Search clinical trials for: Lp-PLA2- inhibitor

Total 68685 results

Meenakshi Ammal Dental College and Hospital

Completed

Serum Lipid Levels and Lp-PLA2 in Chronic Periodontitis

Chronic Periodontitis (Disorder)
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single, Oral Escalating Doses of GSK2647544 in Healthy Volunteers

Alzheimer's Disease

Australia
Yonsei University

Completed

Changes in Body Adiposity by Dual Probiotic Strains Positively Correlated With Changes in Lp-PLA2 Activity in Overweight Adults

Overweight
GlaxoSmithKline

Completed

SB-480848 In Subjects With Coronary Heart Disease

Atherosclerosis

United States, Germany, Estonia, Spain, Argentina, Canada, France, Netherlands, Australia, Bulgaria, Romania, Hungary, Denmark, India, New Zealand, Pakistan
Stanford University
University of California, Davis; Diadexus, Inc.

Completed

Transient Ischemic Attack (TIA) Triage and Evaluation of Stroke Risk

Cerebrovascular Accident

United States
Aristotle University Of Thessaloniki

Unknown

Markers and Calculation of Cardiovascular Risk in the Distinct Phenotypes of Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

Greece
Ziv Hospital

Unknown

The Contribution of Lp-PLA2 Level to the Presence of Coronary Plaques in Patients With Non Alcoholic Fatty Liver Disease (0030-10)

Coronary Artery Disease | Nonalcoholic Fatty Liver Disease

Israel
Taizhou Fourth People's Hospital
Shanghai 10th People's Hospital

Unknown

The Effect of Dan-shen Extract On Lipoprotein Associated PHospholipase A2 Levels IN Patients With Stable Angina Pectoris (DOLPHIN)

Inflammation | Angina, Stable

China
GlaxoSmithKline

Completed

Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).

Atherosclerosis

United States
Mayo Clinic
National Institutes of Health (NIH); National Institute on Aging (NIA)

Completed

Lp-PLA2 and Coronary Atherosclerosis in Humans (AIM 1 and II)

Endothelial Dysfunction | Coronary Atherosclerosis

United States
GlaxoSmithKline

Completed

A Study to Assess the Pharmacokinetics, Safety and Tolerability of Repeat Oral Doses of Darapladib (SB-480848) in Subjects With Severe Renal Impairment

Atherosclerosis

United States
GlaxoSmithKline

Completed

To Estimate the Potential Effects of Repeat Doses of Darapladib on the Pharmacokinetics (PK) of Rosuvastatin as Well as Evaluating Safety and Tolerability in Healthy Volunteers

Atherosclerosis

United States
Yonsei University

Completed

Effects of α-linolenic Acid Supplementation on Hemostasis in Nondiabetic and Hypercholesterolemic Subjects

Hypercholesterolemia

Korea, Republic of
Mayo Clinic
National Heart, Lung, and Blood Institute (NHLBI); GlaxoSmithKline; National...

Completed

Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans

Endothelial Dysfunction

United States
GlaxoSmithKline

Completed

Pharmacokinetic Interaction of Darapladib and CYP 3A4 in Healthy Subjects

Atherosclerosis

United States
GlaxoSmithKline

Completed

An Imaging Study in Patients With Atherosclerosis Taking Rilapladib or Placebo for 12 Weeks

Atherosclerosis

United States
GlaxoSmithKline

Completed

The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial (STABILITY)

Atherosclerosis

United States, Argentina, Australia, France, Germany, Netherlands, Taiwan, Bulgaria, Estonia, Poland, Russian Federation, Spain, Belgium, Canada, Peru, Philippines, Sweden, Thailand, Korea, Republic of, Hong Kong, Hungary, Slovakia, Ukrain... and more
GlaxoSmithKline

Terminated

GSK2647544 RD, DDI in Healthy Young and Elderly Volunteers

Alzheimer's Disease

United Kingdom
GlaxoSmithKline

Terminated

A Positron Emission Tomography (PET) Study to Investigate the Brain Biodistribution of 18F GSK2647544 in Healthy Subjects to Determine Its Ability to Cross the Blood-brain-barrier.

Alzheimer's Disease

United Kingdom
Yonsei University

Completed

Impact of an 8-week Linoleic Acid Intake in Soy Oil on Lp-PLA2 Activity in Healthy Adults

Healthy Subjects

Korea, Republic of
Xention Ltd

Completed

A Study on the Effects of TA-8995 on Lp(a) in Subjects With Elevated Lp(a)

Elevated Lp(a)

Denmark
Technische Universität Dresden
Kaneka Pharma Europe N.V.

Recruiting

Effect of Lipoprotein(a) Elimination by Lipoprotein Apheresis on Cardiovascular Outcomes (MultiSELECt)

Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia

Germany
Alexhander Izhaki

Completed

ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?

Acute Chest Syndrome

Israel
GlaxoSmithKline
The TIMI Study Group

Completed

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial (SOLID-TIMI 52)

Acute Coronary Syndrome

United States, France, Netherlands, Ukraine, Germany, Taiwan, Bulgaria, Hungary, Poland, Russian Federation, Argentina, Belgium, Peru, Philippines, Sweden, Thailand, Israel, Spain, Korea, Republic of, Australia, Czechia, Japan, New... and more
Centre Hospitalier Universitaire de Nice

Completed

Impact of Child Positioning on Pain During a Lumbar Puncture (PHIPA-PEPL)

Hematological Malignancies

France
Changi General Hospital

Not yet recruiting

Elevated Lipoprotein(a) in Hospital Staff (LPACO)

Cardiovascular Diseases | Hypercholesterolemia | Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia

Singapore
Wake Forest University Health Sciences
National Cancer Institute (NCI); KeraNetics, LLC

Completed

Study of KeraStat Cream for Radiation Dermatitis During Head and Neck Radiotherapy

Head and Neck Cancer | Radiation Dermatitis

United States
Longbio Pharma

Active, not recruiting

A Study of Single and Multiple Dose Administration of LP-001 in Healthy Subjects

Myelodysplastic Syndrome (MDS)

China
Abbott Medical Devices

Terminated

A(f)MAZE-CABG Study (AFMAZE-CABG)

Atrial Fibrillation | Coronary Arteriosclerosis | Coronary Artery Bypass Graft Surgery

Canada, United Kingdom, Netherlands, Norway, Finland, Germany
Longbio Pharma

Recruiting

A Study of Single and Multiple Doses of LP-005 in Healthy Adult Participants

Paroxysmal Nocturnal Hemoglobinuria (PNH)

China
Longbio Pharma

Active, not recruiting

A Study of Single and Multiple Doses of LP-003 in Healthy Adult Participants

Chronic Spontaneous Urticaria

China
Longbio Pharma

Recruiting

Efficacy and Safety of LP-003 in Moderate-to-severe Seasonal Allergic Rhinitis Adult

Seasonal Allergic Rhinitis

China
Newave Pharmaceutical Inc

Recruiting

Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

Follicular Lymphoma | Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Diffuse Large B Cell Lymphoma | Hairy Cell Leukemia | CLL/SLL

United States
Federico II University
University of Catanzaro; Ospedale Nuovo Regina Margherita di Roma Dr. Salvatore...

Completed

Proton Pump Inhibitors and Gastrointestinal Symptoms

Gastrointestinal Symptoms | Small Intestinal Overgrowth

Italy
Guangzhou Lupeng Pharmaceutical Company LTD.

Recruiting

A Study of LP-168 in Participants With Relapse or Refractory Mantle Cell Lymphoma

Mantle Cell Lymphoma (MCL)

China
Sunnybrook Health Sciences Centre

Not yet recruiting

Slow-Stream Expiratory Muscle Strength Training for Veterans With Dysphagia Living in Long-term Care

Cough | Dysphagia | Aging | Aspiration Pneumonia | Dysphagia, Oropharyngeal | Dysphagia, Progressive

Canada
James M Noble, MD, MS, CPH, FAAN
National Institute on Aging (NIA)

Enrolling by invitation

Imaging Inflammation in Alzheimer's Disease

Alzheimer's Disease

United States
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Crenel Lateral Interbody Fusion Combined With Lateral Plate Fixation for LSS Combined With Lumbar Instability

Lumbar Spinal Stenosis | Lumbar Instability
Kanuni Sultan Suleyman Training and Research Hospital

Completed

Comparison of Laparoscopic Pectopexy and Laparoscopic Lateral Suspension Techniques in Uterine-preserving Apical Prolapsus Repair

Pelvic Organ Prolapse

Turkey
University of Zurich

Unknown

Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin

Lichen Planus (LP)

Switzerland
Universidade Federal do Rio de Janeiro

Completed

Linear Running Periodization x Nonlinear (Running)

Healthy
Medtronic Spinal and Biologics

Completed

Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD

Cervical Degenerative Disc Disease

United States
Newave Pharmaceutical Inc

Recruiting

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

Acute Myeloid Leukemia | Multiple Myeloma | Myelofibrosis | Chronic Lymphocytic Leukemia | Non Hodgkin Lymphoma | Acute Lymphocytic Leukemia | Myelodysplastic/Myeloproliferative Neoplasm | Small Lymphocytic Lymphoma | Chronic Myelomonocytic Leukemia-2 | Richter Transformation | T-cell-prolymphocytic Leukemia and other conditions

United States
Sakarya University

Completed

Comparison of Erector Spina Plane Block and Lumbar Plexus Block in Femoral Fracture Surgery

Femur Fracture | Erector Spinae | Lumbar Plexus | Ultrasound Guide

Turkey
Amgen

Completed

A Cross-sectional Study of Lipoprotein(a) Levels in Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)

Atherosclerotic Cardiovascular Disease

Canada, United States, Belgium, Spain, China, Korea, Republic of, Australia, Netherlands, Austria, Czechia, Taiwan, Hungary, Italy, Portugal, United Kingdom, Greece, Hong Kong, Turkey, France, Bulgaria, Germany, Finland, Japan, Sweden, ... and more
Gradalis, Inc.

Completed

Phase I Intratumoral Pbi-shRNA STMN1 LP in Advanced and/or Metastatic Cancer (STMN1-LP)

Metastatic Cancer | Advanced Cancer | Solid Tumors

United States
Guangzhou Lupeng Pharmaceutical Company LTD.

Completed

A Study of LP-168 in Healthy Volunteers

Multiple Sclerosis | NMO Spectrum Disorder

China
Children's Hospital of Philadelphia

Active, not recruiting

Ultrasound Assisted Lumbar Puncture in the Neonate

Lumbar Puncture

United States
Yonsei University

Completed

Blood Pressure Lowering Effect of Supplementation With Korea Red Ginseng Associated With Reductions in Circulating Lp-PLA2 Activity and Lysophospatidylcholines and an Increase in Dihydrobiopterin in Prehypertensive Subjects

Prehypertension
Guangzhou Lupeng Pharmaceutical Company LTD.

Completed

The Mass Balance Study of LP-168 in Healthy Subjects

Clinical Pharmacology

China

Search clinical trials for: Lp-PLA2- inhibitor

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