Search clinical trials for: MYK-224

Total 555 results

Bristol-Myers Squibb

Completed

A Study to Assess the Drug Interaction Between MYK-224 and Itraconazole and Verapamil in Healthy Participants

Healthy Participants

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Safety, Tolerability, and Drug Levels of MYK-224 Administered in Single and Multiple Doses in Healthy Adult Japanese Participants

Healthy Volunteers

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Absorption, Metabolism, and Excretion (ADME) of BMS-986435

Healthy Volunteers

United States
Bristol-Myers Squibb

Recruiting

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) (AURORA-HFpEF)

Heart Failure

United States, Spain, Canada, Italy, Poland
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy (MERCUTIO)

Cardiomyopathy, Hypertrophic

United States, Poland, Spain, Italy
Peel Therapeutics Inc

Recruiting

A Study to Evaluate PEEL-224 in Patients With Advanced Solid Tumors

Advanced Solid Tumor

United States
MyoKardia, Inc.

Completed

A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) (MAVERICK-HCM)

Non-obstructive Hypertrophic Cardiomyopathy

United States
MyoKardia, Inc.

Completed

Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (EXPLORER-HCM)

Obstructive Hypertrophic Cardiomyopathy

United States, France, Germany, Czechia, Spain, Belgium, Denmark, Portugal, Netherlands, Israel, Poland, United Kingdom, Italy
Rubius Therapeutics

Terminated

RTX-224 Monotherapy in Patients With Solid Tumors

Non Small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Urothelial Carcinoma | Cutaneous Melanoma | TNBC - Triple-Negative Breast Cancer

United States
MedImmune LLC
GlaxoSmithKline

Completed

Study to Assess the Safety, Tolerability, and Pharmacokinetics of AMP-224 in Patients With Advanced Cancer

Cancer

United States
Amgen

Completed

A Phase 1 Study in Subjects With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma

United States, Australia
MyoKardia, Inc.

Completed

A Single Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of MYK-491

Dilated Cardiomyopathy

Australia
University Hospital, Basel, Switzerland

Recruiting

Functional Soft Palate Reconstruction

Soft Palate Reconstruction

Switzerland
Hadassah Medical Organization

Unknown

Comparison of Soft and Hard Tissue Thickness in the Anterior Regions of the Upper and Lower Jaws Taken From CBCT Versus Clinical Measurements

Soft and Hard Tissue Biotype
Bristol-Myers Squibb

Completed

Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER (PIONEER-OLE)

Hypertrophic Cardiomyopathy

United States
MyoKardia, Inc.

Completed

Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-461

Hypertrophic Cardiomyopathy

United States
MyoKardia, Inc.

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Oral Doses of MYK-461 in Healthy Volunteers

Healthy

Australia
MyoKardia, Inc.

Completed

Single Ascending Dose Study of MYK-461 in Healthy Volunteers

Healthy

United Kingdom
Bristol-Myers Squibb

Completed

A Study to Evaluate the Effects of Mavacamten in Healthy Participants

Healthy Participants

United States
Memorial Sloan Kettering Cancer Center
Amgen

Completed

A Study of T-VEC (Talimogene Laherparepvec) With or Without Radiotherapy for Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors

Melanoma | Merkel Cell Carcinoma | Other Solid Tumors

United States
Boston University Charles River Campus
American Heart Association; Harvard University; Spaulding Rehabilitation Hospital

Completed

Effects of Soft Robotic Exosuit on Exercise Capacity, Biomakers of Neuroplasticity, and Motor Learning After Stroke

Stroke

United States
Johnson & Johnson Vision Care, Inc.

Completed

Controlling Myopia Progression With Soft Contact Lenses (Contact Lens Control)

Myopia

United States
Chung Shan Medical University

Completed

Soft Peripheral Contact Lens for Eye Elongation Control (SPACE):1-year Results of a Double-blinded Randomized Con-trolled Trial

Soft Contact Lens

Taiwan
Merck Sharp & Dohme LLC

Completed

Study of Pembrolizumab (MK-3475) as Monotherapy in Participants With Advanced Hepatocellular Carcinoma (MK-3475-224/KEYNOTE-224)

Hepatocellular Carcinoma
Bristol-Myers Squibb

Completed

A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure

Heart Failure With Reduced Ejection Fraction

United States
Guang'anmen Hospital of China Academy of Chinese...

Unknown

The Study of MicroRNA Genomics of Blood Stasis Syndrome and of Coronary Heart Disease

Coronary Heart Disease | Unstable Angina | Blood Stasis Syndrome

China
University Hospital "Sestre Milosrdnice"

Not yet recruiting

The Impact of Rhinoplasty Approach and Used Autologous Cartilage Grafts on the Nasal Skin-soft Tissue Envelope Metabolism

Rhinoplasty | Nasal Skin-soft Tissue Envelope Metabolism | Lactic Acid | Autologous Cartilage Grafting
MyoKardia, Inc.

Completed

A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction (PIONEER-HCM)

Cardiomyopathy, Hypertrophic Obstructive | Left Ventricular Outflow Tract Obstruction

United States
Bristol-Myers Squibb

Terminated

Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other Causalities

Primary Familial Dilated Cardiomyopathy

United States, Germany, Spain, United Kingdom
National Cancer Institute (NCI)

Recruiting

Testing Atezolizumab With or Without Selinexor in Patients >= 18 Years Old With Alveolar Soft Part Sarcoma, the Axiom Study

Metastatic Alveolar Soft Part Sarcoma | Unresectable Alveolar Soft Part Sarcoma | Advanced Soft Tissue Sarcoma | Advanced Alveolar Soft Part Sarcoma

United States
Cairo University

Unknown

Measuring Quality of Life of Versacryl Relined Dentures

Denture Liners
Ionis Pharmaceuticals, Inc.

Completed

A Study to Assess the Safety, Efficacy, and Pharmacokinetics of Multiple Doses of ION224

Steatohepatitis, Nonalcoholic

United States, Puerto Rico
Attenuon

Unknown

Randomized Trial of ATN-224 and Temozolomide in Advanced Melanoma

Melanoma

United States
Federal University of São Paulo

Completed

Assessment of the Effectiveness of Low-Level Laser Therapy on the Hands of Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Brazil
MyoKardia, Inc.

Completed

Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491

Dilated Cardiomyopathy | Heart Failure With Reduced Ejection Fraction

United States, France, United Kingdom, Sweden, Germany, Netherlands, Poland
Catharina Ziekenhuis Eindhoven

Completed

Oropharyngeal Space in Videolaryngoscopy

Intubation Complication | Abrasion of Soft Palate

Netherlands
Géraldine Martens
Centre Hospitalier Universitaire Dinant Godinne - UCL Namur

Completed

Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness

Pathologic Processes | Stroke | Central Nervous System Diseases | Neurocognitive Disorders | Brain Injuries | Craniocerebral Trauma | Trauma, Nervous System | Disorder of Consciousness | Contracture | Spasticity as Sequela of Stroke | Hypertonic Disorder

Belgium
University of Alabama at Birmingham

Withdrawn

Customizing Myopia Control With Multifocal Toric Contact Lens

Refractive Errors | Myopia
Yung Sheng Optical Co., Ltd.

Completed

Clinical Evaluation of the Safety and Efficacy of Yung Sheng 55 % Color Contact Lens

Myopia
Attenuon
Prostate Cancer Clinical Trials Consortium

Unknown

Study of ATN-224 in Patients With Prostate Cancer

Prostate Cancer

United States
Visioneering Technologies, Inc

Recruiting

Extended Depth of Focus Contact Lenses for Presbyopia

Presbyopia

United States
Seoul National University Hospital
Samsung Medical Center; Asan Medical Center; Seoul National University Bundang... and other collaborators

Terminated

Pazopanib for Metastatic Alveolar Soft Part Sarcoma

Metastatic Alveolar Soft Part Sarcoma

Korea, Republic of
Bristol-Myers Squibb

Active, not recruiting

A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

Hypertrophic Cardiomyopathy | Non-obstructive Hypertrophic Cardiomyopathy | Obstructive Hypertrophic Cardiomyopathy

Denmark, United States, Belgium, Czechia, France, Germany, Israel, Italy, Netherlands, Poland, Portugal, Spain, United Kingdom
HOYA Lamphun Ltd

Unknown

Three-month Clinical Evaluation of DSiHy Daily Disposable Silicone Hydrogel Contact Lenses

Contact Lenses
Fu Jen Catholic University

Not yet recruiting

3D-Printed Aerosolized Medication Delivery Assist Device in Patients With Chronic Respiratory Diseases

Chronic Pulmonary Disease

Taiwan
Tianjin Eye Hospital

Recruiting

Soft Contact Lens Fitting With Different Sagittal Height

Myopia

China
Roessingh Research and Development

Recruiting

Soft-robotic Glove Support of High-demand Tasks

Neuromuscular Diseases | Sarcopenia

Netherlands
Boston University Charles River Campus
Harvard University; Spaulding Rehabilitation Hospital

Recruiting

Robotic Exosuit Augmented Locomotion (REAL) in the Clinic and Community (REAL-m)

Stroke

United States
Yung Sheng Optical Co., Ltd.

Completed

Clinical Evaluation of the Safety and Efficacy of Yung Sheng 38% Color Contact Lens

Myopia
Yung Sheng Optical Co., Ltd.

Completed

A Prospective, Randomized, Double-blind, Parallel, Active-controlled Clinical Study of Silicone Hydrogel Monthly Soft Contact Lens for the Safety and Effectiveness in Visual Correction.

Myopia

Taiwan

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