Development of a Predictive Index for Probable Depression Among Secondary School Students

A Longitudinal Study for Identifying Predictors of Incidence/Remission of Probable Depression and Developing a Predictive Index for Probable Depression Among Secondary School Students

The present study aims to develop a new predictive index to predict future depression of adolescents by using factors including individual, interpersonal and environmental. The index can be used to predict likelihood of students who are non-probable depression cases convert into probable depression cases. In addition, the investigators also test the factors of depression remission. It can hence be used in school setting to identify high-risk students, and provide them with secondary interventions that are designed by considering modifiable significant variables identified in this unique, large-scale, longitudinal study.

Study Overview

• Status: Recruiting
• Conditions: Depression; Stress; Youth
• Intervention / Treatment: Other: Observation

Detailed Description

A 12-month longitudinal study will be conducted in secondary school settings.

The investigators will investigate incidence of probable depression (i.e., from non-depression, CESD<16, at baseline to probable depression, CESD≥16, at month 12) and remission of probable depression.

The investigators will investigate factors that can prospectively predict new cases/remission of probable depression, including both well-documented risk/protective factors and some under-examined but potentially important local factors (e.g. school/academic stress, psychological resilience). The relative importance of the risk/protective factors at different socio-ecological levels will be compared and their combined effect will be identified.

Based on the selected factors, the investigators will derive a new prediction index called the Adolescent Depression Prediction Index (ADPI) in a model building sample and test its performance in predicting incidence of depression in a validation sample among secondary school students in Hong Kong.

• Study Type: Observational
• Enrollment (Anticipated): 4799

Contacts and Locations

Study Locations

• Hong Kong
  • Hong Kong, Hong Kong
    • Recruiting
    • China Holiness Church Living Spirit College
    • Contact: Phone Number: 2958 9694
  • Hong Kong, Hong Kong
    • Recruiting
    • Christian Alliance SW Chan Memorial College (Christian Alliance SW Chan Memorial Secondary School)
    • Contact: Phone Number: 2670 9229
  • Hong Kong, Hong Kong
    • Recruiting
    • Ho Ngai College ( Sponsored By Sik Sik Yuen)
    • Contact: Phone Number: 2441 7100
  • Hong Kong, Hong Kong
    • Recruiting
    • Kit Sam Lam Bing Yim Secondary Schoo
    • Contact: Phone Number: 2337 9594

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years to 16 years (CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Out of the 18 districts in Hong Kong, nine randomly selected districts will select randomly two schools and while the rest nine will randomly select one school. Replacements of schools will be made upon refusals. Within the selected schools, all Secondary 1-4 students will be invited to join the study. Students will be asked to fill in baseline questionnaires in the absence of teachers in classroom settings.

Description

Inclusion Criteria:

• Secondary 1 (seventh year of formal education) to Secondary 4 Chinese students, who are studying local mainstream schools in Hong Kong.
• Able to read Chinese and speak either Cantonese or Mandarin.

Exclusion Criteria:

• Eligible students whose parents refuse to give consent to take part in the study.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Non-cases; Secondary school students (seventh to tenth years of education) without probable depression at baseline interview.	Other: Observation; The anonymous structured questionnaire will be self-administered by the participating students in the absence of their teachers in class-room settings.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of probable depression	To examine the incidence of probable depression from non-depression (CESD<16) at baseline to probable depression (CESD>=16) at month 12.	12 months
Adolescent Depression Prediction Index (ADPI)	To develop a new prediction index ADPI and test test its performance in predicting incidence of depression.	12 months

Collaborators and Investigators

• Sponsor: Chinese University of Hong Kong

Study record dates

Study Major Dates

• Study Start (ACTUAL): October 30, 2020
• Primary Completion (ANTICIPATED): August 1, 2023
• Study Completion (ANTICIPATED): August 1, 2023

Study Registration Dates

• First Submitted: August 19, 2019
• First Submitted That Met QC Criteria: August 19, 2019
• First Posted (ACTUAL): August 21, 2019

Study Record Updates

• Last Update Posted (ACTUAL): March 17, 2022
• Last Update Submitted That Met QC Criteria: March 16, 2022
• Last Verified: March 1, 2022

More Information

Terms related to this study

• Keywords: Adolescent; Depression; Stress; Resilience
• Additional Relevant MeSH Terms: Behavioral Symptoms; Mental Disorders; Mood Disorders; Depression; Depressive Disorder
• Other Study ID Numbers: HMRF16171001

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No