Search clinical trials for: Glucagon pharmacodynamics

Total 2943 results

Maisa N. Feghali, MD

Recruiting

Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes

Gestational Diabetes

United States
Duke University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (POPS or POP02)

Heart Failure | Pain | Pneumonia | Hypertension | Edema | Hemophilia | Insomnia | Pulmonary Arterial Hypertension | Coagulation Disorder | Asthma in Children | Down Syndrome | Attention Deficit Hyperactivity Disorder | Bronchopulmonary Dysplasia | Hypokalemia | Hyperphosphatemia | Primary Hyperaldosteronism | Adrenal Insufficiency and other conditions

United States, Canada
University Hospital, Gentofte, Copenhagen
The Novo Nordisk Foundation Center for Basic Metabolic Research

Completed

The Role of the Kidneys and Liver in the Elimination of Glucagon (MCR_EndCir)

Liver Cirrhosis | Chronic Kidney Diseases | Hyperglucagonemia

Denmark
GlaxoSmithKline

Completed

Safety and Efficacy Study of Albiglutide Liquid Drug Product in Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

United States
GlaxoSmithKline

Completed

Scintigraphy Study to Assess Gastric Emptying in Healthy Subjects Given GSK716155 or Placebo.

Diabetes Mellitus, Type 2

United States
GlaxoSmithKline

Completed

A Phase 1 Study to Evaluate the Safety and Tolerability of GSK1362885 in Healthy Normal Subjects

Diabetes Mellitus, Type 2

United States
Hospira, now a wholly owned subsidiary of Pfizer

Completed

Pharmacokinetics (PK) and Pharmacodynamics (PD) of Mayne Glucagon for Injection Compared With Glucagen® (Novo Nordisk) in Healthy Volunteers

Hypoglycemia

United Kingdom
GlaxoSmithKline

Completed

Pharmacokinetics/Pharmacodynamics of Albiglutide

Diabetes Mellitus, Type 2

United States
Sanofi

Withdrawn

A Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Single Dose of SAR438544 in Comparison to Glucagon in Type 1 Diabetes Mellitus Patients Under Induced Hypoglycemia

Type 1 Diabetes Mellitus
Sanofi

Completed

A Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Doses of SAR438544 in Comparison to Placebo and Glucagon in Healthy Subjects and Type 1 Diabetes Mellitus Patients

Type 1 Diabetes Mellitus

United States
Biodel

Completed

Pharmacokinetics and Pharmacodynamics of BIOD-961 vs. Marketed Glucagons

Hypoglycemia
Huashan Hospital
University of Florida; Unity Health Toronto; University of Massachusetts, Worcester

Completed

Pharmacokinetics Study of Gamma-aminobutyric Acid (GABA-PK)

Glucose Metabolism Disorders | Metabolic Diseases | Immune System Diseases | Autoimmune Diseases | Diabetes Mellitus | Endocrine System Diseases | Diabetes Mellitus, Type 1

China
Ligand Pharmaceuticals
Medpace, Inc.; Beckloff Associates, Inc.

Completed

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
AstraZeneca
Parexel

Not yet recruiting

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

Opioid Use Disorder

United States
Novo Nordisk A/S

Not yet recruiting

Investigating How CagriSema, Semaglutide and Cagrilintide Regulate Insulin Effects in the Body of People With Type 2 Diabetes

Diabetes Mellitus, Type 2

Germany
Western University, Canada
Unity Health Toronto; Lawson Health Research Institute; Queen Elizabeth II Health...

Not yet recruiting

Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

Obesity | Chronic Kidney Disease

Canada
Korea United Pharm. Inc.

Not yet recruiting

A Study to Compare and Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of UI059 and UIC202201

Gastro-Intestinal Disorder

Korea, Republic of
Shenzhen Institute of Advanced Technology, Chinese...

Recruiting

The Effect of Weekly Semaglutide Treatment on Energy Expenditure

Obesity; Drug

China
Novo Nordisk A/S

Not yet recruiting

A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight

Obesity

United Kingdom, Germany, Canada, United States, France
University Hospital, Geneva

Not yet recruiting

Investigation of the Evolution of Gastric Emptying by Gastric Ultra Sonography in Patients Treated With GLP-1 Receptor Agonists on a 7 Days Pausing Period.

Diabetes Mellitus, Type 2 | Anesthesia | Pulmonary Aspiration of Gastric Contents
McGill University Health Centre/Research Institute...

Not yet recruiting

Alleviating Carbohydrate Counting for Patients With Type-1 Diabetes Using a Closed Loop System With Weekly Subcutaneous Semaglutide (SEMA SMA)

Diabetes Mellitus | Type 1 Diabetes

Canada
Guangdong Hengrui Pharmaceutical Co., Ltd

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SHR-4597 Inhalation in Healthy Subjects and Asthmatic Patients

Healthy Subjects | Asthmatic Patients
Changchun GeneScience Pharmaceutical Co., Ltd.

Recruiting

A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Dose Escalation of GS1-144 Tablets and the Effects of Food on the Pharmacokinetics of GS1-144 in a Chinese Population

Healthy Volunteer | Vasomotor System; Labile

China
Ali Aminian

Not yet recruiting

Fibrosis Lessens After Metabolic Surgery (FLAMES)

Obesity | Liver Fibrosis | Non-Alcoholic Fatty Liver Disease | Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) | Metabolic Dysfunction-Associated Steatohepatitis (MASH)

United States, Sweden, Ireland, Finland, United Kingdom, Spain, Switzerland, Brazil, Canada, Italy, Kuwait, India, Mexico
Eli Lilly and Company
Regeneron Pharmaceuticals

Not yet recruiting

A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity

Obesity

United States, Mexico
Eli Lilly and Company

Not yet recruiting

A Drug-Drug Interaction (DDI) Study of Orforglipron With Carbamazepine in Healthy Participants

Healthy

United States
Capital Medical University

Not yet recruiting

Exploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment

Idiopathic Intracranial Hypertension
University of Oxford
NIHR Oxford Health Biomedical Research Centre

Not yet recruiting

Semaglutide and Cognition in Healthy Volunteers (OxSENSE)

Cognitive Change

United Kingdom
Peking Union Medical College Hospital
Xiangya Hospital of Central South University; Ruijin Hospital; China-Japan Friendship...

Recruiting

The Study of Monitoring and Dosing Guidance of Direct Oral Anticoagulants Based on Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics

Pulmonary Embolism

China
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Not yet recruiting

Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery

Delirium, Postoperative
Changchun BCHT Biotechnology Co.
The First Affiliated Hospital of Yunnan University of Traditional Chinese... and other collaborators

Not yet recruiting

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of the Fully Human Anti-tetanus Toxin Monoclonal Antibody A82 / B86 Injection Combination Formulation

Clostridium Tetanus
Equilibra Bioscience LLC

Recruiting

A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B)

Hemophilia A | Hemophilia B | Healthy Participants

United States
RenJi Hospital

Recruiting

Comparison of the Efficacy and Safety of SGLT2i and GLP-1 Receptor Agonists in Obese Patients With Kidney Disease

Obesity | Chronic Kidney Diseases

China
BeiGene

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single- and Multiple-Ascending Doses and Food Effect of BGB-45035

Autoimmune Diseases | Healthy Volunteers | Healthy Subjects | Healthy Participants | Healthy Adult Participants
Chengdu Brilliant Pharmaceutical Co., Ltd.

Not yet recruiting

Efficacy and Safety of Semaglutide Injection in Subjects With Type 2 Diabetes

Type 2 Diabetes Mellitus
Vanderbilt University Medical Center

Recruiting

GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab (GLP-TEP)

Type 1 Diabetes

United States
Biocad

Recruiting

Study of the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of BCD-180 in Patients With Axial Spondyloarthritis (LEVENTA)

Axial Spondyloarthritis

Russian Federation, Belarus
IgGenix Australia Pty Ltd

Not yet recruiting

Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of IGNX001

Peanut Allergy
First Affiliated Hospital of Zhejiang University

Recruiting

The Effect of Dulaglutide as an Adjuvant Therapy on Cognitive Function in Bipolar Disorder Patients With Obesity

Obesity | Bipolar Disorder | Cognition

China
Mozart Therapeutics Australia Pty Ltd

Not yet recruiting

Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients

Type 1 Diabetes | Celiac Disease | Healthy Volunteers

Australia
The University of Hong Kong

Not yet recruiting

GLP-1 Receptor Agonist for Reduction of Myocardial Injury After Non-cardiac Surgery (GLUMINS)

Myocardial Injury

China
Novo Nordisk A/S

Recruiting

A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and Exercise (REIMAGINE 1)

Type 2 Diabetes

United States, Serbia, Italy, Poland, China, Hungary, Saudi Arabia
Novo Nordisk A/S

Recruiting

A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without Metformin (REIMAGINE 3)

Type 2 Diabetes

United States, Japan, Serbia, South Africa, China, Slovakia
Imperial College London

Not yet recruiting

The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes

Steroid-Induced Diabetes | Steroid Induced Hyperglycemia

United Kingdom
ProGen. Co., Ltd.

Recruiting

A Study to Assess Safety, Pharmacokinetics and Pharmacodynamics of PG-102(MG12) in Healthy Volunteers

Healthy | Overweight

Korea, Republic of
Kallyope Inc.

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-757 and K-833 in Overweight/Obese Patients With Type 2 Diabetes

Obesity | Type 2 Diabetes Mellitus (T2DM)

United States
Attikon Hospital

Recruiting

The Effect of Semaglutide on Cardiovascular Markers and Liver Function

Diabetes Type 2

Greece
Dong-A ST Co., Ltd.

Not yet recruiting

Clinical Trial to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DA-4505 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Locally Advanced or Metastatic Solid Tumors

Locally Advanced or Metastatic Solid Tumors
Novo Nordisk A/S

Recruiting

A Study on How CagriSema Affects Levels of Atorvastatin and Warfarin in the Blood of Participants With Excess Body Weight

Obesity

Canada
Beijing Suncadia Pharmaceuticals Co., Ltd

Not yet recruiting

Study on the Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of SHR-2004 Injection in Adult Patients With Atrial Fibrillation

Atrial Fibrillation

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