Search clinical trials for: Multiple ascending doses (MAD)

Total 17487 results

Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.
R&G Pharma Studies Co.,Ltd.

Completed

To Evaluate the Safety, Tolerability, and Pharmacokinetics Profile in Healthy Chinese Volunteers of TG-2349

Healthy Chinese Volunteers

China
Galapagos NV

Completed

A Study to Evaluate the Effects of a Single and Multiple Oral Doses of GLPG3121 in Adult, Healthy, Male Subjects

Healthy

Belgium
Hoffmann-La Roche

Completed

A Single Ascending And Multiple Ascending Dose Study of RO5271983 in Healthy Volunteers

Healthy Volunteer

New Zealand
Theravance Biopharma

Completed

SAD and MAD Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of TD-1473 in Healthy Subjects

Healthy

United States
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-777991 in Healthy Subjects

Healthy

Netherlands
Universidad Complutense de Madrid

Active, not recruiting

Effect of Soft Tissue Augmentation With an Acellular Dermal Matrix in Marginal Bone Levels Around Implants

Dental Implant Failure Nos

Spain
Aurinia Pharmaceuticals Inc.

Completed

Voclosporin in Healthy Japanese Volunteers

Volunteers

Philippines
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of IBI356 in Healthy Participants and in Atopic Dermatitis Patients

Healthy Participants | Atopic Dermatitis Patients

China
Shanghai Jiatan Pharmatech Co., Ltd

Completed

Sudapyridine (WX-081) in Healthy Volunteers

Healthy

China
Theravance Biopharma

Completed

Multiple Ascending Dose Study of TD-1439 in Healthy Adult and Elderly Subjects

Healthy Adults, Elderly Subjects

United States
Abbott

Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of the ABT-333 Tablet

HCV Infection

United States
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-1014-6470 in Healthy Subjects

Healthy

Netherlands
Chiesi Farmaceutici S.p.A.

Completed

A Study to Investigate Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of CHF6333 in Healthy Subjects (CHF6333 FIH)

Cystic Fibrosis | Non-Cystic Fibrosis Bronchiectasis

Belgium
Kowa Company, Ltd.

Completed

A Study to Evaluate the Safety of K-755 in Healthy Volunteers

Healthy

Australia
EnnovaBio Australia Pharmaceuticals Pty Ltd

Not yet recruiting

A First-in-Human SAD/MAD Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ENC1018 in Healthy Adult Subjects

Healthy
The VA Western New York Healthcare System

Unknown

A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder

Obstructive Sleep Apnea
7 Hills Pharma, LLC
Frontage Clinical Services, Inc.

Completed

A Phase 1 SAD and MAD Study of the Safety, Tolerability and PK of 7HP349 in Normal Healthy Male Subjects

Solid Tumor

United States
ZYUS Life Sciences Inc.
Novotech (Australia) Pty Limited; ZYUS Life Sciences Australia Pty Ltd

Completed

Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain Evaluation (HOPE)

Healthy | Osteoarthritis

Australia
University of Alberta

Recruiting

The Effect of Mandibular Advancement Devices on Markers of Cardiovascular Health in Obstructive Sleep Apnea Patients

Obstructive Sleep Apnea

Canada
JMackem Co., Ltd
Seoul National University Hospital

Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Oral Administration of AJH-2947 in Healthy Korean and/or Caucasian Adult Male Subjects

Diabetic Neuropathies | Neuropathic Pain | Post Herpetic Neuralgia

Korea, Republic of
Centre hospitalier de l'Université de Montréal...

Recruiting

Tolerance and Benefits of Mandibular Advanced Device for Snoring and Sleep Apnea in Oropharyngeal Cancer. (Ronco-Onco)

Snoring | Sleep Apnea | Oral Cancer | Oral Squamous Cell Carcinoma | Pharynx Cancer

Canada
University Hospital Schleswig-Holstein

Recruiting

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes

Safety Issues | Pharmacokinetic

Germany
Universidad Autonoma de Baja California

Completed

Supporting the Medication Adherence of Older Mexican Adults Through External Cues Provided With Ambient Displays

Medication Adherence | Medication Compliance

Mexico
ethisch.comite@uza.be

Completed

PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea (PROMAD)

Obstructive Sleep Apnea Syndrome

Belgium
Chiesi Farmaceutici S.p.A.

Completed

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Inhaled CHF6001 (CHF6001Ext)

Chronic Obstructive Pulmonary Disease

United Kingdom
Spero Therapeutics
Simbec Research

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers

Healthy Volunteers

United Kingdom
University Hospital, Antwerp

Completed

Efficacy of Additional Titration During Oral Appliance Treatment for Sleep-disordered Breathing.

Obstructive Sleep Apnea Syndrome

Belgium
University of Barcelona

Suspended

Side Effects of the Mandibular Advancement Device for Apnea Treatment on Dental Occlusion and Masticatory Function

Obstructive Sleep Apnea

Spain
Inmagene LLC

Completed

Study to Evaluate IMG-004 in Healthy Participants

Healthy Participants

United States
AstraZeneca
Parexel

Recruiting

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 Following Single and Multiple Ascending Doses Via Oral Administration to Healthy Participants

Healthy Participants

United States
Pharmacobio

Recruiting

A Phase I Study of DDN-A-0101 in Healthy Volunteers and Elder People

Alzheimer Disease

Korea, Republic of
Beijing Jishuitan Hospital

Recruiting

A New Objective Titration Procedure for the Treatment of Mandibular Advancement Device in OSAHS Patients

Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)

China
Syneos Health
SynerK Pharmatech (Suzhou) Limited

Recruiting

Dose Escalation of SNK-396 in Participants With Elevated Low-Density Lipoprotein Cholesterol

Elevated Low-Density Lipoprotein Cholesterol

Australia
ResMed

Recruiting

Long-term Benefits of CPAP or MAD Treatment on the Sleep of OSAS Patients (REMAP)

OSA

France
Johns Hopkins University

Withdrawn

Feasibility and Efficacy of Dietary Interventions for Older Adults With Subjective Cognitive Decline

Cognitive Impairment | Alzheimer Disease
VA Office of Research and Development

Completed

A Randomized Cross Over Trial of Two Treatments for Sleep Apnea in Veterans With Post-Traumatic Stress Disorder

Obstructive Sleep Apnea

United States
All India Institute of Medical Sciences, New Delhi

Unknown

Comparison of Efficacy of LGIT and MAD Among Children With Drug Resistant Epilepsy

Drug Resistant Epilepsy | Ketogenic Dieting

India
Erasmus Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Recruiting

MAD Trial: Myopia Atropine Dose (MAD)

Progressive Myopia

Netherlands
GlaxoSmithKline

Completed

First Time in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of GSK3389404 in Healthy Subjects

Hepatitis B

United Kingdom
Rob Erskine
University of East Anglia

Completed

Resistance Exercise and Hydrolyzed Collagen Supplementation

Diet, Food, and Nutrition

United Kingdom
University of Copenhagen
Sygekassernes Helsefond; Københavns Kommune; The Danish Dental Association; Postgraduate... and other collaborators

Active, not recruiting

Sleep, Upper Airway and Dental Occlusion in Children With Large Overjet

Overjet, Dental

Denmark
National Cancer Centre, Singapore

Recruiting

Impacts of Durian Consumption on Human Microbiome and Metabolome in Healthy Staff Volunteers (DURIOME)

Diet, Food and Nutrition

Singapore
Biogen

Completed

Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of BIIB033 in Healthy Japanese Participants

Multiple Sclerosis | Central Nervous System (CNS) Demyelinating Disease

United Kingdom
Case Western Reserve University

Completed

Mindfulness Attitude to Deliver Dietary Approach to Stop Hypertension (MADDASH)

Prehypertension
ViiV Healthcare

Terminated

Evaluation of the Safety, Tolerability and Pharmacokinetics (PK) of GSK3732394 First-Time-in-Human (FTIH) Study

HIV Infections

United States
University of Minnesota

Completed

Effect of Bran Fiber Type on Subjective and Objective Measures of Appetite

Food

United States
University Medicine Greifswald

Completed

Side Effects of Mandibular Advancement Devices

Obstructive Sleep Apnea Syndrome | Temporomandibular Disorders

Germany
The University of Tennessee, Knoxville

Withdrawn

Fruit & Vegetable Provision Study

Food Security

United States
AstraZeneca

Completed

Single and Multiple Ascending Dose Study for NKTR-118 and Cross-over Study to Investigate the Effect of Food for NKTR-118 in Japanese Healthy Subjects (Japan SMAD)

Healthy

Japan
Biogen

Completed

Multiple Ascending Doses of PF-04958242 in Subjects With Stable Schizophrenia (MAD)

Schizophrenia

United States

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