial Hypercholesterolemia | ASCVD

United States, Canada, Czechia, Denmark, Germany, Hungary, Netherlands, Poland, South Africa, Spain, Sweden, Ukraine, United Kingdom
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of Inclisiran in Japanese Participants With High Cardiovascular Risk and Elevated LDL-C (ORION-15)

Hypercholesterolemia | Heterozygous Familial Hypercholesterolemia

Japan
LIB Therapeutics LLC
Medpace, Inc.

Enrolling by invitation

Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reduction (LIBerate-OLE)

Familial Hypercholesterolemia | Elevated Cholesterol | Cardiovascular Disease With Mention of Arteriosclerosis

United States, Israel, Norway, South Africa, Turkey, India
Mental Health Services in the Capital Region, Denmark
TrygFonden, Denmark; Ministry of the Interior and Health, Denmark; Municipality...

Completed

VIA Family - Family Based Early Intervention Versus Treatment as Usual

Adolescent | Psychotic Disorders | Schizophrenia | Child | Bipolar Disorder | Parent-Child Relations | Mental Disorders, Severe | Early Intervention | Child of Impaired Parents | Depressive Disorder, Recurrent

Denmark
University of Pisa
Azienda Ospedaliero, Universitaria Pisana; Azienda Ospedaliero-Universitaria... and other collaborators

Enrolling by invitation

Adding Motion to Contact: A New Model for Low-cost Family Centered Very-early Onset Intervention in Very Preterm-born Infants (NTM)

Brain Injuries | Premature Birth

Italy
Immunovia, Inc.

Completed

A Study of IMMray™ PanCan-d Test for Early Detection of Pancreatic Cancer in High-risk Groups

Pancreatic Ductal Adenocarcinoma | Familial Pancreatic Cancer | FAMMM - Familial Atypical Mole Malignant Melanoma Syndrome

United States, Sweden, Canada, Spain, United Kingdom
Bayer

Completed

Study Performed at Various Medical Centers to Learn More About Survival and Expected Course of Pulmonary Arterial Hypertension, a Type of High Blood Pressure in the Lungs Related to the Narrowing of the Small Blood Vessels in the Lungs (START)

Pulmonary Arterial Hypertension

Argentina
Sanko University

Completed

Effectiveness of Family Collaborative Physiotherapy Programs With High-risk Infants

Cerebral Palsy | Infant, Premature, Diseases | Infant, Newborn, Disease | Infant Development | Infant, Very Low Birth Weight | Infant, Small for Gestational Age | Infant Asphyxia | Infant of Diabetic Mother

Turkey
Pfizer's Upjohn has merged with Mylan to form Viatris...
The Cleveland Clinic

Completed

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen (PRECISION)

Arthritis, Rheumatoid

United States, Taiwan, Philippines, Mexico, Canada, Australia, Colombia, Brazil, Ukraine, Costa Rica, Hong Kong, Panama, Peru
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Unknown

Gliogene: Brain Tumor Linkage Study

Glioma | Brain Tumor

United States, Finland, Sweden, Denmark, Israel, United Kingdom
Beijing Anzhen Hospital

Unknown

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With High Risk Coronary Artery Disease (FORWARD) (FORWARD)

Dyslipidemia | High Risk Coronary Artery Disease

China
Esperion Therapeutics, Inc.

Completed

Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)

Hypercholesterolemia | Atherosclerotic Cardiovascular Diseases

United States, United Kingdom, Germany, Poland, Netherlands, Canada
Esperion Therapeutics, Inc.

Completed

Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular Risk (CLEAR Wisdom)

Hypercholesterolemia | Atherosclerotic Cardiovascular Disease

United States
University of Pennsylvania

Completed

Eating Phenotypes for Childhood Obesity in the Context of Familial Obesity Risk

Obesity

United States
University of Michigan
Michigan Department of Community Health

Completed

Interventions to Increase Screening by Breast Cancer Survivors and Their High Risk Female Relatives

Breast Cancer | Breast Cancer in Young Women | Breast Cancer in Women With a Strong Family History

United States
University of Arkansas

Withdrawn

Pancreatic Cancer Screening of High-Risk Individuals in Arkansas

Pancreatic Neoplasms | Colorectal Neoplasms, Hereditary Nonpolyposis | BRCA1 Gene Mutation | BRCA2 Gene Mutation | Hereditary Pancreatitis | Ataxia Telangiectasia | Peutz-Jegher's Syndrome | Familial Atypical Mole-Malignant Melanoma Syndrome

United States
Weill Medical College of Cornell University
Sidney R. Baer, Jr. Foundation

Completed

Cognitive Behavioral Therapy for the Prevention of Paranoia in Adolescents at High Risk

Prodromal Symptoms | ARMS | APS

United States
Amgen

Completed

A Study to Evaluate Tolerability and Efficacy of Evolocumab (AMG 145) in Japanese Subjects (AMG145)

Hypercholesterolemia and High Risk for Cardiovascular Events

Japan
European Institute of Oncology

Terminated

Fenretinide in Healthy Young Women at Genetic and Familial Risk

High-Risk Cancer

Italy
Beth Israel Deaconess Medical Center
National Institute of Mental Health (NIMH); Boston Children's Hospital

Completed

Computer-Aided Learning for Managing Stress (CALMS)

Psychosis

United States
Vanderbilt University Medical Center
National Cancer Institute (NCI)

Completed

Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer

Colorectal Cancer | Precancerous Condition | Hereditary Non-polyposis Colon Cancer

United States
Pfizer

Completed

A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial Hypercholesterolemia (SPIRE-FH)

Heterozygous Familial Hypercholesterolemia

Canada, Netherlands, United Kingdom, United States, Spain, Poland, Finland, Norway, South Africa, Italy, Bulgaria
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN)

Hypercholesterolemia

Japan
MaineHealth
Robert Wood Johnson Foundation

Completed

Early Detection and Intervention for the Prevention of Psychosis (EDIPP)

Depression | Psychotic Disorders | Schizophrenia | Bipolar Disorder

United States
Alexion Pharmaceuticals

Terminated

A Study to Identify and Characterize LAL-D Patients in High-risk Populations

Lysosomal Acid Lipase Deficiency

United States
University of California, Los Angeles
National Institute of Mental Health (NIMH)

Completed

Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder

Bipolar Disorder

United States
Nantes University Hospital

Terminated

Endomicrocancer: Confocal Endomicroscopy in Patients With High Risk of Colorectal Cancer

Familial Adenomatous Polyposis | Inflammatory Bowel Disease (IBD)

France
National Cancer Institute (NCI)

Completed

Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer

Breast Neoplasm | Hereditary Neoplastic Syndrome

United States
Fudan University

Recruiting

Clinical Study of T3011 Intravesical Instillation for Treatment of NMIBC Patients

Bladder Cancer

China
University Hospital, Bordeaux

Not yet recruiting

COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial (COLTRANE)

On-pump Cardiac Surgery | High Risk for Bleeding | Autotransfusion

France
Tanta University

Recruiting

Trendelenburg Maneuver Versus Passive Leg Raising Test for Fluid Responsiveness in High-Risk Surgical Patients

Passive Leg Raising | High-Risk Surgical Patients | Trendelenburg Maneuver

Egypt
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Toripalimab for High-risk Locally Advanced Cervical Cancer

Cervical Cancers

China
Children's Hospital of Fudan University

Not yet recruiting

High-Intensity Interval Training(HIIT) on Cardio-metabolic Risk in School-age Children

Cardiovascular Syndrome, Metabolic
Peking University Third Hospital
Peking University; The First Affiliated Hospital of Anhui Medical University; First Affiliated Hospital, Sun Yat-Sen University and other collaborators

Recruiting

Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC)

Pre-Eclampsia | High Risk Pregnancy | Twin Pregnancy, Antepartum Condition or Complication | Pre-Term | Twin Dichorionic Diamniotic Placenta | Twin to Twin Transfusion as Antepartum Condition | Twin Placenta | Twin Monochorionic Diamniotic Placenta

China
Centro Cardiologico Monzino
Politecnico di Milano; Fondazione IRCCS Policlinico San Matteo di Pavia; Scientific...

Recruiting

Trustworthy, Integrated Artificial Intelligence Tools for Predicting High-risk CORonary PlaqueS (AI-CORPS)

Coronary Artery Disease | Coronary Computed Tomography Angiography

Italy
Monash University Malaysia
Ministry of Higher Education, Malaysia

Recruiting

Peer-led Digital Health Lifestyle Intervention for a Low Income Community at Risk for Cardiovascular Diseases (MYCardio-PEER)

Primary Prevention of Cardiovascular Diseases

Malaysia
The First Affiliated Hospital of Soochow University

Not yet recruiting

Treatment of High-risk Newly Diagnosed Multiple Myeloma With Minimal Residual Disease Detection

Multiple Myeloma | Newly Diagnosed | MRD | High Risk
Assistance Publique - Hôpitaux de Paris
Centre Leon Berard; Institut National de la Santé Et de la Recherche Médicale... and other collaborators

Not yet recruiting

Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers (PGLEXPO2)

Environmental Exposure | SDH Gene Mutation | SDH-Related Familial Paraganglioma | SDHx-Related Syndromes

France

Search clinical trials for: Familial high risk

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