Search clinical trials for: KIT secondary mutation

Total 14460 results

Centre Leon Berard

Completed

Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (ImadGist)

Gastrointestinal Stromal Tumors | Resected Gastrointestinal Stromal Tumors | Non-metastatic | High Risk of Recurrence | KIT Gene Mutation

France
Institut de Recherches Internationales Servier
Celgene Corporation

Active, not recruiting

Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation

Untreated AML | Newly Diagnosed Acute Myeloid Leukemia (AML) | AML Arising From Myelodysplastic Syndrome (MDS) | AML Arising From Antecedent Hematologic Disorder (AHD) | AML Arising After Exposure to Genotoxic Injury

United States, Germany, Netherlands
Chang Gung Memorial Hospital

Completed

Regorafenib in GIST With Secondary C-KIT Exon 17 Mutation

Gastrointestinal Stromal Tumour (GIST)

Taiwan
Sebastian Bauer
Hannover Medical School; University Hospital Tuebingen; Universitätsmedizin Mannheim and other collaborators

Unknown

POETIG Trial - POnatinib After rEsisTance to Imatinib in GIST (POETIG)

GIST, Malignant | KIT Gene Mutation | KIT Exon 13 Mutation

Germany
Children's Hospital of Soochow University

Recruiting

Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation

AML, Childhood | C-KIT Mutation | Refractory AML | Relapse/Recurrence | Core Binding Factor Acute Myeloid Leukemia

China
Sardocor Corp.

Not yet recruiting

Modulation of SERCA2a of Intra-Myocytic Calcium Trafficking in Cardiomyopathy Secondary to Duchenne Muscular Dystrophy (MUSIC-DMD)

DMD-Associated Dilated Cardiomyopathy
Sarcoma Alliance for Research through Collaboration
Dana-Farber Cancer Institute; Cogent Biosciences, Inc.; The Life Raft Group

Not yet recruiting

SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST

Gastrointestinal Stromal Tumors | GIST

United States
University College, London
Place2Be; Anna Freud

Recruiting

Evaluating Knowledge Insight Tools (KIT) for Reducing Anxiety and Low Mood in UK Secondary School Students

Depression | Anxiety | Low Mood | Internalizing Problems

United Kingdom
Rigel Pharmaceuticals
Nationwide Children's Hospital

Not yet recruiting

Study of Olutasidenib and Temozolomide in HGG

Astrocytoma | High Grade Glioma | Oligodendroglioma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | Spinal Tumor | Astrocytoma, Grade III | Astrocytoma, Grade IV | IDH1 Mutation | WHO Grade IV Glioma | Thalamus Tumor | IDH1 R132 | IDH1 R132C | IDH1 R132H and other conditions

United States, Australia, United Kingdom, Canada, Germany, Netherlands
Institute of Hematology & Blood Diseases Hospital...

Not yet recruiting

A Study of c-Kit Mutation as MRD in Acute Myeloid Leukemia

C-KIT Mutation
Changi General Hospital
Khoo Teck Puat Hospital; Singapore General Hospital; Tan Tock Seng Hospital; Sengkang... and other collaborators

Recruiting

11C-Metomidate PET/CT for Endocrine Hypertension and Characterisation of Adrenal Tumours

Primary Aldosteronism | Primary Aldosteronism Due to Aldosterone Producing Adenoma | Adrenal Tumors

Singapore
M.D. Anderson Cancer Center
Bayer

Not yet recruiting

Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.

Gastrointestinal Stromal Tumors

United States
Pfizer

Recruiting

A Study to Learn About the Study Medicine Sisunatovir in Adults With Respiratory Syncytial Virus (RSV) Infection

Respiratory Syncytial Virus Infection

United States, Japan, China, Canada
UK Kidney Association

Recruiting

National Registry of Rare Kidney Diseases (RaDaR)

Vasculitis | AL Amyloidosis | Tuberous Sclerosis | Fabry Disease | Cystinuria | Focal Segmental Glomerulosclerosis | IgA Nephropathy | Bartter Syndrome | Pure Red Cell Aplasia | Membranous Nephropathy | Atypical Hemolytic Uremic Syndrome | Autosomal Dominant Polycystic Kidney Disease | Cystinosis | Nephronophthisis | BK Nephropathy and other conditions

United Kingdom
Columbia University
National Institute on Aging (NIA)

Recruiting

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

Lumbar Spinal Stenosis | Cardiomyopathy, Hypertrophic | Cardiac Amyloidosis | ATTR Amyloidosis Wild Type | ATTR Gene Mutation | ATTRV122I Amyloidosis

United States
Regeneron Pharmaceuticals

Recruiting

A Natural History Study in Pediatric Participants With Hearing Loss Due to OTOF, GJB2, or GJB2/GJB6 Mutations (ENSEMBLE)

Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF) | Biallelic Mutations in the Gap Junction Beta 2 (GJB2) Gene | Digenic Mutations in GJB2/Gap Junction Beta 6 (GJB6) Genes

United States
Taiho Oncology, Inc.

Recruiting

REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors) (REZILIENT3)

Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation

United States, Spain, Canada, Italy, Israel, Japan, United Kingdom, Korea, Republic of, Germany, France, Turkey, Belgium, Netherlands, Philippines, Poland, Singapore
Federico II University

Recruiting

Identification of Oral Lesions Through an Autofluorescence System

Keratosis | Oral Disease | Oral Cancer | Oral Leukoplakia | Oral Lichen Planus | Secondary Prevention | Autofluorescence

Italy
Servier Affaires Médicales

Recruiting

An Open-label Phase 3b Study of Ivosidenib in Combination With Azacitidine in Adult Patients Newly Diagnosed With IDH1m Acute Myeloid Leukemia (AML) Ineligible for Intensive Induction Chemotherapy.

Acute Myeloid Leukemia (AML)

Netherlands, Italy, Austria, France
Xijing Hospital

Recruiting

Exploring the Molecular Mechanism Based on KIT Mutation (EMMBKM)

GIST

China
October 6 University
Beni-Suef University; National Heart Institute, Egypt

Recruiting

Effect of Dapagliflozin on Secondary Mitral Regurgitation

Dilated Cardiomyopathy

Egypt
Bayer
Regeneron Pharmaceuticals

Recruiting

A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion) (QUASAR)

Macular Edema Secondary to Retinal Vein Occlusion

Japan, Korea, Republic of, China, Israel, Lithuania, United States, Italy, Spain, Hungary, Portugal, Serbia, Poland, United Kingdom, Thailand, Czechia, Austria, Germany, Turkey, Australia, Bulgaria, Estonia, France, Georgia, Latvia, Mal... and more
The First Affiliated Hospital of Soochow University

Recruiting

Avapritinib in CBF-AML With KIT Mutations

Core Binding Factor Acute Myeloid Leukemia | KIT Mutation-Related Tumors

China
Regeneron Pharmaceuticals

Recruiting

A Study of DB-OTO, an Adeno-associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations (CHORD)

Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)

Spain, United Kingdom, United States
Deciphera Pharmaceuticals LLC

Recruiting

A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib (INSIGHT)

GIST

United States, Korea, Republic of, Spain, France, Taiwan, Italy, Australia, Canada, Germany, United Kingdom, Netherlands, Brazil, Chile, Poland
National Cardiovascular Center Harapan Kita Hospital...

Recruiting

The Effectivity of the Mobile App "HARKIT I-Care" in Secondary Prevention in Post-ACS Patients

Acute Coronary Syndrome

Indonesia
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Recruiting

Genetic Characterization of Cardiomyopathies (POLICARDIOMIO2021)

Cardiomyopathies

Italy
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

A Phase Ib Study of HS-10352 Plus Fulvestrant in Patients With Advanced Breast Cancer

Breast Cancer

China
Cairo University
Children's Cancer Hospital Egypt 57357

Recruiting

Clinical Assessment of Injectable Flowable Composite With Giomer Technology vs High Viscosity Glass Ionomer Restorations in ART for Cancer Patients

Discoloration, Tooth | Secondary Caries | Fracture Tooth

Egypt
Nanfang Hospital of Southern Medical University
Peking University People's Hospital; Guangzhou First People's Hospital; Sun Yat-Sen... and other collaborators

Recruiting

G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for Secondary Acute Myeloid Leukemia Undergoing Allo-HSCT

Allogeneic Hematopoietic Stem Cell Transplantation | Conditioning | Secondary Acute Myeloid Leukemia Evolving From MDS

China
Vitti Labs, LLC

Recruiting

Safety and Effectiveness of VL-PX10 + VL-P22 Treatment on Pulmonary Fibrosis Secondary to Covid-19

Pulmonary Fibrosis | COVID-19 Respiratory Infection

United States
Cristina Avendaño Solá

Recruiting

Early Treatment With Candesartan vs Placebo in Genetic Carriers of Dilated Cardiomyopathy (EARLY-GENE Trial) (EARLY-GENE)

Cardiomyopathy, Dilated

Spain
Eisai Co., Ltd.

Recruiting

A Study of Tazemetostat on Safety in Participants With Relapsed or Refractory Follicular Lymphoma With Enhancer of Zeste Homolog 2 (EZH2) Gene Mutation in Japan

Lymphoma, Follicular

Japan
Novartis Pharmaceuticals

Recruiting

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)

Relapsing Multiple Sclerosis

United States, Canada, China, Spain, Italy, France, Slovenia, Japan, Turkey, Argentina, Estonia, Greece, Mexico, Poland, Sweden, Croatia, South Africa, Brazil, Slovakia, Bulgaria, Romania, India, Portugal, United Kingdom, Puerto Rico
Tenaya Therapeutics

Recruiting

Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy (MyCLIMB)

Cardiomyopathy

United States, Canada, United Kingdom, Spain
Centre Leon Berard

Recruiting

Efficiency of Imatinib Treatment After 10 Years of Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (Gist-Ten)

C-KIT Mutation | Metastatic Gastrointestinal Stromal Tumor (GIST) | Advanced Gastrointestinal Stromal Tumor (GIST)

France
Chang Gung Memorial Hospital

Recruiting

Phenylalanine-free Diet for Patients With Secondary Hyperphenylalaninemia in ICU

Non-Phenylketonuric Hyperphenylalaninemia

Taiwan
Lady Davis Institute

Recruiting

Doxycycline vs Isotretinoin for Acneiform Eruptions of TKI

Acneiform Eruptions | Cancer, Treatment-Related

Canada
Ludwig-Maximilians - University of Munich
Charité Universitätsmedizin, Department of Hematology, Oncology and Tumor...

Not yet recruiting

Centralized Tumour Board and Secondary Intervention Rate in mCRC

Metastatic Colorectal Cancer | Multidisciplinary Communication | RAS Mutation | Secondary Intervention
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Prognostic Stage IIIC Breast Cancer AJCC v8 | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Melanoma | Stage IV Lung Cancer AJCC v8 | Locally Advanced Malignant Solid Neoplasm | Locally... and other conditions

United States
RasCal Therapeutics, Inc.

Recruiting

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

Glioblastoma | Pancreatic Cancer | Lung Cancer | Colon Cancer | Advanced Malignant Solid Neoplasm | RAS Mutation

United States
Weill Medical College of Cornell University
Basser Research Center for BRCA

Recruiting

FaCT Trial (Facilitated Cascade Testing Trial)

BRCA1 Mutation | BRCA2 Mutation

United States
National Eye Institute (NEI)
National Cancer Institute (NCI)

Recruiting

Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4

Stargardt-Like Macular Dystrophy

United States
Novartis Pharmaceuticals

Recruiting

Special Drug Use-results Surveillance of Tabrecta Tablets

Non-small Cell Lung Cancer

Japan
National Cancer Institute (NCI)

Recruiting

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Gastric Cancer | Gastric Neoplasm | Gastrointestinal Stromal Tumor (GIST) | Gastrointestinal Stromal Sarcoma | Gastrointestinal Stromal Neoplasm

United States
University of Pennsylvania

Recruiting

Evaluating Cascade Communication Methods (ECHO)

BRCA1 Mutation | BRCA2 Mutation

United States
Mark Vincent
AstraZeneca

Recruiting

Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer With Osimertinib Third-line Rechallenge (OCELOT)

Non-Small Cell Lung Cancer

Canada
AB Science

Recruiting

Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic Treatment

Indolent Systemic Mastocytosis

France, Netherlands, Germany, United Kingdom, Russian Federation, Poland, Romania, Ukraine
Pfizer

Recruiting

Special Investigation for VIZIMPRO Tablets (Secondary Data Collection Study; Safety and Efficacy of VIZIMPRO Under Japanese Medical Practice)

EGFR Mutation-positive Inoperable or Reccrent NSCLC

Japan
Chinese University of Hong Kong

Recruiting

Development of a Predictive Index for Probable Depression Among Secondary School Students

Depression | Stress | Youth

Hong Kong

Search clinical trials for: KIT secondary mutation

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