Search clinical trials for: Moderate to severe acute pain

Total 472878 results

The Fourth Affiliated Hospital of Zhejiang University...

Not yet recruiting

Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery

Postoperative Pain
UNICEF - Venezuela

Recruiting

Treatment of Acute Malnutrition in Outpatient Care Services in Venezuela: a Prospective Cohort Research

Wasting | Acute Malnutrition in Childhood | Child Malnutrition

Venezuela
Guangdong Second Provincial General Hospital

Recruiting

Construction of Perioperative Medical Data Platform and Its Typical Practice to Predict Postoperative Acute Moderate to Severe Pain With Machine Learning Models

Acute Pain | Anesthesia | Risk Reduction

China
Pharmbio Korea Co., Ltd.

Recruiting

Study of PBK_L1704 for the Treatment of Moderate to Severe Acute Pain After Bunionectomy in South Korea

Acute Pain

Korea, Republic of
B.P. Koirala Institute of Health Sciences

Completed

Association of Preoperative Pain With Moderate to Severe Acute Pain After Laparoscopic Cholecystectomy.

Pain, Postoperative

Nepal
Scilex Pharmaceuticals, Inc.
Worldwide Clinical Trials

Completed

Safety and Efficacy of SP-103 in Subjects With Moderate to Severe Acute Lower Back Pain

Moderate to Severe Acute Lower Back Pain

United States
Hackensack Meridian Health

Terminated

Ketamine for Pain in the Emergency Department

Acute Pain

United States
UNICEF - Venezuela

Terminated

Simplified Treatment Protocol for Acute Malnutrition in Venezuela

Wasting | Acute Malnutrition in Childhood | Child Malnutrition

Venezuela
Centre Hospitalier de Saint-Brieuc

Completed

Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients

Acute Respiratory Distress Syndrome | Ventilator-Induced Lung Injury

France
Unither Pharmaceuticals, France
EXCELYA Bordeaux

Completed

Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction

Acute Pain

France, Russian Federation, Belgium, Hungary, United Kingdom
Catholic University of the Sacred Heart

Suspended

Artificial Increase in Chest Wall Elastance as an Alternative to Prone Positioning in Moderate-to-severe ARDS. (ALTERPRONE)

Acute Respiratory Distress Syndrome

Italy
Saskatchewan Health Authority - Regina Area

Completed

Airway Pressure Release Ventilation for Moderate-to-severe Acute Respiratory Distress Syndrome (EARL)

Acute Respiratory Distress Syndrome

Canada
I.M. Sechenov First Moscow State Medical University

Completed

Noninvasive Ventilation in Moderate-to-severe COVID-19-associated Acute Respiratory Distress-syndrome (COVID-NIV)

Covid19 | ARDS

Russian Federation
University Hospital, Montpellier

Completed

Impact of the Obstructive Sleep Apnea Syndrome (OSAS) on the Ventricular Remodeling After Acute Myocardial Infarction (SAS-IDM)

Recent Acute Myocardial Infarction

France
Jiangsu HengRui Medicine Co., Ltd.

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of HR18042 Tablets in the Treatment of Postoperative Pain of Impacted Tooth.

Moderate to Severe Acute Pain

China
Menarini Group

Completed

Tramadol Hydrochloride and Dexketoprofen Trometamol for the Oral Treatment of Moderate to Severe Acute Pain Following Removal of Impacted Lower Third Molar (DAVID)

Acute Pain

Italy, Hungary, Spain, Poland, United Kingdom
Trevena Inc.

Completed

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty

Acute Pain

United States
Trevena Inc.

Completed

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy (APOLLO-1)

Acute Pain

United States
Trevena Inc.

Completed

A Study of TRV130 for the Treatment of Pain After Bunionectomy

Acute Pain

United States
Mercy Health Ohio

Terminated

Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain

Pain, Acute

United States
Mallinckrodt

Terminated

Pharmacokinetics (PK) and Safety Study of XARTEMIS® XR in Postsurgical Adolescent Subjects With Moderate to Severe Acute Pain

Acute Pain

United States
Mallinckrodt

Completed

A Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of IV Acetaminophen for the Treatment of Acute Pain in Pediatric Patients

Acute Pain

United States
Mallinckrodt

Terminated

Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain

Acute Pain, Postoperative

United States
Laboratorios del Dr. Esteve, S.A.
Premier Research Group plc

Completed

Co-crystal E-58425 vs Tramadol and Celecoxib for Moderate to Severe Acute Pain After Bunionectomy. Phase III Clinical Trial.

Acute Post-surgical Pain

United States
Mundipharma SAS
AXONAL; Exystat

Completed

Efficacy and Safety of Penthrox® Combined With a Standard Analgesia (SoC) in Adult Patients Admitted to the Emergency Department With Moderate to Severe Pain Associated With Trauma (Pen ASAP)

Pain, Acute

France
Montefiore Medical Center

Completed

Safety Study of Intravenous Hydromorphone Using Incremental 1mg Doses up to 2mg for Adult ED Patients

Pain

United States
AcelRx Pharmaceuticals, Inc.

Completed

Study to Evaluate the Overall Performance of the Zalviso System™ (Sufentanil Sublingual Tablet System) 15 mcg

Moderate-to-severe Acute Pain

United States
Grünenthal GmbH
Depomed

Terminated

Use of Tapentadol Oral Solution for Pain After Surgery in Children From Newborn to Less Than 2 Years Old

Moderate to Severe Acute Postoperative Pain

United States, United Kingdom, Poland
AcelRx Pharmaceuticals, Inc.
U.S. Army Medical Research and Development Command

Completed

Open-Label Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg for Acute Pain

Moderate-to-severe Acute Pain

United States
University of Utah

Terminated

A Dosing and Efficacy Study of Intra-nasal Sufentanil for Moderate to Severe Pain

Pain | Opiate

United States
Mallinckrodt

Withdrawn

Pharmacokinetics and Safety of MNK-155 in Postsurgical Adolescent Subjects With Moderate to Severe Acute Pain

Acute Pain

United States
AcelRx Pharmaceuticals, Inc.

Completed

A Multicenter, Open-Label Trial to Evaluate the Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg in Patients With Post-Operative Pain

Acute Moderate-to-severe Pain

United States
Novartis Pharmaceuticals

Completed

Efficacy of Lumiracoxib in Relieving Moderate to Severe Post-dental Surgery Pain, Compared to Both Placebo and Celecoxib

Pain

United States
Charleston Laboratories, Inc

Completed

A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip

Pain | Nausea | Vomiting

United States
Joseph Hazelton

Completed

A Double-Blind, Randomized, Active- and Placebo-Controlled, Multiple-Dose Multi-Center Phase 3 Study of the Safety and Efficacy of CL-108 in the Treatment of Moderate to Severe Acute Pain and Opioid-Induced Nausea and Vomiting (OINV)

Pain | Nausea | Vomiting

United States
Menarini Group

Completed

Oral Treatment for Gynaecological Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride (DAVID lap)

Acute Pain

Romania, Poland, Hungary, Latvia, Lithuania, Russian Federation, Slovakia, Spain
Menarini Group

Completed

Oral Treatment for Orthopaedic Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride (DAVID-art)

Acute Pain

Serbia, Latvia, Spain, Hungary, Lithuania, Poland, Taiwan, Czech Republic, Germany, Ukraine
Purdue Pharma LP

Withdrawn

Pharmacokinetics, Safety, and Efficacy of Intravenous Dosing of Buprenorphine in Pediatric Patients Who Require Opioid Analgesia for Acute Moderate to Severe Pain

Other Acute Postoperative Pain | Prolonged Endotracheal Intubation
Janssen Pharmaceutica

Withdrawn

A Safety and Effectiveness Study of Immediate Release Tapentadol Hydrochloride Among Filipino Patients With Moderate to Severe Acute Non-Cancer Pain

Moderate to Severe Acute Non-Cancer Pain
Merck Sharp & Dohme LLC

Withdrawn

Safety and Efficacy Study of an Etoricoxib and Tizanidine Fixed Dose Combination in Participants With Moderate to Severe Acute Low Back Pain (MK-0663B-164)

Low Back Pain
Janssen Cilag N.V./S.A.

Terminated

Safety and Efficacy Study of Fentanyl Iontophoretic Transdermal System (ITS) for Management of Moderate to Severe Acute Pain in Participants Who Have Undergone Elective Spine or Orthopedic Surgery

Pain, Postoperative

Belgium
Xian-Janssen Pharmaceutical Ltd.

Completed

An Efficacy and Safety Study of Tramadol Hydrochloride-Paracetamol in Treatment of Moderate to Severe Acute Neck-Shoulder Pain and Low Back Pain

Low Back Pain | Neck Pain | Shoulder Pain
QRxPharma Inc.

Completed

Extension Study to Evaluate the Safety of Q8003 in Patients With Acute Moderate to Severe Pain

Acute Moderate to Severe Pain

United States
Pfizer

Completed

A Clinical Study To Characterize The Pharmacokinetics And The Effects Of Food On Oxycodone In Healthy Volunteers

Chronic Pain | Analgesia | Acute Pain | Opioid-related Disorders | Narcotic Abuse

United States
International Food Policy Research Institute
UNICEF; Ethiopian Public Health Association

Not yet recruiting

Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia (R-SWITCH)

Wasting | Malnutrition, Child | Acute Malnutrition, Severe
University of Macau

Not yet recruiting

Acute Effects of Exercise Combined With Ketone Ester Supplement

Cognitive Change | Overweight and Obesity | Ketoses, Metabolic
Antonios Likourezos

Not yet recruiting

Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED (KETAFEN)

Pain, Acute
Mesoblast, Ltd.

Not yet recruiting

Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain (HyaluronicAcid)

Degenerative Disc Disease
The Second Affiliated Hospital of Chongqing Medical...
Wuhan University; Tongji Hospital; The First Affiliated Hospital of Zhengzhou... and other collaborators

Recruiting

Effect of Noise Isolation on the Incidence of Moderate to Severe Postoperative Pain

Postoperative Pain

China
University Hospital, Rouen

Not yet recruiting

Nebulized Fentanyl in Healthy Volunteers (AEROfen)

Emergencies | Analgesia

France

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