Search clinical trials for: Glycoprotein inhibitor

Total 67982 results

Peking University Third Hospital

Recruiting

Effect of Oral D-mannose Tablets on Pharmacokinetics of Dabigatranate in Healthy Adults

Health

China
Dongyang Liu

Recruiting

Pharmacokinetic Study to Evaluate Dabigatran Etexilate in Elderly Subjects

Health, Subjective | Nonvalvular Atrial Fibrillation

China
Cairo University
Aswan Heart Centre

Not yet recruiting

Upfront Premedication For Reduction of Microvascular Obstruction and No-reflow in Treating ST-segment Elevation Myocardial Infarction (UPFRONT-STEMI)

STEMI | No-Reflow Phenomenon | Large Thrombus Burden
Fundación EPIC

Recruiting

Parenteral Antiplatelet Agents in Real-world Spanish PCI Patients (PATREAL)

Acute Coronary Syndrome | Ischemic Heart Disease

Spain
Radboud University Medical Center
UMC Utrecht; Erasmus Medical Center; Academisch Medisch Centrum - Universiteit... and other collaborators

Recruiting

Rare Bleeding Disorders in the Netherlands (RBIN)

Rare Bleeding Disorders

Netherlands
University of Luebeck

Recruiting

Glycoprotein IIb/IIIa Inhibitors Versus Standard Therapy in Patients With Myocardial Infarction and No-reflow (REVERSE-FLOW)

Acute Myocardial Infarction

Germany
Italian Sarcoma Group

Completed

ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma (ISG/OS-2)

Osteosarcoma

Italy
Organon and Co
Duke Clinical Research Institute

Completed

EARLY ACS: Early Glycoprotein IIb/IIIa Inhibition in Patients With Non-ST-segment Elevation Acute Coronary Syndrome (Study P03684AM2)(COMPLETED)

Myocardial Ischemia | Acute Coronary Syndrome
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Digoxin (P-Glycoprotein Substrate) in Healthy Participants

Healthy

United States
AstraZeneca
Parexel

Completed

A Study to Assess the Effect of AZD5462 on the Pharmacokinetics of Midazolam, Rosuvastatin and Digoxin

Healthy Participants

United States
Merck KGaA, Darmstadt, Germany

Completed

Effect of Tepotinib on the PK of the P-gp Substrate Dabigatran Etexilate

Healthy

Germany
Corcept Therapeutics

Completed

Effect of Relacorilant on the Pharmacokinetics of the Sensitive P-glycoprotein Substrate Dabigatran Etexilate in Healthy Participants

Neoplasms | Cushing Syndrome

United States
Astellas Pharma Global Development, Inc.
Pfizer

Completed

A Study to Evaluate the Effect of Multiple Doses of Enzalutamide on the Pharmacokinetics of Substrates of P-glycoprotein (Digoxin) and Breast Cancer Resistant Protein (Rosuvastatin) in Male Subjects With Prostate Cancer

Prostate Cancer

Moldova, Republic of
Acticor Biotech

Completed

Glenzocimab in SARS-Cov-2 Acute Respiratory DistrEss syNdrome Related to COVID-19 (GARDEN)

COVID-19 | Acute Respiratory Distress Syndrome | ARDS | SARS-CoV Infection

France
Theravance Biopharma

Completed

A Fixed-Sequence, Two-Period, Open-Label Drug-Drug Interaction Study to Assess the Effect of an Inhibitor of Cytochrome P450 Isoenzyme 3A4 and Permeability Glycoprotein 1 on the Pharmacokinetics of TD-1211

Healthy

United States
Unity Health Toronto
University of Toronto; Li Ka Shing Knowledge Institute

Unknown

Proof-of-Concept: A Pilot, Randomized, Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia

Immune Thrombocytopenia

Canada
Washington University School of Medicine

Completed

Efavirenz and Ritonavir on Human Brain P-Glycoprotein

Drug Effects

United States
Celgene
Covance

Completed

Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males

Healthy

United States
University of Cologne
Umm Al-Qura University

Completed

Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein

AOD Effects and Consequences

Germany
Weill Medical College of Cornell University

Completed

Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation

Kidney Failure, Chronic

United States
Janssen-Cilag International NV

Completed

A Study to Evaluate the Effect of Cyclosporine, a P-Glycoprotein, Breast Cancer Resistance Protein, and Organic-Anion-Transporting Polypeptide Inhibitor, on Pimodivir in Healthy Adults

Healthy

Belgium
Cardiovascular Institute of the South Clinical...

Completed

ClearWay Rx Readmission Registry (ClearWay)

Acute Myocardial Infarction

United States
Assiut University

Unknown

Platelet Glycoproteins in Inherited Thrombocytopathy: Association With Aggregation Studies and Bleeding Severity

Bleeding | Platelet Dysfunction

Egypt
Sony Tuteja
American College of Clinical Pharmacy

Completed

Pharmacogenetics to Predict Drug Interactions in Kidney Transplant Recipients

Kidney Transplantation

United States
Icahn School of Medicine at Mount Sinai

Completed

Aspirin Resistance and Percutaneous Coronary Intervention (PCI) (RESIST)

Stable Angina

United States
Toray Industries, Inc

Completed

TRK-700 Drug-Drug Interaction Study With Digoxin and Midazolam

Healthy

Japan
Thomas Jefferson University
Bristol-Myers Squibb

Completed

Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus (ACT)

Healthy | Venous Thromboembolism | Pharmacokinetics

United States
National Institutes of Health Clinical Center (CC)

Completed

Influence of the MDR1 Genotype on Blood Levels of Indinavir and Saquinavir in Healthy Volunteers

HIV Infections | Healthy

United States
National Institutes of Health Clinical Center (CC)
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

The Interaction of Two HIV Medications With Blood Clot Medications in Healthy Volunteers

HIV

United States
University of Utah
Cubist Pharmaceuticals LLC

Completed

Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin

Pharmacokinetics | Drug Interactions

United States
University Hospital, Geneva

Unknown

Drug Metabolism and Antidepressant (METADEP)

Depression

Switzerland
Eisai Inc.

Completed

A Pharmacokinetic Study to Assess the Influence of P-glycoprotein Inhibition and Simultaneous CYP3A4 and P-glycoprotein Induction on E7080 Pharmacokinetics Following Single Dose Oral Administration of 24 mg E7080 to Healthy Volunteers

Healthy Volunteers | P-glycoprotein

United States
Eisai Inc.

Completed

A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers

Healthy Volunteers

United States
Boehringer Ingelheim

Completed

The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)

Healthy

Germany
Shenyang Northern Hospital

Completed

BivaliRudin in Acute Myocardial Infarction vs Glycoprotein IIb/IIIa and Heparin :a Randomised Controlled Trial. (BRIGHT)

Percutaneous Coronary Intervention | Acute Myocardial Infarction

China
Boehringer Ingelheim

Completed

Effects of Tipranavir (With Ritonavir) Capsule and Liquid Formulation on Cytochrome P450 and P-glycoprotein Activity in Healthy Volunteers

Healthy
Jules Desmeules

Completed

Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot

Healthy Volunteers

Switzerland
Boehringer Ingelheim

Completed

Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers

Healthy
Pfizer

Completed

Drug Interaction Study Between Bosutinib And Dabigatran

Healthy

United States
TC Erciyes University

Completed

Intracoronary Tirofiban on No-Reflow Phenomena

No-Reflow Phenomenon

Turkey
Cardiology Research UBC
University of British Columbia

Completed

BRIEF-PCI: Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention

Myocardial Infarction | Coronary Artery Disease

Canada
National Cancer Institute (NCI)

Completed

PXD101 and Bortezomib in Treating Patients With Advanced Solid Tumors or Lymphomas

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma and other conditions

United States
University of Colorado, Denver
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology

Healthy

United States
Pusan National University Yangsan Hospital
AstraZeneca

Unknown

Comparison of Antiplatelet Effect of Ticagrelor vs Tirofiban in Patients With Non-ST Elevation Acute Coronary Syndrome (TE-CLOT)

Non-ST Segment Elevation Acute Coronary Syndrome

Korea, Republic of
Università degli Studi di Ferrara

Completed

Facilitation Through Aggrastat By drOpping or Shortening Infusion Line in Patients With ST-segment Elevation Myocardial Infarction Compared to or on Top of PRasugrel Loading dOse (FABOLUS PRO)

ST Segment Elevation Myocardial Infarction

Italy
Marco Valgimigli

Unknown

Multicentre 2x2 Factorial Randomised Study Comparing Tirofiban Versus Abciximab and SES Versus BMS in AMI

Myocardial Infarction

Italy
Università degli Studi di Ferrara

Completed

Study of Tirofiban Administration in Patients With Aspirin and or Clopidogrel Resistance (3T/2R)

Angioplasty, Transluminal, Percutaneous Coronary

Italy
Janssen-Cilag Pty Ltd

Completed

Pre-transplant Assessment of Tacrolimus Blood Level Concentration, as a Predictor of Tacrolimus Dose Requirements After Kidney Transplantation

Kidney Transplantation | Transplantation
ViiV Healthcare
Pfizer

Completed

Effect Of Maraviroc On The Pharmacokinetics Of Digoxin

HIV Infections | Healthy

Singapore
Hanmi Pharmaceutical Company Limited

Completed

Duration of P-glycoprotein Inhibition After Oral Administration of HM30181AK Tablet (PGP inhibitor)

Healthy

Korea, Republic of

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