Search clinical trials for: High tumour burden

Total 22436 results

Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition (DETERMINE)

Melanoma | Neoplasms by Histologic Type | Lymphoproliferative Disorders | Neoplasms by Site | Cancer | Colorectal Neoplasms | Endometrial Neoplasms | Malignant Neoplasm | Malignancy

United Kingdom
Cambridge University Hospitals NHS Foundation Trust
National Institute for Health Research, United Kingdom

Not yet recruiting

Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer

Pancreatic Cancer
Supergene, LLC

Not yet recruiting

Non-immunogenic Recombinant Staphylokinase vs Placebo in Patients With Intermediate High-risk Pulmonary Embolism

Pulmonary Embolism

Russian Federation
Elin Tragardh
Lund University

Recruiting

AI-based Measurements of Tumour Burden in PSMA PET-CT

Prostate Cancer

Sweden
Barretos Cancer Hospital
Fundação de Amparo à Pesquisa do Estado de São Paulo; Farmoquimica S.A.; Hospital...

Not yet recruiting

Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated With Imiquimod

Biomarkers | HSIL, High-Grade Squamous Intraepithelial Lesions | Vaginal Microbiome
Hoffmann-La Roche

Recruiting

A Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors With Resectable Disease With Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H) (IMperator)

Solid Tumors

Spain
Atrial Fibrillation Network

Not yet recruiting

Early Atrial Fibrillation Ablation for Stroke Prevention in Patients With High Comorbidity Burden (EASThigh-AFNET 11)

Atrial Fibrillation

Germany, Australia, Canada, Netherlands, United Kingdom
Region Skane
Lund University; Helsinki University Central Hospital; The George Institute for... and other collaborators

Recruiting

Stepcare Extended Follow-up Substudy

Cognitive Impairment | Caregiver Burden | Hypoxia, Brain | Cardiac Arrest With Successful Resuscitation

Sweden, Finland, United Kingdom, Switzerland, New Zealand, Australia, Norway, Germany, Luxembourg
Singapore General Hospital
National Cancer Centre, Singapore; National Neuroscience Institute Singapore; Duke-NUS Centre of Quantitative Medicine and other collaborators

Not yet recruiting

FET PET in Differentiating Tumour Progression From Pseudoprogression in High Grade Glioma (FET PET in HGG)

Glioma, Malignant
International Vaccine Institute
London School of Hygiene and Tropical Medicine; Karolinska Institutet; Centers...

Not yet recruiting

Global Burden Estimation of Human Papillomavirus (GLOBE-HPV) (HPV)

HPV Infection

Zambia, Bangladesh, Congo, The Democratic Republic of the, Ghana, Nepal, Pakistan, Sierra Leone, Tanzania
M.D. Anderson Cancer Center
Bristol-Myers Squibb

Recruiting

Phase 2 Trial of Obinutuzumab and CC-99282 for Patients With Previously Untreated High Tumor Burden Follicular Lymphoma

Follicular Lymphoma | Tumor

United States
Institut du Cancer de Montpellier - Val d'Aurelle

Recruiting

Unravelling Tumour Biology In Ovarian Cancer With Precision Imaging (MR-O-MICS)

High Grade Serous Ovarian Cancer

France
University of Roma La Sapienza

Not yet recruiting

Vesical Imaging-Reporting and Data System (VI-RADS) Followed by Photodynamic Trans-urethral Resection of Bladder Tumours (PDD-TURBT) to Avoid Secondary Resections (Re-TURBT) in Non-Muscle Invasive Bladder Cancers (NMIBCs) (CUT-less)

Non-muscle-invasive Bladder Cancer | Non-Muscle Invasive Bladder Urothelial Carcinoma | High Risk Non-Muscle Invasive Bladder Urothelial Carcinoma
Tata Memorial Centre

Recruiting

Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study (PARCERII)

Cervical Cancer | Endometrial Cancer

India
Sociedad de Lucha Contra el Cáncer del Ecuador

Not yet recruiting

5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas

Glioma | Neoplasms, Neuroepithelial | Neuroectodermal Tumors | Central Nervous System Neoplasms | Brain Tumor | High Grade Glioma | Glioma, Malignant | Neoplasm Malignant | Photosensitizing Agents | Tumour, Residual | Brain Neoplasms, Adult, Malignant

Ecuador
Assiut University

Not yet recruiting

Follow up of Clinical Outcome of Deferred vs Immediate Stenting in High Thrombus Stemi Patients

STEMI
Qilu Hospital of Shandong University

Recruiting

Efficacy and Safety of Apantamide Combined With Docetaxel and ADT vs. Apantamide Combined With ADT in Patients With High Tumor Burden mHSPC: a Multicenter and Prospective Cohort Study

Cohort Studies

China
Assiut University

Not yet recruiting

In-hospital Clinical Outcome of Deferred Stenting Versus Immediate Stenting in the Management of Acute STEMI Presenting With High Thrombus Burden.

Coronary Thrombosis
Marengo Therapeutics, Inc.

Recruiting

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors (START-001)

Neoplasms | Urogenital Neoplasms | Neoplasms by Site | Carcinoma | Epstein-Barr Virus Infections | Advanced Solid Tumors | Vulvar Neoplasms | Vulvar Diseases | Abdominal Neoplasm | Lung Neoplasm | Papillomavirus Infection | Genital Neoplasm, Female

United States, Canada
Wuhan Union Hospital, China

Recruiting

High-Resolution Assessment of Extracranial Plaques in a Multiple Centers Evolocumab Randomized Study

Cerebral Atherosclerosis

China
Vaishalee Kenkre
Epizyme, Inc.; University of Wisconsin, Madison

Recruiting

A Study of Tazemetostat With Rituximab and Abbreviated Bendamustine in the Frontline Treatment of High Tumor Burden Follicular Lymphoma

Follicular Lymphoma

United States
Hospital Universitario Getafe
Spanish Research Center for Respiratory Diseases

Recruiting

Global BurdEn of MechanIcal VeNtilatIon (GEMINI). VeNtilatIon (GEMINI Study) 2022 for VENTILAGROUP. (GEMINI)

Mechanical Ventilation | Usual Care | Noninvasive Positive Pressure Ventilation | High Flow Oxygen Therapy

Spain
Liverpool John Moores University
University of Liverpool; Liverpool Heart and Chest Hospital NHS Foundation... and other collaborators

Recruiting

High-intensity Interval Training in Patients With Atrial Fibrillation (HIIT-AF)

Atrial Fibrillation

United Kingdom
University of Turku
Philips Electronics Nederland BV; Precordior Ltd; Emfit, Corp.; Everon Ltd; Remotea...

Recruiting

Low Workload Concept for the Detection of Silent Atrial Fibrillation (AF) and Atrial Fibrillation Burden in Patients at High Risk of AF and Stroke (CARE-DETECT)

Pathologic Processes | Heart Diseases | Cardiovascular Diseases | Postoperative Complications | Atrial Fibrillation | Arrhythmias, Cardiac

Finland
Bambino Gesù Hospital and Research Institute

Recruiting

GD2-CAR T Cells for Pediatric Brain Tumours

High Grade Glioma | Medulloblastoma, Childhood | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Embryonal Tumor | Brain Tumor Adult | Brain Tumor, Pediatric

Italy
University Medical Center Goettingen

Recruiting

Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic Burden (Reduce-MFA)

Aortic Stenosis, Severe

Germany
Anthony Tang

Recruiting

Randomized Ablation-based AF Rhythm-control Versus Rate-control in Patients With HF and High-burden AF Extend (RAFT-AF Extend)

Heart Failure | Atrial Fibrillation

Canada
Oxford University Hospitals NHS Trust
Surgical Intervention Trials Unit (trial oversight); NIHR Direct Delivery Team... and other collaborators

Recruiting

HIFU Ablation of Soft Tissue Sarcoma (SarcAblate)

Soft Tissue Sarcoma | Desmoid; Abdominal

United Kingdom
Medicenna Therapeutics, Inc.
Merck Sharp & Dohme LLC

Recruiting

A Beta-only IL-2 ImmunoTherapY Study (ABILITY-1)

Clear Cell Renal Cell Carcinoma | Cervical Cancer | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Fallopian Tube Cancer | Solid Tumor | Squamous Cell Carcinoma of Head and Neck | Bladder Cancer | Skin Cancer | Triple Negative Breast Cancer | Advanced Solid Tumor | Primary Peritoneal Cancer | Endometrial Carcinoma and other conditions

United States, Australia, Korea, Republic of, Canada
Fondazione Italiana Linfomi - ETS

Recruiting

Shortened vs Standard Chemotherapy Combined With Immunotherapy for the Initial Treatment of Patients With High Tumor Burden Follicular Lymphoma

Follicular Lymphoma

Italy
oubai, MD/PhD

Recruiting

R-CDOP Regimen in the Treatment of Newly Diagnosed Non-Hodgkin's Lymphoma With High Tumor Burden

Diffuse Large B Cell Lymphoma | Follicular Lymphoma Grade 3B

China
J.M. de Laat
Radboud University Medical Center; University Medical Center Groningen; Maastricht... and other collaborators

Recruiting

Precision Radiotherapy Using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 Patients (PRIME)

Multiple Endocrine Neoplasia Type 1 | Neuroendocrine Tumor of Pancreas

Netherlands
Oslo University Hospital

Recruiting

HAI-Floxuridine, or Liver-Tx, Combined With 2nd Line Chemotherapy Versus 2nd Line Chemotherapy Alone for Patients With Colorectal Liver Metastases and Heavy Tumour Burden. (EXCALIBUR1+2)

Colorectal Cancer | Chemotherapy Effect | Liver Metastases

Norway
Oslo University Hospital

Recruiting

EXtended CriteriA Treatment for LIver Metastases and Heavy Tumour BURden (EXCALIBUR3)

Colorectal Cancer | Liver Metastases

Norway
Novo Nordisk A/S

Recruiting

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) (ESSENCE)

Non-alcoholic Steatohepatitis

United States, Korea, Republic of, Australia, Taiwan, Italy, Israel, Canada, Netherlands, Czechia, Malaysia, Spain, Denmark, China, United Kingdom, Singapore, Japan, Puerto Rico, Portugal, Switzerland, Ireland, Belgium, Romania, Ger... and more
SonoClear AS

Recruiting

SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue

Glioblastoma | High Grade Glioma | Low-grade Glioma | Brain Tumour

Germany, Slovakia, Italy
British Columbia Cancer Agency
Hoffmann-La Roche

Recruiting

Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity (CAPTIV-8)

Sarcoma | Breast Cancer | Head and Neck Cancer | Gynecologic Cancer | Lung Cancer | Skin Cancer | Gastrointestinal Cancer | Unknown Primary Tumors | Genitourinary Cancer

Canada
University Health Network, Toronto
Women's College Hospital; Jewish General Hospital; IWK Health Centre; British Columbia... and other collaborators

Recruiting

Cell-free DNA in Hereditary And High-Risk Malignancies (CHARM)

Hereditary Cancer Syndrome

Canada
Guangdong Provincial People's Hospital
West China Hospital; Shenzhen People's Hospital; Fifth Affiliated Hospital, Sun... and other collaborators

Recruiting

Thrombus Aspiration in STEMI Patients With High Thrombus Burden

ST-segment Elevation Myocardial Infarction (STEMI)

China
UNICANCER

Recruiting

Endocrine Therapy With Abemaciclib or Chemotherapy as Initial Metastatic Treatment in ER+/HER2- Breast Cancer (AMBRE)

Cancer Metastatic

France
Pfizer
Arena is a wholly owned subsidiary of Pfizer

Recruiting

An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis (ELEVATE UC OLE)

Ulcerative Colitis

Poland, Japan, Georgia, Estonia, United States, Australia, Korea, Republic of, Lithuania, Italy, Turkey, Spain, Romania, Serbia, Germany, France, Bulgaria, Austria, Belarus, Canada, Croatia, Czechia, Denmark, Hungary, Israel, Latvia, Lebanon and more
Imperial College London
Wellcome Trust

Recruiting

Additional Treatments to the Local Tumour for Metastatic Prostate Cancer: Assessment of Novel Treatment Algorithms (IP2-ATLANTA)

Prostate Cancer | Metastatic Prostate Cancer

United Kingdom
Celgene

Recruiting

A Study to Evaluate the Relationship of Lenalidomide With Tumor Flare Reaction and High Tumor Burden in Participants With Relapsed or Refractory Mantle Cell Lymphoma

Lymphoma, Mantle-Cell

Spain, Italy, Germany, Austria, France, Greece, Netherlands
Sun Yat-sen University

Recruiting

PD-1 Antibody Combined With COX Inhibitor in MSI-H/dMMR or High TMB Colorectal Cancer (PCOX)

Colorectal Cancer

China
Nanobiotix

Recruiting

NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy

Metastatic Renal Cell Carcinoma | Squamous Cell Carcinoma of Head and Neck | Radiotherapy | Immunotherapy | Microsatellite Instability-High Solid Malignant Tumour | Metastasis From Malignant Tumor of Liver | Metastasis From Malignant Tumor of Cervix | Metastasis From Malignant Melanoma of Skin (Disorder) and other conditions

United States
Yonsei University

Not yet recruiting

Pembrolizumab in Combination With Paclitaxel in the Hormone Receptor-positive Metastatic Breast Cancer With High Tumor Mutational Burden Selected by Whole Exome Sequencing: Korean Cancer Study Group Trial (KCSG BR20-16)

Metastatic Breast Cancer

Korea, Republic of
Peking University People's Hospital

Recruiting

RIC Regimen for Elderly or High Comorbidity Burden Patients Receiving Haplo-HSCT

Myelodysplastic Syndromes | Acute Leukemia

China
Sichuan University
Geneplus-Beijing Co. Ltd.

Recruiting

A Prospective Study of Constructing Immune Repertoire to Monitor the Therapeutic Effect in NSCLC Patients

Non-small Cell Lung Cancer

China
AHS Cancer Control Alberta

Recruiting

A Study to Evaluate a New Way to Identify/Diagnose Tumours With Somatostatin Receptors Using [68]Ga-HA-DOTATATE and to Ensure it is Safe to Use

Neuroendocrine Tumors

Canada
University College, London

Recruiting

Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours

Cancer | Breast Cancer | Colorectal Cancer | Prostate Cancer | Gastro-oesophageal Cancer

Ireland, United Kingdom

Search clinical trials for: High tumour burden

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