Search clinical trials for: Genes signature

Total 3573 results

Washington University School of Medicine
The Foundation for Barnes-Jewish Hospital; Swim Across America

Recruiting

NeoTAILOR: ABiomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II/III ER-positive, HER2-negative Breast Cancer

Breast Cancer | Cancer of the Breast

United States
Institut Pasteur
Höpital La Pitié-Salpêtrière

Not yet recruiting

Cellular microRNA Signatures in Multiple Sclerosis (SEP-MIR)

Multiple Sclerosis, Relapsing-Remitting

France
NRG Oncology
National Cancer Institute (NCI); Natera, Inc.

Recruiting

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)

Stage III Colon Cancer

United States, Canada
AbbVie

Completed

A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain

Endometriosis

United States, Canada, Puerto Rico
Institut Pasteur de Madagascar
Johns Hopkins Bloomberg School of Public Health; National Tuberculosis Program... and other collaborators

Completed

Dried Blood Spot Test to Assess TB in Pregnancy (DROPTB2)

Tuberculosis

Madagascar
Jonathan A. Bernstein, MD

Completed

The Utility of Functionally Relevant Signature Genes in Assessing the Clinical Outcomes of Dupilumab Treatment

Eczema | Atopic Dermatitis

United States
Myriad Genetic Laboratories, Inc.

Terminated

Long-term Study to Evaluate and Clinical Outcomes in Patients With Favorable Intermediate Risk Localized Prostate Cancer

Prostate Cancer

United States
Myriad Genetic Laboratories, Inc.
VA Salt Lake City Health Care System

Terminated

Prospective Prolaris Value and Efficacy (P-PROVE)

Prostate Cancer

United States
Pfizer

Terminated

LGX818 for Patients With BRAFV600 Mutated Tumors (SIGNATURE)

Solid Tumor | Hematologic Malignancies

United States
Agendia

Completed

NBRST: Prospective Neo-adjuvant REGISTRY Trial (NBRST)

Breast Cancer

United States
University of Florida
National Institute of General Medical Sciences (NIGMS)

Completed

TEMporal PostOperative Pain Signatures (TEMPOS)

Pain, Postoperative

United States
Curatek Pharmaceuticals, LLC

Completed

Multi-Center Study of New Medications to Treat Vaginal Infections (SMART GIVES)

Vaginal Infection

United States
Pontificia Universidad Catolica de Chile
Geneprodx

Unknown

Clinical Validation of ThyroidPrint: A Gene Expression Signature for Diagnosis of Indeterminate Thyroid Nodules

Indeterminate Thyroid Cytology

United States
Enloe Health
Robert A. Winn Diversity in Clinical Trials Award Program

Not yet recruiting

A Pilot Study of Genetic Testing Uptake Through Enhanced Oncology Nurse-Led Intervention (GENESIS)

Solid Tumor, Adult
Hospital Universitari Vall d'Hebron Research Institute
Hospital General Universitario Gregorio Marañon; Hospital Clinic of Barcelona; Germans Trias i Pujol Hospital and other collaborators

Recruiting

Zinc Supplementation to Improve Prognosis in Patients With Compensated Advanced Chronic Liver Disease.

Hepatocellular Carcinoma | Portal Hypertension | Advanced Chronic Liver Disease

Spain
Universitaire Ziekenhuizen KU Leuven
Research Foundation Flanders

Recruiting

Connectivity and Neural Signatures of Consciousness in Unresponsive States (CONSCIUS)

Seizures | Traumatic Brain Injury | Consciousness Disorders | Acute Brain Injury

Belgium
Biohaven Therapeutics Ltd.

Recruiting

BHV-7000 Acute Treatment of Bipolar Mania

Bipolar Disorder

United States
Sohag University

Recruiting

Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo

Vitiligo

Egypt
Hospital Universitari Vall d'Hebron Research Institute
Universitat Pompeu Fabra; IDIAPJgol

Recruiting

Study of the Drivers of Late Diagnosis of Alcohol Related Diseases, Alone or in Combination With Metabolic Dysfunconal Associated Fatty Liver Disease, Implementation and Evaluation of Itnerventions to Reduce Its Burden. (StopALD)

Alcohol Use Disorder | Alcohol-related Liver Disease | Metabolic and Alcohol Related/Associated Liver Disease | Metabolic Disfunction Associated Steatotic Liver Disease

Spain
Peking Union Medical College Hospital

Not yet recruiting

A Study to Evaluate the Safety and Tolerability of GEN6050X in Duchenne Muscular Dystrophy. (GEN6050XIIT)

Duchenne Muscular Dystrophy (DMD)
Scipher Medicine

Recruiting

PREDICT Therapy Selection for JAK, T-cell, or IL-6 Inhibitor Therapies Using a Molecular Signature Response Classifier (PREDICT) (PREDICT)

Rheumatoid Arthritis

United States
The Affiliated Hospital Of Guizhou Medical University

Not yet recruiting

Population Pharmacokinetic Study of the Effect of Polymorphisms in the ABCB1 and CES1 Genes on the Pharmacokinetics of Dabigatran

Combined Analysis of Polymorphisms and Dabigatran Pharmacokinetic Parameters
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

A Bioavailability Study of Two Different PEG-rhGH Preparations.

Pediatric Growth Hormone Deficiency (PGHD)

China
Ataturk University

Not yet recruiting

The Effect of Mobile-Based Education on Postoperative Recovery and Quality of Life in Thyroidectomy Patients

Thyroid Diseases | Thyroid | Healthy Lifestyle
Changchun GeneScience Pharmaceutical Co., Ltd.

Recruiting

A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Dose Escalation of GS1-144 Tablets and the Effects of Food on the Pharmacokinetics of GS1-144 in a Chinese Population

Healthy Volunteer | Vasomotor System; Labile

China
Sensorion

Not yet recruiting

A Phase I/II Clinical Trial With SENS-501 in Children Suffering From Severe to Profound Hearing Loss Due to Otoferlin (OTOF) Mutations (AUDIOGENE)

Otorhinolaryngologic Diseases | Ear Diseases | Hearing Disorders | Deafness | Hearing Loss, Sensorineural | Congenital Deafness | DFNB9 | OTOF Gene Mutation

France
Children's Hospital of Philadelphia

Not yet recruiting

ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

Beta-Thalassemia

United States
National Cancer Institute (NCI)

Not yet recruiting

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Chronic Lymphocytic Leukemia (CLL)

Leukemia, Lymphocytic, Chronic, B-Cell | B-Cell Chronic Lymphocytic Leukemia | B-Lymphocytic Leukemia, Chronic

United States
University Hospital, Angers

Not yet recruiting

Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes (PHEMOP)

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Myeloproliferative Neoplasm

France
Ractigen Therapeutics.

Recruiting

A Study of RAG-01 in Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Who Have Failed Bacillus Calmette Guérin (BCG) Therapy

Non-Muscle-Invasive Bladder Cancer (NMIBC)

Australia
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
Federico II University; Istituto Auxologico Italiano; Università degli Studi...

Recruiting

Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks

Beckwith-Wiedemann Syndrome

Italy
Fondazione Policlinico Universitario Agostino Gemelli...
IRCCS Azienda Ospedaliero-Universitaria di Bologna; Federico II University; Azienda... and other collaborators

Not yet recruiting

Transgender and Gender Diverse Individuals Screening for Breast Cancer (GENESIS)

Breast Cancer
Third Affiliated Hospital, Sun Yat-Sen University

Recruiting

Effect of Probiotics Before Cesarean Section on Postoperative Recovery in Pregnant Women

Microbiota | Postoperative Recovery

China
Ataturk University

Recruiting

Effect of Three Different Postcesarean Analgesic Techniques on QbsQor-10 Score: Prospective, Randomized Trial

Postoperative Recovery

Turkey
Pfizer

Recruiting

A Study to Learn How the Body Processes the Study Medicine Called Osivelotor (PF-07940367) in People With Loss of Liver Function

Liver Diseases

United States
IRCCS SYNLAB SDN
Federico II University

Recruiting

Potential Role of Sirtuins as Epigenetic Biomarkers of the Patient With Atherosclerosis or Calcific Aortic Stenosis

Atherosclerosis and Calcific Aortic Stenosis With and Without Diabetes

Italy
Maria Joyera Rodríguez

Not yet recruiting

Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels (3TR-ICS-COPD)

Chronic Obstructive Pulmonary Disease

United Kingdom, Spain, Netherlands, Germany
Ahmet Yuksek

Recruiting

Bispectral Index, Suppression Rate and Emergence Agitation in Spine Surgeries

Emergence Agitation | Anesthesia Recovery | Bispectral Index Monitor

Turkey
IRCCS SYNLAB SDN
Fondazione Santobono Pausilipon

Recruiting

Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells.

Acute Lymphoblastic Leukemia, Pediatric

Italy
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Recruiting

Target of Suv420h1/2 in Hepatocytes

NAFLD

Italy
Texas Tech University

Not yet recruiting

Mitochondrial DNA Signatures of Poor Aerobic Exercise Trainability in Young Adults Born Preterm

Preterm Birth
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

A Bioequivalence Study of Two Different PEG-rhGH Preparations.

Pediatric Growth Hormone Deficiency (PGHD)

China
National Institute of Allergy and Infectious Diseases...

Recruiting

Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease

Chronic Granulomatous Disease (CGD) | X-Linked Chronic Granulomatous Disease

United States
University of Lausanne Hospitals

Recruiting

A Brief Case Management Intervention for People Involuntarily Admitted to a Psychiatric Hospital (CARP)

Psychiatric Disorder | Involuntary Psychiatric Hospitalization

Switzerland
Janssen Research & Development, LLC

Recruiting

A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer (MoonRISe-1)

Non-Muscle Invasive Bladder Cancer

United States, Israel
Changchun GeneScience Pharmaceutical Co., Ltd.
Sixth Affiliated Hospital, Sun Yat-sen University

Recruiting

Long-term Follow-up Safety of a Single Injection of GenSci094 for Ovarian Stimulation Using Daily Recombinant FSH as Reference

Infertility

China
City of Hope Medical Center

Recruiting

Stage II/III Colorectal Cancer Recurrence (CENSURE)

Colorectal Cancer | Colorectal Adenocarcinoma | Colorectal Cancer Stage II | Colorectal Cancer Stage III | Colorectal Cancer Recurrent

Spain, United States, China
Tenaya Therapeutics
Medical University of South Carolina; Johns Hopkins University; University of... and other collaborators

Recruiting

Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (RIDGE)

Arrhythmogenic Right Ventricular Cardiomyopathy

United States, Italy, United Kingdom, France, Sweden, Germany
Beijing Friendship Hospital

Recruiting

Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy

Postoperative Vomiting | Laparoscopic Sleeve Gastrectomy | Postoperative Recovery | Opioid-Free Anesthesia

China
University Hospital, Geneva

Recruiting

Electroencephalographic Signatures of Neuropsychiatric Fluctuations in Parkinson's Disease (Transition)

Parkinson Disease

Switzerland

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