Search clinical trials for: Hippo pathway

Total 1940 results

LMU Klinikum
German Research Foundation

Recruiting

Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training (BrainTrain)

Schizophrenia | Exercise | Neuronal Plasticity

Germany
Ikena Oncology

Recruiting

Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects With Advanced Solid Tumors

Solid Tumor | Solid Tumors, Adult | Malignant Pleural Mesothelioma (MPM) | Epithelioid Hemangioendothelioma (EHE) | NF2 Deficient Mesothelioma | Other NF2 Deficient Solid Tumors and Solid Tumors With YAP1/TAZ Fusion Genes | NF2 Deficiency | YAP1 or TAZ Gene Fusions

United States, United Kingdom
Gregory Jicha, MD, PhD
National Institute on Aging (NIA)

Recruiting

Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging (SMArT-HS)

Dementia | Mild Cognitive Impairment

United States
St. Jude Children's Research Hospital

Recruiting

Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

Glioma | Ganglioglioma | Pleomorphic Xanthoastrocytoma | Diffuse Astrocytoma | Pilocytic Astrocytoma | Optic Pathway Glioma | Pilomyxoid Astrocytoma

United States
Hao Feng

Enrolling by invitation

The Role and Mechanism of GPER-Hippo-CBS/H2S Pathway in Preeclampsia

Preeclampsia

China
Regina Elena Cancer Institute
Fondazione Policlinico Universitario Agostino Gemelli IRCCS; University of... and other collaborators

Active, not recruiting

Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer

Gastric Cancer | DNA Damage

Italy
César Díaz García

Completed

Follicular Activation in Poor Responders (FAPPOR)

Infertility

Spain
Mario Negri Institute for Pharmacological Research
Associazione Italiana per la Ricerca sul Cancro

Completed

Neoadjuvant Zoledronate and Atorvastatin in Triple Negative Breast Cancer (YAPPETIZER)

Triple Negative Breast Cancer

Italy
Neuromed IRCCS

Completed

Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm

Aortic Aneurysm

Italy
Forever Young d.o.o.
Medigroup Health System, Jevremova hospital; Saint James Hospital Malta; Re-medika...

Unknown

Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation (SEGOVA)

Menopause | Menopause, Premature | Premature Ovarian Failure | Ovarian Failure, Premature | Ovarian Failure | Ovarian Insufficiency | Ovarian Insufficiency, Primary | Premature Ovarian Failure 2A | Premature Ovarian Failure 3 | Premature Ovarian Failure 4 | Premature Ovarian Failure 1 | Premature Ovarian Failure... and other conditions

Malta, North Macedonia, Serbia
Anders Nyboe Andersen

Completed

Follicle Activation by Inhibition of the Hippo Pathway

Infertility

Denmark
Third Affiliated Hospital, Sun Yat-Sen University
National University of Singapore

Unknown

The Activation of Hippo Pathway in Nasal Polyps

Nasal Polyps

China
Regina Elena Cancer Institute

Unknown

Targeting the Hippo Transducer TAZ in Breast Cancer With Statins (TRINACRIA)

Breast Neoplasms
Xuanwu Hospital, Beijing

Not yet recruiting

Subiculum Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis(SESTB)

Epilepsy, Drug Resistant

China
Basque Health Service
Health Department of the Basque Government

Recruiting

Asthma Crisis in Paediatrics: Impact of a Care Pathway in Primary and Hospital Care

Asthma in Children | Implementation Science | Inappropriate Prescribing

Spain
Xie Kangjie

Recruiting

Predictive Effect of TGF-β Combined With INS-PI3K-AKT Signaling Pathway Related Proteins (ADNP, MAP6, Pgc-1α) for POD on Diabetes Patients

Diabetes | Postoperative Delirium

China
Mayo Clinic

Recruiting

NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Metastatic Cholangiocarcinoma | Refractory Cholangiocarcinoma | Stage III Hilar Cholangiocarcinoma AJCC v8 | Stage IV Hilar Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Advanced Cholangiocarcinoma

United States
Hitit University

Recruiting

Schroth Treatment and Proprioception Pathway

Adolescent Idiopathic Scoliosis

Turkey
Konstantinos Toutouzas
Université Catholique de Louvain; University of Patras; Centre Hospitalier Universitaire... and other collaborators

Not yet recruiting

3rd Generation Resorbable Magnesium Scaffolds vs Biodegradable Polymer Stents in NSTE/ACS

Coronary Artery Disease | Acute Coronary Syndrome

Belgium, Switzerland, Greece
University of Alberta

Not yet recruiting

Pharmacist Case Finding and Intervention for Vascular Prevention Trial (PRxOACT)

Cardiovascular Disease | Diabetes | Dyslipidemia | Blood Pressure | Cardiovascular Risk Factors
Hasan Kalyoncu University

Not yet recruiting

The Effect of Hippotherapy Simulator in Children With Spastic Cerebral Palsy

Cerebral Palsy

Turkey
Institute for Cardiovascular Diseases "Dedinje"
Abbott Medical Devices

Recruiting

Southeastern Europe Microcirculation Registry (SATURATION)

Coronary Artery Disease | Coronary Microvascular Dysfunction | Angina, Microvascular

Serbia, Greece, Croatia, Israel, Slovenia
ASST Ovest Milanese
Hippocrates Research; Bonalive Biomaterials Ltd

Recruiting

RCT on Bioactive Glass S53P4 in Diabetic Foot Osteomyelitis in the Forefoot (DFORCT) (DFORCT)

Osteomyelitis - Foot

Italy
Massachusetts General Hospital

Not yet recruiting

The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia

Schizophrenia

United States
Assistance Publique Hopitaux De Marseille

Recruiting

Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway (BIOCEPTION)

Lung Cancer | Smoking-related Pathology | Atheroma | Non-progressive Cancer > 5 Years

France
The Cleveland Clinic

Not yet recruiting

Engaging Patients in Prenatal Genetic Testing Decisions as a Pathway to Improve Obstetric Outcomes (OPUS)

Prenatal Disorder

United States
Mayo Clinic

Not yet recruiting

Stereotactic Body Radiation Therapy Plus Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy for Treatment of Metastatic, Recurrent Hormone-Sensitive Prostate Cancer, DIVINE Trial (DIVINE)

Recurrent Prostate Cancer | Castration-resistant Prostate Cancer | Stage IVB Prostate Cancer AJCC v8 | Recurrent Castration-Sensitive Prostate Carcinoma

United States
University of Alberta
Alberta Innovates Health Solutions

Not yet recruiting

Digital Health Pathway for Children With Medical Complexity Requiring Tracheostomy (DECIDE-T)

Tracheostomy

Canada
Stony Brook University
Massachusetts General Hospital; Mclean Hospital

Recruiting

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Bipolar Disorder | Bipolar Disorder Type 1

United States
University Hospital, Toulouse
Janssen, LP; Ligue contre le cancer, France

Not yet recruiting

Real-life Management of Patients Eligible for CAR-T Cell Therapy (CARAVAGE)

Hemopathy

France
Medical College of Wisconsin

Not yet recruiting

Molecular Analyses to Identify Pathways of Endocrine Resistance Following Short Term Neoadjuvant Endocrine Treatment in Patients With Hormone Receptor-Positive HER2-negative Breast Cancer

Breast Cancer

United States
University of Alabama at Birmingham

Not yet recruiting

Establishment of an Interdisciplinary Functional Neurological Disorder (FND) Treatment Program and Development of a Clinical Care Pathway for FND

Convulsion, Non-Epileptic | Functional Neurological Disorder | Functional Seizure

United States
Tianjin Medical University Cancer Institute and...

Recruiting

Osimertinib Plus Dalpiciclib in Patients With EGFR-mutant, CDK4/6 Pathway Aberrant, Advanced Non-small Cell Lung Cancer Following Acquired Resistance to Third-generation EGFR TKI: a Phase II Trial

Non-small Cell Lung Cancer | EGFR Activating Mutation | EGFR-TKI Resistant Mutation | Cell Cycle Deregulation

China
Chinese University of Hong Kong

Not yet recruiting

To Evaluate an MRI-based Optimized Prostate Cancer Diagnostic Pathway Powered by Artificial Intelligence

Prostate Cancer

Hong Kong
Institut Jean-Godinot
Université de Reims Champagne-Ardenne

Not yet recruiting

Development of a Questionnaire on Patients' Perception of Their Oncology Care Pathway (Onco-PREMs) (OncoPREMs)

Cancer
University of Michigan
National Institute on Drug Abuse (NIDA)

Not yet recruiting

Adversity, Brain and Opioid Use Study

Healthy | Opioid Use Disorder

United States
University of Michigan
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Not yet recruiting

Guideline to Implementation: A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation

Constipation

United States
Karolinska University Hospital

Not yet recruiting

Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome

Critical Illness | Hypophosphatemia | Refeeding Syndrome

Sweden, Czechia, Italy
Elsan

Not yet recruiting

Innovative Care Pathway in Physical Activity and Behavior Change in Coronary Patients Post-cardiac Rehabilitation (APIC)

Individualised Physical Activity Program | Coronary Patient
Eli Lilly and Company

Recruiting

A Study of Lebrikizumab (LY3650150) in Adult Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Belgium, Italy, United States, Bulgaria
Pr. Nicolas GIRERD

Recruiting

PAtient Treatment Analysis: Hospital and Wide-ranging Out-of-hospital Care Assessment Yields Insights Into Heart Failure Outcomes (PATHWAY-HF)

Heart Failure

France
University of Alberta
Alberta Health services

Recruiting

Optimizing the Management of Staphylococcus Aureus Bacteremia (OPTIMUS-SAB)

Staph Aureus Bacteremia

Canada
Acumen Pharmaceuticals

Recruiting

A Study to Evaluate Efficacy and Safety of Intravenous ACU193 in Participants With Early Alzheimer's Disease (ALTITUDE-AD) (ALTITUDE-AD)

Alzheimer Disease

United States, France, Italy, Germany, Spain, Canada, Poland, United Kingdom
Fondazione del Piemonte per l'Oncologia

Recruiting

INSIDE: Identification of Genomic Screening Pathways in Cancer Patients With DNA Repair Alterations (INSIDE)

Prostate Cancer

Italy
Ziauddin University

Not yet recruiting

Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial (MROSF)

Oral Submucous Fibrosis

Pakistan
Institut de cancérologie Strasbourg Europe

Not yet recruiting

Hippotherapy Teenager-pediatric Radiotherapy (T-QAP)

Radiotherapy

France
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies (3776)

Noonan Syndrome | Costello Syndrome | RASopathy | Cardio-Facio-Cutaneous Syndrome

Italy
University of Edinburgh

Not yet recruiting

Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology (ORACLE)

Coronary Artery Disease | Angina, Stable
Nested Therapeutics, Inc

Recruiting

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors (NST-628)

Glioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene Mutation

United States, Australia
University of Alabama at Birmingham

Not yet recruiting

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway (VITAL-IMPACT)

Cardiovascular Diseases | Obesity | Insulin Sensitivity/Resistance | Metabolic Disease | Energy Expenditure | Metabolism

United States

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