Search clinical trials for: Human immune challenge

Total 77254 results

Ifakara Health Institute
University of Oxford

Not yet recruiting

In-vivo Transmission Model in Semi-immune Adults

Controlled Human Malaria Infection | Malaria Transmission | Induced Blood Stage Malaria Infection | Malaria Challenge

Tanzania
University of Oxford

Recruiting

KLH Challenge to Explore the Human Immune Response

Immune Response

United Kingdom
Wake Forest University Health Sciences
National Institute on Aging (NIA); Health Resources and Services Administration...

Recruiting

Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

HIV | Aging

United States
USDA, Western Human Nutrition Research Center

Recruiting

Postprandial Monocyte Study (PPMS)

Inflammation | Nutrition | Immune System

United States
GlaxoSmithKline

Recruiting

Efficacy and Safety of GSK3923868 Inhalation Powder, During Experimental Human Rhinovirus Infection in Participants With Mild Asthma

Pulmonary Disease, Chronic Obstructive

United Kingdom
Dalhousie University
National Institute of Allergy and Infectious Diseases (NIAID); Vanderbilt University... and other collaborators

Recruiting

Establishing a Controlled Human Infection Model of Bordetella Pertussis

Pertussis

Canada
University of Oxford
Sanaria Inc.; KEMRI-Wellcome Trust Collaborative Research Program; Kenya Medical...

Active, not recruiting

Controlled Human Malaria Infection Transmission Model - Phase A (CHMI-TransMod)

Malaria,Falciparum

Kenya
National Cancer Institute (NCI)

Completed

Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia | Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

United States
Imperial College London

Completed

Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen

Asthma | Latent Tuberculosis | Allergic Rhinitis

United Kingdom
National Institute of Allergy and Infectious Diseases...

Completed

Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenza Vaccine Via the Intranasal Versus Intramuscular Route

Influenza

United States
University of Southampton
University Hospital Southampton NHS Foundation Trust

Completed

Defining the Immune Response to Nasopharyngeal Colonisation by the Commensal Neisseria Lactamica (Lac-7)

Meningitis, Bacterial

United Kingdom
Centers for Disease Control and Prevention
University of Pennsylvania; Botswana Ministry of Health

Completed

Evaluating Accuracy, Impact, and Operational Challenges of GeneXpert Use for TB Case Finding Among HIV-infected Persons (XPRES)

Tuberculosis | Human Immunodeficiency Virus

Botswana
GlaxoSmithKline

Completed

Evaluation of Antibody Persistence and Immune Memory Against the Hepatitis B Antigen in Previously Vaccinated Children

Hepatitis B

Slovakia
GlaxoSmithKline

Completed

Evaluation of Antibody Persistence & Immune Memory in Subjects Vaccinated During Adolescence With Twinrix™

Hepatitis B | Hepatitis A

Belgium, Czechia
GlaxoSmithKline

Completed

Evaluation of Immune Memory to Twinrix or Comparator by Challenge Dose Administration 4 Years After Primary Vaccination

Hepatitis B | Hepatitis A

Belgium, Czechia
GlaxoSmithKline

Completed

Hepatitis B Antibody Persistence and Immune Response to Hepatitis B Vaccine Challenge in Previously Vaccinated Children

Hepatitis B

Germany
Uniformed Services University of the Health Sciences
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Immune Responses After Human Subject Challenge With Sand Fly Bites

Healthy

United States
GlaxoSmithKline

Completed

Immune Response to Hepatitis B Vaccine Challenge Dose in Subjects Who Received a Primary Neonatal Hepatitis B Vaccine.

Hepatitis B

Thailand
GlaxoSmithKline

Completed

Persistence of Hepatitis B Antibody Levels & Immune Response to a Hepatitis B Vaccine Challenge

Hepatitis B

Germany
Immune Targeting Systems Ltd

Completed

Safety, Tolerability, Efficacy and Immunogenicity of an Influenza A Vaccine (FP-01.1) in Healthy Volunteers Following Virus Challenge

Influenza A

United Kingdom
University of Oxford
Sanaria Inc.; KEMRI-Wellcome Trust Collaborative Research Program; University... and other collaborators

Unknown

Controlled Human Malaria Infection in Semi-Immune Kenyan Adults. (CHMI-SIKA) (CHMI-SIKA)

Malaria

Kenya
Sanaria Inc.
Barcelona Centre for International Health Research

Completed

Optimization of Controlled Human Malarial Infection by Injection of P. Falciparum Sporozoites in Non-Immune Adults

Malaria

Spain
Sanaria Inc.
Institute of Tropical Medicine, University of Tuebingen

Completed

Controlled Human Malarial Infection by Intravenous Injection of Plasmodium Falciparum Sporozoites in Non-Immune Adults

Malaria

Germany
NHS Greater Glasgow and Clyde
University of Glasgow

Unknown

Impact of Immune Challenge on Triple Network Connectivity in Humans

Major Depression
National Institute of Allergy and Infectious Diseases...
Asthma and Allergic Diseases Cooperative Research Centers

Terminated

Human Rhinovirus Infection and Airway Remodeling Mediators

Asthma

Canada
Hvivo

Completed

Discovering New Treatments for Asthma and COPD. A New Human Rhinvovirus for Human Challenge

Rhinovirus
Immune Targeting Systems Ltd

Completed

Safety and Reactogenicity of a H1N1 Influenza Challenge Virus in Healthy Volunteers

Influenza A

Belgium
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Study of Dust Mite Inhalation in Humans

Allergy | Mild Asthma

United States
Fraunhofer-Institute of Toxicology and Experimental...

Completed

Characterization of Aerosol Generation and Transport in the Human Lung

Asthma
St George's, University of London
University of British Columbia; Bill and Melinda Gates Foundation; Wellcome Trust and other collaborators

Completed

Human Innate Immune Responses To Mycobacterial Aerodigestive Tract Infection (UBC-INNATE01)

Bacterial Infections

United Kingdom
Oxagen Ltd

Completed

OC000459 Dose Finding Study in Hay Fever Sufferers.

Allergic Rhinitis

Austria
GlaxoSmithKline

Recruiting

A Study to Find and Confirm the Dose and Assess Safety, Reactogenicity and Immune Response of a Vaccine Against Pandemic H5N1 Influenza Virus in Healthy Younger and Older Adults

Influenza, Human

United States
University Health Network, Toronto
GlaxoSmithKline

Not yet recruiting

Belimumab in Autoimmune Hepatitis (BELief)

Autoimmune Hepatitis
Adicet Bio, Inc

Not yet recruiting

A Phase 1 Study of ADI-001 in Lupus Nephritis

Autoimmune Diseases | Lupus Nephritis
Washington University School of Medicine

Not yet recruiting

Evaluating the Human Immune Response to the JYNNEOS Vaccine

Virus Diseases | Vaccinia

United States
bioLytical Laboratories

Not yet recruiting

A Study to Evaluate the Performance, Usability, and Result Interpretation of INSTI® HIV Self-Test

Human Immunodeficiency Virus I Infection | Human Immunodeficiency Virus II Infection
Shanghai Unicar-Therapy Bio-medicine Technology...
Peking University People's Hospital; The First Affiliated Hospital of Soochow...

Not yet recruiting

Clinical Trial of ssCART-19 Cell Injection in the Treatment of Relapsed or Refractory Acute Lymphoblastic Leukemia (Including Central Nervous System Infiltration)

Relapsed or Refractory Acute Lymphoblastic Leukemia

China
bioLytical Laboratories
St Vincent's Hospital Melbourne

Not yet recruiting

A Prospective Cross-Sectional Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis HBsAg Test at the Point-Of-Care Sites

Hepatitis B | Hepatitis B Infection

Australia
bioLytical Laboratories

Recruiting

A Prospective Cross-Sectional Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis HBsAg Test at the Point-Of-Care Site Settings

Hepatitis B | Hepatitis B Infection

South Africa
Dana-Farber Cancer Institute
Eli Lilly and Company

Not yet recruiting

ALPINE: Maintenance Letrozole/Abemaciclib vs Pembrolizumab

Endometrial Cancer | Recurrent Endometrial Cancer | TP53

United States
Octapharma

Not yet recruiting

Phase 3 Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks

Acute Hereditary Angio Edema
Société des Produits Nestlé (SPN)

Not yet recruiting

Efficacy of Two HMOs in Chinese Infants

Healthy Infants
Beijing Friendship Hospital

Not yet recruiting

A Study on Factors of Biochemical Response in Autoimmune Hepatitis

Autoimmune Hepatitis

China
Filipa Lynce, MD
Merck Sharp & Dohme LLC; Zentalis Pharmaceuticals

Not yet recruiting

A Phase I/II Single-arm Trial of Azenosertib (ZN-c3) Combined With Carboplatin and Pembrolizumab in Patients With Metastatic Triple-negative Breast Cancer (ZAP-IT)

Breast Cancer | Triple Negative Breast Cancer | Breast Cancer Female | HER2-negative Breast Cancer | Hormone Receptor Negative Malignant Tumor Breast Triple

United States
Washington University School of Medicine
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Not yet recruiting

Bridges2Scale: Testing Implementation Strategies

HIV/AIDS
Kyverna Therapeutics

Recruiting

A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Refractory Lupus Nephritis (KYSA-3)

Lupus Nephritis | Lupus Nephritis - WHO Class IV | Lupus Nephritis - WHO Class III

Germany
Roswell Park Cancer Institute

Not yet recruiting

Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic Malignancies

Recurrent Mantle Cell Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Refractory Chronic Lymphocytic Leukemia | Refractory Mantle Cell Lymphoma | Recurrent High Grade B-Cell Lymphoma | Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell... and other conditions

United States
Guangdong Ruishun Biotech Co., Ltd
Changhai Hospital; Peking University People's Hospital; RenJi Hospital; The Affiliated...

Not yet recruiting

A Study of RJMty19 in Refractory Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus

China
BioNTech SE
DualityBio Inc.

Not yet recruiting

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

Endometrial Cancer
National Cancer Institute (NCI)

Not yet recruiting

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular Lymphoma | Follicular Lymphoma With Unusual Cytological Features

Search clinical trials for: Human immune challenge

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